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Oncolytics Biotech (ONCY)
NASDAQ:ONCY

Oncolytics Biotech (ONCY) AI Stock Analysis

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ONCY

Oncolytics Biotech

(NASDAQ:ONCY)

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Neutral 43 (OpenAI - 5.2)
Rating:43Neutral
Price Target:
$0.87
▼(-11.82% Downside)
The score is driven primarily by weak financial performance (no revenue, large losses, heavy cash burn) and heightened balance-sheet strain from sharply reduced equity. Technical indicators also point to a weak trend and bearish momentum. Valuation provides only limited support because the negative P/E reflects ongoing losses and there is no dividend yield provided.

Oncolytics Biotech (ONCY) vs. SPDR S&P 500 ETF (SPY)

Oncolytics Biotech Business Overview & Revenue Model

Company DescriptionOncolytics Biotech Inc., a development-stage biopharmaceutical company, focuses on the discovery and development of pharmaceutical products for the treatment of cancer. Its lead product is pelareorep, an intravenously delivered immunotherapeutic agent for the treatment of solid tumors and hematological malignancies. Oncolytics Biotech Inc. has a co-development agreement with Merck KGaA and Pfizer Inc. to co-develop pelareorep in combination with paclitaxel and avelumab, a human anti-PD-L1 antibody for the treatment of hormone receptor-positive/human epidermal growth factor 2-negative metastatic breast cancer; and PrECOG LLC. The company was incorporated in 1998 and is headquartered in Calgary, Canada.
How the Company Makes Money

Oncolytics Biotech Earnings Call Summary

Earnings Call Date:May 14, 2025
(Q1-2025)
|
% Change Since: |
Next Earnings Date:Mar 05, 2026
Earnings Call Sentiment Positive
The earnings call reflects a strong positive sentiment with significant advancements in clinical data and strategic financial moves. The highlights, particularly in clinical trial progress and promising data across several cancer types, outweigh the challenges such as the ongoing CEO search and reduced R&D spending.
Q1-2025 Updates
Positive Updates
Clinical Data Exceeds Expectations
Oncolytics Biotech's clinical data for pelareorep continues to exceed expectations, particularly in difficult-to-treat malignancies such as pancreatic cancer, breast cancer, and anal carcinoma.
Positive Results in Breast Cancer Studies
Pelareorep-based combination therapy substantially outperformed standard care treatments in two randomized Phase 2 studies for HR-positive/HER2-negative metastatic breast cancer.
Promising Pancreatic and Anal Cancer Data
Interim results from the GOBLET Cohort 4 showed a 33% objective response rate in relapsed anal carcinoma, including a complete response lasting over 15 months. Additionally, the pancreatic cancer cohort is progressing with more than half of the required patients enrolled.
Favorable Safety Profile and Versatility
Pelareorep demonstrates a remarkable safety profile and versatility, showing potential in multiple cancer types and combinations with different chemotherapies and checkpoint inhibitors.
Financial Flexibility Through Share Purchase Agreement
A $20 million share purchase agreement with Alumni Capital provides Oncolytics with access to capital, enhancing financial flexibility.
Negative Updates
Ongoing CEO Search
The search for a new CEO is still ongoing, indicating a potential leadership gap in the interim period.
Reduced Research and Development Spending
Research and development expenses decreased to $4.1 million from $5.7 million in Q1 2024, primarily due to reduced manufacturing and clinical trial costs.
Company Guidance
During the first quarter conference call for Oncolytics Biotech in 2025, the company provided guidance on several key metrics related to the development of their cancer therapeutic, pelareorep (pela). They reported cash and cash equivalents of $15.3 million, which is expected to provide financial runway through the third quarter of 2025. Net cash used in operating activities was $6.5 million, a decrease from $7.5 million in the same period last year. General and administrative expenses remained consistent at $3 million, while research and development expenses decreased to $4.1 million from $5.7 million in Q1 2024. The net loss for the quarter was $6.7 million, or $0.08 per share, compared to $6.9 million or $0.09 per share in the previous year. The company also announced a $20 million share purchase agreement with Alumni Capital to extend their financial runway. Oncolytics is advancing their clinical trials, particularly focusing on breast and pancreatic cancer, with promising efficacy data from randomized Phase 2 studies and plans for future registrational opportunities.

Oncolytics Biotech Financial Statement Overview

Summary
Income Statement
Balance Sheet
Cash Flow
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue0.000.000.000.000.000.00
Gross Profit0.000.00-298.59K-301.11K-360.57K-332.65K
EBITDA-35.41M-34.88M-20.19M-18.71M-20.58M-16.45M
Net Income-35.27M-31.71M-20.56M-19.08M-20.98M-16.78M
Balance Sheet
Total Assets15.06M20.19M38.82M37.33M45.88M34.35M
Cash, Cash Equivalents and Short-Term Investments12.35M15.94M34.91M32.14M41.26M31.22M
Total Debt835.00K1.06M423.00K373.00K655.00K402.06K
Total Liabilities14.94M14.20M11.26M10.83M9.78M9.59M
Stockholders Equity115.00K5.98M27.56M26.50M36.10M24.75M
Cash Flow
Free Cash Flow-26.48M-27.20M-28.46M-23.41M-22.72M-22.10M
Operating Cash Flow-26.47M-26.97M-28.45M-23.36M-22.43M-22.07M
Investing Cash Flow-13.00K-239.00K20.22M-20.40M-285.95K-29.30K
Financing Cash Flow18.74M6.64M31.99M12.21M33.02M39.77M

