Cardiff Oncology, Inc. (CRDF)
NASDAQ:CRDF
Top Page
Cardiff Oncology
(NASDAQ:CRDF)
Select Model
Select Model
Rating:45Neutral
Price Target:
$1.50
▼(-5.06% Downside)
Action:ReiteratedDate:02/25/26
The score is primarily constrained by weak financial performance (minimal revenue, large ongoing losses, and sustained cash burn with shrinking equity), reinforced by bearish technical momentum (below key moving averages and negative MACD). Offsetting factors include a low-debt balance sheet and positive program-related corporate updates that could improve prospects if regulatory/clinical milestones are achieved.
Positive Factors
Very low leverage / low debt
The company’s minimal debt burden (debt-to-equity ~0.02) materially lowers default and refinancing risk during costly late-stage development. This structural balance-sheet strength preserves strategic optionality for partnering, milestone-based financing, or staged investment while clinical programs advance.
Negative Factors
Sustained negative operating cash flow
Persistent negative operating cash flow, worsening to about -$37.9M in 2025, creates an enduring funding requirement. Over a 2–6 month horizon this increases dependence on equity or partner financing, raising dilution risk and potentially constraining program pacing absent non-dilutive deals or milestone receipts.
Read all positive and negative factors
Positive Factors
Negative Factors
Very low leverage / low debt
The company’s minimal debt burden (debt-to-equity ~0.02) materially lowers default and refinancing risk during costly late-stage development. This structural balance-sheet strength preserves strategic optionality for partnering, milestone-based financing, or staged investment while clinical programs advance.
Read all positive factors
Cardiff Oncology (CRDF) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$108.02M
Dividend YieldN/A
Average Volume (3M)705.46K
Price to Earnings (P/E)―
Beta (1Y)1.19
Revenue Growth-27.29%
EPS Growth16.40%
CountryUS
Employees32
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-0.11
Shares Outstanding68,364,980
10 Day Avg. Volume562,035
30 Day Avg. Volume705,460
Financial Highlights & Ratios
PEG Ratio0.15
Price to Book (P/B)4.14
Price to Sales (P/S)316.73
P/FCF Ratio-4.95
Enterprise Value/Market Cap0.85
Enterprise Value/Revenue154.10
Enterprise Value/Gross Profit-8.15
Enterprise Value/Ebitda-1.96
Forecast
1Y Price Target
$7.43Price Target Upside370.25% Upside
Rating ConsensusStrong Buy
Number of Analyst Covering6
EPS Forecast (FY)-0.59
Revenue Forecast (FY)$357.00K
Cardiff Oncology Business Overview & Revenue Model
Company Description
Cardiff Oncology, Inc., a clinical-stage oncology company, develops medicine treatment for cancer patients in California. Its lead drug candidate is onvansertib, an oral selective Polo-like Kinase 1 Inhibitor for anti-cancer therapeutics; CY140, a...
How the Company Makes Money
Cardiff Oncology is a clinical-stage biotech company and, based on publicly available disclosures typical for companies at this stage, it does not primarily generate recurring revenue from commercial product sales because its lead product candidat...
Cardiff Oncology Earnings Call Summary
Earnings Call Date:Feb 27, 2025
(Q4-2024)
| % Change Since: |
Next Earnings Date:Apr 30, 2026
Earnings Call Sentiment Positive
The earnings call highlighted strong initial clinical data, successful capital raising efforts, and a solid financial position. However, some dependency on future FDA meetings and the early stage of PFS data might pose challenges. Overall, the sentiment is optimistic with clear progress, yet some uncertainties remain.Positive Updates
Encouraging Initial Data from CRDF-004 Trial
The trial showed a 64% ORR for patients on the 30 mg dose of onvansertib, compared to a 33% ORR in the control arm, indicating a strong efficacy signal.
Negative Updates
Pending FDA Discussions
While progress has been made, key decisions regarding dose selection and trial design depend on future FDA meetings, which could impact timelines.
Read all updates
Q4-2024 Updates
Positive
Negative
Encouraging Initial Data from CRDF-004 Trial
The trial showed a 64% ORR for patients on the 30 mg dose of onvansertib, compared to a 33% ORR in the control arm, indicating a strong efficacy signal.
