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Pulse Biosciences (PLSE)
NASDAQ:PLSE

Pulse Biosciences (PLSE) AI Stock Analysis

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PLSE

Pulse Biosciences

(NASDAQ:PLSE)

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Neutral 50 (OpenAI - 5.2)
Rating:50Neutral
Price Target:
$14.50
▼(-1.49% Downside)
The score is held down primarily by very weak financial performance (minimal revenue, negative gross profit, and heavy ongoing cash burn). Offsetting this, technical indicators suggest near-term stabilization, and the latest earnings call points to meaningful clinical/regulatory progress and early commercial traction, though losses and spending remain elevated. Valuation is constrained by negative earnings and no dividend yield data.
Positive Factors
Clinical validation and positive early human results
Robust early human outcomes demonstrate the nsPFA platform can achieve effective tissue ablation with favorable safety. This clinical validation materially de-risks regulatory pathways, supports future label expansion and durable physician adoption, strengthening long-term commercial prospects.
Regulatory momentum: FDA IDE approvals
Obtaining IDEs for cardiac catheter and surgical programs is a structural milestone enabling pivotal clinical enrollment. Regulatory clearance progress reduces execution risk, opens a path to commercial market entry in electrophysiology, and underpins multi-indication scaling over the coming years.
Relatively conservative balance sheet and low leverage
Low leverage provides financial flexibility to fund ongoing trials and early commercialization compared with highly indebted peers. A stronger capital structure lengthens runway, lowers near-term refinancing pressure and supports strategic investments while clinical programs progress.
Negative Factors
Minimal revenue and negative gross profit
Revenue remains near-zero and product costs exceed sales, meaning the business is not yet self-sustaining. Absent material revenue scale or margin improvement, persistent losses will erode equity and necessitate external financing, posing a durable risk to shareholder value.
Sustained high cash burn and operating outflows
Large negative operating and free cash flows indicate cash consumption closely tracks losses. Continued burn pressures runway and forces fundraising or spending cuts, which can dilute shareholders or slow commercialization investments critical for long-term revenue growth.
Commercial model hinges on adoption and reimbursement
The device-plus-consumables model requires sustained procedure volumes, favorable reimbursement and multi-indication adoption to generate recurring revenue. Slow clinician uptake or unfavorable payer dynamics would structurally limit consumable attach rates and long-term scaling of margins and revenue.

Pulse Biosciences (PLSE) vs. SPDR S&P 500 ETF (SPY)

Pulse Biosciences Business Overview & Revenue Model

Company DescriptionPulse Biosciences, Inc. operates as a novel bioelectric medicine company. It offers CellFX System, a tunable, software-enabled, and console-based platform that delivers nano second duration pulses of electrical energy to non-thermally clear targeted cells while sparing adjacent non-cellular tissue to treat a various medical condition by using its Nano-Pulse Stimulation technology. The company was formerly known as Electroblate, Inc. and changed its name to Pulse Biosciences, Inc. in December 2015. Pulse Biosciences, Inc. was incorporated in 2014 and is headquartered in Hayward, California.
How the Company Makes MoneyPulse Biosciences generates revenue primarily through the sale and leasing of its CellFX System to dermatologists and other healthcare providers. The company may also earn revenue from service agreements, training, and support services related to the use of its systems. Additionally, Pulse Biosciences could engage in strategic partnerships or collaborations with other healthcare organizations to further expand the application of its technology and enhance its market presence. Key factors contributing to its earnings include the adoption and integration of its technology within clinical practices and potential expansion into international markets.

