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Salarius Pharmaceuticals Inc (SLRX)
NASDAQ:SLRX

Salarius Pharmaceuticals (SLRX) AI Stock Analysis

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SLRX

Salarius Pharmaceuticals

(NASDAQ:SLRX)

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Neutral 42 (OpenAI - 5.2)
Rating:42Neutral
Price Target:
$0.63
▼(-5.15% Downside)
The score is held down primarily by weak financial fundamentals (no revenue, ongoing losses, and continued cash burn) and very bearish technicals (price below key moving averages with negative MACD). Corporate-event risk is also high due to the active Nasdaq delisting situation, while financing/merger actions provide only partial offset.
Positive Factors
Strategic Partnerships
Strategic partnerships with larger pharmaceutical companies can provide Salarius Pharmaceuticals with essential funding and resources for drug development, potentially accelerating the path to commercialization and enhancing long-term growth prospects.
Innovative Drug Development
Salarius Pharmaceuticals' focus on developing innovative therapies like seclidemstat positions it to address unmet needs in oncology, potentially capturing significant market share in the cancer treatment sector over time.
Limited Leverage
A low debt-to-equity ratio suggests that Salarius Pharmaceuticals has limited leverage, providing financial flexibility and reducing the risk of financial distress, which is beneficial for long-term stability.
Negative Factors
Declining Revenues
The sharp decline in revenues highlights significant operational challenges and raises concerns about the company's ability to generate sustainable income, impacting its long-term financial health.
Persistent Losses
Ongoing net losses and negative cash flows indicate operational inefficiencies and liquidity issues, which could hinder Salarius Pharmaceuticals' ability to invest in R&D and sustain its business model over the long term.
Decreasing Equity
The significant decrease in stockholders' equity reflects accumulated losses, signaling potential financial instability and a weakened balance sheet, which could limit future growth and investment opportunities.

Salarius Pharmaceuticals (SLRX) vs. SPDR S&P 500 ETF (SPY)

Salarius Pharmaceuticals Business Overview & Revenue Model

Company DescriptionSalarius Pharmaceuticals, Inc., a clinical-stage biotechnology company, focuses on developing epigenetic-based cancer treatments. Its lead candidate is Seclidemstat (SP-2577), a small molecular inhibitor which is in Phase I/II clinical trial for the treatment of advanced solid tumors, as well as Ewing sarcoma. The company also offers SP-3164, a small molecular protein degrader for the treatment of hematological and solid tumors. It has a strategic partnership with The University of Utah Research Foundation for the exclusive license with respect to patent rights protecting SP-2577 and related compounds; HLB Life Sciences to develop, produce, manufacture, use, and sell the drug in South Korea; and Cancer Prevention and Research Institute of Texas for product development activities, as well as a research partnership with the Cancer Epigenetics Institute at Fox Chase Cancer Center to identify new indications and biomarkers for SP-2577. The company is headquartered in Houston, Texas.
How the Company Makes MoneySalarius Pharmaceuticals generates revenue through a combination of strategic partnerships, licensing agreements, and government or private grants. The company's revenue model heavily relies on collaboration with larger pharmaceutical companies for the development and commercialization of its proprietary drug candidates. These partnerships often involve upfront payments, milestone payments based on the achievement of specific development or regulatory milestones, and potential royalties on net sales of successfully commercialized products. Additionally, Salarius may secure funding through research grants and subsidies aimed at supporting innovative cancer treatments. As of now, the company is largely in the clinical development phase, and its revenue streams are primarily associated with these developmental and collaborative efforts rather than direct product sales.

