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Gri Bio, Inc. (GRI)
NASDAQ:GRI
US Market

GRI Bio (GRI) AI Stock Analysis

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GRI

GRI Bio

(NASDAQ:GRI)

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Neutral 43 (OpenAI - 5.2)
Rating:43Neutral
Price Target:
$3.00
▲(971.43% Upside)
The score is held down primarily by weak financial performance (ongoing losses, inconsistent revenue, and persistent cash burn) and very bearish technicals (price far below key moving averages with negative MACD). Corporate events provide some upside via positive Phase 2a IPF data and financing, but listing/compliance concerns and the absence of supportive valuation metrics limit the overall rating.
Positive Factors
Promising Phase 2a IPF data
Robust Phase 2a molecular and functional signals support clinical proof-of-concept for GRI-0621 as a disease‑modifying IPF therapy. Durable clinical differentiation can unlock partnerships, label expansion and reduced late‑stage clinical risk, strengthening long‑term pipeline value.
U.S. composition‑of‑matter patent
Composition‑of‑matter IP provides meaningful exclusivity for GRI‑0621, supporting pricing power, licensing leverage, and competitive moat. Strong patent protection materially enhances the long‑term commercial prospects and partner interest versus unprotected biologics in the same space.
Expanded capital‑raising capacity
Shelf registration and a larger ATM program increase the company’s structural ability to access public capital markets when needed, extending runway and enabling R&D investment. This persistent financing optionality supports program continuity despite operating losses.
Negative Factors
Persistent cash burn
Sustained negative operating and free cash flow creates continuous financing needs and exacerbates dilution risk. Over months this undermines autonomy over development timelines and increases sensitivity to capital market conditions and partner funding availability.
Revenue collapse and ongoing losses
Abrupt loss of revenue and recurring net losses signal weak commercial sustainability and force reliance on financing rather than operating cash. This structural lack of revenue predictability elevates execution risk for advancing clinical programs and achieving self‑funding.
Listing/compliance and dilution pressures
Reverse splits, prior Nasdaq non‑compliance and repeated equity offerings reflect fragile equity metrics and recurring dilution. These structural governance and listing risks can impair investor confidence, liquidity and long‑term access to favorable capital, raising funding cost.

GRI Bio (GRI) vs. SPDR S&P 500 ETF (SPY)

GRI Bio Business Overview & Revenue Model

Company DescriptionGRI Bio, Inc., a clinical-stage biopharmaceutical company, focuses on discovering, developing, and commercializing therapies that target diseases leading to inflammatory, fibrotic, and autoimmune disorders in the United States. Its lead product candidate is GRI-0621, an oral inhibitor of type 1 Natural Killer T cells, which is in phase IIa clinical trial for the treatment of severe fibrotic lung diseases, such as idiopathic pulmonary fibrosis. The company's portfolio also includes GRI-0803, a novel oral agonist of type 2 Natural Killer T cells that is in preclinical development for the treatment of autoimmune disorders; a proprietary library of 500+ compounds; and GRI-0124 and GRI-0729 for balance inflammatory immune responses. GRI Bio, Inc. was formerly known as Glycoregimmune, Inc. GRI Bio, Inc. was founded in 2009 and is based in LA Jolla, California.
How the Company Makes MoneyGRI Bio generates revenue through the development and commercialization of its proprietary therapies. The primary revenue streams include licensing agreements with pharmaceutical companies and potential milestone payments and royalties from successful drug candidates developed using their platform technology. Additionally, GRI Bio may engage in strategic partnerships and collaborations with other biotech firms to co-develop and market new therapies. The company's earnings are significantly influenced by its ability to advance drug candidates through clinical trials and secure regulatory approvals, as well as the establishment of lucrative partnerships with larger pharmaceutical entities.

