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Pulse Biosciences (PLSE)
NASDAQ:PLSE

Pulse Biosciences (PLSE) AI Stock Analysis

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Pulse Biosciences

(NASDAQ:PLSE)

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Neutral 52 (OpenAI - 5.2)
Rating:52Neutral
Price Target:
$19.50
▲(4.11% Upside)
Action:ReiteratedDate:02/28/26
The score is held back primarily by very weak financial performance (minimal revenue, large losses, and accelerating cash burn). Offsetting factors include constructive technical positioning and an earnings narrative showing strong clinical/regulatory momentum, but valuation support is limited given ongoing unprofitability and no dividend.
Positive Factors
Clinical efficacy
Robust first‑in‑human AF outcomes with high procedural success and durable 12‑month freedom from arrhythmia support a clinically differentiated therapy. Durable efficacy and markedly shorter procedure times can drive hospital adoption, increase throughput, and create persistent clinical preference versus legacy ablation methods.
Regulatory momentum
Multiple IDE approvals de‑risk the regulatory pathway and enable U.S. pivotal data generation. Successful completion of planned 2026 enrollments would materially advance market access prospects, shorten time to broader commercial clearance, and support durable scaling across EP and surgical markets.
Intellectual property
A large and growing patent portfolio builds meaningful barriers around nsPFA technology and associated consumables. Strong IP supports a razor‑and‑blades model by protecting system and disposable sales, enabling licensing options, and raising competitor entry costs over the medium term.
Negative Factors
Very limited revenue
Product sales remain nominal and gross margin is effectively zero, indicating the installed base and consumable repeat revenue are not yet validated. Without scalable, margin‑positive product revenue, the company cannot self‑fund growth and commercial scale remains materially uncertain over the next several quarters.
Accelerating cash burn
Large negative operating cash flows and a significant year‑over‑year cash decline create a structural reliance on external financing. Persistent burn constrains strategic optionality, risks dilution from future raises, and could force timing compromises on commercialization or clinical programs if capital markets deteriorate.
Reimbursement and commercial timing risk
Broad adoption depends on reimbursement and additional clearances that management expects will take multiple quarters. This structural dependency delays scalable revenue, makes hospital and payer uptake uncertain, and prolongs the period before the razor‑and‑blades economics can meaningfully contribute to cash generation.

Pulse Biosciences (PLSE) vs. SPDR S&P 500 ETF (SPY)

Pulse Biosciences Business Overview & Revenue Model

Company DescriptionPulse Biosciences, Inc. operates as a novel bioelectric medicine company. It offers CellFX System, a tunable, software-enabled, and console-based platform that delivers nano second duration pulses of electrical energy to non-thermally clear targeted cells while sparing adjacent non-cellular tissue to treat a various medical condition by using its Nano-Pulse Stimulation technology. The company was formerly known as Electroblate, Inc. and changed its name to Pulse Biosciences, Inc. in December 2015. Pulse Biosciences, Inc. was incorporated in 2014 and is headquartered in Hayward, California.
How the Company Makes MoneyPulse Biosciences generates revenue primarily through the sale and leasing of its CellFX System to dermatologists and other healthcare providers. The company may also earn revenue from service agreements, training, and support services related to the use of its systems. Additionally, Pulse Biosciences could engage in strategic partnerships or collaborations with other healthcare organizations to further expand the application of its technology and enhance its market presence. Key factors contributing to its earnings include the adoption and integration of its technology within clinical practices and potential expansion into international markets.

