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Repligen Corp (RGEN)
NASDAQ:RGEN
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Repligen (RGEN) AI Stock Analysis

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RGEN

Repligen

(NASDAQ:RGEN)

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Neutral 68 (OpenAI - 4o)
Rating:68Neutral
Price Target:
$182.00
▲(9.41% Upside)
Repligen's overall stock score reflects strong earnings call performance and positive technical indicators, tempered by high valuation concerns. The company's financial performance is stable, with opportunities for improvement in profitability. The positive sentiment from the earnings call and technical momentum are significant strengths, while the high P/E ratio is a notable risk.
Positive Factors
Organic Growth
Strong organic growth across all franchises indicates robust demand for Repligen's products, supporting long-term revenue expansion and market position.
Geographical Expansion
Significant growth in Asia Pacific and other regions enhances Repligen's global footprint, diversifying revenue streams and reducing dependency on any single market.
Gross Margin Improvement
Improved gross margins reflect better cost management and operational efficiency, which can lead to sustained profitability and competitive pricing strategies.
Negative Factors
China Market Challenges
Challenges in the Chinese market could hinder growth prospects and affect revenue, given China's significant role in the global biopharmaceutical landscape.
Filtration Growth Constraints
Slower than expected growth in filtration may impact overall revenue growth, as this segment is crucial to Repligen's product offerings and market strategy.
Gene Therapy Platform Impact
The anticipated decline from a key gene therapy customer could affect short-term revenue, highlighting vulnerability to customer-specific demand fluctuations.

Repligen (RGEN) vs. SPDR S&P 500 ETF (SPY)

Repligen Business Overview & Revenue Model

Company DescriptionRepligen Corporation develops and commercializes bioprocessing technologies and systems for use in biological drug manufacturing process in North America, Europe, the Asia Pacific, and internationally. It offers Protein A ligands that are the binding components of Protein A affinity chromatography resins; and cell culture growth factor products. The company's chromatography products include OPUS pre-packed chromatography columns, which are used in the purification of biologics; and OPUS smaller-scale columns that are used in the high throughput process development screening, viral clearance validation studies, and scale down validation of chromatography processes. It also offers ELISA test kits; and chromatography resins under the CaptivA brand. In addition, the company provides filtration products, such as XCell Alternating Tangential Flow systems that are filtration devices used in upstream perfusion and cell culture processing; TangenX flat sheet cassettes, which are used in downstream biologic drug concentration and formulation processes; KrosFlo tangential flow filtration and tangential flow depth filtration systems; Spectra/Por laboratory and process dialysis products, and SpectraFlo dynamic dialysis systems; and ProConnex single-use hollow fiber. Further, it provides process analytics products, such as slope spectroscopy systems under the SoloVPE, FlowVPE, and FlowVPX brands. The company sells its products to life sciences, biopharmaceutical, and diagnostics companies; laboratory researchers; and contract manufacturing organizations. Repligen Corporation has collaboration agreements with Navigo Proteins GmbH to develop multiple affinity ligands. Repligen Corporation was incorporated in 1981 and is headquartered in Waltham, Massachusetts.
How the Company Makes MoneyRepligen generates revenue through the sale of its bioprocessing products and solutions to pharmaceutical and biotechnology companies. The company's revenue model is primarily based on product sales, which include consumables, instruments, and systems used in the biomanufacturing process. Key revenue streams come from the sale of chromatography resins, filtration systems, and other essential bioprocessing technologies. Additionally, Repligen benefits from long-term partnerships with major pharmaceutical companies, which often involve supply agreements for its proprietary products. The company's focus on innovation and expanding its product portfolio, coupled with increasing demand for biologics, further contributes to its earnings.