GRI Bio Financial Statement Overview

Summary
Financials show elevated risk: persistent operating/net losses, revenue dropping to $0 in 2025 after $22.5M in 2024, and ongoing cash burn (about -$10.2M operating/free cash flow in 2025). The main offset is low leverage and positive equity in the latest period, but dependence on external funding remains high.
Income Statement
8
Very Negative
Profitability is very weak: the company reports persistent operating losses and net losses across all years provided (e.g., net loss of about $12.0M in 2025 vs. about $8.2M in 2024). Revenue visibility is also poor—revenue fell to $0 in 2025 after $22.5M in 2024, and most other years show $0 revenue—making earnings highly dependent on funding rather than operations. A modest positive is that losses have not been steadily accelerating every year, but the overall trajectory remains meaningfully negative.
Balance Sheet
52
Neutral
Leverage appears low in the most recent periods, with total debt of ~$71K in 2025 and a very low debt-to-equity ratio (~0.01), alongside positive equity (~$6.0M). However, returns on equity are deeply negative due to ongoing losses (roughly -2.0 in both 2024 and 2025), and the company previously had negative equity in 2020–2022, highlighting historical balance-sheet strain and reliance on external financing to rebuild the equity base.
Cash Flow
12
Very Negative
Cash generation is weak: operating cash flow and free cash flow are consistently negative (about -$10.2M operating cash flow and -$10.2M free cash flow in 2025). While free cash flow burn improved versus 2024 (free cash flow growth shown as +10.6%), the business still consumes substantial cash each year, which increases funding risk. The relationship between free cash flow and net income is near 1.0 mainly because both are significantly negative, rather than indicating strong cash conversion.
BreakdownDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue0.0022.54M0.000.000.00
Gross Profit-4.00K-4.00K-57.00K-50.00K-73.00K
EBITDA-11.97M-8.20M-10.90M-2.51M-9.21M
Net Income-11.96M-8.21M-13.04M-3.22M-9.30M
Balance Sheet
Total Assets8.67M5.74M2.96M383.00K218.00K
Cash, Cash Equivalents and Short-Term Investments8.23M5.03M1.81M9.00K90.00K
Total Debt71.00K119.00K14.00K673.00K3.61M
Total Liabilities2.66M1.71M2.70M2.01M4.94M
Stockholders Equity6.01M4.03M259.00K-1.63M-4.72M
Cash Flow
Free Cash Flow-10.19M-8.61M-9.00M-1.09M-847.00K
Operating Cash Flow-10.19M-8.61M-8.99M-1.08M-847.00K
Investing Cash Flow-3.00K0.00-8.00K-3.00K0.00
Financing Cash Flow13.39M11.83M10.80M1.01M600.00K

GRI Bio Technical Analysis

Technical Analysis Sentiment
Negative
Last Price0.28
Price Trends
50DMA
19.14
Negative
100DMA
36.00
Negative
200DMA
39.46
Negative
Market Momentum
MACD
-3.81
Negative
RSI
20.41
Positive
STOCH
5.63
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For GRI, the sentiment is Negative. The current price of 0.28 is below the 20-day moving average (MA) of 5.43, below the 50-day MA of 19.14, and below the 200-day MA of 39.46, indicating a bearish trend. The MACD of -3.81 indicates Negative momentum. The RSI at 20.41 is Positive, neither overbought nor oversold. The STOCH value of 5.63 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for GRI.

GRI Bio Risk Analysis

GRI Bio disclosed 58 risk factors in its most recent earnings report. GRI Bio reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

GRI Bio Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
44
Neutral
$3.08M-0.15-82.17%-3.27%51.83%
43
Neutral
$4.13M-0.01-238.17%98.22%
33
Underperform
$2.19M>-0.01-263.57%-34.58%96.41%
29
Underperform
$3.50M-0.05-168.95%90.27%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
GRI
GRI Bio
2.64
-249.64
-98.95%
OGEN
Oragenics
0.75
-8.13
-91.54%
INM
InMed Pharmaceuticals
1.00
-2.15
-68.25%
KTTA
Pasithea Therapeutics Corp
0.84
-1.90
-69.34%
ONCO
Onconetix
1.35
-55.12
-97.61%

