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Bicycle Therapeutics Ltd (BCYC)
NASDAQ:BCYC
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Bicycle Therapeutics (BCYC) AI Stock Analysis

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BCYC

Bicycle Therapeutics

(NASDAQ:BCYC)

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Neutral 45 (OpenAI - 4o)
Rating:45Neutral
Price Target:
$7.50
▲(1.35% Upside)
Bicycle Therapeutics' overall stock score is primarily impacted by its weak financial performance, characterized by declining revenues and persistent losses. The technical analysis indicates a bearish long-term trend, although short-term indicators are neutral. The valuation is unfavorable due to a negative P/E ratio, reflecting the company's ongoing challenges in achieving profitability. The absence of earnings call data and corporate events means these factors did not influence the score.
Positive Factors
Proprietary Technology
The proprietary Bicycle platform provides a competitive edge in developing targeted therapies, potentially leading to innovative treatments and partnerships.
Low Leverage
Minimal leverage indicates a conservative capital structure, reducing financial risk and providing flexibility for future investments or R&D.
Collaborative Revenue Model
Collaborations with larger pharmaceutical companies provide diversified revenue streams and potential for growth through milestone payments and royalties.
Negative Factors
Declining Revenue
Significant challenges in revenue generation indicate potential issues in market penetration or product adoption, impacting long-term sustainability.
Negative Profit Margins
Ongoing losses and negative margins reflect operational inefficiencies and high costs, which may hinder future profitability and growth.
Cash Flow Challenges
Negative cash flow indicates financial strain and limits the company's ability to fund operations and invest in growth without external financing.

Bicycle Therapeutics (BCYC) vs. SPDR S&P 500 ETF (SPY)

Bicycle Therapeutics Business Overview & Revenue Model

Company DescriptionBicycle Therapeutics plc, a clinical-stage biopharmaceutical company, develops a class of medicines for diseases that are underserved by existing therapeutics. Its lead product candidate is BT1718, a bicycle toxin conjugate (BTC), which is in Phase I/IIa clinical trials targeting tumors that express Membrane Type 1 matrix metalloprotease. The company's oncology product candidates also comprise BT5528, a BTC that is in a Phase I/II clinical trial targeting EphA2; and BT8009, which is in Phase I/II clinical trial targeting Nectin-4. In addition, it is developing THR-149, a plasma kallikrein inhibitor that completed Phase II clinical trials for the treatment of diabetic macular edema; BT7480, a Bicycle tumor-targeted immune cell agonist (TICA) targeting Nectin-4 and agonizing; BT7455, an EphA2/CD137 Bicycle TICA, which is in preclinical studies; and BT1718, a BTC that target tumors, that is in Phase I/IIa clinical trial that express Membrane Type 1 matrix metalloproteinase. Further, the company collaborates with biopharmaceutical companies and organizations to develop programs in therapeutic areas, such as anti-infective, cardiovascular, ophthalmology, and respiratory indications. It has a clinical trial and license agreement with the Cancer Research Technology Limited and Cancer Research UK; research collaboration agreements with AstraZeneca, Sanofi, Oxurion, and the Dementia Discovery Fund; and discovery collaboration and license agreement with Genentech for the discovery and development of Bicycle peptides for multiple immuno-oncology targets. Bicycle Therapeutics plc was incorporated in 2009 and is headquartered in Cambridge, the United Kingdom.
How the Company Makes MoneyBicycle Therapeutics generates revenue through a combination of product development partnerships, licensing agreements, and potential milestone payments from collaborations with larger pharmaceutical companies. The company collaborates with industry partners to develop its product candidates, which can lead to upfront payments, research funding, and milestone payments as the products progress through clinical development. Additionally, Bicycle may receive royalties on sales of any products that result from these partnerships. The company also aims to capitalize on its proprietary technology to attract investments and grants that can further support its research and development efforts.

