Monopar Therapeutics Inc (MNPR)
NASDAQ:MNPR
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Monopar Therapeutics Inc
(NASDAQ:MNPR)
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Rating:48Neutral
Price Target:
$56.00
▼(-0.39% Downside)
Action:ReiteratedDate:04/21/26
The score is held back primarily by weak financial performance (pre-revenue profile with persistent losses and cash burn, plus unusually volatile latest-period financials). Technicals are neutral-to-mixed, offering limited support. Offsetting some of this, corporate updates are constructive, highlighted by strong Phase 3 ALXN1840 data and a commercialization-focused executive hire.
Positive Factors
Late-stage clinical success (ALXN1840)
Robust Phase 3 FoCus data showing greater and durable neurologic improvement versus standard of care represents a durable, program-level fundamental: it meaningfully derisks the lead asset, supports regulatory filings, and increases the long-term commercial potential in a rare-disease niche with limited alternatives.
Negative Factors
Persistent cash burn
Sustained negative operating and free cash flow imposes persistent funding requirements and increases the probability of future dilutive financings. That structural cash burn constrains runway, forces frequent capital raises, and can impair long-term strategic optionality and negotiating leverage with partners or acquirers.
Read all positive and negative factors
Positive Factors
Negative Factors
Late-stage clinical success (ALXN1840)
Robust Phase 3 FoCus data showing greater and durable neurologic improvement versus standard of care represents a durable, program-level fundamental: it meaningfully derisks the lead asset, supports regulatory filings, and increases the long-term commercial potential in a rare-disease niche with limited alternatives.
Read all positive factors
Monopar Therapeutics Inc (MNPR) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$356.36M
Dividend YieldN/A
Average Volume (3M)192.79K
Price to Earnings (P/E)―
Beta (1Y)1.49
Revenue GrowthN/A
EPS Growth44.89%
CountryUS
Employees14
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-1.99
Shares Outstanding6,692,140
10 Day Avg. Volume209,213
30 Day Avg. Volume192,788
Financial Highlights & Ratios
PEG Ratio-0.98
Price to Book (P/B)<0.01
Price to Sales (P/S)0.00
P/FCF Ratio-0.04
Enterprise Value/Market Cap-172.08
Enterprise Value/RevenueN/A
Enterprise Value/Gross ProfitN/A
Enterprise Value/Ebitda4.02K
Forecast
1Y Price Target
$113.40Price Target Upside101.71% Upside
Rating ConsensusStrong Buy
Number of Analyst Covering5
EPS Forecast (FY)-3.63
Revenue Forecast (FY)N/A
Monopar Therapeutics Inc Business Overview & Revenue Model
Company Description
Monopar Therapeutics Inc., a clinical-stage biopharmaceutical company, engages in developing therapeutics for the treatment of cancer in the United States. Its lead product candidate in development is Validive, a clonidine hydrochloride mucobuccal...
How the Company Makes Money
As a clinical-stage biotechnology company, Monopar Therapeutics does not have a disclosed, established product-sales business and typically does not generate recurring revenue from marketed drugs; instead, its operations are generally funded throu...
Monopar Therapeutics Inc Financial Statement Overview
Summary
Income Statement
12
Very Negative
Balance Sheet
58
Neutral
Cash Flow
18
Very Negative
| Breakdown | Dec 2025 | Mar 2025 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|
Income Statement | |||||
| Total Revenue | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Gross Profit | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| EBITDA | -16.70M | -16.16M | -8.83M | -10.54M | -9.13M |
| Net Income | -13.72M | -15.59M | -8.40M | -10.52M | -9.10M |
Balance Sheet | |||||
| Total Assets | 140.72B | 60.29M | 7.35M | 13.23M | 20.52M |
| Cash, Cash Equivalents and Short-Term Investments | 61.83B | 60.21M | 7.27M | 13.12M | 20.30M |
| Total Debt | 154.92M | 0.00 | 0.00 | 8.41K | 0.00 |
| Total Liabilities | 2.89B | 5.25M | 1.76M | 3.14M | 1.58M |
| Stockholders Equity | 137.83B | 55.04M | 5.59M | 10.09M | 18.94M |
Cash Flow | |||||
| Free Cash Flow | -12.20B | -6.40M | -7.86M | -7.23M | -7.32M |
| Operating Cash Flow | -12.20B | -6.40M | -7.86M | -7.23M | -7.32M |
| Investing Cash Flow | -63.45B | -14.34M | 4.93M | -4.92M | 0.00 |
| Financing Cash Flow | 91.57B | 59.29M | 2.03M | 32.87K | 10.88M |
Monopar Therapeutics Inc Technical Analysis
Negative
56.22
Price Trends
56.46
Negative
64.10
Negative
62.08
Negative
Market Momentum
-0.07
Negative
48.41
Neutral
70.83
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For MNPR, the sentiment is Negative. The current price of 56.22 is above the 20-day moving average (MA) of 55.80, below the 50-day MA of 56.46, and below the 200-day MA of 62.08, indicating a neutral trend. The MACD of -0.07 indicates Negative momentum. The RSI at 48.41 is Neutral, neither overbought nor oversold. The STOCH value of 70.83 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for MNPR.
Monopar Therapeutics Inc Risk Analysis
Monopar Therapeutics Inc disclosed 79 risk factors in its most recent earnings report. Monopar Therapeutics Inc reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Monopar Therapeutics Inc Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
49 Neutral | $513.00M | -2.55 | -1849.88% | ― | 209.14% | 11.31% | |
49 Neutral | $336.78M | -6.10 | -300.94% | ― | ― | ― | |
48 Neutral | $356.36M | -35.28 | -0.04% | ― | ― | 44.89% | |
48 Neutral | $413.76M | -2.36 | -49.24% | ― | 8.72% | -1049.63% | |
46 Neutral | $116.90M | -4.09 | -82.00% | ― | -13.30% | 28.02% | |
42 Neutral | $41.37M | -1.59 | -83.02% | ― | ― | 9.75% |
* Healthcare Sector Average
MNPR
Monopar Therapeutics Inc
53.25
9.89
22.81%
CRDF
Cardiff Oncology
1.71
-0.97
-36.19%
VNDA
Vanda
7.00
2.41
52.51%
VSTM
Verastem
5.84
-1.17
-16.69%
MREO
Mereo Biopharma Group Plc
0.26
-2.29
-89.80%
SLN
Silence Therapeutics
7.13
3.22
82.35%
Monopar Therapeutics Inc Corporate Events
Business Operations and StrategyProduct-Related Announcements
Monopar Highlights Strong Phase 3 Data for ALXN1840
Positive
Apr 20, 2026
On April 19, 2026, Monopar Therapeutics reported new analyses from the randomized Phase 3 FoCus trial showing that ALXN1840 (tiomolibdate choline) delivered greater neurologic benefit than standard of care in Wilson disease patients with neurologi...
Business Operations and StrategyExecutive/Board Changes
Monopar Appoints Chief Commercial and Strategy Officer Rodriguez
Positive
Mar 2, 2026
On March 2, 2026, Monopar Therapeutics Inc. announced it had appointed veteran biopharma executive Susan Rodriguez as its Chief Commercial and Strategy Officer, a newly created role. Rodriguez, who has over 30 years of industry experience, will sh...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.