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Verastem (VSTM)
NASDAQ:VSTM
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Verastem (VSTM) AI Stock Analysis

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VSTM

Verastem

(NASDAQ:VSTM)

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Neutral 44 (OpenAI - 4o)
Rating:44Neutral
Price Target:
Verastem's overall stock score is primarily impacted by its weak financial performance, characterized by ongoing losses and negative equity. However, positive technical indicators and recent corporate events, such as the $75M private placement, provide some optimism for future growth. Valuation remains constrained by negative earnings, but strategic initiatives and product development efforts could drive improvements. The stock represents a speculative opportunity, with potential upside if financial health and operational efficiencies improve.
Positive Factors
Strategic Partnerships
The $75M private placement strengthens Verastem's financial position, supporting strategic initiatives and potential product launches, which can enhance long-term growth prospects.
Product Development
The focus on product development, particularly in Low-Grade Serous Ovarian Cancer, indicates a commitment to expanding its pipeline, which can drive future revenue and market position.
Market Opportunities
Identifying potential market opportunities for drug candidates suggests Verastem is strategically positioning itself to capture market share, which could lead to sustainable revenue growth.
Negative Factors
Financial Instability
Negative equity and a concerning debt-to-equity scenario highlight financial instability, posing risks to long-term sustainability and operational flexibility.
Cash Flow Challenges
Negative cash flows indicate reliance on external financing, which can be risky if funding sources diminish, affecting Verastem's ability to sustain operations.
Profitability Issues
Persistent net losses and negative profitability margins suggest operational inefficiencies, challenging Verastem's ability to achieve sustainable financial health.

Verastem (VSTM) vs. SPDR S&P 500 ETF (SPY)

Verastem Business Overview & Revenue Model

Company DescriptionVerastem, Inc. (VSTM) is a biopharmaceutical company focused on developing and commercializing medicines to improve the survival and quality of life for cancer patients. The company primarily operates in the oncology sector, with a strong emphasis on targeting malignant cells and the tumor microenvironment. Its core products and services revolve around innovative therapies for cancer treatment, particularly targeting specific pathways involved in cancer cell proliferation and survival.
How the Company Makes MoneyVerastem makes money through the development and commercialization of its oncology therapies. The company's revenue model includes income from product sales, particularly from its commercialized therapies, licensing agreements, and potential milestone payments from strategic partnerships. These partnerships often involve collaboration with other pharmaceutical companies for the development and marketing of its drug candidates. Additionally, Verastem may receive research and development funding from these partnerships, contributing to its financial earnings. The company's ability to generate revenue is significantly influenced by the success of its clinical trials, regulatory approvals, and market acceptance of its drugs.

Verastem Earnings Call Summary

Earnings Call Date:Nov 04, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Mar 12, 2026
Earnings Call Sentiment Positive
The earnings call highlighted successful product launch and strong financial positioning, with significant revenue generation and advancements in clinical trials. However, continued expenses and the need for additional trial enrollment present challenges.
Q3-2025 Updates
Positive Updates
Strong Commercial Launch of AVMAPKI FAKZYNJA CO-PACK
Achieved $11.2 million in net product revenue in the third quarter, surpassing expectations. High levels of physician engagement and patient retention were noted, with 133 prescribers and prescriptions from both academic and community settings.
Advancement in Clinical Trials
Completed enrollment of the RAMP-205 expansion cohort for first-line pancreatic cancer and the confirmatory Phase III RAMP-301 trial in recurrent LGSOC. Cleared two monotherapy doses in the G12D program without dose-limiting toxicities.
Financial Stability
Ended the third quarter with $137.7 million in cash, cash equivalents, and investments. Expected runway into the second half of 2026 with ongoing commercial and clinical developments.
Broad Payer Coverage
Payer coverage exceeded 80% for the AVMAPKI FAKZYNJA CO-PACK, with a mix of commercial and Medicare payers, ensuring seamless access for patients.
Negative Updates
Continued Expenses and Losses
Reported a non-GAAP adjusted net loss of $39.4 million for the third quarter, driven by R&D and SG&A expenses related to commercial activities and clinical trials.
Need for Additional Enrollment in RAMP-301
The IDMC recommended adding approximately 30 more patients to the RAMP-301 trial, indicating uncertainty in reaching required event rates for conclusive data.
Company Guidance
During the call, Verastem Oncology provided robust guidance and updates on their third quarter of 2025 performance, emphasizing the successful commercial launch of AVMAPKI FAKZYNJA CO-PACK for KRAS-mutated recurrent low-grade serous ovarian cancer (LGSOC). The company reported a net product revenue of $11.2 million for the quarter, surpassing expectations, driven by adoption among both academic centers and community oncologists. Key objectives for the launch include physician engagement, patient initiation and retention, and streamlined reimbursement, all showing positive trends. Approximately 65% of prescriptions were generated by the top 100 organizations, with a split of 60% from gynecological oncologists and 40% from medical oncologists. The company also highlighted advancements in their clinical pipeline, including the enrollment of the RAMP-205 pancreatic cancer trial and the RAMP-301 confirmatory trial in recurrent LGSOC. They reported progress in their VS-7375 program, clearing initial monotherapy doses with no dose-limiting toxicities and outlined plans to accelerate clinical paths. Financially, Verastem ended the quarter with $137.7 million in cash, cash equivalents, and investments, projecting runway into the second half of 2026. The company remains focused on building on their momentum and strategic imperatives, expecting important data readouts in the first half of 2026.

