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Gri Bio, Inc. (GRI)
NASDAQ:GRI
US Market

GRI Bio (GRI) AI Stock Analysis

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GRI

GRI Bio

(NASDAQ:GRI)

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Neutral 42 (OpenAI - 5.2)
Rating:42Neutral
Price Target:
$0.29
▼(-86.05% Downside)
The score is held down primarily by weak financial performance (heavy losses and ongoing cash burn) and bearish technical trend/momentum. Valuation is constrained by unprofitable earnings and no dividend support. Offsetting these risks, recent corporate updates (positive Phase 2a data and new financing) provide incremental support but do not overcome the current financial and trend weakness.
Positive Factors
Clinical Proof-of-Concept
Mechanistic flow cytometry demonstrating iNKT inhibition and a shift to anti-fibrotic cytokines strengthens durable proof-of-concept for GRI-0621. This biological validation supports progression to larger trials, enhances differentiation vs. SOC, and increases partner/regulatory interest long-term.
Positive Phase 2a Topline Results
Meeting primary and secondary endpoints with improvements in collagen turnover biomarkers and FVC suggests potential disease-modifying effects. These durable clinical signals materially de-risk development, improve the case for pivotal trials, and bolster long-term commercialization and partnership prospects.
Improved Near-Term Funding
Closing an $8M offering that lifted stockholders' equity above Nasdaq minimum meaningfully extends runway and reduces immediate liquidity stress. This capital raise buys time to achieve clinical milestones, lowering short-term financing urgency and preserving strategic options for partnering or further funding.
Negative Factors
Sustained Cash Burn
Persistent negative operating and free cash flow (~-$9.2M TTM) indicates the company is not self-funding development. Over months this necessitates recurring external financing, raising dilution risk and constraining investments in late-stage trials or commercialization until material revenue or partnerships emerge.
Large Ongoing Losses
Modest revenue with large operating losses and deeply negative margins reflect a biotech still in intensive R&D/burn mode. Without scalable recurring revenue or successful product commercialization, negative returns on capital will persist, limiting ability to build sustained operating leverage.
Listing/Compliance Risk
A Nasdaq non-compliance notice creates a structural governance and capital access risk. Potential delisting or remediation requirements could force accelerated, dilutive financings, distract management, and reduce investor confidence, materially impacting long-term strategic flexibility until resolved.

GRI Bio (GRI) vs. SPDR S&P 500 ETF (SPY)

GRI Bio Business Overview & Revenue Model

Company DescriptionGRI Bio, Inc., a clinical-stage biopharmaceutical company, focuses on treating inflammatory, fibrotic, and autoimmune diseases in the United States. Its product pipeline comprises GRI-0621, which is in phase II clinical development for the treatment of idiopathic pulmonary fibrosis; GRI-0803 which is in phase I trial for the treatment of systematic lupus erythematosus; GRI-0124, which is in pre-clinical development for the treatment of primary sclerosing cholangitis; and GRI-0729 in pre-clinical development. The company also develops ADAIR and ADMIR for treatment of attention -deficit/hyperactivity disorder. GRI Bio, Inc. was formerly known as Glycoregimmune, Inc. GRI Bio, Inc. was founded in 2009 and is based in LA Jolla, California.
How the Company Makes MoneyGRI Bio generates revenue through the development and commercialization of its proprietary therapies. The primary revenue streams include licensing agreements with pharmaceutical companies and potential milestone payments and royalties from successful drug candidates developed using their platform technology. Additionally, GRI Bio may engage in strategic partnerships and collaborations with other biotech firms to co-develop and market new therapies. The company's earnings are significantly influenced by its ability to advance drug candidates through clinical trials and secure regulatory approvals, as well as the establishment of lucrative partnerships with larger pharmaceutical entities.

