Diamedica Therapeutics Inc (DMAC)
NASDAQ:DMAC
US Market
Advertisement

Diamedica Therapeutics (DMAC) AI Stock Analysis

Compare
547 Followers

Top Page

DMAC

Diamedica Therapeutics

(NASDAQ:DMAC)

Select Model
Select Model
Select Model
Neutral 42 (OpenAI - 4o)
Rating:42Neutral
Price Target:
Diamedica Therapeutics faces significant financial hurdles with no revenue and rising net losses, leading to a low financial performance score. Technical analysis presents mixed signals, adding uncertainty. Despite this, the company's optimistic guidance and significant progress in clinical trials offer some potential, reflected in a moderate earnings call score. However, the speculative nature of its valuation due to the absence of earnings and dividends remains a key risk.
Positive Factors
Clinical Progress
The advancement in the preeclampsia program with DM199 highlights potential for new treatments in a field with unmet needs, strengthening DiaMedica's pipeline.
Financial Runway
A strong financial position ensures DiaMedica can continue its R&D efforts and clinical trials without immediate funding pressure, supporting long-term project viability.
Board Appointment
The addition of an experienced board member can enhance strategic decision-making and potentially facilitate partnerships or acquisitions, benefiting long-term growth.
Negative Factors
Zero Revenue
The absence of revenue underscores the company's reliance on successful clinical outcomes and partnerships, posing a risk to financial sustainability if milestones are not met.
Increasing Net Losses
Rising net losses highlight financial strain and the need for successful product commercialization to offset costs, challenging long-term profitability.
R&D Expense Growth
Increased R&D expenses reflect ongoing investment in clinical trials but also strain financial resources, necessitating future revenue generation to sustain operations.

Diamedica Therapeutics (DMAC) vs. SPDR S&P 500 ETF (SPY)

Diamedica Therapeutics Business Overview & Revenue Model

Company DescriptionDiamedica Therapeutics (DMAC) is a clinical-stage biopharmaceutical company focused on developing novel treatments for neurological and kidney diseases. The company leverages its expertise in therapeutic innovation to address unmet medical needs, primarily within the sectors of neurology and nephrology. Diamedica's core products include investigational therapies aimed at treating acute ischemic stroke and chronic kidney disease.
How the Company Makes MoneyDiamedica Therapeutics generates revenue primarily through strategic partnerships, collaborations, and licensing agreements with larger pharmaceutical companies. These arrangements often include upfront payments, milestone payments based on the achievement of certain development or regulatory goals, and royalties on future sales of successfully commercialized products. The company also seeks funding through public and private financing to support its research and development efforts, which is crucial for advancing its pipeline candidates through clinical trials.

Diamedica Therapeutics Earnings Call Summary

Earnings Call Date:Nov 12, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Mar 31, 2026
Earnings Call Sentiment Neutral
The earnings call presented a mixed outlook for DiaMedica Therapeutics. While there were positive developments in the preeclampsia program and a strong cash position, challenges such as slow enrollment in the stroke trial and increased operating expenses indicate areas of concern.
Q3-2025 Updates
Positive Updates
Positive Interim Results for DM199 in Preeclampsia
The interim results from Part 1a of the Phase 2 trial in South Africa showed statistically significant reductions in both systolic and diastolic blood pressure, improved uterine artery blood flow, and no placental barrier crossing, indicating a strong safety profile.
Increased Cash Position
As of September 30, 2025, DiaMedica's cash, cash equivalents, and short-term investments stood at $55.3 million, an increase from $30 million as of June 30, 2025, due to net proceeds from a July private placement.
No Safety Concerns in ReMEDy2 Stroke Trial
The independent Data Safety Monitoring Board reported no safety concerns after reviewing safety data from the first 50 participants in the ReMEDy2 stroke trial.
Negative Updates
Slow Enrollment in ReMEDy2 Stroke Trial
Enrollment rates for the ReMEDy2 stroke trial are lower than initially projected due to changes in stroke referral patterns, which may delay the interim analysis until the second half of 2026.
Increased Operating Expenses
R&D expenses rose to $6.4 million for the quarter and $17.9 million year-to-date, up from $5 million and $12.6 million, respectively, in the previous year, primarily due to the ReMEDy2 trial and expansion of the clinical team.
Higher Net Losses
Net losses for the three and nine-month periods ending September 30, 2025, were $8.6 million and $24.0 million, respectively, compared to $6.3 million and $16.5 million for the same periods in 2024.
Company Guidance
During the Q3 2025 earnings call, DiaMedica Therapeutics provided several updates on their clinical programs, particularly focusing on their lead product candidate, DM199. The company emphasized the promising interim results from Part 1a of their Phase 2 trial for preeclampsia, highlighting statistically significant reductions in both systolic and diastolic blood pressure across cohorts 6 through 9, and improvements in uterine artery pulsatility index, signifying enhanced placental perfusion. Additionally, the trial confirmed that DM199 does not cross the placental barrier, underscoring its safety profile. DiaMedica is advancing towards expanding the study to include early onset preeclampsia and fetal growth restriction cohorts, with completion of the expansion cohort anticipated in the first half of 2026. In their stroke program, the ReMEDy2 trial faced enrollment challenges due to changes in stroke referral patterns, prompting an updated enrollment forecast and expected interim analysis completion in the second half of 2026. Financially, DiaMedica reported a cash position of $55.3 million as of September 30, 2025, with R&D expenses increasing to $17.9 million for the first nine months of 2025, reflecting ongoing clinical progress.

