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OKYO Pharma Limited Sponsored ADR (OKYO)
NASDAQ:OKYO
US Market

OKYO Pharma Limited Sponsored ADR (OKYO) AI Stock Analysis

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OKYO

OKYO Pharma Limited Sponsored ADR

(NASDAQ:OKYO)

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Neutral 51 (OpenAI - 5.2)
Rating:51Neutral
Price Target:
$2.00
▼(-30.56% Downside)
The score is held down primarily by weak fundamentals (pre-revenue, ongoing losses, negative free cash flow, and negative equity) despite improved 2025 cost and cash-burn trends and zero debt. Technicals are a meaningful offset with strong momentum above key moving averages, while valuation remains challenged due to negative earnings and no indicated dividend yield.
Positive Factors
Phase 2 proof-of-concept efficacy
Clear Phase 2 proof-of-concept materially reduces scientific and clinical risk for urcosimod, supporting progression to larger registrational trials. Over the medium term this validates the therapeutic hypothesis, strengthens competitive positioning in an underserved NCP market, and helps attract partners or licensing interest.
Regulatory alignment de-risks pivotal path
FDA concurrence on endpoints, sample size, powering and CMC reduces regulatory uncertainty and execution risk for the planned Phase 2b/3. This durable alignment raises the probability that pivotal data will be considered sufficient for registration, shortens development timelines, and improves strategic planning and partner confidence.
Experienced ophthalmology leadership
Bringing a CEO with proven ophthalmology launch experience strengthens commercial strategy, trial-to-market planning and regulatory interactions. Over the next several months this enhances the company’s ability to design registrational programs with launch viability in mind and improves credibility with partners and investors.
Negative Factors
Pre-revenue with recurring losses
Being pre-revenue with persistent net losses and negative free cash flow means the business model depends entirely on R&D success and external capital. Structurally, this sustains dilution and execution risk over the coming months and leaves key development milestones contingent on successful financing or partnerships.
Negative stockholders' equity
Negative shareholders' equity signals solvency fragility and limited financial flexibility even with no debt. Over the medium term this can restrict access to non-dilutive financing or credit, deter certain partnerships, and increase the likelihood that future capital raises will be dilutive or conditional.
Persistent negative cash flow
Although cash burn improved in 2025, free cash flow remains negative annually and operations consume cash. This structural funding requirement means the company will need additional capital to complete pivotal trials; funding uncertainty can delay milestones, constrain development choices, or force unfavorable financing terms.

OKYO Pharma Limited Sponsored ADR (OKYO) vs. SPDR S&P 500 ETF (SPY)

OKYO Pharma Limited Sponsored ADR Business Overview & Revenue Model

Company DescriptionOKYO Pharma Limited, a preclinical biopharmaceutical company, engages in developing therapeutics for patients suffering from inflammatory eye diseases and ocular pain in the United Kingdom. Its lead product includes OK-101 for the treatment of dry eye disease. The company is also developing OK-201, a bovine adrenal medulla, lipidated-peptide preclinical analogue candidate for the treatment of neuropathic ocular pain. OKYO Pharma Limited was incorporated in 2007 and is headquartered in London, the United Kingdom.
How the Company Makes MoneyOKYO Pharma Limited generates revenue primarily through the development and potential commercialization of its drug candidates. The company makes money by advancing its therapeutic products through clinical trials and ultimately obtaining regulatory approvals to market them. Revenue streams may include licensing agreements with larger pharmaceutical companies, milestone payments, and royalties from any successful commercialization of its treatments. Additionally, OKYO may engage in strategic partnerships or collaborations that provide funding and resources to support its research and development efforts.