Repligen Earnings Call Summary

Earnings Call Date:Jul 29, 2025
(Q2-2025)
|
% Change Since: |
Next Earnings Date:Feb 25, 2026
Earnings Call Sentiment Positive
The earnings call reflects a strong performance with significant organic growth, record order growth, and improved financial guidance. However, challenges remain, particularly with the China market and gene therapy headwinds. Despite these challenges, the company is optimistic about its strategic investments and future growth opportunities.
Q2-2025 Updates
Positive Updates
Strong Organic Non-COVID Growth
Repligen achieved 17% organic non-COVID growth in Q2 2025, marking the highest growth rate since 2022. This includes 20% revenue growth in biopharma and strong performance across all regions.
Record Order Growth
Orders grew over 20% year-over-year and high teens organically, marking the eighth consecutive quarter of orders exceeding non-COVID revenue.
Capital Equipment Performance
Capital equipment revenue returned to growth in the high teens, with orders growing greater than 20%, driven by traction in ATS and downstream systems.
Chromatography Segment Success
Chromatography had a record quarter with greater than 40% revenue growth, driven by large-scale column demand from pharma and Europe.
Positive Financial Guidance
Repligen increased its revenue guidance to $715 million to $735 million, reflecting 12.5% to 15.5% organic non-COVID growth.
Negative Updates
China Market Challenges
While China orders picked up significantly, the company remains cautious due to potential tariff-related dynamics affecting future performance.
Gene Therapy Revenue Headwind
The gene therapy platform represented $10 million of revenue in the first half of 2025 with minimal incremental revenue expected for the remainder of the year, posing a 1% headwind to guidance.
Muted New Modality Demand
New modalities revenue grew mid-teens, but orders were flat, leading to expectations of muted demand in the second half of 2025.
Gross Margin Pressure
Gross margin was flat year-over-year at 51.1%, with mix and tariffs slightly impacting margins.
Company Guidance
During Repligen Corporation's second quarter 2025 earnings call, the company provided detailed financial guidance for the full year. Repligen reported a 17% organic non-COVID revenue growth, with key performance driven by Chromatography, which saw over 40% revenue growth, and Filtration, which posted mid-teens non-COVID growth. The company experienced a strong demand for consumables, with capital equipment growing in the high teens. Geographically, all regions saw mid-teens growth, with China orders notably rebounding. Repligen raised its organic growth guidance, expecting full-year revenue between $715 million to $735 million, reflecting 12.5% to 15.5% organic non-COVID growth. The company aims for gross margins of 52% to 53% and an adjusted operating margin between 13.5% and 14.5%. The strategy includes doubling the company's size in the medium term, focusing on organic growth with modest M&A assumptions, maintaining profitability, and expanding gross margins and operating leverage.

Repligen Financial Statement Overview

Summary
Repligen demonstrates moderate financial health with growth in revenue and operational efficiency. The balance sheet is stable with manageable leverage, though profitability metrics like net profit margin and return on equity are areas for improvement. Cash flow generation is positive, supporting operational needs. Overall, the company is on a stable trajectory with opportunities to enhance profitability and cash flow efficiency.
Income Statement
65
Positive
Repligen's income statement shows moderate growth and profitability. The TTM (Trailing-Twelve-Months) revenue growth rate is 5.04%, indicating a recovery from previous declines. Gross profit margin improved to 47.90% TTM, reflecting efficient cost management. However, net profit margin remains low at 0.25% TTM, suggesting challenges in converting revenue into profit. EBIT and EBITDA margins have improved, indicating better operational efficiency.
Balance Sheet
70
Positive
The balance sheet reflects a stable financial position with a debt-to-equity ratio of 0.33 TTM, indicating manageable leverage. The equity ratio is healthy, suggesting a strong asset base. However, return on equity is low at 0.09% TTM, highlighting limited returns on shareholder investments. Overall, the balance sheet shows stability with room for improvement in profitability.
Cash Flow
68
Positive
Cash flow analysis reveals positive trends with a free cash flow growth rate of 1.66% TTM, indicating improved cash generation. The operating cash flow to net income ratio is nearly 1, suggesting good cash conversion. However, the free cash flow to net income ratio is 0.81 TTM, indicating some challenges in translating profits into free cash flow. Overall, cash flow management appears solid with potential for further optimization.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue707.89M634.44M632.36M801.54M670.53M366.26M
Gross Profit321.25M274.64M278.44M455.71M391.25M194.35M
EBITDA133.76M80.26M145.32M277.31M203.27M98.42M
Net Income1.74M-25.51M35.60M185.96M128.29M59.93M
Balance Sheet
Total Assets2.92B2.83B2.83B2.53B2.36B1.90B
Cash, Cash Equivalents and Short-Term Investments748.75M757.36M751.32M623.76M603.81M717.29M
Total Debt688.87M686.25M711.80M422.96M366.05M275.42M
Total Liabilities840.62M856.95M866.34M620.90M608.29M373.74M
Stockholders Equity2.08B1.97B1.96B1.91B1.75B1.53B
Cash Flow
Free Cash Flow106.48M142.49M74.93M38.74M47.74M36.28M
Operating Cash Flow130.89M175.39M113.92M172.08M119.02M62.63M
Investing Cash Flow-154.49M-86.38M-123.28M-233.24M-221.17M-201.38M
Financing Cash Flow-13.95M-82.90M248.96M-13.34M961.00K305.92M

