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Mirum Pharmaceuticals Inc (MIRM)
NASDAQ:MIRM
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Mirum Pharmaceuticals (MIRM) AI Stock Analysis

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MIRM

Mirum Pharmaceuticals

(NASDAQ:MIRM)

Rating:58Neutral
Price Target:
$74.00
▼(-0.27% Downside)
Mirum Pharmaceuticals' strong revenue growth and positive earnings call are offset by financial challenges and valuation concerns. The technical analysis indicates strong momentum, but potential overbought conditions suggest caution.
Positive Factors
Financial performance
Mirum Pharmaceuticals is recognized for having a cash-flow positive, high-growth commercial business with multiple credible growth opportunities.
Product approval
Livmarli's approval in Japan for Alagille syndrome and progressive familial intrahepatic cholestasis led to a favorable pricing adjustment.
Revenue growth
Rapid growth in Livmarli revenues has surpassed management’s expectations, driven primarily by new patient identification.
Negative Factors
Market competition
Even with competition, volixibat is seen as well-positioned in large rare diseases, with its potential to differentiate on efficacy and benefit from market developments.
Product differentiation
Livmarli's oral tablet formulation could narrow the competitive gap in PFIC new patient starts.

Mirum Pharmaceuticals (MIRM) vs. SPDR S&P 500 ETF (SPY)

Mirum Pharmaceuticals Business Overview & Revenue Model

Company DescriptionMirum Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the development and commercialization of novel therapies for debilitating rare and orphan diseases. The company's lead product candidate is LIVMARLI, an investigational oral drug for the treatment of progressive familial intrahepatic cholestasis disease, as well as for the treatment of Alagille syndrome and biliary atresia disease. It also develops Volixibat drug for treatment of intrahepatic cholestasis of pregnancy and primary sclerosing cholangitis. Mirum Pharmaceuticals, Inc. was incorporated in 2018 and is headquartered in Foster City, California.
How the Company Makes MoneyMirum Pharmaceuticals generates revenue primarily through the sale of its approved products, including Maralixibat, which is marketed to healthcare providers for the treatment of cholestatic liver diseases. The company also engages in strategic partnerships and collaborations with other pharmaceutical firms to enhance its research and development capabilities, which can lead to milestone payments and royalties based on the success of its partnered programs. Additionally, Mirum may benefit from government grants or incentives aimed at supporting research in rare diseases, contributing to its overall revenue streams.

Mirum Pharmaceuticals Earnings Call Summary

Earnings Call Date:Aug 06, 2025
(Q2-2025)
|
% Change Since: |
Next Earnings Date:Nov 12, 2025
Earnings Call Sentiment Positive
The earnings call reflects a strong performance by Mirum Pharmaceuticals, highlighted by significant revenue growth and positive pipeline developments. While there are challenges such as high operating expenses and variability in international sales, the positive aspects significantly outweigh the negatives.
Q2-2025 Updates
Positive Updates
Strong Revenue Growth
Mirum Pharmaceuticals reported total revenues of $128 million for Q2 2025, representing a 64% growth over the same quarter last year. The company has raised its full-year guidance for 2025 to $490 million to $510 million, positioning for nearly 50% top-line growth.
Livmarli Performance
Livmarli continues to be a key driver, with strong demand in the U.S. and international markets. The recent U.S. launch of a single tablet per dose formulation adds convenience for patients.
Pipeline Progress
The VISTAS Phase IIb study in primary sclerosing cholangitis is on track, with top-line data expected in Q2 2026. The company is also making progress in the VANTAGE PBC and EXPAND studies, and plans to start a Phase II study of MRM-3379 in Fragile X syndrome by year-end.
Positive Financial Outlook
Mirum is operating cash flow positive and expects to continue this trend for the full year. Cash, cash equivalents, and investments were $322 million as of June 30, a $29 million increase from the end of last year.
International Expansion
Livmarli growth is strong internationally, with a successful launch in Japan through partner Takeda. The international markets contributed $31 million in net product sales in Q2.
Negative Updates
High Operating Expenses
Total operating expenses for the quarter were $133 million, with significant R&D and SG&A expenses contributing to the total.
Variability in International Sales
International sales, particularly through partner Takeda in Japan, are subject to large periodic orders, leading to quarter-to-quarter revenue variability.
Company Guidance
On the call, Mirum Pharmaceuticals provided strong guidance for 2025, raising their full-year revenue forecast to between $490 million and $510 million, reflecting anticipated close to 50% top-line growth. This increase is driven by the impressive performance of Livmarli, which contributed significantly with $128 million in total revenue for the second quarter, marking a 64% growth compared to the previous year. The company highlighted the successful expansion in both Alagille syndrome and PFIC markets, with Livmarli's demand exceeding expectations, particularly in PFIC where increased disease awareness and genetic testing are identifying more patients. Internationally, Mirum experienced durable growth, supported by the recent launch in Japan by their partner, Takeda. With Livmarli's potential seen as exceeding $1 billion in revenue, Mirum's strategic focus on commercial execution and pipeline advancement, including pivotal studies like the VISTAS Phase IIb in PSC, sets the stage for an exciting 2026. Furthermore, the company reported financial robustness with cash, cash equivalents, and investments of $322 million, reflecting a $29 million increase from the previous year-end.