Pulse Biosciences Earnings Call Summary

Earnings Call Date:Feb 19, 2026
(Q4-2025)
|
% Change Since: |
Next Earnings Date:May 07, 2026
Earnings Call Sentiment Neutral
The call conveyed strong clinical and technology progress—IDE approvals, compelling early efficacy data with high 12‑month success rates, rapid procedure times, and substantial IP expansion—which materially de-risks key scientific and regulatory milestones. However, the financial picture remains early-stage: product revenue is still nominal, gross margin was effectively negligible in the quarter, operating losses persist, cash reserves declined substantially year-over-year, and broader commercialization hinges on additional regulatory clearances and reimbursement processes that may take multiple quarters. Overall, the narrative balances important clinical/strategic momentum against clear near-term financial and commercialization constraints.
Q4-2025 Updates
Positive Updates
Strong Clinical Efficacy in nPulse Electrophysiology Feasibility Studies
European feasibility data presented at AF Symposium: 100% procedural success (6 months) and 96% procedural success (1 year) for evaluable patients; 90% freedom from atrial arrhythmia at 12 months (Kaplan–Meier). Reported routine ablation procedure times of 6–8 minutes (company assertion) with potential to cut total procedure times by over 50% versus legacy approaches.
Multiple IDE Approvals and Pivotal Trial Progress
Company secured IDE approvals for both the electrophysiology catheter (nPulse) and the cardiac surgical clamp (NANOCLAMP AF) and plans to commence and complete nPulse IDE enrollment in 2026 (protocol cited ~155 patients); NANOCLAMP AF pivotal study targets ~136 patients across ~20 sites with enrollment expected to conclude in 2026.
Expanding Intellectual Property Estate
Pulse added 67 issued and 77 pending patents in 2025 (equivalent to ~one new piece of IP every 2.5 days). Total IP: 250 granted patents and ~180 pending patents, strengthening barriers to entry for nsPFA technology.
Vybrance Initial Commercial Traction
Vybrance revenue in Q4 2025 was $264,000 (company described as 'nominal' revenue), up from $86,000 in Q3 2025 — a sequential increase of approximately 207% — driven by both system and disposable (electrode) sales during an intentionally limited launch.
Focused Strategic Partnerships and Regulatory Pathway Planning
Management is actively pursuing mapping and EP ecosystem partnerships to accelerate commercial launch; plans to finalize CE submission for the nPulse catheter in H2 2026 with potential CE Mark in 2027 and intends to file for CE Mark for the surgical clamp by end of 2026.
Operational Discipline and Liquidity Tools
GAAP costs and expenses decreased by $1.7M year-over-year to $18.5M in Q4 2025 (approx. 8% reduction vs prior-year period). Company completed a $200M shelf registration to provide flexibility for financing if needed and stated cash runway to support clinical programs through major 2026 inflection points.
Negative Updates
Very Limited Revenue Base and High COGS
Q4 2025 total revenue was only $264,000 while cost of product revenue was $260,000, leaving minimal gross margin from product sales in the quarter and signaling early-stage commercial traction.
Continued Operating Losses
GAAP net loss for Q4 2025 was $17.4M (improved from $19.4M prior-year period, ~10.3% improvement), but non-GAAP net loss worsened to $12.2M in Q4 2025 from $10.4M (an increase of ~17.3%), driven by rising clinical trial and early commercial launch costs.
Cash Decline and Elevated Cash Burn
Cash and cash equivalents declined to $80.7M as of Dec 31, 2025 from $118M a year earlier (a ~31.6% decrease YoY) and decreased ~$14.5M versus Q3 2025. Cash used in operating activities in Q4 2025 was $14.8M versus $9.1M in the prior-year quarter (increase of ~62.6%), indicating accelerating cash consumption tied to trials and commercialization.
Rising Non-GAAP Operating Expenses
Total non-GAAP costs and expenses increased by $2.0M year-over-year to $13.3M in Q4 2025 (approx. +17.7%), reflecting higher investment in clinical trials and early commercial launch activity that is increasing near-term cash needs.
Regulatory and Reimbursement Dependencies Delay Broader Commercialization
Management emphasized a deliberate limited launch of Vybrance pending stronger data, reimbursement progress and additional FDA therapeutic clearances; leadership expects reimbursement and additional labeling to take multiple quarters (management cited ~4–8 quarters), which constrains near-term scalable revenue growth.
Need for Additional Funding or Partnerships to Scale
Although a $200M shelf registration provides flexibility, management acknowledged additional funding or partnerships may be required to support broader commercialization and later-stage scaling beyond current liquidity and warrant proceeds; timing and form of future financing remain open.
Company Guidance
The company’s guidance focused on clinical and market development milestones and included numerous operational and financial metrics: clinically, Pulse expects to commence nPulse cardiac catheter IDE enrollment in the next 1–2 months and to start and complete enrollment in 2026 (IDE target ~155 patients), to complete enrollment in the NANOCLAMP AF surgical IDE (136 patients at ~20 sites) during 2026, to finish the PRECISE benign thyroid nodule study enrollment of 50 patients in the next few months and expand to 100 over the following two quarters, to complete an MD Anderson IDE for papillary thyroid microcarcinoma by year-end 2026, to finalize an EP CE submission in H2 2026 with potential CE Mark in 2027 and to file for a cardiac clamp CE submission by end‑2026; key clinical performance metrics cited include a 5‑second single‑shot PVI, routine procedure times of 6–8 minutes (potentially cutting total procedure times by >50%), 100% procedural success at 6 months, 96% procedural success at 1 year (evaluable patients), and 90% freedom from atrial arrhythmia at 12 months (KM); IP and commercial metrics included adding 67 issued and 77 pending patents in 2025 (total 250 issued, 180 pending), continued disciplined limited launch of Vybrance (Q4 Vybrance revenue $264k vs. $86k in Q3; Q4 cost of product revenue $260k), Q4 GAAP costs/expenses $18.5M (down $1.7M YoY) and non‑GAAP costs/expenses $13.3M (up $2.0M YoY), Q4 GAAP net loss $17.4M (non‑GAAP net loss $12.2M), cash and equivalents $80.7M (vs. $118M a year earlier; down $14.5M vs. Q3), Q4 operating cash use $14.8M (vs. $9.1M YoY, $13.0M in Q3), a $200M shelf registration to support funding needs, and emphasis on mapping partnerships and improved mapping integration for the IDE to accelerate adoption.