OKYO Pharma Limited Sponsored ADR Financial Statement Overview

Summary
Financial profile remains weak: the company is pre-revenue with recurring net losses and negative free cash flow. Positives include a sharp improvement in 2025 losses and cash burn and zero debt, but negative stockholders’ equity signals a fragile solvency position and continued reliance on external funding.
Income Statement
12
Very Negative
The company remains pre-revenue (revenue is 0 across all reported years), and profitability is weak with persistent net losses. Losses improved materially in 2025 (net loss of about $4.7M vs. ~$16.8M in 2024), indicating better cost control, but the business still has no revenue base and negative operating results (EBITDA and EBIT remain deeply negative). Overall, the trajectory is improving, but earnings quality is still very weak due to the lack of commercialization.
Balance Sheet
28
Negative
Leverage is currently low (total debt is 0 in 2024 and 2025), which is a balance-sheet positive. However, stockholders’ equity is negative in 2024 and 2025, which is a key solvency risk signal and limits financial flexibility. Total assets increased sharply in 2025 versus 2024, but the negative equity position keeps the balance sheet profile fragile despite the absence of debt.
Cash Flow
24
Negative
Cash burn remains significant, but improved meaningfully in 2025: operating cash outflow was about $1.8M vs. ~$9.5M in 2024, and free cash flow similarly improved to roughly -$1.8M. Free cash flow has been negative every year shown, consistent with an R&D-heavy biotech model, and ongoing funding needs are likely unless revenues emerge or spending stays constrained. Cash flow performance is improving, but still structurally negative.
BreakdownTTMDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue0.000.000.000.000.000.00
Gross Profit-2.17K-2.56K-3.87K-3.80K-2.42K-13.09K
EBITDA-9.58M-7.08M-15.75M-13.18M-6.21M-3.35M
Net Income-4.61M-4.71M-16.83M-13.27M-5.43M-3.35M
Balance Sheet
Total Assets4.64M3.68M1.54M5.20M4.30M7.09M
Cash, Cash Equivalents and Short-Term Investments4.22M1.56M826.85K4.05M2.70M6.89M
Total Debt185.79K0.000.002.22M0.0098.76K
Total Liabilities8.06M9.23M7.42M7.26M1.35M1.77M
Stockholders Equity-3.42M-5.55M-5.88M-2.05M2.95M5.32M
Cash Flow
Free Cash Flow-3.10M-1.81M-9.49M-7.70M-5.47M-1.61M
Operating Cash Flow-3.10M-1.81M-9.49M-7.70M-5.47M-1.60M
Investing Cash Flow-1.21K-1.21K0.00-5.92K-1.67K-18.11K
Financing Cash Flow6.42M2.66M6.21M9.32M2.15M7.83M

OKYO Pharma Limited Sponsored ADR Technical Analysis

Technical Analysis Sentiment
Negative
Last Price2.88
Price Trends
50DMA
2.12
Negative
100DMA
2.19
Negative
200DMA
2.22
Negative
Market Momentum
MACD
-0.04
Positive
RSI
46.43
Neutral
STOCH
26.79
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For OKYO, the sentiment is Negative. The current price of 2.88 is above the 20-day moving average (MA) of 2.32, above the 50-day MA of 2.12, and above the 200-day MA of 2.22, indicating a bearish trend. The MACD of -0.04 indicates Positive momentum. The RSI at 46.43 is Neutral, neither overbought nor oversold. The STOCH value of 26.79 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for OKYO.

OKYO Pharma Limited Sponsored ADR Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
57
Neutral
$375.18M-8.93-47.85%-19.69%
54
Neutral
$156.89M-1.16-85.93%-60.99%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
51
Neutral
$78.61M-16.75
50
Neutral
$77.77M-0.46-209.00%40.22%
49
Neutral
$57.88M-0.89-76.44%-10.03%11.06%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
OKYO
OKYO Pharma Limited Sponsored ADR
2.10
0.97
85.84%
BMEA
Biomea Fusion
1.11
-2.87
-72.11%
ABOS
Acumen Pharmaceuticals
2.57
1.09
73.65%
TCRX
TScan Therapeutics
1.00
-1.44
-59.05%
ZURA
Zura Bio
6.32
4.61
269.59%

