Placental Safety And Maternal‑fetal BenefitDM199 does not cross the placenta and demonstrates strong vasodilation with early signs of improved placental perfusion, indicating potential to extend time to delivery and lower maternal‑fetal complications.
Rapid Blood Pressure EffectStatistically significant and clinically meaningful blood pressure reductions with rapid onset at higher doses suggest DM199 could provide immediate control of severe hypertension in preeclampsia.
Regulatory EngagementA pre‑IND meeting with the FDA to discuss Phase 2 plans for DM199 in preeclampsia reduces regulatory uncertainty and supports smoother trial initiation in the US.