Read all positive updates
Company Guidance
During the Cardiff Oncology Fourth Quarter 2024 Financial Results and Business Update Conference Call, guidance was provided on several key metrics and future plans for the company. The company highlighted an initial data set from the CRDF-004 trial, which showed a 64% overall response rate (ORR) for patients on the 30 mg dose of onvansertib, compared to 33% in the control arm. The trial focuses on first-line RAS-mutated metastatic colorectal cancer (mCRC), and aims to complete enrollment of 90 evaluable patients in early 2025. The company plans to release additional clinical data in the first half of 2025. Financially, Cardiff Oncology reported $91.7 million in cash and short-term investments as of December 31, 2024, following a $40 million capital raise. The company projects that these resources will support operations into the first quarter of 2027, with a quarterly cash burn of $10.3 million in Q4 2024. Additionally, Cardiff Oncology strengthened its intellectual property portfolio with a new patent for onvansertib, expected to expire no earlier than 2043.Cardiff Oncology Financial Statement Overview
Summary
Income Statement
18
Very Negative
Balance Sheet
62
Positive
Cash Flow
24
Negative
| Breakdown | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|
Income Statement | |||||
| Total Revenue | 593.00K | 683.00K | 488.00K | 386.00K | 359.00K |
| Gross Profit | -311.00K | 683.00K | 488.00K | 386.00K | 359.00K |
| EBITDA | -44.97M | -48.25M | -45.01M | -39.67M | -28.40M |
| Net Income | -45.88M | -45.43M | -41.44M | -38.70M | -28.29M |
Balance Sheet | |||||
| Total Assets | 61.88M | 97.19M | 81.64M | 116.19M | 149.54M |
| Cash, Cash Equivalents and Short-Term Investments | 58.30M | 91.75M | 74.82M | 105.27M | 140.82M |
| Total Debt | 832.00K | 1.52M | 2.15M | 2.71M | 3.12M |
| Total Liabilities | 16.50M | 14.24M | 11.90M | 9.85M | 9.13M |
| Stockholders Equity | 45.39M | 82.95M | 69.74M | 106.34M | 140.42M |
Cash Flow | |||||
| Free Cash Flow | -37.97M | -37.77M | -31.47M | -34.71M | -23.25M |
| Operating Cash Flow | -37.92M | -37.69M | -30.89M | -33.82M | -23.04M |
| Investing Cash Flow | 1.34M | 13.73M | 36.20M | 38.15M | -131.45M |
| Financing Cash Flow | 2.58M | 53.78M | 0.00 | 75.00K | 35.45M |
Cardiff Oncology Technical Analysis
Negative
1.58
Price Trends
1.81
Negative
2.16
Negative
2.41
Negative
Market Momentum
-0.09
Positive
35.64
Neutral
17.13
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CRDF, the sentiment is Negative. The current price of 1.58 is below the 20-day moving average (MA) of 1.79, below the 50-day MA of 1.81, and below the 200-day MA of 2.41, indicating a bearish trend. The MACD of -0.09 indicates Positive momentum. The RSI at 35.64 is Neutral, neither overbought nor oversold. The STOCH value of 17.13 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for CRDF.
Cardiff Oncology Risk Analysis
Cardiff Oncology disclosed 56 risk factors in its most recent earnings report. Cardiff Oncology reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Cardiff Oncology Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
53 Neutral | $404.72M | ― | -77.91% | ― | -76.59% | 94.03% | |
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
49 Neutral | $111.52M | -2.91 | -1292.68% | ― | ― | ― | |
46 Neutral | $92.99M | -0.90 | -87.28% | ― | -82.53% | -52.00% | |
45 Neutral | $108.02M | -4.09 | -82.00% | ― | -27.29% | 16.40% | |
43 Neutral | $163.01M | -2.09 | -49.86% | ― | -100.00% | 11.02% |
* Healthcare Sector Average
CRDF
Cardiff Oncology
1.58
-1.11
-41.26%
ONCY
Oncolytics Biotech
0.96
0.43
82.16%
AVTX
Avalo Therapeutics
17.76
12.00
208.33%
GLSI
Greenwich LifeSciences
22.82
13.23
137.96%
MOLN
Molecular Partners
3.85
0.31
8.76%
PYXS
Pyxis Oncology
1.48
0.52
54.17%
Cardiff Oncology Corporate Events
Business Operations and StrategyExecutive/Board Changes
Cardiff Oncology Formalizes Executive Departures Amid Strategic Review
Neutral
Apr 2, 2026
Cardiff Oncology disclosed that on January 26, 2026 its CEO, Dr. Mark Erlander, and CFO, James Levine, stepped down as part of a strategic review, and on March 27, 2026 the company formalized their departures with separation agreements. Erlander w...
Business Operations and StrategyProduct-Related Announcements
Cardiff Oncology advances onvansertib program in colorectal cancer
Positive
Feb 25, 2026
Cardiff Oncology has outlined new clinical data and development plans for its PLK1 inhibitor onvansertib, highlighting strong efficacy signals in first-line RAS-mutant metastatic colorectal cancer, including a 72% confirmed overall response rate a...
Business Operations and StrategyExecutive/Board Changes
Cardiff Oncology Overhauls Leadership to Advance Onvansertib
Positive
Jan 27, 2026
On January 27, 2026, Cardiff Oncology announced a major executive leadership transition as it prepares to move its lead cancer therapy, onvansertib, toward late-stage clinical development. Board member and experienced biotech executive Mani Mohind...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.