OKYO Pharma Limited Sponsored ADR Corporate Events

OKYO Pharma Advances Urcosimod With Positive Interim Results and FDA Alignment on Phase 2b/3 NCP Trial
Jan 30, 2026

On January 30, 2026, OKYO Pharma reported interim results for the six months ended September 30, 2025, highlighting a series of clinical, regulatory and financial milestones that advance its lead drug urcosimod for neuropathic corneal pain. Over the period, the company generated positive long-term stability data for urcosimod, secured FDA Fast Track Designation for its use in NCP, and reported strong topline Phase 2 proof‑of‑concept data in 18 patients, with 75% of per‑protocol participants achieving more than 80% pain reduction on the Visual Analogue Scale after 12 weeks, while also outlining a registration strategy that includes a planned 150‑patient multicenter Phase 2b/3 trial. OKYO supplemented this clinical progress with $1.9 million in non‑dilutive funding in July 2025 and improved its balance sheet to $4.2 million in cash and $4.6 million in total assets as of the period end, while narrowing its comprehensive loss to $3.0 million from $3.2 million a year earlier. In early 2026 the company further strengthened its leadership and regulatory position by appointing ophthalmology industry veteran Robert J. Dempsey as chief executive officer, transitioning former CEO Gary S. Jacob to chief development officer, and securing FDA alignment in a January 28, 2026 Type C meeting on the design, endpoints, and chemistry, manufacturing and controls strategy for the planned Phase 2b/3 urcosimod trial, in a move that de‑risks its pivotal program and positions OKYO as an emerging player in addressing a major unmet need in ophthalmology.

The most recent analyst rating on (OKYO) stock is a Hold with a $2.00 price target. To see the full list of analyst forecasts on OKYO Pharma Limited Sponsored ADR stock, see the OKYO Stock Forecast page.

OKYO Pharma’s Urcosimod Phase 2 Data Accepted for Presentation at 2026 ASCRS Meeting
Jan 30, 2026

On January 30, 2026, OKYO Pharma announced that Phase 2 proof-of-concept efficacy and safety data for its lead candidate urcosimod in neuropathic corneal pain have been accepted for presentation at the 2026 American Society of Cataract and Refractive Surgery Annual Meeting in Washington, DC, scheduled for April 11, 2026. The acceptance, following a competitive review process, provides scientific validation and visibility for the positive pain-reduction signals and corneal nerve health trends seen in OKYO’s recently completed Phase 2 NCP trial, supporting the company’s strategy to advance urcosimod into a larger 150-patient Phase 2b/3 study in the first half of 2026 and potentially strengthen its positioning in the underserved market for NCP, which currently lacks FDA-approved therapies.

The most recent analyst rating on (OKYO) stock is a Hold with a $2.00 price target. To see the full list of analyst forecasts on OKYO Pharma Limited Sponsored ADR stock, see the OKYO Stock Forecast page.

OKYO Pharma Wins FDA Backing on Phase 2b/3 Design for Urcosimod in Neuropathic Corneal Pain
Jan 28, 2026

On January 28, 2026, OKYO Pharma announced it had held a successful Type C meeting with the U.S. Food and Drug Administration regarding the planned Phase 2b/3 human clinical trial of urcosimod for neuropathic corneal pain. The FDA confirmed that the proposed primary endpoint of Visual Analogue Scale pain reduction at Week 12 is clinically meaningful, endorsed the study design, sample size and powering assumptions, agreed that the Ocular Pain Assessment Survey is appropriate supportive evidence, and aligned on the company’s chemistry, manufacturing and controls strategy without raising material issues—collectively helping to de-risk the path toward a pivotal trial and potential future registration. Urcosimod, which already holds an IND and fast track designation for NCP and has produced positive Phase 2 data, is expected to enter a 120-patient Phase 2b/3 multiple-dose study in the first half of this year, marking a key value-inflection point for OKYO and a potentially important advance in a condition that currently lacks any FDA-approved therapies.

