Want to see PLSE full AI Analyst Report?
Top Page
Pulse Biosciences
(NASDAQ:PLSE)
Select Model
Select Model
Rating:60Neutral
Price Target:
$37.00
▲(22.39% Upside)
Action:Reiterated
Date:07/30/26
The score is held back primarily by weak financial performance (large losses and sustained cash burn despite early revenue growth). Offsetting this, the technical setup is strong with the stock trading well above major moving averages, and the latest earnings updates and corporate events highlight meaningful clinical/regulatory momentum and improving trial execution. Valuation support is limited due to negative earnings and no dividend.
Positive Factors
Clinical / Regulatory Momentum
Surpassing the enrollment midpoint and accelerating the U.S. IDE materially reduces time-to-market and regulatory execution risk. Completion of a robust pivotal trial supports PMA timing, strengthens clinical credibility, and meaningfully de-risks commercialization and reimbursement discussions over the next 2–6 months.
Negative Factors
Sustained Cash Burn
Very large and persistent operating cash outflows indicate the business consumes material capital to advance trials and operations. Continued burn requires external financing or rapid commercial scaling, creating dilution risk and constraining strategic optionality if near‑term revenue or milestones lag expectations.
Read all positive and negative factors
Positive Factors
Negative Factors
Clinical / Regulatory Momentum
Surpassing the enrollment midpoint and accelerating the U.S. IDE materially reduces time-to-market and regulatory execution risk. Completion of a robust pivotal trial supports PMA timing, strengthens clinical credibility, and meaningfully de-risks commercialization and reimbursement discussions over the next 2–6 months.
Read all positive factors
Pulse Biosciences (PLSE) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$2.43B
Dividend YieldN/A
Average Volume (3M)189.63K
Price to Earnings (P/E)―
Beta (1Y)1.30
Revenue GrowthN/A
EPS Growth-13.79%
CountryUS
Employees116
SectorHealthcare
Sector Strength45
IndustryMedical - Instruments & Supplies
Share Statistics
EPS (TTM)-1.09
Shares Outstanding69,209,710
10 Day Avg. Volume222,519
30 Day Avg. Volume189,626
Financial Highlights & Ratios
PEG Ratio-0.73
Price to Book (P/B)11.47
Price to Sales (P/S)2643.82
P/FCF Ratio-17.00
Enterprise Value/Market Cap<0.01
Enterprise Value/Revenue<0.01
Enterprise Value/Gross Profit>-0.01
Enterprise Value/Ebitda>-0.01
Forecast
1Y Price Target
$33.50Price Target Upside10.82% Upside
Rating ConsensusModerate Buy
Number of Analyst Covering2
EPS Forecast (FY)-1.14
Revenue Forecast (FY)$2.73M
Pulse Biosciences Business Overview & Revenue Model
Company Description
Pulse Biosciences, Inc. is an innovative firm specializing in bioelectric medicine. Their primary offering is the CellFX System, a sophisticated, console-based platform that is precisely controlled via software. This system utilizes its proprietar...
How the Company Makes Money
Pulse Biosciences generates revenue primarily through the commercialization of its nsPFA-based platform and related procedure consumables. Key revenue streams typically include: (1) sales (or placement) of capital equipment systems used to deliver...
Pulse Biosciences Earnings Call Summary
Earnings Call Date:May 04, 2026
(Q1-2026)
| % Change Since: |
Next Earnings Date:Nov 16, 2026
Earnings Call Sentiment Positive
The call emphasized substantial clinical progress and clear operational momentum: landmark European feasibility results (strong efficacy and low SAE rate), initiation and acceleration of the U.S. pivotal IDE trial, regulatory milestones and expanded clinical programs (surgical clamp and Vybrance). These positive milestones were balanced against near‑term commercial immaturity (very small product revenue), rising R&D/clinical spend driving wider GAAP and non‑GAAP losses, and a material quarterly cash burn that reduced cash balances. Management has strengthened leadership, prioritized the high‑value catheter program and secured financing flexibility (shelf and ATM) to support execution. On balance, the clinical and operational advances meaningfully outweigh the financial and timing challenges reported.Positive Updates
Landmark European Feasibility Data — Strong Efficacy and Safety
European feasibility study (n=177) showed outstanding outcomes: 100% procedure success at 6 months (95/95 evaluable), 96% procedure success at 1 year (24-hour Holter evaluable), and a 90% Kaplan‑Meier estimated freedom from recurrent AF/atrial flutter/atrial tachycardia at 1 year. Safety profile: serious adverse event rate of 1.7% across 177 treated subjects.
