Inconsistent Multi-metric EfficacyKey arrhythmia measures have not reliably improved within the same patients, raising concern that averaged results may hide inconsistent individual responses across cardiac markers.
Medication Confounding In Small StudiesBackground use or changes of anti-arrhythmic medications in small cohorts can create the appearance of efficacy, complicating assessment of the true drug benefit without adjustment for medication effects.
Safety Risk And Binary Investor ReactionA new or worsening safety signal or continued absence of a coherent efficacy pattern across cardiac measures would erode the investment thesis and likely increase volatility as investors revert valuation toward existing assets.