The most recent analyst rating on (OKYO) stock is a Hold with a $2.00 price target. To see the full list of analyst forecasts on OKYO Pharma Limited Sponsored ADR stock, see the OKYO Stock Forecast page.

OKYO Pharma Wins FDA Compassionate-Use Clearance for Urcosimod in Severe Neuropathic Corneal Pain
Jan 23, 2026

On January 23, 2026, OKYO Pharma announced that the U.S. Food and Drug Administration authorized a single-patient expanded access (compassionate use) Investigational New Drug application for the use of urcosimod (0.05%) in a patient with severe neuropathic corneal pain treated by a physician at the University of South Florida. The authorization allows urcosimod to be used in a setting where there are currently no FDA-approved therapies for NCP and limited treatment options, underscoring both the unmet medical need and the growing clinical interest in the drug’s dual anti-inflammatory and pain-modulating mechanism. The decision builds on urcosimod’s prior IND and fast track status for NCP and follows positive Phase 2 data, as the company prepares to launch a 120-patient Phase 2b/3 multiple-dose study this year, a development that could strengthen OKYO’s position in the ocular pain and inflammatory eye disease market if subsequent trials confirm its efficacy and safety.

The most recent analyst rating on (OKYO) stock is a Hold with a $2.00 price target. To see the full list of analyst forecasts on OKYO Pharma Limited Sponsored ADR stock, see the OKYO Stock Forecast page.

OKYO Pharma Names Ophthalmology Veteran Robert J. Dempsey as CEO to Drive Next Growth Phase
Jan 5, 2026

On January 5, 2026, OKYO Pharma appointed ophthalmology industry veteran Robert J. Dempsey as Chief Executive Officer and an executive board member, while former CEO Gary S. Jacob, Ph.D., moved into the role of Chief Development Officer and remained on the board. The board-approved leadership transition, effective immediately, is designed to maintain strategic continuity while sharpening OKYO’s commercial and development focus as it advances its flagship drug urcosimod for neuropathic corneal pain and other ocular inflammatory disorders; Dempsey’s track record in launching and commercializing blockbuster eye therapies such as Xiidra and Restasis is expected to strengthen OKYO’s positioning in the ophthalmology market and support the company’s next phase of growth around its planned larger Phase 2 NCP program.

The most recent analyst rating on (OKYO) stock is a Hold with a $2.00 price target. To see the full list of analyst forecasts on OKYO Pharma Limited Sponsored ADR stock, see the OKYO Stock Forecast page.

OKYO Pharma Rings Nasdaq Opening Bell as Urcosimod Advances After Positive Phase 2 NCP Data
Dec 19, 2025

On December 19, 2025, OKYO Pharma marked its progress in developing treatments for neuropathic corneal pain by having Executive Chairman and Founder Gabriele Cerrone and the management team ring the Opening Bell at the Nasdaq MarketSite in Times Square, New York. The ceremony highlighted the company’s clinical advances with its lead candidate urcosimod, which recently delivered positive Phase 2 results in NCP, demonstrating favorable corneal nerve outcomes and pain reduction in patients facing a debilitating condition without approved therapies. OKYO is leveraging this momentum as it prepares a larger, multicenter Phase 2 trial of urcosimod in NCP, planned to begin in the first quarter of 2026, underscoring its bid to strengthen its position in ocular pain therapeutics and signaling potential long-term implications for patients and investors if subsequent trials confirm these early efficacy signals.

The most recent analyst rating on (OKYO) stock is a Buy with a $7.00 price target. To see the full list of analyst forecasts on OKYO Pharma Limited Sponsored ADR stock, see the OKYO Stock Forecast page.