Negative Updates
Very Limited Product Revenue Scale
Total Q1 revenue was $401,000 (comprised of nPulse Catheter and Vybrance disposable sales) with cost of product revenue of $370,000, indicating very limited commercial sales and low near‑term product contribution.
Read all updates
Q1-2026 Updates
Positive
Negative
Landmark European Feasibility Data — Strong Efficacy and Safety
European feasibility study (n=177) showed outstanding outcomes: 100% procedure success at 6 months (95/95 evaluable), 96% procedure success at 1 year (24-hour Holter evaluable), and a 90% Kaplan‑Meier estimated freedom from recurrent AF/atrial flutter/atrial tachycardia at 1 year. Safety profile: serious adverse event rate of 1.7% across 177 treated subjects.
Read all positive updates
Company Guidance
The company tightened near‑term guidance across clinical, regulatory and financial plans: enrollment for the U.S. IDE pivotal NANOPULSE‑AF is now expected to complete in early Q4 2026 (vs prior end‑2026), leveraging a protocol that allows up to 30 sites (up to ~215 patients) with per‑site caps of ~15–20% (low‑20s patients/site) and a Bayesian mix of 6‑ and 12‑month follow‑up to shorten study duration and accelerate the PMA filing; CE submission for the nPulse catheter is targeted in H2 2026 with potential CE Mark mid‑2027; the NANOCLAMP‑AF surgical IDE (target 136 patients at ~20 sites) is now expected to finish enrollment by end‑H1 2027; PRECISE‑BTN was expanded to 100 patients (50 enrolled) and Vybrance generated ~$400K revenue in Q1; PTMC feasibility (up to 30 patients) completed first‑patient enrollments with full enrollment expected by year‑end 2026; Q1 financial guidance/context: revenue $401K, cost of product revenue $370K, GAAP operating expenses $19.6M (+$1.6M YoY), non‑GAAP operating expenses $17.4M (+$4.7M YoY), GAAP net loss $18.6M, non‑GAAP net loss $16.4M, cash $68.3M (down $12.4M QoQ), operating cash use $14.6M in Q1, plus a $200M shelf registration and ~ $60M ATM availability — all cited alongside clinical metrics from the 177‑patient EU feasibility study (100% 6‑month procedure success, 96% 1‑year 24‑hr Holter success, 90% KM freedom at 1 year, 1.7% SAE rate) and surgical feasibility signals (≈60+ patients, 94% PVI at ~3 months, avg ablation time 41 seconds), supporting the company’s expectation of faster enrollment and accelerated time to market.Pulse Biosciences Financial Statement Overview
Summary
Income Statement
14
Very Negative
Balance Sheet
62
Positive
Cash Flow
18
Very Negative
| Breakdown | TTM | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Mar 2022 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 751.00K | 350.00K | 0.00 | 0.00 | 700.00K | 1.42M |
| Gross Profit | -684.00K | -1.26M | 0.00 | -1.21M | -11.24M | -550.00K |
| EBITDA | -74.10M | -71.71M | -52.41M | -39.90M | -57.15M | -62.51M |
| Net Income | -74.57M | -72.78M | -53.59M | -42.21M | -58.51M | -63.66M |
Balance Sheet | ||||||
| Total Assets | 81.62M | 96.11M | 132.46M | 59.15M | 77.88M | 54.25M |
| Cash, Cash Equivalents and Short-Term Investments | 68.32M | 80.73M | 118.04M | 44.37M | 61.14M | 28.61M |
| Total Debt | 7.16M | 7.53M | 8.90M | 9.14M | 75.96M | 11.25M |
| Total Liabilities | 15.32M | 15.46M | 17.60M | 14.79M | 80.13M | 18.56M |
| Stockholders Equity | 66.30M | 80.66M | 114.86M | 44.36M | -2.25M | 35.69M |
Cash Flow | ||||||
| Free Cash Flow | -55.50M | -54.44M | -36.47M | -33.16M | -47.41M | -54.53M |
| Operating Cash Flow | -55.20M | -54.12M | -36.34M | -33.04M | -47.01M | -54.10M |
| Investing Cash Flow | -323.00K | -335.00K | -125.00K | -121.00K | -401.00K | 7.56M |
| Financing Cash Flow | 4.56M | 17.15M | 110.14M | 16.39M | 79.94M | 62.69M |
Pulse Biosciences Technical Analysis
Positive
30.23
Price Trends
28.31
Positive
25.13
Positive
20.67
Positive
Market Momentum
2.79
Negative
72.17
Negative
91.73
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For PLSE, the sentiment is Positive. The current price of 30.23 is below the 20-day moving average (MA) of 31.35, above the 50-day MA of 28.31, and above the 200-day MA of 20.67, indicating a bullish trend. The MACD of 2.79 indicates Negative momentum. The RSI at 72.17 is Negative, neither overbought nor oversold. The STOCH value of 91.73 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for PLSE.