GRI Bio Financial Statement Overview

Summary
GRI Bio shows progress in revenue and equity but faces profitability and cash flow challenges. The high operational costs and cash burn pose risks, despite a strong equity position.
Income Statement
GRI Bio's income statement shows some improvement in revenue from the previous year, with a TTM (Trailing-Twelve-Months) total revenue of $4.91 million, up from $0 in 2022. However, the company continues to face significant challenges in profitability, as indicated by negative net income and EBIT margins. The EBIT margin for the TTM is -103.5%, and the net profit margin is -167%, highlighting ongoing operational inefficiencies and high costs relative to revenue.
Balance Sheet
The balance sheet reflects a stronger equity position, with stockholders' equity of $56.33 million as of the latest period, a recovery from previous negative equity figures. However, the debt-to-equity ratio is low at 0.002, indicating minimal leverage, which could be a positive factor in reducing financial risk. The equity ratio stands at 98.14%, showcasing a strong equity base relative to total assets, albeit with limited asset growth.
Cash Flow
GRI Bio's cash flow statement shows a negative operating cash flow and free cash flow in the TTM, with free cash flow at -$8.61 million. The operating cash flow to net income ratio is 1.05, suggesting the company is burning cash at a rate close to its net losses. Free cash flow growth remains negative, indicating ongoing challenges in generating cash from operations.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue6.33M0.000.000.000.000.00
Gross Profit-4.00K-4.00K-57.00K-50.00K-73.00K0.00
EBITDA-11.24M-8.20M-10.90M-2.51M-9.21M-1.46M
Net Income-11.24M-8.21M-13.04M-3.22M-9.30M-2.53M
Balance Sheet
Total Assets4.78M5.74M2.96M383.00K218.00K955.00K
Cash, Cash Equivalents and Short-Term Investments4.05M5.03M1.81M9.00K90.00K109.00K
Total Debt84.00K119.00K14.00K673.00K3.61M336.00K
Total Liabilities2.79M1.71M2.70M2.01M4.94M2.41M
Stockholders Equity1.99M4.03M259.00K-1.63M-4.72M-1.45M
Cash Flow
Free Cash Flow-9.21M-8.61M-9.00M-1.09M-847.00K-3.71M
Operating Cash Flow-9.21M-8.61M-8.99M-1.08M-847.00K-3.71M
Investing Cash Flow0.000.00-8.00K-3.00K0.00-2.00K
Financing Cash Flow8.52M11.83M10.80M1.01M600.00K-4.00K

GRI Bio Technical Analysis

Technical Analysis Sentiment
Negative
Last Price2.05
Price Trends
50DMA
1.25
Negative
100DMA
1.52
Negative
200DMA
1.62
Negative
Market Momentum
MACD
-0.30
Negative
RSI
23.88
Positive
STOCH
58.21
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For GRI, the sentiment is Negative. The current price of 2.05 is above the 20-day moving average (MA) of 0.39, above the 50-day MA of 1.25, and above the 200-day MA of 1.62, indicating a bearish trend. The MACD of -0.30 indicates Negative momentum. The RSI at 23.88 is Positive, neither overbought nor oversold. The STOCH value of 58.21 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for GRI.

GRI Bio Risk Analysis

GRI Bio disclosed 58 risk factors in its most recent earnings report. GRI Bio reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

GRI Bio Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
44
Neutral
$3.51M-0.18-82.17%-3.27%51.83%
42
Neutral
$2.87M-0.02-397.84%98.22%
33
Underperform
$2.67M>-0.01-263.57%-34.58%96.41%
29
Underperform
$3.54M-0.05-168.95%90.27%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
GRI
GRI Bio
0.28
-12.13
-97.71%
OGEN
Oragenics
0.85
-8.90
-91.28%
INM
InMed Pharmaceuticals
1.25
-2.97
-70.38%
KTTA
Pasithea Therapeutics Corp
0.92
-1.70
-64.85%
ONCO
Onconetix
1.72
-53.53
-96.89%

GRI Bio Corporate Events

Private Placements and FinancingRegulatory Filings and Compliance
GRI Bio Expands At-The-Market Equity Offering Capacity
Neutral
Jan 9, 2026

On January 9, 2026, GRI Bio, Inc. filed a prospectus supplement to increase the maximum amount of common stock it may issue under its at-the-market offering agreement with H.C. Wainwright & Co. to an aggregate of $7.38 million in new shares, on top of approximately $6.17 million of stock already sold under the program. The company also obtained a waiver of certain provisions in a December 11, 2025 securities purchase agreement to allow further issuances under this at-the-market facility, and its counsel Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. issued a legal opinion confirming that shares sold pursuant to the program will be validly issued, fully paid and nonassessable, underscoring GRI Bio’s continued reliance on equity issuance as a funding mechanism and clarifying the legal framework for investors participating in these offerings.

The most recent analyst rating on (GRI) stock is a Hold with a $0.29 price target. To see the full list of analyst forecasts on GRI Bio stock, see the GRI Stock Forecast page.

