Olema Pharmaceuticals (OLMA) AI Stock Analysis

• Market Cap: $2.13B
• Dividend Yield: N/A
• Average Volume (3M): 2.23M
• Price to Earnings (P/E): ―
• Beta (1Y): 0.73
• Revenue Growth: N/A
• EPS Growth: 17.23%
• Country: US
• Employees: 96
• Sector: Healthcare
• Sector Strength: 45
• Industry: Biotechnology
• EPS (TTM): -0.49
• Shares Outstanding: 78,659,920
• 10 Day Avg. Volume: 813,280
• 30 Day Avg. Volume: 2,228,528
• PEG Ratio: -0.94
• Price to Book (P/B): 0.84
• Price to Sales (P/S): 0.00
• P/FCF Ratio: -3.28
• Enterprise Value/Market Cap: 0.24
• Enterprise Value/Revenue: N/A
• Enterprise Value/Gross Profit: -4.02K
• Enterprise Value/Ebitda: -3.19
• 1Y Price Target: $42.00
• Price Target Upside: 55.15% Upside
• Rating Consensus: Strong Buy
• Number of Analyst Covering: 11
• EPS Forecast (FY): N/A
• Revenue Forecast (FY): N/A

• Rating: 52 Neutral
• Price Target: $26.00 ▼(-3.95% Downside)

The score is held back primarily by weak financial performance (no revenue, widening losses, and rising cash burn), partially offset by a low-debt balance sheet. Technicals are moderately supportive on a longer-term basis but mixed near-term, while valuation is challenged by negative earnings. A notable positive is the recent encouraging trial data supporting the Phase 3 program.

Positive Factors

Strategic Collaboration

The collaboration with Novartis could enhance Olema's market position and support long-term growth through shared resources and expertise in developing breast cancer treatments.

Clinical Pipeline Advancements

Advancements in the clinical pipeline, particularly the Phase 3 trials, indicate progress towards commercialization, which is crucial for future revenue generation and market competitiveness.

Strong Equity Position

A strong equity position with minimal debt provides financial stability and flexibility, enabling Olema to invest in R&D and strategic initiatives without immediate financial pressure.

Negative Factors

Zero Revenue

The absence of revenue highlights the risk associated with Olema's reliance on future drug approvals and partnerships for financial sustainability, posing a challenge to long-term viability.

Increasing Net Losses

Rising net losses indicate financial strain, necessitating external funding and potentially diluting shareholder value, which could impact long-term financial health.

Negative Cash Flow

Negative cash flow reflects high cash burn typical for biotech firms, highlighting the need for continuous capital infusion to sustain operations and fund ongoing R&D activities.

Olema Pharmaceuticals Business Overview & Revenue Model

Company Description

Olema Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, focuses on the discovery, development, and commercialization of therapies for women's cancers. Its lead product candidate is OP-1250, an estrogen receptor (ER) antagonist and a selective ER degrader, which is in Phase 1/2 clinical trial for the treatment of recurrent, locally advanced, or metastatic estrogen receptor-positive, human epidermal growth factor receptor 2-negative breast cancer. The company was formerly known as CombiThera, Inc. and changed its name to Olema Pharmaceuticals, Inc. in March 2009. Olema Pharmaceuticals, Inc. was incorporated in 2006 and is headquartered in San Francisco, California.

How the Company Makes Money

Olema Pharmaceuticals makes money primarily through the development and commercialization of its drug candidates. As a clinical-stage company, its revenue model is heavily reliant on advancing its lead product candidate, OP-1250, through clinical trials and, ultimately, gaining regulatory approval for commercialization. The company may also enter into partnerships or licensing agreements with larger pharmaceutical companies, which could provide upfront payments, milestone payments, and royalties based on the sales of successfully developed drugs. Additionally, Olema may generate revenue through collaborations with research institutions or by securing grants to support its research and development activities.

Olema Pharmaceuticals Financial Statement Overview

Summary

Olema Pharmaceuticals is experiencing significant financial strain with zero revenue and increasing net losses. The company maintains a strong equity position with minimal debt, but the lack of revenue and negative cash flows pose significant risks, necessitating continued reliance on external financing.

Income Statement

Olema Pharmaceuticals has consistently reported zero revenue over the years, which is typical for biotechnology firms in the development phase. However, the company has experienced increasing net losses, with the most recent year showing a net income loss of $129.47 million, up from $96.66 million the previous year. The lack of revenue and increasing losses indicate financial strain and risk, contributing to a low income statement score.

Balance Sheet

The balance sheet shows a strong equity position with a stockholders' equity of $408.96 million. The company has minimal debt, resulting in a low debt-to-equity ratio. However, the company's total assets are largely composed of cash and equivalents, indicating limited asset diversification. The equity ratio remains healthy, but the absence of revenue-generating assets poses a risk to future financial stability.

Cash Flow

Operating cash flow has been negative and worsening, with a current deficit of $104.35 million. Free cash flow is similarly negative, reflecting high cash burn rates typical for biotech firms in R&D phases. Positive financing cash flow indicates reliance on external funding to sustain operations. The negative cash flow metrics highlight cash management challenges and reliance on capital markets for liquidity.