OKYO Pharma Chairman Increases Stake Amid Promising Drug Trials
Dec 15, 2025

On December 15, 2025, OKYO Pharma Limited announced that Panetta Partners Limited, associated with Executive Chairman Gabriele Cerrone, acquired 24,551 of the company’s ordinary shares on NASDAQ, increasing Cerrone’s total holding to 10,516,297 shares. This acquisition highlights the confidence in OKYO’s ongoing development of urcosimod, a promising treatment for neuropathic corneal pain and dry eye disease, which has shown significant results in Phase 2 trials, potentially enhancing the company’s market position in ophthalmology.

The most recent analyst rating on (OKYO) stock is a Buy with a $7.00 price target. To see the full list of analyst forecasts on OKYO Pharma Limited Sponsored ADR stock, see the OKYO Stock Forecast page.

OKYO Pharma Reports Positive Phase 2 Results for Urcosimod in Neuropathic Corneal Pain
Dec 11, 2025

On December 11, 2025, OKYO Pharma Limited announced new analyses from a Phase 2 clinical trial of urcosimod, showing positive results in treating neuropathic corneal pain (NCP). The trial demonstrated that patients treated with 0.05% urcosimod experienced not only a reduction in pain but also favorable changes in corneal nerve structure, unlike the placebo group. These findings suggest urcosimod’s potential as a first-in-class therapeutic approach for NCP, highlighting its promise in restoring corneal nerve health and supporting further development.

The most recent analyst rating on (OKYO) stock is a Buy with a $5.00 price target. To see the full list of analyst forecasts on OKYO Pharma Limited Sponsored ADR stock, see the OKYO Stock Forecast page.

OKYO Pharma’s Chairman Increases Stake Amidst Phase 2 Trial Completion
Dec 3, 2025

On December 3, 2025, OKYO Pharma Limited announced that Panetta Partners Limited, associated with Executive Chairman Gabriele Cerrone, acquired 27,051 of the company’s ordinary shares on NASDAQ, increasing his total holdings to 10,491,746 shares. This acquisition underscores confidence in OKYO’s strategic direction, particularly as it advances urcosimod, which recently completed a Phase 2 trial for neuropathic corneal pain, potentially strengthening its market position in the ophthalmology sector.

The most recent analyst rating on (OKYO) stock is a Buy with a $7.00 price target. To see the full list of analyst forecasts on OKYO Pharma Limited Sponsored ADR stock, see the OKYO Stock Forecast page.

OKYO Pharma’s Chairman Increases Stake with Recent Share Acquisition
Nov 21, 2025

On November 21, 2025, OKYO Pharma Limited announced that Panetta Partners Limited, associated with Executive Chairman Gabriele Cerrone, acquired 82,018 ordinary shares of the company on NASDAQ, increasing his total holding to 10,464,695 shares. This acquisition signifies a strong vote of confidence from the leadership in the company’s future prospects, particularly as OKYO has recently completed a Phase 2 trial of urcosimod for treating neuropathic corneal pain, a condition lacking FDA-approved therapies.

The most recent analyst rating on (OKYO) stock is a Buy with a $7.00 price target. To see the full list of analyst forecasts on OKYO Pharma Limited Sponsored ADR stock, see the OKYO Stock Forecast page.

OKYO Pharma to Present Urcosimod at OIS XV
Nov 18, 2025

On November 18, 2025, OKYO Pharma Limited announced that its CEO, Gary S. Jacob, will present at the Ophthalmology Innovation Summit (OIS) XV in San Diego, scheduled for November 22, 2025. The presentation will focus on urcosimod, OKYO’s lead investigational drug for treating neuropathic corneal pain (NCP), a condition with no FDA-approved therapies. The announcement highlights OKYO’s recent positive Phase 2 trial results and its plans for a larger clinical trial, underscoring the company’s commitment to addressing unmet medical needs in the ophthalmic field.

The most recent analyst rating on (OKYO) stock is a Buy with a $7.00 price target. To see the full list of analyst forecasts on OKYO Pharma Limited Sponsored ADR stock, see the OKYO Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jan 15, 2026