Pulse Biosciences Risk Analysis
Pulse Biosciences disclosed 61 risk factors in its most recent earnings report. Pulse Biosciences reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 3 New Risks
1.
Our operating results may fluctuate significantly, which makes our future operating results difficult to predict and could cause our operating results to fall below expectations. Q4, 2023
2.
We may fail to meet our publicly announced guidance or other expectations about our business and future operating results, which could cause our stock price to decline. Q4, 2023
3.
If we are unable to manage the anticipated growth of our business, our future revenue and operating results may be harmed. Q4, 2023
Pulse Biosciences Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
72 Outperform | $1.53B | -144.81 | -2.91% | ― | -5.48% | -666.94% | |
67 Neutral | $311.28M | -8.69 | -246.44% | ― | 17.41% | -189.91% | |
61 Neutral | $1.30B | -7.12 | -7.56% | ― | -5.87% | -175.46% | |
60 Neutral | $2.43B | -32.23 | -86.67% | ― | ― | -13.79% | |
53 Neutral | $1.21B | -58.00 | -6.07% | ― | 4.03% | 70.55% | |
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
51 Neutral | $1.14B | -0.94 | -56.31% | ― | -3.87% | -258.96% |
* Healthcare Sector Average
PLSE
Pulse Biosciences
38.24
23.52
159.78%
AZTA
Azenta
30.74
1.61
5.53%
QDEL
QuidelOrtho
16.32
-8.08
-33.11%
STAA
Staar Surgical
23.12
-3.83
-14.21%
BLFS
BioLife Solutions
33.93
13.29
64.39%
SMTI
Sanara MedTech
34.09
9.73
39.94%
Pulse Biosciences Corporate Events
Business Operations and StrategyProduct-Related Announcements
Pulse Biosciences advances NANOPULSE-AF pivotal study enrollment
Positive
Jul 29, 2026
On July 29, 2026, Pulse Biosciences reported that its NANOPULSE-AF pivotal clinical study, which began in April 2026, has surpassed the enrollment midpoint in patients with recurrent, drug-resistant, symptomatic paroxysmal atrial fibrillation. The...
Executive/Board ChangesShareholder Meetings
Pulse Biosciences Shareholders Approve Board and Auditor Slate
Positive
Jun 12, 2026
On June 11, 2026, Pulse Biosciences, Inc. held its 2026 Annual Meeting of Stockholders as a virtual event via live audio webcast, where shareholders voted on board composition and auditor selection. All seven director nominees, including Robert W....
Business Operations and StrategyPrivate Placements and Financing
Pulse Biosciences Announces Redemption of Remaining 200% Warrants
Positive
Jun 10, 2026
On June 10, 2026, Pulse Biosciences said it plans to redeem the remaining “200% Warrants” issued in its July 3, 2024 rights offering, after the stock’s volume-weighted average price exceeded the $22.00 trigger for 20 consecutive ...
Business Operations and StrategyPrivate Placements and Financing
Pulse Biosciences Authorizes Insider Purchases Under Equity Program
Positive
May 6, 2026
On May 5, 2026, Pulse Biosciences’ board authorized TD Securities (USA) LLC, acting as sales agent under a February 19, 2026 Equity Distribution Agreement, to sell up to about $60 million of the company’s common stock to one or more co...
Business Operations and StrategyExecutive/Board ChangesFinancial DisclosuresPrivate Placements and Financing
Pulse Biosciences Highlights Q1 Results, Electrophysiology Focus
Neutral
May 4, 2026
On May 4, 2026, Pulse Biosciences reported first-quarter 2026 results and a sharpened strategic focus on electrophysiology after landmark data for its nPulse Cardiac Catheter System, including high 6- and 12-month procedural success and arrhythmia...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.