Product-Level Sales Momentum
Q4 2025 sales by product: TAVALISSE $45.6M (+47% YoY), GAVRETO $10.2M (+27% YoY), REZLIDHIA $9.6M (+29% YoY).
Profitability and Cash Position
Rigel reported GAAP net income of $367.0 million for full-year 2025 (vs. $17.5M in 2024) and ended 2025 with $155.0 million in cash, cash equivalents and short-term investments (up from $77.3M at end-2024, ~+100%).
Encouraging Clinical Data for R289 (Phase Ib)
In heavily pretreated lower-risk MDS patients (dose escalation, n=33), among 18 evaluable patients at ≥500 mg daily doses, 6 (33%) achieved red cell transfusion independence (RBC-TI ≥8 weeks); median RBC-TI duration ~23 weeks and median time to onset ~2 months. Safety profile: generally well tolerated with low incidence of Grade 3/4 cytopenias/infections and one DLT (Grade 3/4 AST/ALT at 750 mg).
Regulatory Incentives for R289
R289 holds FDA Fast Track designation and orphan drug designation for MDS, supporting an expedited regulatory pathway and potential market exclusivity upon approval.
Proven BD & Portfolio Expansion Track Record
Successful in-licensing/acquisitions of REZLIDHIA (2022) and GAVRETO (2024) illustrate the company’s strategy of leveraging existing commercial infrastructure to scale revenues with limited integration costs.
Positive 2026 Financial Guidance
Guidance for 2026: total revenue $275M–$290M, net product sales $255M–$265M, contract revenues $20M–$25M, and expectation of positive net income while funding clinical programs.
Strong Full-Year Net Product Sales Growth
Net product sales for 2025 were $232.0 million, an increase of $87 million or 60% versus 2024, driven by demand across the three-product portfolio and portfolio expansion.
Record Fourth Quarter Performance
Fourth quarter 2025 net product sales were $65.4 million, up $18.9 million or 41% year-over-year, marking a record quarter.