Inconsistent Efficacy Across Cardiac MeasuresFailure to show reliable improvement in the most important arrhythmia measures within the same patients undermines confidence that PKP2 delivers consistent clinical benefit.
Medication Confounding In Small StudiesBackground use or changes of anti‑arrhythmic medications can create the appearance of efficacy in small studies, complicating assessment of the drug’s true effect without proper normalization.
Safety Signal RiskEmergence of a new or worsening safety signal would materially weaken the investment thesis and push valuation toward support provided only by the company’s existing assets.