Business Operations and StrategyProduct-Related AnnouncementsRegulatory Filings and Compliance
GRI Bio Highlights Positive Phase 2a Data in IPF
Positive
Jan 8, 2026

On January 8, 2026, GRI Bio reported additional positive immune profiling data from its Phase 2a clinical trial of GRI-0621 in idiopathic pulmonary fibrosis, showing inhibition of invariant NKT cells and a shift toward an anti-fibrotic immune profile, with increased interferon-gamma and reduced pro-fibrotic cytokines including IL-4, IL-13, IL-17A, IL-22 and TGF-β across multiple immune cell types in lung and blood samples. These mechanistic findings, which align with previously disclosed safety, tolerability and lung function benefits and suggest disease-modifying activity and fibrosis reversal, bolster clinical proof-of-concept for GRI-0621 and support its differentiation from existing IPF therapies; separately, the company noted that its December 2025 public offering has lifted stockholders’ equity above Nasdaq’s $2.5 million minimum, helping to stabilize its listing compliance position.

The most recent analyst rating on (GRI) stock is a Hold with a $0.24 price target. To see the full list of analyst forecasts on GRI Bio stock, see the GRI Stock Forecast page.

Private Placements and Financing
GRI Bio Closes $8 Million Public Offering
Positive
Dec 12, 2025

On December 12, 2025, GRI Bio announced the closing of an $8.0 million public offering of common stock and Series F warrants, with H.C. Wainwright & Co. as the exclusive placement agent. The proceeds will support product development and corporate purposes, potentially impacting the company’s market position and operations by enhancing its financial resources.

The most recent analyst rating on (GRI) stock is a Buy with a $10.00 price target. To see the full list of analyst forecasts on GRI Bio stock, see the GRI Stock Forecast page.

Private Placements and Financing
GRI Bio Launches $6.7 Million Public Offering
Neutral
Dec 12, 2025

On December 11, 2025, GRI Bio, Inc. initiated a public offering involving shares of common stock, pre-funded warrants, and Series F warrants, aiming to raise approximately $6.7 million. The company plans to use the proceeds for working capital, product development, and general corporate purposes, with expectations to fund operations into the fourth quarter of 2026. The offering, expected to close on December 12, 2025, includes agreements with institutional investors and restrictions on further stock issuance for a specified period.

The most recent analyst rating on (GRI) stock is a Buy with a $10.00 price target. To see the full list of analyst forecasts on GRI Bio stock, see the GRI Stock Forecast page.

Product-Related Announcements
GRI Bio Announces Positive Phase 2a Trial Results
Positive
Dec 10, 2025

On December 10, 2025, GRI Bio announced positive topline results from its Phase 2a clinical trial of GRI-0621 for idiopathic pulmonary fibrosis (IPF). The study met its primary and secondary endpoints, showing that GRI-0621 was well tolerated and improved biomarkers related to fibrosis and lung repair. The results suggest GRI-0621’s potential as a disease-modifying treatment for IPF, offering a promising advance in the treatment landscape and potential value for patients and shareholders.

The most recent analyst rating on (GRI) stock is a Buy with a $10.00 price target. To see the full list of analyst forecasts on GRI Bio stock, see the GRI Stock Forecast page.

Product-Related Announcements
GRI Bio Reports Positive Phase 2a Trial Results
Positive
Dec 8, 2025

GRI Bio, Inc. has announced positive topline results from its Phase 2a clinical trial evaluating GRI-0621 for the treatment of Idiopathic Pulmonary Fibrosis (IPF). The trial met its primary and certain secondary endpoints, demonstrating that GRI-0621 was well tolerated over a 12-week period and showed potential anti-fibrotic effects, with improvements in serum biomarkers and Forced Vital Capacity (FVC) in treated subjects. No serious adverse events were observed, and the findings suggest a promising impact on fibrosis resolution and lung tissue repair, potentially enhancing GRI Bio’s position in the IPF treatment market.

The most recent analyst rating on (GRI) stock is a Buy with a $10.00 price target. To see the full list of analyst forecasts on GRI Bio stock, see the GRI Stock Forecast page.

Delistings and Listing ChangesRegulatory Filings and Compliance
GRI Bio Faces Nasdaq Non-Compliance Notice
Negative
Dec 2, 2025

On November 26, 2025, GRI Bio received a notification from Nasdaq indicating non-compliance with the minimum stockholders’ equity requirement for continued listing on The Nasdaq Capital Market, as per their quarterly report for the period ending September 30, 2025. The company has until January 10, 2026, to submit a compliance plan, which, if accepted, could grant them an extension to regain compliance. The notice does not immediately affect their listing status, but failure to comply could lead to delisting, with an option to appeal if necessary.

The most recent analyst rating on (GRI) stock is a Buy with a $10.00 price target. To see the full list of analyst forecasts on GRI Bio stock, see the GRI Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jan 08, 2026