Clinical Data Uncertainty And Market AdoptionSmall sample sizes, a missing dosing cohort's disclosed results, and reliance on a FOLFIRI backbone used by a minority of frontline patients create uncertainty about reproducibility, regulatory outcomes, and eventual market uptake.
Executive Leadership RiskAbrupt departures of the CEO and CFO with only an interim CEO increase execution risk and raise investor concern about strategic continuity during critical trial planning.
Funding And Dilution RiskLimited cash resources and the need for additional capital to initiate a pivotal Phase 3 trial elevate the likelihood of dilutive financing or partnerships that could reduce shareholder value.