aTyr Pharma (ATYR) AI Stock Analysis

• Market Cap: $501.10M
• Dividend Yield: N/A
• Average Volume (3M): 3.49M
• Price to Earnings (P/E): ―
• Beta (1Y): 1.12
• Revenue Growth: -100.00%
• EPS Growth: 10.73%
• Country: US
• Employees: 56
• Sector: Healthcare
• Sector Strength: 44
• Industry: Biotechnology
• EPS (TTM): -0.17
• Shares Outstanding: 89,004,430
• 10 Day Avg. Volume: 3,135,409
• 30 Day Avg. Volume: 3,488,270
• PEG Ratio: -1.12
• Price to Book (P/B): 6.38
• Price to Sales (P/S): 0.00
• P/FCF Ratio: -7.92
• Enterprise Value/Market Cap: 1.01
• Enterprise Value/Revenue: 476.11
• Enterprise Value/Gross Profit: N/A
• Enterprise Value/Ebitda: -1.95
• 1Y Price Target: $22.33
• Price Target Upside: 285.66% Upside
• Rating Consensus: Strong Buy
• Number of Analyst Covering: 7

• Rating: 51 Neutral
• Price Target: $5.50 ▼(-5.01%Downside)

aTyr Pharma's overall score is primarily impacted by its financial challenges, with ongoing losses and cash flow issues posing significant risks. Despite this, the stock demonstrates technical strength with strong upward momentum. Valuation concerns due to a negative P/E ratio further weigh on the score.

Positive Factors

Investor Confidence

Achieving significant steroid reduction and positive quality of life benefits should improve investor confidence on payer access and adoption.

Market Potential

Efzofitimod could be a $2B+ drug in pulmonary sarcoidosis if results are positive.

Trial Design

The study is optimized for success via a favorable steroid tapering trial design and strong study execution by ATYR.

Negative Factors

Data Uncertainty

The company did not specify which dose was used in the patients, making it difficult to compare results to the placebo arm.

Market Risk

If efzofitimod's Phase 3 trial fails, the company has no other late-stage assets and limited cash, thus it could trade down to a ~$50MM market cap.

Trial Duration Concerns

The key unknown is how these patients will behave in the 24-48 weeks — whether they can maintain the regimen/co-treatment at 24 weeks through 48 weeks.

aTyr Pharma Business Overview & Revenue Model

Company Description

aTyr Pharma (ATYR) is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel biological pathways. The company's primary focus lies in the research and development of therapeutics derived from unique protein interactions within the human body, particularly targeting immune, fibrotic, and other serious diseases. aTyr Pharma operates within the biotechnology and pharmaceuticals sectors, aiming to address significant unmet medical needs through its cutting-edge scientific approaches.

How the Company Makes Money

aTyr Pharma makes money primarily through the development and commercialization of its proprietary therapeutic candidates. The company's revenue model is centered around advancing its pipeline of drug candidates through clinical trials and eventually bringing successful treatments to the market. Revenue streams may include milestone payments, licensing agreements, and collaborations with larger pharmaceutical companies. These partnerships can provide significant financial support and resources, allowing aTyr Pharma to further its research and development efforts. Additionally, the company may generate income through grants and funding from governmental and non-governmental organizations interested in supporting innovative medical research.

aTyr Pharma Financial Statement Overview

Summary

aTyr Pharma is facing major financial challenges with negative profitability, declining revenue, and negative cash flows. However, it maintains a strong equity position and manageable debt level.

Income Statement

aTyr Pharma's income statement shows significant challenges with sustained negative profitability. The gross profit margin was 100% in 2024 due to minimal revenue, but the company has a consistent negative net profit margin due to high expenses outweighing revenue, with a net income of -$64 million in 2024. Revenue growth was negative at -33.43% from 2023 to 2024, indicating a decline in sales. The EBIT and EBITDA margins are both negative, reflecting ongoing operational losses.

Balance Sheet

The balance sheet shows a moderate financial position for aTyr Pharma. The debt-to-equity ratio is relatively low at 0.19, suggesting manageable leverage. However, the return on equity (ROE) is negative due to substantial net losses impacting shareholder value. The equity ratio stands at 72.33%, indicating a strong equity position relative to total assets.

Cash Flow

Cash flow analysis for aTyr Pharma reveals ongoing operational cash deficits, with an operating cash flow of -$69 million in 2024. The free cash flow growth rate is negative at -84.64%. The operating cash flow to net income ratio is slightly above 1, indicating operating losses are closely aligned with net income losses.

Breakdown	Dec 2024	Dec 2023	Dec 2022	Dec 2021	Dec 2020
Income Statement
Total Revenue	235.00K	353.00K	10.39M	0.00	10.46M
Gross Profit	235.00K	353.00K	8.69M	-1.30M	-6.84M
EBITDA	-66.37M	-52.18M	-44.71M	-32.47M	-14.64M
Net Income	-64.02M	-50.39M	-45.34M	-33.77M	-16.22M
Balance Sheet
Total Assets	96.83M	120.65M	95.79M	115.54M	38.73M
Cash, Cash Equivalents and Short-Term Investments	72.13M	98.17M	66.15M	107.91M	31.69M
Total Debt	13.28M	15.10M	11.53M	1.38M	2.24M
Total Liabilities	27.00M	30.18M	24.50M	6.41M	7.24M
Stockholders Equity	70.02M	90.66M	71.46M	109.30M	31.65M
Cash Flow
Free Cash Flow	-69.18M	-37.44M	-43.53M	-33.27M	-15.50M
Operating Cash Flow	-69.12M	-33.22M	-41.89M	-33.08M	-15.30M
Investing Cash Flow	17.23M	-20.13M	47.24M	-91.57M	6.90M
Financing Cash Flow	39.86M	66.23M	5.45M	110.03M	16.14M

aTyr Pharma Technical Analysis

• Technical Analysis Sentiment: Positive
• Last Price: 5.79
• 50DMA: Positive
• 100DMA: Positive
• 200DMA: Positive
• MACD: Negative
• RSI: Neutral
• STOCH: Negative

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ATYR, the sentiment is Positive. The current price of 5.79 is above the 20-day moving average (MA) of 5.32, above the 50-day MA of 4.68, and above the 200-day MA of 3.63, indicating a bullish trend. The MACD of 0.25 indicates Negative momentum. The RSI at 64.67 is Neutral, neither overbought nor oversold. The STOCH value of 85.14 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for ATYR.

aTyr Pharma Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
ATAI	62 Neutral	$531.99M	―	-62.43%	―	-0.90%	-89.51%
ARCT	57 Neutral	$348.50M	―	-27.40%	―	15.40%	35.42%
Sector *	52 Neutral	kr5.61B	11.26	-62.48%	1.93%	26.20%	22.87%
GLUE	52 Neutral	$321.70M	83.48	2.88%	―	―	61.09%
ATYR	51 Neutral	$501.10M	―	-79.51%	―	-100.00%	10.73%
OLMA	46 Neutral	$314.05M	―	-41.59%	―	―	0.42%
AURA	43 Neutral	$406.75M	―	-56.24%	―	―	9.22%

aTyr Pharma Corporate Events

aTyr Pharma Stockholders Approve Key Proposals at Annual Meeting

At the recent Annual Meeting, aTyr Pharma‘s stockholders approved several key proposals, including the election of two Class I directors, the ratification of Ernst & Young LLP as the independent public accounting firm for the fiscal year ending December 31, 2025, and the approval of amendments to the 2015 Stock Plan. These decisions, supported by a significant number of votes, reflect the company’s strategic direction and governance priorities, potentially impacting its operational and financial strategies moving forward.