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Rigel (RIGL)
NASDAQ:RIGL
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Rigel (RIGL) AI Stock Analysis

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RIGL

Rigel

(NASDAQ:RIGL)

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Outperform 82 (OpenAI - 4o)
Rating:82Outperform
Price Target:
$44.00
▲(16.25% Upside)
Rigel's strong financial performance and positive earnings call are the most significant factors driving the high score. The stock's attractive valuation and bullish technical indicators further support its potential, though caution is advised due to the RSI nearing overbought levels.
Positive Factors
Revenue Growth
The significant revenue growth demonstrates Rigel's strong market position and successful product commercialization, indicating robust demand and effective sales strategies.
Pipeline Advancements
Advancements in Rigel's drug development pipeline, particularly in R289, suggest potential for future product approvals and long-term growth in the hematology and oncology sectors.
Cash Generation
Strong cash flow growth enhances Rigel's financial flexibility, supporting ongoing R&D investments and strategic initiatives, crucial for sustaining long-term operations.
Negative Factors
High Leverage
Elevated leverage could strain Rigel's financial stability, limiting its ability to invest in growth opportunities and increasing vulnerability to economic downturns.
Negative Return on Equity
Negative ROE indicates Rigel's challenges in generating returns from equity, potentially impacting investor confidence and long-term shareholder value.
Program Termination
The termination of the CNS program could reduce Rigel's diversification in its pipeline, impacting its strategic growth and innovation potential in the long term.

Rigel (RIGL) vs. SPDR S&P 500 ETF (SPY)

Rigel Business Overview & Revenue Model

Company DescriptionRigel Pharmaceuticals, Inc., a biotechnology company, discovers and develops small molecule drugs to treat hematologic disorders, cancer, and rare immune diseases. The company offers Tavalisse, an oral spleen tyrosine kinase inhibitor for the treatment of adult patients with chronic immune thrombocytopenia. It also develops Fostamatinib that is in phase III clinical trial for the treatment of warm autoimmune hemolytic anemia; phase III clinical trial for the treatment of hospitalized COVID-19 patients; and phase III clinical trial for the treatment of COVID-19. In addition, the company is developing R289, an oral interleukin receptor associated kinase 1/4 inhibitor, which is in phase I clinical trial for autoimmune, inflammatory, and hematology-oncology diseases; and R552, a receptor-interacting serine/threonine-protein kinase 1 inhibitor that has completed phase I clinical trial for autoimmune and inflammatory diseases. It has research and license agreements with AstraZeneca AB for the development and commercialization of R256, an inhaled JAK inhibitor; BerGenBio AS for the development and commercialization of AXL inhibitors in oncology; and Daiichi Sankyo to develop murine double minute 2 inhibitors for solid and hematological malignancies, as well as license and supply agreement with Kissei Pharmaceutical Co., Ltd. to develop and commercialize Fostamatinib. The company also has a license agreement and strategic collaboration with Eli Lilly and Company to co-develop and commercialize R552 for various indications, including autoimmune and inflammatory diseases, as well as other non-central nervous system (non-CNS) disease development candidates. Rigel Pharmaceuticals, Inc. was incorporated in 1996 and is headquartered in South San Francisco, California.
How the Company Makes MoneyRigel Pharmaceuticals generates revenue through several key streams, primarily from the commercialization of its approved therapies. The company earns money by selling its marketed drugs, which include treatments for specific hematologic conditions. Additionally, Rigel may receive milestone payments and royalties from partnerships with larger pharmaceutical companies that involve co-development or licensing agreements for its drug candidates. Research and development collaborations also contribute to its revenue, allowing Rigel to leverage its technology and expertise while sharing costs and risks with partners. The success of its clinical trials and the subsequent approval of new therapies are critical factors influencing its earnings potential.

