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Repligen (RGEN)
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Repligen (RGEN) AI Stock Analysis

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RGEN

Repligen

(NASDAQ:RGEN)

Rating:58Neutral
Price Target:
$126.00
▲(1.34% Upside)
Repligen's overall stock score is driven by its mixed financial performance and technical indicators suggesting bearish momentum. The positive outlook from the earnings call, with strong organic growth and increased guidance, partially offsets the valuation concerns due to negative earnings. The company's strategic focus on non-COVID growth areas and operational efficiency are key strengths.
Positive Factors
Earnings
Repligen's revenue of $182.4 million exceeded both the estimate of $177.1 million and the consensus of $175.2 million, highlighting strong financial performance.
Growth Strategy
Repligen expects to double its revenues in the medium-term with minimal contribution from mergers and acquisitions, indicating a robust organic growth strategy.
Market Position
Repligen's differentiated product portfolio is yielding outsized growth in a normalizing bioprocessing market, with non-COVID organic growth up 17% and orders up over 20% year-over-year.
Negative Factors
Earnings Guidance
Repligen expects full-year 2025 GAAP net earnings of $0.76 - $0.85 per diluted share, down from the original guidance range of $0.90 - $0.99 per diluted share.
Margin Pressure
Margins missed due to product mix dynamics, creating a 300-basis-point gross margin headwind.
Market Sentiment
A recent downturn in gene therapy sentiment due to recent news creates a 1% headwind in the newly raised FY25 guidance.

Repligen (RGEN) vs. SPDR S&P 500 ETF (SPY)

Repligen Business Overview & Revenue Model

Company DescriptionRepligen Corporation develops and commercializes bioprocessing technologies and systems for use in biological drug manufacturing process in North America, Europe, the Asia Pacific, and internationally. It offers Protein A ligands that are the binding components of Protein A affinity chromatography resins; and cell culture growth factor products. The company's chromatography products include OPUS pre-packed chromatography columns, which are used in the purification of biologics; and OPUS smaller-scale columns that are used in the high throughput process development screening, viral clearance validation studies, and scale down validation of chromatography processes. It also offers ELISA test kits; and chromatography resins under the CaptivA brand. In addition, the company provides filtration products, such as XCell Alternating Tangential Flow systems that are filtration devices used in upstream perfusion and cell culture processing; TangenX flat sheet cassettes, which are used in downstream biologic drug concentration and formulation processes; KrosFlo tangential flow filtration and tangential flow depth filtration systems; Spectra/Por laboratory and process dialysis products, and SpectraFlo dynamic dialysis systems; and ProConnex single-use hollow fiber. Further, it provides process analytics products, such as slope spectroscopy systems under the SoloVPE, FlowVPE, and FlowVPX brands. The company sells its products to life sciences, biopharmaceutical, and diagnostics companies; laboratory researchers; and contract manufacturing organizations. Repligen Corporation has collaboration agreements with Navigo Proteins GmbH to develop multiple affinity ligands. Repligen Corporation was incorporated in 1981 and is headquartered in Waltham, Massachusetts.
How the Company Makes MoneyRepligen generates revenue primarily through the sale of its bioprocessing products and technologies. Key revenue streams include the sale of chromatography resins, filtration products, and other consumables used in biomanufacturing processes. The company also derives income from its services related to product development and customer support. Significant partnerships with leading biopharmaceutical companies enhance its market presence and contribute to its earnings by ensuring consistent demand for its products. Additionally, Repligen's focus on innovation and expansion into new markets helps to drive growth and diversify its revenue base.

Repligen Earnings Call Summary

Earnings Call Date:Jul 29, 2025
(Q2-2025)
|
% Change Since: 3.92%|
Next Earnings Date:Nov 04, 2025
Earnings Call Sentiment Positive
Repligen's earnings call presented a strong performance with significant growth in non-COVID areas, particularly in biopharma and chromatography. Despite challenges from the gene therapy platform and muted biotech orders, the company's overall financial health, strategic initiatives, and increased guidance portray a positive outlook.
Q2-2025 Updates
Positive Updates
Strong Organic Non-COVID Growth
Repligen reported 17% organic non-COVID growth in Q2 2025, marking their highest growth rate since 2022. This growth was driven by strong performances across various segments such as Chromatography and Filtration.
Biopharma and CDMO Revenue Surge
Biopharma revenues grew 20% year-over-year, with orders also growing over 20%. CDMO revenues saw meaningful increases, with orders growing double digits.
Record Chromatography Revenue
Chromatography had a record quarter with greater than 40% revenue growth, driven by large-scale column demand from pharma in Europe.
Improved Guidance and Market Outlook
Repligen increased its 2025 revenue guidance to $715 million to $735 million, reflecting 12.5% to 15.5% organic non-COVID growth.
Strong Order Growth
Orders grew over 20% year-over-year and high teens organically, marking the eighth consecutive quarter of orders exceeding non-COVID revenue.
Sustainability Efforts Recognized
Repligen was named by Newsweek as one of the world's greenest companies in 2025, with a 25% reduction in waste generation last year.
Negative Updates
Gene Therapy Platform Revenue Headwind
The gene therapy platform represented $10 million of revenue in the first half of 2025, and the updated guidance assumes minimal incremental revenue from this platform for the remainder of the year, posing a 1% headwind.
Muted Biotech Orders
While biotech revenues grew high teens, orders remained muted due to a 42% drop in biotech funding compared to Q2 2024.
Tariff and Mix Headwinds on Margins
Tariffs and a higher-than-normal mix of procured resins in Chromatography posed headwinds to margins, alongside a 1 point margin impact from COVID revenue comparison.
Company Guidance
During the earnings call, Repligen provided financial guidance for the full year 2025, emphasizing strong organic growth and operational performance. The company reported a 17% organic non-COVID growth in Q2 2025, marking the highest growth rate since 2022. Biopharma revenues grew by 20%, with orders increasing over 20% year-over-year. The revenue guidance for 2025 was raised to $715 million to $735 million, reflecting 12.5% to 15.5% organic non-COVID growth. Additionally, adjusted gross margins are expected to be in the range of 52% to 53%, with operating margins projected to be between 13.5% and 14.5%. Repligen also expects adjusted diluted earnings per share to be between $1.65 and $1.72, reflecting a 5% to 9% growth compared to the previous year. The company remains focused on strategic investments and operational efficiency to deliver above-market growth.