Diamedica Therapeutics Financial Statement Overview

Summary
Diamedica Therapeutics, operating in the biotechnology sector, exhibits typical financial characteristics of a company in the development phase. The absence of revenue coupled with increasing net losses highlights the need for successful product development and eventual commercialization. While the balance sheet shows low leverage, diminishing cash reserves could pose a risk to its operational sustainability without additional funding. The firm's reliance on external financing to support negative cash flows underscores the challenges in achieving financial independence.
Income Statement
10
Very Negative
Diamedica Therapeutics has consistently reported zero revenue, reflecting its developmental stage focus typical in the biotechnology industry. The company incurred significant net losses over the years, with a noticeably increasing net loss from $13.6M in 2022 to $24.4M in 2024. The lack of revenue growth and persistent negative net income are significant concerns.
Balance Sheet
45
Neutral
The company's balance sheet shows a high equity ratio, with stockholders' equity consistently making up a significant portion of total assets (87.9% in 2024). The debt-to-equity ratio remains low, indicating limited leverage, which is positive. However, declining total assets from $54.2M in 2023 to $46.3M in 2024, alongside decreasing cash reserves, may constrain future financial flexibility.
Cash Flow
30
Negative
Diamedica's cash flow situation highlights ongoing operational cash outflows, with operating cash flow deteriorating from -$18.7M in 2023 to -$22.1M in 2024. Free cash flow has also been negative, reflecting the cash burn typical in biotech firms without commercial products. The company relies heavily on financing activities to support its cash flow needs, which may not be sustainable long-term.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue13.80M0.000.000.000.000.00
Gross Profit6.90M0.000.000.000.000.00
EBITDA-33.16M-26.64M-21.24M-13.98M-13.62M-12.68M
Net Income-31.93M-24.44M-19.38M-13.68M-13.59M-12.29M
Balance Sheet
Total Assets57.05M46.34M54.16M34.40M45.55M28.09M
Cash, Cash Equivalents and Short-Term Investments55.32M44.15M52.90M33.50M45.11M27.51M
Total Debt266.00K340.00K400.00K469.00K52.00K118.00K
Total Liabilities5.42M5.63M3.10M2.57M1.53M2.08M
Stockholders Equity51.62M40.72M51.06M31.83M44.02M26.01M
Cash Flow
Free Cash Flow-27.77M-22.10M-18.75M-11.59M-12.27M-9.23M
Operating Cash Flow-27.73M-22.08M-18.73M-11.51M-12.25M-9.19M
Investing Cash Flow-4.98M8.56M-18.30M11.54M-20.54M-16.13M
Financing Cash Flow31.91M11.99M36.84M-6.00K30.09M28.84M

Diamedica Therapeutics Technical Analysis

Technical Analysis Sentiment
Negative
Last Price5.93
Price Trends
50DMA
6.77
Negative
100DMA
5.79
Positive
200DMA
5.22
Positive
Market Momentum
MACD
-0.22
Positive
RSI
41.56
Neutral
STOCH
28.65
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For DMAC, the sentiment is Negative. The current price of 5.93 is below the 20-day moving average (MA) of 6.53, below the 50-day MA of 6.77, and above the 200-day MA of 5.22, indicating a neutral trend. The MACD of -0.22 indicates Positive momentum. The RSI at 41.56 is Neutral, neither overbought nor oversold. The STOCH value of 28.65 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for DMAC.

Diamedica Therapeutics Risk Analysis

Diamedica Therapeutics disclosed 61 risk factors in its most recent earnings report. Diamedica Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Diamedica Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
47
Neutral
$452.42M-42.31%83.28%
45
Neutral
$268.37M-107.79%-52.08%-69.35%
42
Neutral
$326.16M-64.12%-29.73%
40
Underperform
$330.08M-1.36-74.88%18.39%
38
Underperform
$312.08M-83.98%-35.62%
37
Underperform
$41.17M-0.25-97.61%-40.16%78.28%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
DMAC
Diamedica Therapeutics
5.93
1.92
47.88%
TVRD
Tvardi Therapeutics
4.03
-7.17
-64.02%
CAPR
Capricor Therapeutics
5.60
-13.01
-69.91%
RCKT
Rocket Pharmaceuticals
3.05
-10.93
-78.18%
BNTC
Benitec Biopharma
13.16
2.48
23.22%
ANNX
Annexon Biosciences
2.71
-3.41
-55.72%

Diamedica Therapeutics Corporate Events

Executive/Board Changes
DiaMedica Therapeutics Appoints Daniel J. O’Connor to Board
Positive
Feb 24, 2025

On February 20, 2025, DiaMedica Therapeutics appointed Daniel J. O’Connor to its Board of Directors, recognizing his extensive experience in the biopharmaceutical industry. O’Connor’s leadership background, including his role in the acquisition of Ambrx Biopharma by Johnson & Johnson, positions him as a valuable asset to DiaMedica as it continues to advance its pipeline of treatments for acute ischemic stroke and preeclampsia.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Apr 30, 2025