Repligen Technical Analysis

Technical Analysis Sentiment
Positive
Last Price166.35
Price Trends
50DMA
149.62
Positive
100DMA
134.78
Positive
200DMA
134.43
Positive
Market Momentum
MACD
5.76
Negative
RSI
61.19
Neutral
STOCH
84.22
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For RGEN, the sentiment is Positive. The current price of 166.35 is above the 20-day moving average (MA) of 155.62, above the 50-day MA of 149.62, and above the 200-day MA of 134.43, indicating a bullish trend. The MACD of 5.76 indicates Negative momentum. The RSI at 61.19 is Neutral, neither overbought nor oversold. The STOCH value of 84.22 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for RGEN.

Repligen Risk Analysis

Repligen disclosed 41 risk factors in its most recent earnings report. Repligen reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Repligen Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
78
Outperform
$5.13B44.328.30%11.49%-2.89%
68
Neutral
$9.63B6,654.470.08%11.74%
67
Neutral
$6.37B41.069.81%0.27%9.19%23.06%
60
Neutral
$8.19B19.9915.80%1.48%2.50%25.05%
60
Neutral
$4.83B-7.90%1.19%5.43%-245.18%
56
Neutral
$5.73B-4.69%6.23%17.53%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
RGEN
Repligen
166.35
15.89
10.56%
ATR
AptarGroup
123.28
-47.36
-27.75%
MMSI
Merit Medical Systems
86.39
-18.44
-17.59%
TFX
Teleflex
114.41
-77.76
-40.46%
STVN
Stevanato Group
22.58
2.59
12.96%
BLCO
Bausch + Lomb Corporation
16.56
-2.91
-14.95%

Repligen Corporate Events

Repligen’s Q3 Earnings Call: Strong Growth and Positive Outlook
Oct 30, 2025

Repligen’s Q3 Earnings Call: Strong Performance and Positive Outlook

Repligen Corporation Reports Strong Q3 2025 Results
Oct 29, 2025

Repligen Corporation is a global life sciences company that specializes in developing and commercializing innovative bioprocessing technologies and systems, primarily serving biopharmaceutical drug developers and contract development and manufacturing organizations (CDMOs). The company is headquartered in Waltham, Massachusetts, with manufacturing sites in the U.S. and Europe.

Business Operations and StrategyExecutive/Board ChangesRegulatory Filings and Compliance
Repligen Appoints Violetta Hughes as Chief Accounting Officer
Positive
Sep 2, 2025

On September 2, 2025, Repligen Corporation announced the appointment of Violetta Hughes as the new Chief Accounting Officer, effective September 1, 2025. This strategic move aims to enhance the company’s financial reporting infrastructure and compliance with the Sarbanes–Oxley Act. Ms. Hughes, a seasoned finance executive with over 25 years of experience, will replace Jason K. Garland, who will continue as the Chief Financial Officer focusing on corporate strategy and growth. Her extensive background in financial governance and SOX compliance is expected to bring significant improvements to Repligen’s financial transparency and strategic decision-making processes.

The most recent analyst rating on (RGEN) stock is a Buy with a $207.00 price target. To see the full list of analyst forecasts on Repligen stock, see the RGEN Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 25, 2025