Efficacy ConcernsLow-dose data has not yet met the threshold for success based on discussions with investors, as only one of three low-dose patients showed a clear PVC reduction, signaling that high-dose efficacy is crucial for the program’s future.
Safety ConcernsLexeo did report an SVT event in one patient, which investors view as a concern to monitor, raising the question of whether the event was treatment-related.
Stock DilutionWe expect the financing to extend runway into 2028, but it creates substantial dilution.