Pulse Biosciences Earnings Call Summary

Earnings Call Date:Nov 05, 2025
(Q3-2025)
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% Change Since: |
Next Earnings Date:Mar 26, 2026
Earnings Call Sentiment Neutral
The earnings call highlighted significant progress in clinical trials and regulatory approvals, promising initial revenues, and positive clinical outcomes. However, the financials showed increased costs and cash usage, resulting in a higher net loss.
Q3-2025 Updates
Positive Updates
Progress in nPulse Vybrance System Adoption
The nPulse Vybrance percutaneous electrode system for soft tissue ablation showed strong product market fit in the pilot program. Over 200 patients have been treated, and procedure volumes increased sequentially this quarter.
Regulatory and Clinical Trial Advancements
Received FDA investigational device exemption approval for the nPulse cardiac surgery system for atrial fibrillation. Initiated NANOCLAMP AF study, the first PFA study approved by FDA for a surgical cardiac ablation device.
Positive Clinical Outcomes for nPulse 360 Catheter
Encouraging initial clinical outcomes from Europe for the nPulse 360 Catheter confirm its potential for advancing AF treatment. 150 patients enrolled in the ongoing feasibility study.
Initial Revenues Generated
Pulse Biosciences recognized initial revenues of $86,000 from nPulse capital and Vybrance disposable sales during the limited market release.
Negative Updates
Increased Costs and Net Loss
Total GAAP costs and expenses increased by $6.8 million to $20.5 million compared to the prior year. GAAP net loss was $19.4 million compared to $12.7 million in the prior year period.
Cash Usage Increase
Cash used in operating activities increased to $13 million for the third quarter, up from $9 million in the prior year period.
Company Guidance
During the Q3 2025 earnings call for Pulse Biosciences, the company provided several key metrics and guidance on their progress and future plans. Pulse Biosciences reported total revenue of $86,000, marking initial revenues from nPulse capital and Vybrance disposable sales following a limited market release. Total GAAP costs and expenses for the quarter increased to $20.5 million, up from $13.7 million in the prior year, largely due to expanding organizational expenses and noncash stock-based compensation of $5.6 million. The company recorded a GAAP net loss of $19.4 million, compared to $12.7 million in the previous year. Cash and cash equivalents as of September 30, 2025, were $95.2 million, down from $79 million the previous year. The company is focused on advancing its clinical trials, including the PRECISE-BTN study for benign thyroid nodules and the IDE pivotal study for the nPulse cardiac surgical system, with up to 136 patients to be enrolled across 20 sites. Additionally, they are progressing with European feasibility studies and expect to enroll 150 patients for the nPulse 360 Catheter in Europe. Looking ahead, the company anticipates growing disposables and system sales as procedure acceptance increases and plans to maintain commercial headcount while expanding market access and patient outcomes.

Pulse Biosciences Financial Statement Overview

Summary
Pulse Biosciences faces significant financial challenges, marked by persistent losses, lack of revenue growth, and high cash burn. The financial health is buoyed by equity financing, yet this raises sustainability concerns without a clear path to operational profitability. Strategic adjustments are essential to improve revenue generation and operational efficiency, ensuring long-term viability.
Income Statement
Pulse Biosciences has consistently struggled with profitability, as evidenced by negative net income and EBIT across all years. The absence of revenue in recent years highlights significant challenges in achieving market penetration and product adoption. The net profit margin is negative due to sustained losses, indicating a need for strategic pivots or operational improvements. The company has not shown revenue growth, which is critical for future viability.
Balance Sheet
The balance sheet shows a relatively strong equity position with stockholders' equity increasing over recent years, supported by substantial financing inflows. The company maintains a low debt-to-equity ratio, indicating lower financial leverage and potential for future borrowing if needed. However, the negative equity in 2022 and fluctuating asset base reflect operational instability. The equity ratio has been volatile, reflecting the financial restructuring efforts undertaken by the company.
Cash Flow
The cash flow statement indicates persistent negative operating cash flow, which is a critical concern for sustainability. Although there has been substantial financing inflow, this is primarily used to cover operational deficits. There is no positive free cash flow growth, and the free cash flow to net income ratio reflects ongoing cash burn. Operating cash flow to net income is negative, indicating inefficiencies in cash generation from core activities.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue86.00K0.000.00700.00K1.42M0.00
Gross Profit-460.00K0.00-1.21M-11.24M-550.00K-665.00K
EBITDA-75.77M-55.08M-42.37M-56.70M-61.87M-48.87M
Net Income-74.73M-53.59M-42.21M-58.51M-63.66M-49.74M
Balance Sheet
Total Assets108.77M132.46M59.15M77.88M54.25M41.29M
Cash, Cash Equivalents and Short-Term Investments95.21M118.04M44.37M61.14M28.61M20.48M
Total Debt7.89M8.90M9.14M75.96M11.25M11.36M
Total Liabilities16.07M17.60M14.79M80.13M18.56M18.40M
Stockholders Equity92.69M114.86M44.36M-2.25M35.69M22.89M
Cash Flow
Free Cash Flow-48.77M-36.47M-33.16M-47.41M-54.53M-35.81M
Operating Cash Flow-48.51M-36.34M-33.04M-47.01M-54.10M-35.37M
Investing Cash Flow-283.00K-125.00K-121.00K-401.00K7.56M10.04M
Financing Cash Flow64.97M110.14M16.39M79.94M62.69M30.89M