Bicycle Therapeutics Financial Statement Overview

Summary
Bicycle Therapeutics shows strong revenue growth and maintains a robust cash position. However, consistent net losses and negative cash flows from operations indicate financial challenges. The company relies heavily on external financing, typical for biotech, but it poses a risk if financing conditions change.
Income Statement
25
Negative
Bicycle Therapeutics shows strong revenue growth over the years, with Total Revenue increasing from $10.39M in 2020 to $25.73M in TTM. However, the company is still experiencing significant net losses, as reflected in the negative Net Profit Margin and EBIT Margin. The Gross Profit Margin has improved, but the high negative EBIT and EBITDA margins indicate operational inefficiencies.
Balance Sheet
45
Neutral
The balance sheet is supported by a strong cash position, with substantial cash reserves exceeding total debt, resulting in negative net debt. The Debt-to-Equity ratio is low, indicating low leverage. However, the Return on Equity is negative due to ongoing net losses, which is a concern for profitability.
Cash Flow
30
Negative
The company has a negative Free Cash Flow, but the cash flow from financing activities remains strong, indicating reliance on external funding. The Operating Cash Flow to Net Income ratio is below ideal levels, reflecting operational challenges. However, the company’s ability to raise significant financing is a positive factor.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue19.28M35.27M26.98M14.46M11.70M10.39M
Gross Profit-38.99M-137.69M-129.52M-67.15M-33.18M-22.76M
EBITDA-274.80M-164.89M-183.40M-112.96M-64.08M-50.68M
Net Income-242.36M-169.03M-180.66M-112.72M-66.82M-51.01M
Balance Sheet
Total Assets832.18M956.87M595.34M410.61M479.79M161.15M
Cash, Cash Equivalents and Short-Term Investments721.45M879.52M526.42M339.15M438.68M135.99M
Total Debt7.20M9.49M44.96M44.33M44.34M15.78M
Total Liabilities163.27M163.81M224.41M139.83M133.54M65.69M
Stockholders Equity668.91M793.06M370.93M270.78M346.25M95.46M
Cash Flow
Free Cash Flow-210.62M-165.96M-63.56M-105.10M-16.82M-18.99M
Operating Cash Flow-208.64M-164.72M-60.63M-86.11M-14.79M-17.79M
Investing Cash Flow-1.91M-1.24M-2.93M-18.99M-2.03M-1.20M
Financing Cash Flow-31.81M519.75M250.03M6.69M320.73M62.84M

Bicycle Therapeutics Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price7.40
Price Trends
50DMA
7.51
Negative
100DMA
7.74
Negative
200DMA
9.64
Negative
Market Momentum
MACD
>-0.01
Negative
RSI
54.19
Neutral
STOCH
76.37
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For BCYC, the sentiment is Neutral. The current price of 7.4 is above the 20-day moving average (MA) of 7.13, below the 50-day MA of 7.51, and below the 200-day MA of 9.64, indicating a neutral trend. The MACD of >-0.01 indicates Negative momentum. The RSI at 54.19 is Neutral, neither overbought nor oversold. The STOCH value of 76.37 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for BCYC.

Bicycle Therapeutics Risk Analysis

Bicycle Therapeutics disclosed 75 risk factors in its most recent earnings report. Bicycle Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Bicycle Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
67
Neutral
$570.41M-138.21-15.65%85.40%40.95%
56
Neutral
$738.12M-20.38103.70%
48
Neutral
$638.93M-6.21
45
Neutral
$512.87M-31.58%-51.13%7.57%
39
Underperform
$483.16M-3.01-80.09%60.14%
35
Underperform
$834.58M-4.17-0.69%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
BCYC
Bicycle Therapeutics
7.40
-15.23
-67.30%
KOD
Kodiak Sciences
15.80
13.19
505.36%
ETON
Eton Pharmaceuticals
21.27
15.27
254.50%
OPT
Opthea Limited Sponsored ADR
3.20
-0.87
-21.38%
NBTX
Nanobiotix
16.24
10.49
182.43%
BCAX
Bicara Therapeutics Inc.
11.71
-13.76
-54.02%

Bicycle Therapeutics Corporate Events

Executive/Board ChangesBusiness Operations and Strategy
Bicycle Therapeutics Expands Board with New Appointments
Positive
Sep 8, 2025

On September 8, 2025, Bicycle Therapeutics announced the expansion of its Board of Directors from eight to ten members, appointing Roger Dansey, M.D., and Hervé Hoppenot as new directors. Both appointees bring extensive expertise in oncology research, drug development, and commercialization, which is expected to enhance the company’s strategic initiatives in developing next-generation targeted therapies. The appointments are seen as a strategic move to strengthen the company’s leadership as it progresses with its pipeline and anticipates upcoming milestones.

Executive/Board ChangesBusiness Operations and StrategyFinancial Disclosures
Bicycle Therapeutics Appoints Charles Swanton to Board
Neutral
Aug 8, 2025

On August 6, 2025, Bicycle Therapeutics announced the appointment of Charles Swanton, M.D., Ph.D., to its Board of Directors and Scientific Committee, effective August 12, 2025. This appointment is part of the company’s efforts to strengthen its clinical leadership and scientific advisory capabilities. Additionally, Bicycle Therapeutics reported its second-quarter 2025 financial results, highlighting significant progress in its research and development pipeline, including ongoing trials for zelenectide pevedotin in various cancers. The company also announced a strategic cost realignment, primarily through workforce reduction, to extend its financial runway into 2028, while continuing to focus on disciplined capital allocation and operational flexibility.

Shareholder MeetingsBusiness Operations and Strategy
Bicycle Therapeutics Approves Proposals at Annual Meeting
Positive
Jun 17, 2025

On June 17, 2025, Bicycle Therapeutics held its annual general meeting where all proposals, including director re-elections and auditor appointments, were approved by shareholders. The meeting saw high shareholder participation, with approximately 98.63% of shares represented, reflecting strong support for the company’s governance and strategic direction.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Sep 25, 2025