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MapLight Therapeutics, Inc. (MPLT)
NASDAQ:MPLT
US Market
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MapLight Therapeutics, Inc. (MPLT) AI Stock Analysis

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MPLT

MapLight Therapeutics, Inc.

(NASDAQ:MPLT)

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Neutral 53 (OpenAI - 5.2)
Rating:53Neutral
Price Target:
$27.00
▲(54.37% Upside)
Action:Reiterated
Date:05/19/26
The score is primarily held back by accelerating losses and cash burn despite a strong, low-leverage balance sheet. Technicals are mixed (intermediate trend support but weak near-term price action), and valuation offers limited support due to negative earnings and no dividend.
Positive Factors
Low leverage and sizable equity
A very low debt-to-equity ratio and substantial equity provide durable financial flexibility for a clinical-stage biotech. This capital base supports ongoing trials, enables partner discussions and reduces near-term default risk, giving management runway to execute development plans without immediate forced financing.
Negative Factors
Accelerating operating cash burn
Rapidly rising negative operating cash flow materially shortens the time before additional funding is needed. Higher burn increases dilution or financing risk, constrains strategic optionality and can force budget cuts or delayed programs if trial results or capital markets weaken, pressuring long-term execution.
Read all positive and negative factors
Positive Factors
Negative Factors
Low leverage and sizable equity
A very low debt-to-equity ratio and substantial equity provide durable financial flexibility for a clinical-stage biotech. This capital base supports ongoing trials, enables partner discussions and reduces near-term default risk, giving management runway to execute development plans without immediate forced financing.
Read all positive factors

MapLight Therapeutics, Inc. (MPLT) vs. SPDR S&P 500 ETF (SPY)

MapLight Therapeutics, Inc. Business Overview & Revenue Model

Company Description
MapLight Therapeutics, Inc. operates as a clinical-stage biopharmaceutical company for patients suffering from debilitating central nervous system disorders. The company's products include ML-007C-MA, a fixed-dose combination of an M 1 /M 4 muscar...
How the Company Makes Money
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MapLight Therapeutics, Inc. Financial Statement Overview

Summary
Pre-revenue with persistent and widening losses (net loss ~-$161M in 2025 vs. ~-$78M in 2024) and accelerating cash burn (operating cash flow ~-$138M in 2025 vs. ~-$79M in 2024) are major weaknesses. Offsetting this, the balance sheet is strong with minimal leverage (debt-to-equity ~0.01) and sizable equity, providing near-term financial flexibility.
Income Statement
18
Very Negative
Balance Sheet
78
Positive
Cash Flow
34
Negative
BreakdownTTMDec 2025Dec 2024Dec 2023Dec 2022
Income Statement
Total Revenue0.000.000.000.000.00
Gross Profit-574.00K-578.00K-701.00K-556.00K-574.00K
EBITDA-208.65M-168.50M-76.88M-55.15M-29.44M
Net Income-199.48M-161.15M-77.58M-55.71M-30.02M
Balance Sheet
Total Assets418.79M479.51M136.92M91.41M39.39M
Cash, Cash Equivalents and Short-Term Investments310.11M305.10M108.80M79.77M27.66M
Total Debt5.59M5.80M6.58M5.92M6.27M
Total Liabilities18.95M21.14M21.72M20.13M18.52M
Stockholders Equity399.83M458.37M115.19M71.28M20.87M
Cash Flow
Free Cash Flow-164.26M-138.61M-79.58M-52.47M-27.32M
Operating Cash Flow-163.76M-138.14M-78.81M-52.01M-26.58M
Investing Cash Flow-293.70M-323.21M-80.79M-462.00K-746.00K
Financing Cash Flow463.02M469.82M118.06M104.57M33.17M

MapLight Therapeutics, Inc. Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
53
Neutral
$1.25B-3.79-69.06%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
46
Neutral
$3.90M-0.36-199.52%97.37%
44
Neutral
$1.72M-0.2099.48%-474.47%
43
Neutral
$23.55M-0.06-83.59%19.36%
43
Neutral
$3.43M-0.23-215.04%-100.00%89.96%
42
Neutral
$4.99M-0.63-203.36%93.30%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
MPLT
MapLight Therapeutics, Inc.
28.75
10.41
56.76%
SCNI
Scinai Immunotherapeutics
0.46
-2.30
-83.30%
SNSE
Sensei Biotherapeutics
17.79
11.88
201.02%
GRI
GRI Bio
2.06
-31.54
-93.87%
DRMA
Dermata Therapeutics
1.26
-6.24
-83.20%
AZTR
Azitra Inc
0.20
-1.71
-89.37%

MapLight Therapeutics, Inc. Corporate Events

Business Operations and StrategyFinancial Disclosures
MapLight Therapeutics Expands Pipeline Amid Rising Quarterly Losses
Negative
May 14, 2026
MapLight Therapeutics reported first-quarter 2026 results on May 14, highlighting an expanded clinical pipeline in schizophrenia, Alzheimer’s disease psychosis and autism spectrum disorder alongside rising operating expenses and losses. The ...
Business Operations and StrategyExecutive/Board ChangesShareholder Meetings
MapLight Therapeutics Announces Board Refresh and New Nominees
Positive
Apr 29, 2026
On April 23, 2026, MapLight Therapeutics, Inc. announced that board members Robert Malenka, M.D., Ph.D., and Jim Trenkle, Ph.D., informed the board they will not stand for reelection at the annual meeting of stockholders scheduled for June 23, 202...
Business Operations and StrategyFinancial Disclosures
MapLight Therapeutics Highlights Growing CNS Pipeline, Strong Cash Position
Positive
Mar 26, 2026
On March 26, 2026, MapLight Therapeutics reported fourth-quarter and full-year 2025 results, highlighting an expanding CNS pipeline and increased RD investment. The company is advancing ML-007C-MA for schizophrenia and Alzheimer’s disease ps...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: May 19, 2026