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Roche Holding (RHHBY)
OTHER OTC:RHHBY
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Roche Holding (RHHBY) AI Stock Analysis

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RHHBY

Roche Holding

(OTC:RHHBY)

Rating:74Outperform
Price Target:
$45.00
▲(15.86%Upside)
Roche Holding's overall score is strengthened by its financial performance and positive earnings call sentiment. While technical analysis indicates a neutral market stance, the company's valuation remains balanced with a reasonable P/E ratio and attractive dividend yield. The absence of impactful corporate events beyond the earnings call allows for a focused evaluation on its fundamental strengths and strategic outlook.
Positive Factors
Clinical Trial Results
Early trontinemab data shows competitive amyloid clearance and improved ARIA rate versus peers, but clinical outcomes will determine success.
Financial Performance
Roche's model was updated and numbers raised post recent business trends, with sales and EPS growth estimates increased.
Product Efficacy
Gazyva showed potential best-in-class profile in lupus nephritis and is likely to be the starter therapy of choice versus GSK's Benlysta.
Negative Factors
Clinical Trial Safety
There was a case of fatal cerebral macrohemorrhage in Part 2, leading to updated trial criteria to exclude patients with superficial siderosis.
Placebo Response
The high placebo response rate in males was notable, where placebo achieved a 66.7% complete renal response compared to 42.9% for Gazyva.

Roche Holding (RHHBY) vs. SPDR S&P 500 ETF (SPY)

Roche Holding Business Overview & Revenue Model

Company DescriptionRoche Holding AG engages in the pharmaceuticals and diagnostics businesses in Switzerland, Germany, the United States, Austria, Netherlands, the United Kingdom, France, Belgium, and internationally. The company offers pharmaceutical products for treating oncology, neuroscience, infectious, immunology, cardiovascular and metabolism, ophthalmology, and respiratory, as well as anemia, cancer, dermatology, hemophilia, inflammatory and autoimmune, neurological, and transplantation. It also offers in vitro tests for the diagnosis of various diseases, such as cancer, diabetes, Covid-19, hepatitis, human papillomavirus, and other diseases. In addition, the company supplies diagnostic instruments and reagents. The company was founded in 1896 and is headquartered in Basel, Switzerland.
How the Company Makes MoneyRoche Holding AG generates revenue primarily through the sale of prescription pharmaceuticals and diagnostic products. In the Pharmaceuticals division, revenue is driven by key therapeutic areas such as oncology, where Roche is a market leader due to its innovative cancer treatments. The Diagnostics division contributes to revenue through the sale of instruments, reagents, and test kits used in disease detection and monitoring. Additionally, Roche has significant partnerships with research institutions and other pharmaceutical companies, which can provide collaborative revenue streams and enhance its research and development capabilities. The company's earnings are further supported by its global distribution network and a strong focus on research and development, allowing it to continually bring new and effective healthcare solutions to market.

Roche Holding Earnings Call Summary

Earnings Call Date:Jul 24, 2025
(Q2-2025)
|
% Change Since: -5.59%|
Next Earnings Date:Jan 29, 2026
Earnings Call Sentiment Positive
The earnings call highlighted strong sales growth in Pharmaceuticals, successful product approvals, and robust pipeline expansion. However, the flat performance in Diagnostics due to China reforms, mixed clinical trial results, and ongoing geopolitical and currency risks were significant concerns. Despite these challenges, the overall performance and strategic advancements suggest a positive outlook.
Q2-2025 Updates
Positive Updates
Strong Group Sales Growth
Overall group sales increased by 7%, with Pharmaceuticals growing by 10% and Diagnostics flat due to China healthcare pricing reforms. Core operating profit grew by 11%, and core EPS increased by 12%.
Pharmaceutical Milestones
Approval of Itovebi in the EU and Susvimo in the U.S., with strong performance in oncology, neurology, and immunology sectors. Vabysmo and Xolair showed significant growth, and Columvi was approved in 35 countries.
Diagnostics Achievements
Launch of Accu-Chek SmartGuide and mass spectrometry solutions, with new segments entering multibillion markets. Core Lab excluding China grew by 9%.
R&D Excellence and Pipeline Expansion
Four medicines moved into Phase III, with an increase in the share of best-in-disease potential assets to 67%. A significant reduction in R&D costs while maintaining robust pipeline growth.
Negative Updates
Diagnostics Impacted by China Reforms
Diagnostics sales were flat due to China healthcare pricing reforms, with a 26% sales decline in China. This impact is expected to continue throughout 2025.
Mixed Study Results
Astegolimab had mixed results in COPD studies, with one positive and one negative trial outcome.
Regulatory Challenges for Columvi
Received a CRL from the FDA for second-line DLBCL indication in the U.S., though the rollout continues ex-U.S.
Currency and Geopolitical Risks
Concerns about ongoing geopolitical turbulences and currency impacts, with a 3-6% negative impact on financial results.
Company Guidance
In the call, Roche provided a comprehensive update on its financial performance and strategic initiatives. The company reported a 7% increase in group sales, with Pharmaceuticals showing strong growth at 10% and even 11% in Q2. Diagnostics remained flat due to pricing reforms in China, but would have grown by 6% without these reforms. Core operating profit rose by 11%, with a 1.1 percentage point increase in the core operating margin, and core EPS grew by 12%. Roche lowered its full-year loss of exclusivity (LOE) impact guidance to CHF 1 billion from CHF 1.2 billion. Key milestones included EU approval of Itovebi, U.S. approval of Susvimo, and several Phase III transitions, including prasi in Parkinson's disease and zosu as a novel antibiotic for gram-negative bacteria. The company highlighted the strong momentum of Vabysmo with 18% growth and Xolair's impressive performance with over 60,000 patients in the U.S. Roche also reaffirmed its commitment to R&D excellence, mentioning a 26% increase in the total value of its portfolio and improvements in pipeline project peak sales by 55%. The company emphasized its disciplined approach to cost management, achieving CHF 1 billion in savings towards a 2030 target of CHF 3 billion, with reinvestments in innovation and productivity. Roche maintained a conservative guidance, citing geopolitical uncertainties but expressed confidence in its ability to deliver, highlighting its track record of exceeding guidance in recent years.