GRI Bio Corporate Events

Business Operations and StrategyPrivate Placements and Financing
GRI Bio Expands At-The-Market Equity Offering Capacity
Neutral
Jan 30, 2026

GRI Bio, Inc. amended its existing at-the-market equity offering program with H.C. Wainwright & Co., LLC on January 29, 2026, effective January 28, 2026, significantly increasing the potential size of the offering. The company raised the aggregate cap on common stock issuable under the program from $10 million to up to $60 million, subject to the amount registered on its prospectus supplement, and obtained waivers of certain provisions in a December 11, 2025 securities purchase agreement to permit these issuances, expanding its flexibility to raise capital through ongoing share sales.

The most recent analyst rating on (GRI) stock is a Sell with a $4.00 price target. To see the full list of analyst forecasts on GRI Bio stock, see the GRI Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
GRI Bio reports promising Phase 2a data in IPF
Positive
Jan 28, 2026

On January 28, 2026, GRI Bio reported additional positive data from its recently completed Phase 2a clinical trial of GRI-0621 in idiopathic pulmonary fibrosis, showing that RNA-sequencing gene expression analysis revealed significant modulation of genes linked to lung injury, myofibroblast activation, extracellular matrix deposition, fibrosis progression, and alveolar repair compared with placebo. The new molecular findings align with earlier biomarker and functional data indicating reduced neutrophil activity, lower pro-fibrotic cytokine levels, increased collagen degradation, and signals consistent with lung repair and regeneration, suggesting that GRI-0621 may act as a disease-modifying therapy that supports true lung tissue regeneration rather than merely slowing decline; these effects were observed alongside a favorable safety profile and secondary endpoint signals, including a higher proportion of patients with no decline in forced vital capacity at 12 weeks versus standard of care, underscoring the candidate’s potential differentiation within the IPF treatment landscape.

The most recent analyst rating on (GRI) stock is a Sell with a $0.22 price target. To see the full list of analyst forecasts on GRI Bio stock, see the GRI Stock Forecast page.

Delistings and Listing ChangesRegulatory Filings and ComplianceShareholder MeetingsStock Split
GRI Bio Announces 1-for-28 Reverse Stock Split
Negative
Jan 21, 2026

On January 21, 2026, GRI Bio, Inc. announced that its board and stockholders had approved a 1-for-28 reverse stock split of its common stock, following a special meeting held on January 15, 2026. The reverse split will take legal effect at 4:01 p.m. Eastern Time on January 23, 2026, with the stock expected to begin trading on a split-adjusted basis on the Nasdaq Capital Market under the existing ticker “GRI” and a new CUSIP number on January 26, 2026. The move will reduce the number of outstanding common shares from approximately 15.0 million to about 536,000 without changing the total authorized share count, and will include proportional adjustments to outstanding options, warrants, convertible securities and equity incentive plans, while cash will be paid in lieu of fractional shares. The company stated that the reverse split is intended to increase its per-share trading price and help it regain compliance with Nasdaq’s minimum bid price requirement, a step that could prove pivotal for maintaining its listing and access to public capital markets, with operational mechanics arranged so that most shareholders will not need to take any action as positions are automatically adjusted by brokers and the transfer agent.

The most recent analyst rating on (GRI) stock is a Hold with a $0.21 price target. To see the full list of analyst forecasts on GRI Bio stock, see the GRI Stock Forecast page.