Oncolytics Biotech Risk Analysis

Oncolytics Biotech disclosed 65 risk factors in its most recent earnings report. Oncolytics Biotech reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Oncolytics Biotech Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
63
Neutral
$130.15M3.4724.38%814.20%
56
Neutral
$160.22M-1.71-103.99%250.00%15.15%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
49
Neutral
$107.72M7.9651.27%
49
Neutral
$174.85M-1.36-49.18%-33.76%17.54%
45
Neutral
$85.91M-2.78-48.89%-9.42%
43
Neutral
$103.37M-3.53-745.66%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ONCY
Oncolytics Biotech
0.99
0.12
14.04%
ATOS
Atossa Therapeutics
0.65
-0.25
-27.44%
ORMP
Oramed Pharm
3.48
1.09
45.61%
ATRA
Atara Biotherapeutics
17.44
1.89
12.15%
ZNTL
Zentalis Pharmaceuticals
2.84
0.09
3.27%
PRLD
Prelude Therapeutics
2.76
1.70
160.38%

Oncolytics Biotech Corporate Events

Oncolytics Biotech Reschedules Shareholder Meeting Amid SEC Delays
Nov 20, 2025

On November 20, 2025, Oncolytics Biotech announced the cancellation and rescheduling of its special meeting of shareholders initially planned for December 15, 2025. The decision was due to delays at the Securities and Exchange Commission caused by a recent U.S. federal government shutdown. The meeting, once rescheduled, will address a series of transactions, including the company’s proposed jurisdiction change from Alberta, Canada, to Nevada, USA. This move could significantly impact Oncolytics’ operational jurisdiction and strategic positioning.

The most recent analyst rating on (ONCY) stock is a Buy with a $7.00 price target. To see the full list of analyst forecasts on Oncolytics Biotech stock, see the ONCY Stock Forecast page.

Oncolytics Biotech Aligns with FDA for Pivotal Pancreatic Cancer Study
Nov 19, 2025

Oncolytics Biotech Inc. announced on November 19, 2025, that it has aligned with the FDA on the design of a pivotal Phase 3 study for pelareorep in combination with standard-of-care therapy for first-line treatment of metastatic pancreatic ductal adenocarcinoma (mPDAC). This trial, set to launch in the first half of 2026, will be the only current registration trial involving an immunotherapy for first-line pancreatic cancer, potentially offering a new treatment option where immunotherapies have shown limited benefits. The study will evaluate pelareorep with chemotherapy, with or without a checkpoint inhibitor, and aims to demonstrate a clinically meaningful survival benefit.

The most recent analyst rating on (ONCY) stock is a Buy with a $3.00 price target. To see the full list of analyst forecasts on Oncolytics Biotech stock, see the ONCY Stock Forecast page.

Oncolytics Biotech Reports Increased Q3 Loss Amid Rising Expenses
Nov 12, 2025

On November 12, 2025, Oncolytics Biotech Inc. released its financial results for the three and nine months ended September 30, 2025. The company reported a net loss of $14.4 million for the third quarter, compared to $9.5 million in the same period last year. The increase in net loss was primarily due to higher general and administrative expenses. Despite the financial challenges, Oncolytics continues to focus on advancing its clinical programs, which are critical to its strategic positioning in the biotech industry.

The most recent analyst rating on (ONCY) stock is a Buy with a $5.00 price target. To see the full list of analyst forecasts on Oncolytics Biotech stock, see the ONCY Stock Forecast page.

Oncolytics Biotech Forms Advisory Board to Advance GI Cancer Treatment
Nov 4, 2025

On November 4, 2025, Oncolytics Biotech announced the formation of a Gastrointestinal Tumor Scientific Advisory Board (SAB) to guide the clinical and regulatory strategy for pelareorep as a treatment for gastrointestinal cancers. The SAB, consisting of leading oncology experts, will play a crucial role in shaping the company’s GI oncology development strategy, including designing registration-enabling studies and exploring pathways for accelerated approval in select tumor types. This initiative is expected to strengthen Oncolytics’ position in the industry and potentially transform the treatment landscape for patients with GI tumors.

The most recent analyst rating on (ONCY) stock is a Buy with a $5.00 price target. To see the full list of analyst forecasts on Oncolytics Biotech stock, see the ONCY Stock Forecast page.

Oncolytics Biotech Reports Promising Anal Cancer Data with Pelareorep
Oct 28, 2025

On October 28, 2025, Oncolytics Biotech announced updated results from their GOBLET study, showing that the combination of pelareorep and atezolizumab achieved a 30% objective response rate in second-line or later squamous cell anal carcinoma (SCAC), more than doubling the current standard of care. The median duration of response was 15.5 months, significantly longer than the 9.5 months for existing treatments. These findings highlight pelareorep’s potential to drive durable tumor control and position Oncolytics for a possible accelerated approval study with the FDA in early 2026.

The most recent analyst rating on (ONCY) stock is a Buy with a $5.00 price target. To see the full list of analyst forecasts on Oncolytics Biotech stock, see the ONCY Stock Forecast page.

Oncolytics Biotech Highlights Pelareorep’s Potential in Cancer Therapy
Oct 10, 2025

On October 10, 2025, Oncolytics Biotech Inc. submitted a corporate presentation to the Securities and Exchange Commission, highlighting the potential of pelareorep as a transformative immunotherapy platform for gastrointestinal tumors. The presentation detailed the mechanism of action, safety profile, and clinical experience of pelareorep, which has shown promising results in various cancer indications. This development positions Oncolytics Biotech as a key player in the oncology sector, potentially impacting stakeholders by offering a novel treatment option for patients with GI tumors.

The most recent analyst rating on (ONCY) stock is a Buy with a $5.00 price target. To see the full list of analyst forecasts on Oncolytics Biotech stock, see the ONCY Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 30, 2025