Pulse Biosciences Financial Statement Overview

Summary
Financials reflect a development-stage profile: minimal revenue and large, widening losses in 2025 alongside accelerating cash burn. The balance sheet is a relative bright spot with low leverage and an equity cushion, but persistent operating losses and negative cash flow remain the dominant risk.
Income Statement
12
Very Negative
The company has essentially no revenue in recent years (including 2023–2025), with losses remaining very large and widening in 2025 (net loss of ~$72.8M vs. ~$53.6M in 2024). Profitability is structurally weak with negative gross profit in multiple years (e.g., 2025 and 2023), indicating the business is still far from covering core costs. A positive is that losses were somewhat lower in 2023–2024 versus the very high loss levels seen in 2021–2022, but the 2025 step-up in losses is a clear setback.
Balance Sheet
62
Positive
Leverage appears manageable in the most recent periods, with low debt relative to equity in 2024–2025 (debt-to-equity ~0.08–0.09) and a solid equity base in 2025 (~$80.7M). However, the balance sheet has shown volatility historically, including negative equity in 2022, and returns on equity remain deeply negative in 2024–2025 due to ongoing losses. Overall, the capital structure looks supportive today, but persistent losses continue to pressure book value over time.
Cash Flow
28
Negative
Cash generation is consistently negative, with operating cash outflows every year shown and a larger burn in 2025 (operating cash flow about -$54.1M vs. -$36.3M in 2024). Free cash flow is also materially negative across the period, and while 2025 free cash flow improved versus 2024 on a growth basis, the absolute level remains a significant drain. A modest positive is that cash burn broadly tracks accounting losses (free cash flow roughly in line with net loss), but the business still relies on external funding until revenue ramps meaningfully.
BreakdownDec 2025Dec 2024Dec 2023Dec 2022Mar 2022
Income Statement
Total Revenue350.00K0.000.00700.00K1.42M
Gross Profit-1.26M0.00-1.21M-11.24M-550.00K
EBITDA-71.71M-55.08M-42.37M-56.70M-61.87M
Net Income-72.78M-53.59M-42.21M-58.51M-63.66M
Balance Sheet
Total Assets96.11M132.46M59.15M77.88M54.25M
Cash, Cash Equivalents and Short-Term Investments80.73M118.04M44.37M61.14M28.61M
Total Debt7.53M8.90M9.14M75.96M11.25M
Total Liabilities15.46M17.60M14.79M80.13M18.56M
Stockholders Equity80.66M114.86M44.36M-2.25M35.69M
Cash Flow
Free Cash Flow-54.44M-36.47M-33.16M-47.41M-54.53M
Operating Cash Flow-54.12M-36.34M-33.04M-47.01M-54.10M
Investing Cash Flow-335.00K-125.00K-121.00K-401.00K7.56M
Financing Cash Flow17.15M110.14M16.39M79.94M62.69M

Pulse Biosciences Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price18.73
Price Trends
50DMA
16.68
Positive
100DMA
16.16
Positive
200DMA
16.14
Positive
Market Momentum
MACD
1.09
Positive
RSI
48.33
Neutral
STOCH
7.77
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For PLSE, the sentiment is Neutral. The current price of 18.73 is below the 20-day moving average (MA) of 20.15, above the 50-day MA of 16.68, and above the 200-day MA of 16.14, indicating a neutral trend. The MACD of 1.09 indicates Positive momentum. The RSI at 48.33 is Neutral, neither overbought nor oversold. The STOCH value of 7.77 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for PLSE.