Roche Holding Financial Statement Overview

Summary
Roche Holding has strong revenue growth and a solid gross profit margin, indicating efficient cost management. However, the decline in net income and return on equity, along with increased leverage, suggests some pressure on profitability. Strong cash flow generation provides a solid financial foundation despite these challenges.
Income Statement
75
Positive
Roche Holding has shown consistent revenue growth with a compound annual growth rate of approximately 1.33% over the past five years. The gross profit margin is strong, averaging around 72.5%, indicating efficient cost management. However, there has been a decline in net income, leading to a reduced net profit margin from 24.5% in 2020 to 13.3% in 2024. EBIT and EBITDA margins have been stable but slightly declining, which could indicate pressure on operational efficiency.
Balance Sheet
80
Positive
The company's equity ratio is solid at around 31.2%, reflecting a stable capital structure. The debt-to-equity ratio has increased due to rising total debt, but it remains manageable at approximately 1.14 in 2024. Return on equity has decreased from 39.4% in 2020 to 26.1% in 2024, suggesting a decline in profitability relative to shareholder equity. The balance sheet remains robust, but the increase in leverage warrants monitoring.
Cash Flow
78
Positive
Roche Holding's operating cash flow is strong, and the company maintains a healthy free cash flow to net income ratio, indicating efficient cash conversion. Free cash flow growth has been positive, but the growth rate has slowed, suggesting potential challenges in maintaining past growth levels. The operating cash flow to net income ratio is above 2, demonstrating strong cash generation capabilities relative to earnings.
BreakdownDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue62.40B60.44B63.28B62.80B58.32B
Gross Profit46.11B44.08B44.44B43.10B41.97B
EBITDA16.62B18.41B20.80B22.19B22.97B
Net Income8.28B11.50B12.42B13.93B14.29B
Balance Sheet
Total Assets101.80B90.47B88.15B92.32B86.14B
Cash, Cash Equivalents and Short-Term Investments17.32B10.51B9.77B13.03B12.33B
Total Debt36.35B30.78B26.54B32.55B15.41B
Total Liabilities65.64B57.20B56.14B63.97B46.37B
Stockholders Equity31.77B29.32B27.99B24.49B36.34B
Cash Flow
Free Cash Flow15.09B11.45B13.34B16.02B11.47B
Operating Cash Flow20.09B16.09B17.89B20.57B18.16B
Investing Cash Flow-11.39B-10.64B-3.57B-6.55B-9.08B
Financing Cash Flow-6.82B-4.24B-15.72B-12.70B-9.24B

Roche Holding Technical Analysis

Technical Analysis Sentiment
Negative
Last Price38.84
Price Trends
50DMA
40.34
Negative
100DMA
40.17
Negative
200DMA
38.74
Positive
Market Momentum
MACD
-0.20
Positive
RSI
38.08
Neutral
STOCH
14.33
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For RHHBY, the sentiment is Negative. The current price of 38.84 is below the 20-day moving average (MA) of 40.27, below the 50-day MA of 40.34, and above the 200-day MA of 38.74, indicating a neutral trend. The MACD of -0.20 indicates Positive momentum. The RSI at 38.08 is Neutral, neither overbought nor oversold. The STOCH value of 14.33 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for RHHBY.

Roche Holding Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
79
Outperform
$228.17B27.5519.76%2.08%15.17%29.15%
79
Outperform
$196.16B12.0439.31%4.04%2.01%
78
Outperform
$402.99B17.9030.21%3.00%4.69%34.88%
76
Outperform
$222.51B16.5932.82%3.46%12.83%-11.92%
74
Outperform
$257.51B22.6731.98%3.51%7.26%-8.64%
73
Outperform
$113.81B11.628.39%4.73%-9.32%120.62%
51
Neutral
$7.35B0.50-65.61%2.47%15.28%1.44%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
RHHBY
Roche Holding
38.84
0.30
0.78%
AZN
AstraZeneca
73.95
-3.81
-4.90%
JNJ
Johnson & Johnson
167.33
11.17
7.15%
MRK
Merck & Company
79.29
-29.35
-27.02%
NVS
Novartis
115.30
8.68
8.14%
SNY
Sanofi
46.75
-3.11
-6.24%
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jul 30, 2025