Verastem Financial Statement Overview

Summary
Verastem is facing significant financial challenges with persistent losses, negative equity, and reliance on external financing. While there are signs of revenue growth, the underlying profitability and cash flows are weak, indicating that the company needs to address operational inefficiencies and improve its financial health to ensure long-term sustainability.
Income Statement
25
Negative
Verastem's income statement highlights significant challenges with profitability. The gross profit margin is positive due to cost control, but net income remains deeply negative, reflecting ongoing losses. The revenue growth rate is misleadingly high, as revenue increased from zero, indicating volatility rather than sustainable growth. EBIT and EBITDA margins are negative, pointing to operational inefficiencies.
Balance Sheet
20
Very Negative
The balance sheet shows a concerning debt-to-equity scenario, with negative equity indicating financial instability. The company's liabilities exceed assets, suggesting potential solvency issues. The equity ratio is negative, further highlighting financial distress. ROE is negative, consistent with the company's net losses.
Cash Flow
30
Negative
Cash flow analysis reveals negative operating and free cash flows, indicating cash burn. The company relies on financing activities for liquidity, posing a risk if financing dries up. The operating cash flow to net income ratio is negative, reflecting cash flow challenges and inefficiencies in converting net income to cash.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue3.40M10.00M0.002.60M606.00K88.52M
Gross Profit-8.44M9.97M-62.00K2.48M400.00K54.77M
EBITDA-181.42M-125.86M-83.17M-71.56M-61.02M-50.41M
Net Income-241.11M-130.64M-87.37M-73.85M-71.20M-67.73M
Balance Sheet
Total Assets176.85M101.54M149.72M95.05M108.66M154.35M
Cash, Cash Equivalents and Short-Term Investments137.71M88.82M138.06M87.89M100.26M141.23M
Total Debt78.92M42.25M41.56M27.07M3.18M22.54M
Total Liabilities192.38M130.43M92.34M47.66M21.10M39.08M
Stockholders Equity-15.53M-28.89M57.37M47.39M87.56M115.27M
Cash Flow
Free Cash Flow-132.65M-104.80M-86.46M-63.67M-53.70M-33.54M
Operating Cash Flow-132.65M-104.77M-86.46M-63.67M-53.50M-33.51M
Investing Cash Flow-8.07M59.97M-44.45M66.19M87.00K-47.36M
Financing Cash Flow165.46M54.78M134.19M51.78M6.88M69.63M

Verastem Technical Analysis

Technical Analysis Sentiment
Negative
Last Price7.93
Price Trends
50DMA
9.05
Negative
100DMA
7.54
Positive
200DMA
6.96
Positive
Market Momentum
MACD
-0.10
Positive
RSI
42.72
Neutral
STOCH
17.72
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For VSTM, the sentiment is Negative. The current price of 7.93 is below the 20-day moving average (MA) of 8.68, below the 50-day MA of 9.05, and above the 200-day MA of 6.96, indicating a neutral trend. The MACD of -0.10 indicates Positive momentum. The RSI at 42.72 is Neutral, neither overbought nor oversold. The STOCH value of 17.72 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for VSTM.

Verastem Risk Analysis

Verastem disclosed 67 risk factors in its most recent earnings report. Verastem reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Verastem Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
54
Neutral
$307.49M-3.89
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
48
Neutral
$595.88M-59.38%-44.41%
47
Neutral
$147.69M-91.93%-17.89%3.93%
47
Neutral
$254.74M-32.38%23.24%
44
Neutral
$544.89M-2888.70%33.79%-26.37%
43
Neutral
$286.20M-75.08%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
VSTM
Verastem
7.93
4.33
120.28%
CRDF
Cardiff Oncology
2.25
-1.84
-44.99%
MREO
Mereo Biopharma Group Plc
1.76
-2.33
-56.97%
MNPR
Monopar Therapeutics Inc
80.76
65.03
413.41%
SLN
Silence Therapeutics
6.45
-11.37
-63.80%
AVIR
Atea Pharmaceuticals
3.25
-0.19
-5.52%

Verastem Corporate Events

Private Placements and Financing
Verastem Announces $75M Private Placement Agreement
Positive
Apr 25, 2025

On April 25, 2025, Verastem, Inc. announced a Securities Purchase Agreement with institutional investors for a private placement of approximately $75 million. The proceeds are intended to support the potential launch of avutometinib and defactinib for low-grade serous ovarian cancer, as well as ongoing clinical research and development. The private placement, led by RTW Investments and involving other investors, is expected to close on April 28, 2025, subject to customary conditions.

Spark’s Take on VSTM Stock

According to Spark, TipRanks’ AI Analyst, VSTM is a Neutral.

Verastem’s stock score reflects significant financial challenges, with persistent losses and reliance on external financing as key risks. However, recent positive corporate developments and technical indicators suggest potential for future growth. The valuation is constrained by negative earnings, limiting immediate investor appeal. Overall, the stock represents a speculative opportunity in the biotechnology sector, with potential upside if strategic initiatives succeed.

To see Spark’s full report on VSTM stock, click here.

Product-Related AnnouncementsBusiness Operations and Strategy
Verastem Unveils Strategic Plans in New Presentation
Positive
Mar 20, 2025

On March 20, 2025, Verastem, Inc. released an updated corporate presentation outlining its strategic plans and product development efforts, particularly in the area of Low-Grade Serous Ovarian Cancer. The announcement highlights the company’s ongoing clinical trials and collaborations, including those with GenFleet Therapeutics, as well as the potential market opportunities for its drug candidates. The release underscores the company’s commitment to advancing its pipeline, despite the inherent risks and uncertainties in drug development and commercialization.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Apr 26, 2025