Pulse Biosciences Risk Analysis

Pulse Biosciences disclosed 61 risk factors in its most recent earnings report. Pulse Biosciences reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Pulse Biosciences Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
63
Neutral
$1.17B-352.26-5.20%-18.82%92.56%
55
Neutral
$1.24B-21.281.69%-9.49%58.97%
52
Neutral
$1.27B-17.34-86.99%-40.63%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
46
Neutral
$989.86M-10.17-24.65%-32.42%-540.37%
45
Neutral
$1.55B-1.36-46.15%-3.43%38.98%
42
Neutral
$182.64M-4.71-27.19%30.55%-340.19%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
PLSE
Pulse Biosciences
18.73
0.86
4.81%
AZTA
Azenta
26.98
-14.13
-34.37%
QDEL
QuidelOrtho
22.74
-16.31
-41.77%
STAA
Staar Surgical
19.90
3.43
20.83%
BLFS
BioLife Solutions
24.20
-0.31
-1.26%
SMTI
Sanara MedTech
20.44
-12.38
-37.72%

Pulse Biosciences Corporate Events

Executive/Board Changes
Pulse Biosciences Announces Resignation of Chief Commercial Officer
Negative
Feb 27, 2026

On February 27, 2026, Pulse Biosciences, Inc. announced that Chief Commercial Officer Kevin P. Danahy resigned from the company, effective immediately, with the board noting his departure was not due to any disagreement over operations, policies, or accounting practices. The company highlighted Danahy’s role as a key member of senior management and its early commercialization efforts, signaling a notable change in its commercial leadership but no underlying dispute or governance concern tied to his exit.

The most recent analyst rating on (PLSE) stock is a Hold with a $19.50 price target. To see the full list of analyst forecasts on Pulse Biosciences stock, see the PLSE Stock Forecast page.

Business Operations and StrategyPrivate Placements and Financing
Pulse Biosciences Establishes New $60 Million ATM Program
Neutral
Feb 19, 2026

On February 19, 2026, Pulse Biosciences entered into a new equity distribution agreement with TD Securities (USA) LLC, allowing the company to sell up to approximately $60 million of its common stock from time to time in at-the-market and other permitted transactions under its existing shelf registration. The company is not obligated to sell any shares, can suspend offers at its discretion, and will pay TD Cowen up to a 3% commission on gross sales, positioning Pulse Biosciences with a refreshed, flexible equity financing channel after terminating a prior at-the-market offering program on February 18, 2026 that still had the same dollar amount remaining unsold.

The termination of the earlier equity distribution agreement and immediate establishment of the new program with TD Cowen effectively roll over the unused capacity for future issuance, helping the company preserve access to incremental capital without committing to a specific financing timeline. This structure may influence shareholder dilution over time, depending on market conditions and the extent to which management chooses to utilize the program for funding its ongoing activities and potential growth initiatives.

The most recent analyst rating on (PLSE) stock is a Buy with a $30.00 price target. To see the full list of analyst forecasts on Pulse Biosciences stock, see the PLSE Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Pulse Biosciences Reports Strong nPulse Atrial Fibrillation Study Results
Positive
Feb 6, 2026

On February 5, 2026, Pulse Biosciences reported 6- and 12‑month results from its first‑in‑human feasibility study of the nPulse Cardiac Catheter System for treating atrial fibrillation, with data presented at the 31st Annual AF Symposium in Boston. In a 150‑patient cohort treated at European centers, the endocardial catheter ablation device, designed to deliver circumferential ablation using proprietary nanosecond PFA energy, achieved 100% procedural success among evaluable patients at six months (75/75) and 96% at 12 months (45/47), with an average of 16.1 applications per procedure, relatively short procedure and fluoroscopy times, and a low 1.3% rate of serious adverse events related to the primary safety endpoint. Company and clinical leaders characterized the results as demonstrating an efficient workflow, durable pulmonary vein isolation, and a favorable safety profile versus typical atrial fibrillation recurrence expectations, positioning the nPulse system as a potentially first‑in‑class and highly differentiated catheter ablation platform as Pulse Biosciences advances its clinical program.

The most recent analyst rating on (PLSE) stock is a Buy with a $25.00 price target. To see the full list of analyst forecasts on Pulse Biosciences stock, see the PLSE Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Pulse Biosciences updates investor deck on cardiac pipeline
Positive
Jan 14, 2026

On January 14, 2025, Pulse Biosciences, Inc. announced that it had posted an updated investor presentation on its website, detailing recent progress in its ongoing product development programs for the nPulse Vybrance Percutaneous Electrode, the nPulse Cardiac Clamp and the nPulse Cardiac Catheter. The investor deck, dated as of January 2026, is intended for use in communications with investors and analysts and underscores the company’s efforts to advance and showcase its cardiac-focused technology pipeline, offering stakeholders a consolidated view of its development trajectory while emphasizing that the materials are summary in nature and subject to standard securities law limitations on liability and updating obligations.

