The score is held down primarily by weak financial performance (no revenue, widening losses, and sustained cash burn), with only the low-debt balance sheet providing partial support. Technicals also lean negative with the stock below key moving averages and a negative MACD. Valuation is difficult to assess given negative earnings and no dividend yield.
Positive Factors
Low leverage / conservative debt profile
Very low reported debt gives PMV Pharmaceuticals financial flexibility over the medium term, reducing interest and refinancing pressure. For a cash-burning clinical biotech, low leverage limits insolvency risk and preserves optionality to structure future financings or partner deals without heavy fixed obligations.
Focused precision oncology franchise
A targeted focus on genetically defined cancer drivers, especially TP53-modulating small molecules, supports a differentiated scientific position. Precision targeting enables clearer patient selection, potentially higher clinical readthrough rates, streamlined development, and stronger partner interest for co-development or licensing.
Partnership-driven funding model
PMV's historical reliance on collaborations and milestone-based payments is a durable early-stage biotech model that shares development risk and reduces the need to build commercial infrastructure. Strategic partnerships can provide non-dilutive cash, validation, and access to commercialization capabilities if programs progress.
Negative Factors
Zero product revenue and widening losses
Sustained absence of product revenue with materially widening operating losses signals continued dependence on financing and unproven commercial economics. Over months, this undermines self-funding capacity, increases shareholder dilution risk, and leaves future program advancement contingent on external capital or partner deals.
Persistent and increasing cash burn
Rising negative operating and free cash flows indicate accelerating funding needs absent revenue. This structural cash burn pressures runway and strategic flexibility, likely necessitating dilutive equity raises or accelerated partnerships, which can constrain long-term plan execution and investor returns.
Eroding shareholder equity and negative ROE
Significant depletion of equity and deeply negative ROE reflect sustained value erosion from recurring losses and capital consumption. Over the medium term this reduces balance-sheet buffers, magnifies sensitivity to financing conditions, and signals the company has yet to translate R&D investment into value-accretive outcomes.
PMV Pharmaceuticals (PMVP) vs. SPDR S&P 500 ETF (SPY)
PMV Pharmaceuticals Business Overview & Revenue Model
Company DescriptionPMV Pharmaceuticals, Inc., a precision oncology company, engages in the discovery and development of small molecule and tumor-agnostic therapies for p53 mutations in cancer. The company's lead product candidate is PC14586, a small molecule that corrects a p53 protein containing the Y220C mutation and restores wild-type p53 function. It is also developing mutant p53 programs, including Wild-type p53 Induced-Phosphatase, R282W, and R273H, as well as other p53 hotspot mutations. The company was formerly known as PJ Pharmaceuticals, Inc. and changed its name to PMV Pharmaceuticals, Inc. in July 2013. PMV Pharmaceuticals, Inc. was incorporated in 2013 and is headquartered in Cranbury, New Jersey.
How the Company Makes MoneyPMV Pharmaceuticals generates revenue primarily through the development and commercialization of its proprietary drug candidates. The company focuses on advancing its pipeline of small-molecule therapies through clinical trials and aims to monetize these assets via out-licensing agreements, partnerships with larger pharmaceutical companies, or direct sales upon regulatory approval. Key revenue streams include milestone payments, royalties, and upfront fees from partnerships and collaborations, which are essential to funding ongoing research and development efforts. The company's financial success is closely tied to the successful advancement of its drug candidates through clinical trials and obtaining necessary regulatory approvals.
PMV Pharmaceuticals Financial Statement Overview
Summary
Overall fundamentals are weak: the company reports $0 revenue, losses are large and worsening (EBIT down to -$92.1M TTM; net loss -$82.7M TTM), and operating/free cash flow remain deeply negative (about -$73M TTM). The main offset is a low-debt balance sheet (~$0.9M total debt), but equity has fallen sharply ($359.1M in 2020 to $121.0M TTM), signaling ongoing capital erosion.