Delistings and Listing ChangesRegulatory Filings and Compliance
GRI Bio Regains Conditional Compliance With Nasdaq Listing Requirements
Neutral
Jan 16, 2026

On January 15, 2026, GRI Bio, Inc. was notified by Nasdaq’s Listing Qualifications Staff that it had conditionally regained compliance with Nasdaq Listing Rule 5550(b)(1), which requires companies with a market value under $35 million and annual net income under $500,000 to maintain at least $2.5 million in stockholders’ equity. The company had previously been found out of compliance based on its Form 10-Q for the quarter ended September 30, 2025, and while the current determination averts an immediate delisting, GRI Bio’s stock remains at risk of future delisting if it fails to maintain the required equity levels in subsequent filings.

The most recent analyst rating on (GRI) stock is a Hold with a $0.23 price target. To see the full list of analyst forecasts on GRI Bio stock, see the GRI Stock Forecast page.

Delistings and Listing ChangesPrivate Placements and FinancingRegulatory Filings and ComplianceShareholder MeetingsStock Split
GRI Bio Shareholders Authorize Reverse Stock Split Plan
Neutral
Jan 15, 2026

On January 15, 2026, GRI Bio, Inc. held a virtual special meeting of stockholders at which shareholders approved an amendment to the company’s certificate of incorporation authorizing a reverse stock split of its common stock at a ratio between 1-for-2 and 1-for-30, with the final ratio and implementation left to the discretion of the board, and also approved the potential adjournment or postponement of the meeting if additional proxies were needed. The corporate actions followed a November 26, 2025 notice from Nasdaq that GRI Bio was not in compliance with the minimum stockholders’ equity requirement for continued listing, and the company’s subsequent completion on December 12, 2025 of an approximately $8 million best-efforts public offering of common stock and warrants, after which GRI Bio believes its stockholders’ equity exceeded the required $2.5 million threshold, though Nasdaq will continue to monitor compliance and the company could still face delisting risk if it falls short in future reporting periods.

The most recent analyst rating on (GRI) stock is a Hold with a $0.23 price target. To see the full list of analyst forecasts on GRI Bio stock, see the GRI Stock Forecast page.

Private Placements and FinancingRegulatory Filings and Compliance
GRI Bio Expands At-The-Market Equity Offering Capacity
Neutral
Jan 9, 2026

On January 9, 2026, GRI Bio, Inc. filed a prospectus supplement to increase the maximum amount of common stock it may issue under its at-the-market offering agreement with H.C. Wainwright & Co. to an aggregate of $7.38 million in new shares, on top of approximately $6.17 million of stock already sold under the program. The company also obtained a waiver of certain provisions in a December 11, 2025 securities purchase agreement to allow further issuances under this at-the-market facility, and its counsel Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. issued a legal opinion confirming that shares sold pursuant to the program will be validly issued, fully paid and nonassessable, underscoring GRI Bio’s continued reliance on equity issuance as a funding mechanism and clarifying the legal framework for investors participating in these offerings.

The most recent analyst rating on (GRI) stock is a Hold with a $0.29 price target. To see the full list of analyst forecasts on GRI Bio stock, see the GRI Stock Forecast page.

Business Operations and StrategyProduct-Related AnnouncementsRegulatory Filings and Compliance
GRI Bio Highlights Positive Phase 2a Data in IPF
Positive
Jan 8, 2026

On January 8, 2026, GRI Bio reported additional positive immune profiling data from its Phase 2a clinical trial of GRI-0621 in idiopathic pulmonary fibrosis, showing inhibition of invariant NKT cells and a shift toward an anti-fibrotic immune profile, with increased interferon-gamma and reduced pro-fibrotic cytokines including IL-4, IL-13, IL-17A, IL-22 and TGF-β across multiple immune cell types in lung and blood samples. These mechanistic findings, which align with previously disclosed safety, tolerability and lung function benefits and suggest disease-modifying activity and fibrosis reversal, bolster clinical proof-of-concept for GRI-0621 and support its differentiation from existing IPF therapies; separately, the company noted that its December 2025 public offering has lifted stockholders’ equity above Nasdaq’s $2.5 million minimum, helping to stabilize its listing compliance position.