Pulse Biosciences Technical Analysis

Technical Analysis Sentiment
Positive
Last Price14.72
Price Trends
50DMA
14.48
Positive
100DMA
15.74
Negative
200DMA
15.96
Negative
Market Momentum
MACD
0.06
Negative
RSI
53.42
Neutral
STOCH
75.49
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For PLSE, the sentiment is Positive. The current price of 14.72 is above the 20-day moving average (MA) of 14.38, above the 50-day MA of 14.48, and below the 200-day MA of 15.96, indicating a neutral trend. The MACD of 0.06 indicates Negative momentum. The RSI at 53.42 is Neutral, neither overbought nor oversold. The STOCH value of 75.49 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for PLSE.

Pulse Biosciences Risk Analysis

Pulse Biosciences disclosed 61 risk factors in its most recent earnings report. Pulse Biosciences reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Pulse Biosciences Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
55
Neutral
$1.72B-30.631.41%-9.49%58.97%
54
Neutral
$2.28B-1.97-44.21%-3.43%38.98%
52
Neutral
$1.20B-363.17-5.20%-18.82%92.56%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
50
Neutral
$997.54M-12.97-86.99%-40.63%
46
Neutral
$1.12B-11.50-24.65%-32.42%-540.37%
42
Neutral
$224.02M-5.77-27.19%30.55%-340.19%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
PLSE
Pulse Biosciences
14.72
-3.30
-18.31%
AZTA
Azenta
37.50
-14.77
-28.26%
QDEL
QuidelOrtho
33.51
-11.10
-24.88%
STAA
Staar Surgical
22.50
0.02
0.09%
BLFS
BioLife Solutions
24.95
-2.02
-7.49%
SMTI
Sanara MedTech
25.07
-7.39
-22.77%

Pulse Biosciences Corporate Events

Business Operations and StrategyExecutive/Board Changes
Pulse Biosciences Adds Veteran Healthtech Leader to Board
Positive
Jan 9, 2026

On January 8, 2026, Pulse Biosciences elected veteran healthtech executive Maria Sainz to its board of directors and appointed her to the audit committee, with the addition formally announced in a January 9, 2026 press release. Sainz, currently president and CEO of portable MRI maker Hyperfine, brings more than three decades of experience leading public and venture-backed medical device companies through clinical, regulatory, financing and M&A milestones, and will receive standard non-employee director cash retainers, the option to convert retainers into equity, reimbursement of board-related expenses, and time-vested stock option grants that further align her incentives with shareholders. The appointment adds deep commercialization and strategic expertise as Pulse advances its first three nsPFA-based programs through key clinical, regulatory and commercial milestones, underscoring the company’s intention to strengthen governance and bolster its ability to compete and scale in interventional and surgical device markets.

The most recent analyst rating on (PLSE) stock is a Hold with a $14.00 price target. To see the full list of analyst forecasts on Pulse Biosciences stock, see the PLSE Stock Forecast page.

Business Operations and StrategyProduct-Related AnnouncementsRegulatory Filings and Compliance
Pulse Biosciences gains FDA IDE for NANOPULSE-AF trial
Positive
Dec 18, 2025

On December 18, 2025, Pulse Biosciences announced that the U.S. Food and Drug Administration approved its Investigational Device Exemption, enabling the company to begin the NANOPULSE-AF clinical study of its nPulse Cardiac Catheter Ablation System for treating recurrent, drug-resistant, symptomatic paroxysmal atrial fibrillation. The single-arm, multicenter, prospective study will enroll up to 145 patients across as many as 30 sites, including three outside the U.S., to evaluate the safety and effectiveness of the nsPFA-based catheter, which is designed to deliver rapid, circumferential pulmonary vein isolation with lower total energy and potentially reduced collateral injury, building on positive initial results from an ongoing European feasibility study and marking a key milestone in the company’s push to establish its next-generation ablation technology in the global electrophysiology market.