Salarius Pharmaceuticals Financial Statement Overview

Summary
Salarius Pharmaceuticals is facing significant financial challenges with declining revenues, persistent losses, and negative cash flows. The company exhibits limited leverage, which is a minor positive, but the decreasing equity and ongoing cash burn highlight substantial financial instability. Immediate strategic changes are necessary to improve financial health.
Income Statement
Salarius Pharmaceuticals has faced declining revenues from $5.23 million in 2020 to $0 in 2024, indicating a severe downturn. The net profit margin is negative due to consistent net losses, reflecting ongoing operational challenges. The absence of EBIT and EBITDA in recent years further highlights operational inefficiencies.
Balance Sheet
The balance sheet shows a declining trend in stockholders' equity, falling from $22.16 million in 2020 to $1.51 million in 2024, driven by accumulated losses. The debt-to-equity ratio remains low, indicating limited leverage, which is a positive aspect. However, the equity ratio has significantly decreased, indicating potential financial instability.
Cash Flow
Free cash flow is consistently negative, reflecting substantial cash outflows. The operating cash flow to net income ratio is unfavorable due to persistent negative cash flows, presenting a liquidity concern. Financing activities have occasionally bolstered cash reserves, but this is unsustainable long-term.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue0.000.000.000.000.005.23M
Gross Profit-1.11K0.000.000.000.005.23M
EBITDA-5.04M-5.73M-12.88M-22.97M-12.79M-7.59M
Net Income-5.00M-5.58M-12.54M-31.61M-12.77M-7.35M
Balance Sheet
Total Assets6.10M3.02M6.59M14.65M40.83M24.93M
Cash, Cash Equivalents and Short-Term Investments4.81M2.43M5.90M12.11M29.21M11.12M
Total Debt0.00221.87K289.64K0.000.00477.03K
Total Liabilities1.85M1.51M1.30M4.27M2.11M2.77M
Stockholders Equity4.25M1.51M5.29M10.38M38.72M22.16M
Cash Flow
Free Cash Flow-4.43M-4.53M-12.85M-19.10M-10.20M-10.31M
Operating Cash Flow-4.43M-4.53M-12.85M-17.60M-10.20M-10.31M
Investing Cash Flow-200.00K0.000.00-1.50M0.00-2.60K
Financing Cash Flow6.16M1.06M6.64M1.99M28.30M17.69M

Salarius Pharmaceuticals Technical Analysis

Technical Analysis Sentiment
Negative
Last Price0.66
Price Trends
50DMA
1.48
Negative
100DMA
3.15
Negative
200DMA
7.32
Negative
Market Momentum
MACD
-0.22
Negative
RSI
21.71
Positive
STOCH
25.26
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For SLRX, the sentiment is Negative. The current price of 0.66 is below the 20-day moving average (MA) of 0.71, below the 50-day MA of 1.48, and below the 200-day MA of 7.32, indicating a bearish trend. The MACD of -0.22 indicates Negative momentum. The RSI at 21.71 is Positive, neither overbought nor oversold. The STOCH value of 25.26 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for SLRX.

Salarius Pharmaceuticals Risk Analysis

Salarius Pharmaceuticals disclosed 44 risk factors in its most recent earnings report. Salarius Pharmaceuticals reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Salarius Pharmaceuticals Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
42
Neutral
$3.42M-0.01-139.55%68.08%
41
Neutral
$1.56M-0.04-60.37%-100.00%86.75%
39
Underperform
$640.51K-0.06178.82%-4121.10%
33
Underperform
$2.58M>-0.01-263.57%-34.58%96.41%
29
Underperform
$3.64M-0.05-168.95%90.27%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
SLRX
Salarius Pharmaceuticals
0.54
-26.47
-98.02%
BDRX
Biodexa Pharmaceuticals
2.51
-41.99
-94.36%
QCLS
Q/C Technologies
4.54
-112.46
-96.12%
SCNI
Scinai Immunotherapeutics
0.75
-3.02
-80.11%
OGEN
Oragenics
0.87
-11.43
-92.90%
ONCO
Onconetix
1.66
-57.95
-97.22%

Salarius Pharmaceuticals Corporate Events

Executive/Board ChangesShareholder Meetings
Salarius Shareholders Back Directors, Executive Pay and Auditor
Positive
Jan 2, 2026

On December 31, 2025, Salarius Pharmaceuticals reconvened its 2025 Annual Meeting of Stockholders, originally held on December 19, 2025, with 39.7% of the 1,051,782 outstanding common shares represented, constituting a quorum. At the meeting, shareholders re-elected two Class I directors to serve until the 2028 annual meeting, approved on a non-binding basis the compensation of the company’s named executive officers and ratified Ernst & Young LLP as the independent registered public accounting firm for the fiscal year ending December 31, 2025, collectively signaling continued shareholder support for the company’s current leadership, governance practices and financial oversight arrangements.

The most recent analyst rating on (SLRX) stock is a Hold with a $0.61 price target. To see the full list of analyst forecasts on Salarius Pharmaceuticals stock, see the SLRX Stock Forecast page.

Delistings and Listing ChangesRegulatory Filings and Compliance
Salarius Pharmaceuticals Appeals Nasdaq Delisting After Bid Deficiency
Negative
Jan 2, 2026

On December 31, 2025, Salarius Pharmaceuticals, Inc. disclosed that it had received notice from Nasdaq that the company was no longer in compliance with the exchange’s $1.00 minimum bid price requirement after its shares traded below that threshold for 30 consecutive business days. Because Salarius conducted a reverse stock split within the prior year and remains under a Mandatory Panel Monitor, it is not eligible for the standard 180-day grace period to cure the deficiency, and, absent an appeal by January 7, 2026, its stock is scheduled for suspension and delisting from The Nasdaq Capital Market effective January 9, 2026, followed by deregistration from Nasdaq. The company said it intends to appeal the delisting determination to a Nasdaq Hearings Panel, which would temporarily stay the suspension and delisting process while Salarius presents a plan to regain compliance, although there is no assurance that the panel will rule in favor of maintaining the listing, leaving shareholders exposed to the risk of the stock moving to a less liquid trading venue.