Repligen Financial Statement Overview

Summary
Repligen's financial performance is mixed. The company shows strengths in its balance sheet with low leverage and a strong equity position. However, challenges in profitability, with declining net income and EBIT margins, are notable concerns. Operational cash flow remains positive despite these issues.
Income Statement
48
Neutral
Repligen's revenue shows a marginal growth from the previous year, but has declined from 2022. The gross profit margin for TTM is approximately 54.88%, indicating decent cost management. However, the company is experiencing negative net income and EBIT margins, highlighting profitability challenges. The EBITDA margin is positive at 13.80%, suggesting some operational efficiency.
Balance Sheet
65
Positive
The company's balance sheet is relatively strong with a debt-to-equity ratio of approximately 0.34, indicating low leverage. The equity ratio is around 69.60%, reflecting a healthy balance of equity financing. However, the return on equity is negative due to net losses, which is a concern for investors seeking returns.
Cash Flow
57
Neutral
Repligen's cash flow statement shows a decrease in free cash flow compared to the annual report, with a negative free cash flow growth rate. The operating cash flow to net income ratio is negative due to the net loss, but operating cash flow remains positive, which indicates underlying operational strength despite profitability concerns.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue645.66M634.44M632.36M801.54M670.53M366.26M
Gross Profit275.86M274.64M308.83M455.71M391.25M209.63M
EBITDA118.93M82.10M127.77M246.93M211.56M101.62M
Net Income-25.37M-25.51M35.60M185.96M128.29M59.93M
Balance Sheet
Total Assets2.85B2.83B2.83B2.52B2.36B1.90B
Cash, Cash Equivalents and Short-Term Investments697.23M757.36M751.32M623.76M603.81M717.29M
Total Debt683.70M686.25M711.80M422.96M366.05M275.42M
Total Liabilities866.66M856.95M866.34M613.96M608.29M373.74M
Stockholders Equity1.99B1.97B1.97B397.27M1.75B65.77M
Cash Flow
Free Cash Flow117.60M142.49M74.93M38.74M47.74M36.28M
Operating Cash Flow145.69M175.39M113.92M172.08M119.02M62.63M
Investing Cash Flow-152.13M-86.38M-123.28M-233.24M-221.17M-201.38M
Financing Cash Flow-78.96M-82.90M248.96M-13.34M961.00K305.92M

Repligen Technical Analysis

Technical Analysis Sentiment
Positive
Last Price124.34
Price Trends
50DMA
122.70
Positive
100DMA
125.70
Negative
200DMA
138.21
Negative
Market Momentum
MACD
-0.08
Negative
RSI
54.95
Neutral
STOCH
90.26
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For RGEN, the sentiment is Positive. The current price of 124.34 is above the 20-day moving average (MA) of 118.71, above the 50-day MA of 122.70, and below the 200-day MA of 138.21, indicating a neutral trend. The MACD of -0.08 indicates Negative momentum. The RSI at 54.95 is Neutral, neither overbought nor oversold. The STOCH value of 90.26 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for RGEN.

Repligen Risk Analysis

Repligen disclosed 41 risk factors in its most recent earnings report. Repligen reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Repligen Peers Comparison

Overall Rating
UnderperformOutperform
Sector (47)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
73
Outperform
$5.37B28.604.36%1.13%1.11%-23.73%
72
Outperform
$5.05B43.308.60%10.14%0.04%
61
Neutral
$6.05B41.419.55%0.28%5.95%7.73%
58
Neutral
$7.12B-0.68%8.73%-245.82%
51
Neutral
$8.25B116.65-20.54%-8.36%-669.36%
47
Neutral
C$213.29M-1.44-30.58%3.10%19.48%-0.04%
45
Neutral
$2.76B-1.78%2.95%47.92%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
RGEN
Repligen
124.34
-29.48
-19.17%
ICUI
ICU Medical
120.95
-34.91
-22.40%
MASI
Masimo
153.87
31.79
26.04%
MMSI
Merit Medical Systems
85.51
-5.51
-6.05%
TFX
Teleflex
120.68
-115.01
-48.80%
STVN
Stevanato Group
22.62
2.68
13.44%

Repligen Corporate Events

Executive/Board ChangesShareholder Meetings
Repligen Holds Annual Shareholders Meeting, Key Decisions Made
Neutral
May 15, 2025

On May 15, 2025, Repligen Corporation held its Annual Meeting of Shareholders, where several key decisions were made. The shareholders elected ten directors to the board, ratified the appointment of Ernst & Young LLP as the independent registered public accounting firm for the fiscal year ending December 31, 2025, approved the compensation of the company’s executive officers, and sanctioned an amendment to the Certificate of Incorporation to limit the liability of certain officers. These decisions are expected to influence Repligen’s governance and operational strategies moving forward.

The most recent analyst rating on (RGEN) stock is a Buy with a $225.00 price target. To see the full list of analyst forecasts on Repligen stock, see the RGEN Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Aug 13, 2025