Rigel Earnings Call Summary

Earnings Call Date:Nov 04, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Mar 03, 2026
Earnings Call Sentiment Positive
The earnings call highlighted Rigel Pharmaceuticals' strong financial performance, significant increases in revenue and net product sales, and advancements in their drug development pipeline. Despite the termination of a specific CNS program by Eli Lilly, the overall tone was positive, focusing on growth and expansion opportunities.
Q3-2025 Updates
Positive Updates
Record Revenue and Net Product Sales
Total revenue of $69.5 million for Q3 2025, with record net product sales of $64.1 million, a 65% year-over-year increase. Raised 2025 revenue guidance to $285 million to $290 million, exceeding previous expectations.
Strong Performance of Commercial Products
TAVALISSE generated $44.7 million in net product sales, a 70% increase from Q3 2024. GAVRETO achieved $11.1 million, a 56% increase, and REZLIDHIA reported $8.3 million, a 50% increase.
Pipeline Advancements
Completion of enrollment in the dose escalation phase of the R289 study. First patient enrolled in the dose expansion phase. Strategic collaborations and expansions for olutasidenib in IDH1 mutated AML and glioma.
Financial Discipline and Profitability
Reported net income of $27.9 million for Q3 2025, up from $12.4 million in Q3 2024. Increased cash balance to $137.1 million.
Negative Updates
Termination of CNS Disease Program
Eli Lilly decided to terminate the CNS disease program, which will become effective after 60 days.
Company Guidance
During Rigel Pharmaceuticals' third-quarter 2025 financial conference call, the company provided updated guidance for the year, reflecting a strong commercial performance and strategic advancements in their development pipeline. Total revenue for the third quarter reached $69.5 million, driven by record net product sales of $64.1 million, marking a 65% year-over-year increase. Rigel's updated 2025 revenue guidance now projects total revenue between $285 million and $290 million, up from a previous range of $270 million to $280 million, with net product sales expected to be between $225 million and $230 million. This represents an anticipated growth rate of 55% to 59% compared to 2024. The company also reported a net income of $27.9 million for the quarter and increased their cash balance to $137.1 million. Additionally, Rigel highlighted its progress in the ongoing Phase Ib study of R289 and strategic collaborations for olutasidenib, contributing to a promising outlook for sustained growth and development in hematology and oncology.

Rigel Financial Statement Overview

Summary
Rigel demonstrates strong revenue growth and profitability improvements, particularly in the latest TTM period. The income statement shows robust sales performance and high gross profit margins. However, the balance sheet reveals high leverage, posing financial risk, and the return on equity is negative. Cash flow generation is strong, but operational cash efficiency could improve.
Income Statement
85
Very Positive
Rigel's income statement shows strong revenue growth with a 31.93% increase in TTM, indicating robust sales performance. The gross profit margin remains high at 89.64%, reflecting efficient cost management. The net profit margin improved significantly to 18.31%, showcasing enhanced profitability. However, historical volatility in EBIT and EBITDA margins suggests potential operational challenges.
Balance Sheet
70
Positive
The balance sheet reveals a high debt-to-equity ratio of 3.29 in TTM, indicating significant leverage, which could pose financial risk. Despite this, the company has improved its equity position over time. The return on equity is negative, suggesting inefficiencies in generating returns from shareholders' equity.
Cash Flow
75
Positive
Rigel's cash flow statement is strong, with an impressive 85.33% growth in free cash flow in TTM, indicating improved cash generation. The free cash flow to net income ratio is healthy at 1.00, showing effective conversion of profits into cash. However, the operating cash flow to net income ratio is moderate, suggesting room for improvement in operational cash efficiency.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue282.08M179.28M116.88M120.24M149.24M108.62M
Gross Profit262.62M160.63M109.77M118.49M148.15M107.73M
EBITDA122.63M28.51M-16.98M-53.87M-11.29M-27.68M
Net Income113.30M17.48M-25.09M-58.57M-17.91M-29.74M
Balance Sheet
Total Assets242.53M163.98M117.22M134.28M167.33M110.38M
Cash, Cash Equivalents and Short-Term Investments137.14M77.32M56.93M58.21M124.97M57.33M
Total Debt60.88M59.97M60.58M41.55M30.57M39.09M
Total Liabilities124.92M160.69M145.87M147.90M136.95M76.35M
Stockholders Equity117.61M3.29M-28.64M-13.62M30.37M34.03M
Cash Flow
Free Cash Flow68.14M31.43M-20.74M-74.21M5.25M-53.45M
Operating Cash Flow68.18M31.47M-5.74M-73.76M5.88M-52.19M
Investing Cash Flow-77.92M4.13M-4.30M72.78M-80.04M47.47M
Financing Cash Flow6.64M-11.64M18.37M6.55M62.67M12.57M