The most recent analyst rating on (PLSE) stock is a Hold with a $14.50 price target. To see the full list of analyst forecasts on Pulse Biosciences stock, see the PLSE Stock Forecast page.

Business Operations and StrategyExecutive/Board Changes
Pulse Biosciences Adds Veteran Healthtech Leader to Board
Positive
Jan 9, 2026

On January 8, 2026, Pulse Biosciences elected veteran healthtech executive Maria Sainz to its board of directors and appointed her to the audit committee, with the addition formally announced in a January 9, 2026 press release. Sainz, currently president and CEO of portable MRI maker Hyperfine, brings more than three decades of experience leading public and venture-backed medical device companies through clinical, regulatory, financing and M&A milestones, and will receive standard non-employee director cash retainers, the option to convert retainers into equity, reimbursement of board-related expenses, and time-vested stock option grants that further align her incentives with shareholders. The appointment adds deep commercialization and strategic expertise as Pulse advances its first three nsPFA-based programs through key clinical, regulatory and commercial milestones, underscoring the company’s intention to strengthen governance and bolster its ability to compete and scale in interventional and surgical device markets.

The most recent analyst rating on (PLSE) stock is a Hold with a $14.00 price target. To see the full list of analyst forecasts on Pulse Biosciences stock, see the PLSE Stock Forecast page.

Business Operations and StrategyProduct-Related AnnouncementsRegulatory Filings and Compliance
Pulse Biosciences gains FDA IDE for NANOPULSE-AF trial
Positive
Dec 18, 2025

On December 18, 2025, Pulse Biosciences announced that the U.S. Food and Drug Administration approved its Investigational Device Exemption, enabling the company to begin the NANOPULSE-AF clinical study of its nPulse Cardiac Catheter Ablation System for treating recurrent, drug-resistant, symptomatic paroxysmal atrial fibrillation. The single-arm, multicenter, prospective study will enroll up to 145 patients across as many as 30 sites, including three outside the U.S., to evaluate the safety and effectiveness of the nsPFA-based catheter, which is designed to deliver rapid, circumferential pulmonary vein isolation with lower total energy and potentially reduced collateral injury, building on positive initial results from an ongoing European feasibility study and marking a key milestone in the company’s push to establish its next-generation ablation technology in the global electrophysiology market.

The most recent analyst rating on (PLSE) stock is a Buy with a $22.00 price target. To see the full list of analyst forecasts on Pulse Biosciences stock, see the PLSE Stock Forecast page.

Executive/Board ChangesShareholder Meetings
Pulse Biosciences Holds 2025 Annual Stockholder Meeting
Neutral
Dec 12, 2025

On December 9, 2025, Pulse Biosciences, Inc. conducted its 2025 Annual Meeting of Stockholders virtually. During the meeting, stockholders elected six directors to serve until the 2026 meeting, ratified Deloitte & Touche LLP as the independent accounting firm for 2025, approved executive compensation, and decided to hold future advisory votes on executive compensation every three years.

The most recent analyst rating on (PLSE) stock is a Buy with a $22.00 price target. To see the full list of analyst forecasts on Pulse Biosciences stock, see the PLSE Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Pulse Biosciences Partners with MD Anderson for Thyroid Cancer Study
Positive
Dec 9, 2025

On December 9, 2025, Pulse Biosciences announced a research collaboration with The University of Texas MD Anderson Cancer Center to explore the use of its nPulse™ Vybrance™ Percutaneous Electrode System for treating thyroid cancers. The FDA has approved the Investigational Device Exemption for this first-in-human clinical feasibility study, which will begin in early 2026, involving 30 subjects across two sites. This collaboration aims to assess the safety and effectiveness of nPulse technology in treating papillary thyroid microcarcinoma, with ongoing preclinical studies on anaplastic thyroid carcinoma, a particularly deadly cancer. The nonthermal mechanism of nsPFA energy is highlighted for its potential to minimize scarring and damage to surrounding structures, positioning it as a promising treatment for both benign and malignant thyroid tumors.

The most recent analyst rating on (PLSE) stock is a Buy with a $22.00 price target. To see the full list of analyst forecasts on Pulse Biosciences stock, see the PLSE Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Feb 28, 2026