The most recent analyst rating on (SLRX) stock is a Hold with a $0.61 price target. To see the full list of analyst forecasts on Salarius Pharmaceuticals stock, see the SLRX Stock Forecast page.

Shareholder Meetings
Salarius Pharmaceuticals Adjourns Annual Meeting Over Quorum Shortfall
Negative
Dec 19, 2025

On December 19, 2025, Salarius Pharmaceuticals convened its 2025 annual meeting of stockholders but was forced to adjourn without conducting business after failing to reach the required 34% quorum, with only about 30% of eligible common shares represented in person or by proxy. The company set December 31, 2025, as the date to reconvene the virtual annual meeting, keeping the October 24, 2025 record date and the existing slate of proposals unchanged, and emphasized the need for additional shareholder participation by encouraging investors of record to submit or maintain their proxies so that key corporate matters can proceed, a step that underscores governance and voting-engagement challenges at the small-cap drug developer.

Executive/Board Changes
Salarius Pharmaceuticals Announces New Executive Appointments
Neutral
Nov 19, 2025

On November 18, 2025, Salarius Pharmaceuticals entered into employment agreements with Frederick E. Pierce, Dr. Barbara Hibner, and Peter Marschel to serve as Chief Executive Officer, Chief Scientific Officer, and Chief Business Officer, respectively. These agreements outline compensation, benefits, and conditions for termination, including severance pay and benefits under certain circumstances, reflecting strategic leadership appointments aimed at strengthening the company’s executive team.

Business Operations and StrategyExecutive/Board ChangesM&A TransactionsPrivate Placements and Financing
Salarius Pharmaceuticals Completes $7M Offering and Merger
Positive
Nov 13, 2025

On November 11, 2025, Salarius Pharmaceuticals announced an underwritten public offering of approximately $7 million, involving common stock and various warrants, with Ladenburg Thalmann & Co. Inc. as the sole underwriter. The offering closed on November 12, 2025, raising net proceeds of around $6.3 million, which will be used to advance clinical development, pay off Decoy Therapeutics’ promissory notes, and for general corporate purposes. Concurrently, Salarius completed a merger with Decoy Therapeutics, making it a wholly-owned subsidiary, and appointed new executives, including Frederick E. Pierce as CEO. This strategic move aims to strengthen Salarius’ market position and expand its research capabilities.

Executive/Board ChangesM&A Transactions
Salarius Pharmaceuticals Approves CEO Bonus for Merger
Neutral
Oct 21, 2025

On October 21, 2025, Salarius Pharmaceuticals‘ Board of Directors approved a transaction bonus for Mark J. Rosenblum, the Acting CEO and CFO, contingent on the completion of a merger agreement with Decoy Therapeutics. The bonus of $225,000 will be paid following the closing of the merger, provided Mr. Rosenblum remains employed through the closing date.

Delistings and Listing ChangesM&A TransactionsRegulatory Filings and Compliance
Salarius Pharmaceuticals Regains Nasdaq Compliance for Merger
Positive
Oct 14, 2025

On October 10, 2025, Salarius Pharmaceuticals regained compliance with Nasdaq’s Equity Standard, a crucial step in its planned merger with Decoy Therapeutics. The merger aims to leverage Decoy’s peptide conjugate therapeutics and Salarius’ assets to target unmet needs in respiratory diseases and GI oncology. The combined company will be led by Decoy’s leadership team and expects to advance its lead asset to an IND application with the FDA within the next year.

Delistings and Listing ChangesPrivate Placements and FinancingRegulatory Filings and Compliance
Salarius Pharmaceuticals Awaits Nasdaq Compliance Confirmation
Neutral
Oct 6, 2025

Salarius Pharmaceuticals has taken steps to regain compliance with Nasdaq’s equity standard by issuing and selling shares to raise its stockholders’ equity above the required $2.5 million threshold. The company is awaiting Nasdaq’s confirmation of compliance, and while its financial closing procedures for the quarter ended September 30, 2025, are incomplete, it anticipates that its upcoming quarterly report will reflect the necessary equity level.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jan 04, 2026