Rigel Technical Analysis

Technical Analysis Sentiment
Positive
Last Price37.85
Price Trends
50DMA
32.43
Positive
100DMA
28.71
Positive
200DMA
24.30
Positive
Market Momentum
MACD
0.42
Negative
RSI
69.06
Neutral
STOCH
43.83
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For RIGL, the sentiment is Positive. The current price of 37.85 is above the 20-day moving average (MA) of 29.67, above the 50-day MA of 32.43, and above the 200-day MA of 24.30, indicating a bullish trend. The MACD of 0.42 indicates Negative momentum. The RSI at 69.06 is Neutral, neither overbought nor oversold. The STOCH value of 43.83 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for RIGL.

Rigel Risk Analysis

Rigel disclosed 59 risk factors in its most recent earnings report. Rigel reported the most risks in the "Legal & Regulatory" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Rigel Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
82
Outperform
$509.06M5.24220.06%79.13%2798.12%
57
Neutral
$483.32M-3.99-65.30%1504.83%56.81%
55
Neutral
$583.94M-62.49%74.95%34.25%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
44
Neutral
$528.20M-2888.70%33.79%-26.37%
41
Neutral
$476.14M-34.63%-23.43%-9.84%
39
Underperform
$477.76M-3.01-80.09%60.14%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
RIGL
Rigel
37.85
22.41
145.14%
LXRX
Lexicon Pharmaceuticals
1.38
0.08
6.15%
VSTM
Verastem
8.16
4.56
126.67%
RGNX
RegenXBio
11.61
0.42
3.75%
BCYC
Bicycle Therapeutics
6.17
-18.53
-75.02%
OPT
Opthea Limited Sponsored ADR
3.20
-0.84
-20.79%

Rigel Corporate Events

Rigel Pharmaceuticals Reports Record Q3 Revenue and Growth
Nov 6, 2025

Rigel Pharmaceuticals’ recent earnings call reflected a robust financial performance, marked by substantial revenue growth and promising advancements in their drug development pipeline. Despite a setback with the termination of a CNS program by Eli Lilly, the overall sentiment was optimistic, focusing on the company’s growth and future expansion opportunities.

Rigel Pharmaceuticals Reports Strong Q3 2025 Results
Nov 5, 2025

Rigel Pharmaceuticals, Inc., a biotechnology company based in South San Francisco, focuses on developing therapies for hematologic disorders and cancer. The company is known for its innovative approach in the biotechnology sector, particularly in the treatment of immune thrombocytopenia and acute myeloid leukemia.

Eli Lilly and Rigel’s Promising Study on Rheumatoid Arthritis Treatment
Aug 25, 2025

Eli Lilly and Company, in collaboration with Rigel Pharmaceuticals, is conducting an adaptive Phase 2a/2b study titled ‘An Adaptive Phase 2a/2b, Randomized, Double-Blind, Placebo-Controlled Study of LY3871801 in Adult Participants With Moderately-to-Severely Active Rheumatoid Arthritis.’ The study aims to evaluate the efficacy and safety of LY3871801 in treating adults with active moderate-to-severe rheumatoid arthritis, a condition that significantly impacts quality of life.

Rigel Pharmaceuticals’ Earnings Call Highlights Robust Growth
Aug 7, 2025

Rigel Pharmaceuticals’ recent earnings call painted a picture of robust growth and optimism. The company reported significant revenue increases and strong commercial performance across its product portfolio. With raised revenue guidance for 2025, Rigel demonstrates confidence in its continued growth trajectory. The call highlighted financial discipline leading to increased profitability, alongside a promising development pipeline. A minor lowlight involved a change in patient response status in a clinical study.

Rigel Pharmaceuticals Reports Strong Q2 2025 Results
Aug 6, 2025

Rigel Pharmaceuticals, Inc. is a biotechnology company based in South San Francisco, specializing in the discovery, development, and commercialization of innovative therapies for hematologic disorders and cancer. The company is known for its focus on hematology and oncology, with a pipeline of products aimed at addressing unmet medical needs in these areas.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 06, 2025