Income Statement
18
Very Negative
The income statement is weak: the company reports $0 revenue across all periods (including TTM (Trailing-Twelve-Months)), while operating losses are large and widening versus earlier years (EBIT from -$34.9M in 2020 to -$92.1M in TTM (Trailing-Twelve-Months)). Net losses remain significant (-$82.7M in TTM (Trailing-Twelve-Months)), indicating a business still in heavy investment mode with no commercial scaling visible in the provided data. A modest positive is that losses are being managed without revenue reliance typical of development-stage biotech, but overall profitability trajectory is unfavorable.
Balance Sheet
62
Positive
The balance sheet is a relative strength due to very low leverage: total debt is only ~$0.9M in TTM (Trailing-Twelve-Months) and debt-to-equity remains minimal (~0.7%). However, equity has declined meaningfully over time ($359.1M in 2020 to $121.0M in TTM (Trailing-Twelve-Months)), reflecting sustained losses and/or capital use. Returns on equity are deeply negative (about -48% in TTM (Trailing-Twelve-Months)), highlighting ongoing value erosion despite the conservative debt profile.
Cash Flow
24
Negative
Cash flow is pressured by consistent cash burn: operating cash flow is negative in every period and deteriorated to -$73.0M in TTM (Trailing-Twelve-Months) versus -$51.3M in 2024. Free cash flow is similarly negative (-$73.1M TTM (Trailing-Twelve-Months)). While free cash flow roughly tracks net loss (cash burn broadly in line with reported losses), the overall trend points to increasing funding needs unless spending is reduced or revenue sources emerge.
Breakdown
TTM
Dec 2024
Dec 2023
Dec 2022
Dec 2021
Dec 2020
Income Statement
Total Revenue
0.00
0.00
0.00
0.00
0.00
0.00
Gross Profit
-64.00K
-1.14M
-1.26M
-650.00K
-1.28M
-318.00K
EBITDA
-88.86M
-73.67M
-67.70M
-72.68M
-56.54M
-34.12M
Net Income
-82.70M
-58.71M
-68.96M
-73.32M
-57.85M
-34.44M
Balance Sheet
Total Assets
133.84M
191.29M
252.15M
270.31M
331.57M
365.53M
Cash, Cash Equivalents and Short-Term Investments
129.25M
169.45M
203.06M
241.05M
297.16M
361.42M
Total Debt
931.00K
1.19M
13.29M
13.98M
11.19M
0.00
Total Liabilities
12.85M
15.21M
26.46M
24.28M
23.01M
6.41M
Stockholders Equity
121.00M
176.08M
225.69M
246.03M
308.56M
359.12M
Cash Flow
Free Cash Flow
-73.12M
-51.94M
-56.62M
-71.74M
-47.92M
-32.89M
Operating Cash Flow
-73.05M
-51.28M
-55.66M
-63.76M
-46.57M
-32.74M
Investing Cash Flow
59.47M
53.35M
-50.55M
-1.37M
-143.58M
27.91M
Financing Cash Flow
285.00K
313.00K
35.58M
958.00K
2.02M
292.97M
PMV Pharmaceuticals Technical Analysis
Technical Analysis Sentiment
Negative
Last Price1.03
Price Trends
50DMA
1.20
Negative
100DMA
1.29
Negative
200DMA
1.24
Negative
Market Momentum
MACD
-0.04
Positive
RSI
34.71
Neutral
STOCH
6.84
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For PMVP, the sentiment is Negative. The current price of 1.03 is below the 20-day moving average (MA) of 1.14, below the 50-day MA of 1.20, and below the 200-day MA of 1.24, indicating a bearish trend. The MACD of -0.04 indicates Positive momentum. The RSI at 34.71 is Neutral, neither overbought nor oversold. The STOCH value of 6.84 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for PMVP.
PMV Pharmaceuticals Risk Analysis
PMV Pharmaceuticals disclosed 77 risk factors in its most recent earnings report. PMV Pharmaceuticals reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 30, 2025