Mirum Pharmaceuticals Financial Statement Overview

Summary
Mirum Pharmaceuticals is experiencing rapid revenue growth, yet it continues to face profitability challenges as indicated by negative net income and EBIT. The balance sheet shows improved equity positions, but high leverage remains a concern. Negative cash flows highlight liquidity risks, although there are signs of operational improvement. Overall, while the company shows promising growth potential, it faces significant financial stability and profitability challenges.
Income Statement
45
Neutral
Mirum Pharmaceuticals has shown significant revenue growth over the years, with TTM revenue at $379.3 million compared to $19.1 million in 2021. However, the company is still reporting negative net income, with a TTM net income of -$77.3 million. Gross profit margins remain strong at 77.1% TTM but the company struggles with negative EBIT and EBITDA margins due to high operational costs.
Balance Sheet
50
Neutral
The balance sheet shows a stable equity position with a TTM stockholders' equity of $233.3 million. The debt-to-equity ratio is relatively high at 1.36, indicating significant leverage. However, the equity ratio is 33.8%, suggesting a moderate level of equity financing. The company faces challenges with liabilities exceeding assets in previous years but has improved its balance sheet recently.
Cash Flow
40
Negative
The company's cash flow from operations is negative at -$6.8 million TTM, indicating potential challenges in generating cash internally. Free cash flow is also negative, impacting liquidity. However, there is a positive trend in operating cash flow to net income ratio, showing some operational improvements compared to past years.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue429.16M336.89M186.37M77.06M19.14M0.00
Gross Profit339.14M255.25M139.34M64.69M17.23M-623.00K
EBITDA-18.79M-48.97M-136.49M-122.41M-65.39M-102.31M
Net Income-58.56M-87.94M-163.41M-135.66M-83.99M-103.27M
Balance Sheet
Total Assets725.83M670.75M646.62M352.91M294.65M240.86M
Cash, Cash Equivalents and Short-Term Investments304.55M280.31M286.33M251.72M156.54M231.82M
Total Debt318.90M317.76M308.14M2.19M2.61M3.26M
Total Liabilities470.67M445.11M397.95M210.87M174.44M68.77M
Stockholders Equity255.16M225.64M248.67M-392.82M120.21M-173.17M
Cash Flow
Free Cash Flow-1.37M9.33M-91.05M-120.41M-151.78M-89.30M
Operating Cash Flow8.99M10.32M-70.94M-120.14M-132.76M-89.08M
Investing Cash Flow-40.13M-90.13M-107.20M7.70M48.55M37.87M
Financing Cash Flow24.25M17.70M336.60M109.09M73.47M181.29M

Mirum Pharmaceuticals Technical Analysis

Technical Analysis Sentiment
Positive
Last Price74.20
Price Trends
50DMA
55.72
Positive
100DMA
49.51
Positive
200DMA
47.55
Positive
Market Momentum
MACD
5.11
Negative
RSI
81.97
Negative
STOCH
96.48
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For MIRM, the sentiment is Positive. The current price of 74.2 is above the 20-day moving average (MA) of 62.29, above the 50-day MA of 55.72, and above the 200-day MA of 47.55, indicating a bullish trend. The MACD of 5.11 indicates Negative momentum. The RSI at 81.97 is Negative, neither overbought nor oversold. The STOCH value of 96.48 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for MIRM.

Mirum Pharmaceuticals Risk Analysis

Mirum Pharmaceuticals disclosed 74 risk factors in its most recent earnings report. Mirum Pharmaceuticals reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Mirum Pharmaceuticals Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
75
Outperform
$2.44B12.1028.49%28.55%196.96%
58
Neutral
$3.73B-24.19%62.33%48.34%
58
Neutral
$3.53B-108.49%20.02%33.45%
54
Neutral
$2.93B-34.80%2816.21%73.33%
54
Neutral
$2.85B-182.60%26.77%24.18%
51
Neutral
$7.83B-0.15-40.10%2.29%21.46%-2.01%
46
Neutral
$2.25B78.99%4227.22%50.80%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
MIRM
Mirum Pharmaceuticals
74.20
32.22
76.75%
ARWR
Arrowhead Pharmaceuticals
21.18
-2.90
-12.04%
CPRX
Catalyst Pharma
20.19
0.21
1.05%
RARE
Ultragenyx Pharmaceutical
30.08
-26.88
-47.19%
IBRX
ImmunityBio
2.34
-1.46
-38.42%
APLS
Apellis Pharmaceuticals
28.22
-10.50
-27.12%

Mirum Pharmaceuticals Corporate Events

Executive/Board ChangesShareholder Meetings
Mirum Pharmaceuticals Holds 2025 Annual Stockholders Meeting
Positive
May 30, 2025

On May 29, 2025, Mirum Pharmaceuticals held its 2025 Annual Meeting of Stockholders, where key decisions were made. Stockholders elected three Class III directors to serve until 2028, ratified Ernst & Young LLP as the independent public accounting firm for 2025, and approved executive compensation, indicating continued support for the company’s leadership and strategic direction.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Aug 23, 2025