The most recent analyst rating on (GRI) stock is a Hold with a $0.24 price target. To see the full list of analyst forecasts on GRI Bio stock, see the GRI Stock Forecast page.

Private Placements and Financing
GRI Bio Closes $8 Million Public Offering
Positive
Dec 12, 2025

On December 12, 2025, GRI Bio announced the closing of an $8.0 million public offering of common stock and Series F warrants, with H.C. Wainwright & Co. as the exclusive placement agent. The proceeds will support product development and corporate purposes, potentially impacting the company’s market position and operations by enhancing its financial resources.

The most recent analyst rating on (GRI) stock is a Buy with a $10.00 price target. To see the full list of analyst forecasts on GRI Bio stock, see the GRI Stock Forecast page.

Private Placements and Financing
GRI Bio Launches $6.7 Million Public Offering
Neutral
Dec 12, 2025

On December 11, 2025, GRI Bio, Inc. initiated a public offering involving shares of common stock, pre-funded warrants, and Series F warrants, aiming to raise approximately $6.7 million. The company plans to use the proceeds for working capital, product development, and general corporate purposes, with expectations to fund operations into the fourth quarter of 2026. The offering, expected to close on December 12, 2025, includes agreements with institutional investors and restrictions on further stock issuance for a specified period.

The most recent analyst rating on (GRI) stock is a Buy with a $10.00 price target. To see the full list of analyst forecasts on GRI Bio stock, see the GRI Stock Forecast page.

Product-Related Announcements
GRI Bio Announces Positive Phase 2a Trial Results
Positive
Dec 10, 2025

On December 10, 2025, GRI Bio announced positive topline results from its Phase 2a clinical trial of GRI-0621 for idiopathic pulmonary fibrosis (IPF). The study met its primary and secondary endpoints, showing that GRI-0621 was well tolerated and improved biomarkers related to fibrosis and lung repair. The results suggest GRI-0621’s potential as a disease-modifying treatment for IPF, offering a promising advance in the treatment landscape and potential value for patients and shareholders.

The most recent analyst rating on (GRI) stock is a Buy with a $10.00 price target. To see the full list of analyst forecasts on GRI Bio stock, see the GRI Stock Forecast page.

Product-Related Announcements
GRI Bio Reports Positive Phase 2a Trial Results
Positive
Dec 8, 2025

GRI Bio, Inc. has announced positive topline results from its Phase 2a clinical trial evaluating GRI-0621 for the treatment of Idiopathic Pulmonary Fibrosis (IPF). The trial met its primary and certain secondary endpoints, demonstrating that GRI-0621 was well tolerated over a 12-week period and showed potential anti-fibrotic effects, with improvements in serum biomarkers and Forced Vital Capacity (FVC) in treated subjects. No serious adverse events were observed, and the findings suggest a promising impact on fibrosis resolution and lung tissue repair, potentially enhancing GRI Bio’s position in the IPF treatment market.

The most recent analyst rating on (GRI) stock is a Buy with a $10.00 price target. To see the full list of analyst forecasts on GRI Bio stock, see the GRI Stock Forecast page.

Delistings and Listing ChangesRegulatory Filings and Compliance
GRI Bio Faces Nasdaq Non-Compliance Notice
Negative
Dec 2, 2025

On November 26, 2025, GRI Bio received a notification from Nasdaq indicating non-compliance with the minimum stockholders’ equity requirement for continued listing on The Nasdaq Capital Market, as per their quarterly report for the period ending September 30, 2025. The company has until January 10, 2026, to submit a compliance plan, which, if accepted, could grant them an extension to regain compliance. The notice does not immediately affect their listing status, but failure to comply could lead to delisting, with an option to appeal if necessary.

The most recent analyst rating on (GRI) stock is a Buy with a $10.00 price target. To see the full list of analyst forecasts on GRI Bio stock, see the GRI Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Feb 02, 2026