The most recent analyst rating on (PLSE) stock is a Buy with a $22.00 price target. To see the full list of analyst forecasts on Pulse Biosciences stock, see the PLSE Stock Forecast page.

Executive/Board ChangesShareholder Meetings
Pulse Biosciences Holds 2025 Annual Stockholder Meeting
Neutral
Dec 12, 2025

On December 9, 2025, Pulse Biosciences, Inc. conducted its 2025 Annual Meeting of Stockholders virtually. During the meeting, stockholders elected six directors to serve until the 2026 meeting, ratified Deloitte & Touche LLP as the independent accounting firm for 2025, approved executive compensation, and decided to hold future advisory votes on executive compensation every three years.

The most recent analyst rating on (PLSE) stock is a Buy with a $22.00 price target. To see the full list of analyst forecasts on Pulse Biosciences stock, see the PLSE Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Pulse Biosciences Partners with MD Anderson for Thyroid Cancer Study
Positive
Dec 9, 2025

On December 9, 2025, Pulse Biosciences announced a research collaboration with The University of Texas MD Anderson Cancer Center to explore the use of its nPulse™ Vybrance™ Percutaneous Electrode System for treating thyroid cancers. The FDA has approved the Investigational Device Exemption for this first-in-human clinical feasibility study, which will begin in early 2026, involving 30 subjects across two sites. This collaboration aims to assess the safety and effectiveness of nPulse technology in treating papillary thyroid microcarcinoma, with ongoing preclinical studies on anaplastic thyroid carcinoma, a particularly deadly cancer. The nonthermal mechanism of nsPFA energy is highlighted for its potential to minimize scarring and damage to surrounding structures, positioning it as a promising treatment for both benign and malignant thyroid tumors.

The most recent analyst rating on (PLSE) stock is a Buy with a $22.00 price target. To see the full list of analyst forecasts on Pulse Biosciences stock, see the PLSE Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Pulse Biosciences Updates Investors on Product Advancements
Neutral
Nov 13, 2025

On November 13, 2025, Pulse Biosciences, Inc. released an updated investor presentation on its website, highlighting recent advancements in its product development programs. This presentation is intended for use in discussions with investors and analysts, showcasing the company’s progress with its nPulse technology products, which could influence its market positioning and stakeholder interests.

The most recent analyst rating on (PLSE) stock is a Buy with a $22.00 price target. To see the full list of analyst forecasts on Pulse Biosciences stock, see the PLSE Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Pulse Biosciences Launches NANOCLAMP AF Clinical Trial
Positive
Oct 24, 2025

On October 24, 2025, Pulse Biosciences announced the enrollment of the first patient in its NANOCLAMP AF clinical trial, marking a significant milestone for the company’s nPulse™ Cardiac Surgical System. This trial aims to demonstrate the safety and effectiveness of the system in treating atrial fibrillation during concomitant surgical procedures, potentially revolutionizing patient care with improved safety and procedural advantages over conventional methods.

The most recent analyst rating on (PLSE) stock is a Buy with a $22.00 price target. To see the full list of analyst forecasts on Pulse Biosciences stock, see the PLSE Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Pulse Biosciences Reveals Promising Study Results
Positive
Oct 10, 2025

On October 10, 2025, Pulse Biosciences announced the results of its first-in-human feasibility study using the nPulse Cardiac Surgical System at the European Association for Cardio-Thoracic Surgery Annual Meeting. The study, which involved 44 patients, demonstrated high success rates in pulmonary vein isolation and posterior box isolation without severe adverse events, indicating the potential for the nPulse system to enhance cardiac surgical ablation for atrial fibrillation.

The most recent analyst rating on (PLSE) stock is a Buy with a $22.00 price target. To see the full list of analyst forecasts on Pulse Biosciences stock, see the PLSE Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jan 09, 2026