Breakdown	TTM	Dec 2024	Dec 2023	Dec 2022	Dec 2021	Dec 2020
Income Statement
Total Revenue	0.00	0.00	0.00	0.00	0.00	0.00
Gross Profit	-128.00K	0.00	0.00	0.00	0.00	-11.00K
EBITDA	-161.30M	-141.87M	-104.58M	-106.63M	-71.33M	-21.52M
Net Income	-149.96M	-129.47M	-96.66M	-104.79M	-71.10M	-22.12M
Balance Sheet
Total Assets	352.45M	450.98M	276.94M	215.65M	295.94M	342.72M
Cash, Cash Equivalents and Short-Term Investments	328.96M	434.09M	261.81M	204.42M	287.25M	338.55M
Total Debt	4.48M	1.43M	2.42M	2.56M	3.29M	0.00
Total Liabilities	44.97M	42.02M	23.05M	18.10M	11.38M	4.58M
Stockholders Equity	307.49M	408.96M	253.90M	197.55M	284.57M	338.14M
Cash Flow
Free Cash Flow	-134.67M	-104.51M	-83.73M	-82.43M	-52.27M	-19.92M
Operating Cash Flow	-134.67M	-104.35M	-83.73M	-82.06M	-50.69M	-19.87M
Investing Cash Flow	-108.00M	-93.53M	-4.85M	91.48M	-275.44M	-56.00K
Financing Cash Flow	242.04M	268.82M	133.41M	476.00K	1.39M	358.40M

Olema Pharmaceuticals Technical Analysis

• Technical Analysis Sentiment: Neutral
• Last Price: 27.07
• 50DMA: Positive
• 100DMA: Positive
• 200DMA: Positive
• MACD: Positive
• RSI: Neutral
• STOCH: Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For OLMA, the sentiment is Neutral. The current price of 27.07 is below the 20-day moving average (MA) of 28.50, above the 50-day MA of 21.60, and above the 200-day MA of 9.74, indicating a neutral trend. The MACD of 0.48 indicates Positive momentum. The RSI at 49.13 is Neutral, neither overbought nor oversold. The STOCH value of 49.75 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for OLMA.

Olema Pharmaceuticals Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
KROS	72 Outperform	$565.45M	12.04	10.43%	―	37798.31%	―
ARVN	61 Neutral	$797.02M	-15.17	―	―	―	―
CMPX	55 Neutral	$969.35M	―	-37.82%	―	-100.00%	-28.79%
OLMA	52 Neutral	$2.13B	-14.11	-59.22%	―	―	17.23%
Sector *	51 Neutral	$7.86B	-0.30	-43.30%	2.27%	22.53%	-2.21%
MGTX	47 Neutral	$622.19M	-3.44	-611.42%	―	96.83%	-61.92%
GOSS	47 Neutral	$557.81M	-3.64	―	―	-58.17%	-116.24%

Olema Pharmaceuticals Corporate Events

Olema Pharmaceuticals Announces Public Stock Offering

On November 18, 2025, Olema Pharmaceuticals announced a public offering of 10,000,000 shares of its common stock at $19.00 per share, expected to close on November 20, 2025. The offering aims to raise approximately $190 million, excluding underwriting discounts and commissions, with an option for underwriters to purchase an additional 1,500,000 shares. This move is part of Olema’s strategy to strengthen its financial position and support its ongoing operations in the competitive pharmaceutical market.

The most recent analyst rating on (OLMA) stock is a Buy with a $32.00 price target. To see the full list of analyst forecasts on Olema Pharmaceuticals stock, see the OLMA Stock Forecast page.

Olema Pharmaceuticals Terminates ATM Prospectus

Olema Pharmaceuticals announced the termination of its ATM Prospectus, effective November 18, 2025, which was related to the sale of its common stock in an ‘at-the-market’ offering. The termination means the company will not sell its common stock under the existing Sales Agreement with TD Securities (USA) LLC until a new prospectus or registration statement is filed, although the Sales Agreement itself remains active.

The most recent analyst rating on (OLMA) stock is a Buy with a $32.00 price target. To see the full list of analyst forecasts on Olema Pharmaceuticals stock, see the OLMA Stock Forecast page.

Olema Pharmaceuticals Reports Positive Phase 1b/2 Trial Results

On October 18, 2025, Olema Pharmaceuticals announced new data from its Phase 1b/2 trial of palazestrant in combination with ribociclib for patients with ER+/HER2- advanced or metastatic breast cancer. The trial results showed encouraging activity with a median progression-free survival of 15.5 months in the 120 mg palazestrant cohort and demonstrated a favorable safety profile. These findings support the ongoing Phase 3 OPERA-02 trial and suggest the potential of palazestrant as a new standard of care in metastatic breast cancer, highlighting its efficacy in both ESR1 mutant and wild-type tumors.

The most recent analyst rating on (OLMA) stock is a Buy with a $28.00 price target. To see the full list of analyst forecasts on Olema Pharmaceuticals stock, see the OLMA Stock Forecast page.