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Lantheus (LNTH)
NASDAQ:LNTH
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Lantheus (LNTH) AI Stock Analysis

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LNTH

Lantheus

(NASDAQ:LNTH)

Rating:66Neutral
Price Target:
$56.00
▲(2.08% Upside)
Lantheus's overall stock score reflects a solid financial foundation and positive corporate developments. However, bearish technical indicators and challenges in maintaining market share weigh on the score. Strategic initiatives and a reasonable valuation provide some support, but the stock faces near-term pressures.
Positive Factors
Growth Potential
Lantheus continues to be well positioned for longer-term growth given their existing market leadership in the PSMA PET imaging space with Pylarify, and expansion into neurodiagnostics & other areas of oncology via recent acquisitions.
Stock Repurchase
The Board of Directors authorized the repurchase of up to $400M of LNTH's common stock, which can be seen as a vote of confidence in the company's future value.
Strategic Acquisitions
The acquisition of Life Molecular Imaging added the FDA-approved NEURACEQ to LNTH's portfolio, expanding its diagnostic and therapeutic capabilities.
Negative Factors
Competitive Pressure
Sustained competitive pressure is creating headwinds for the company's lead asset, PYLARIFY, which resulted in a notable stock price drop.
Market Share Loss
Revenue came in below expectations at $378 million, versus Street consensus of $388 million and our estimate of $383 million, attributable to increased competition, likely from Posluma, that resulted in a loss of market share.
Revenue Guidance Reduction
The company reduced FY25 revenue guidance to $1.475B - $1.51B from the previous range of $1.55B - $1.585B, indicating challenges in maintaining expected growth.

Lantheus (LNTH) vs. SPDR S&P 500 ETF (SPY)

Lantheus Business Overview & Revenue Model

Company DescriptionLantheus Holdings, Inc. develops, manufactures, and commercializes diagnostic and therapeutic products that assist clinicians in the diagnosis and treatment of heart, cancer, and other diseases worldwide. It provides DEFINITY, a microbubble ultrasound enhancing agent used in ultrasound exams of the heart; TechneLite, a technetium generator for nuclear medicine; Xenon-133 to assess pulmonary function; Neurolite to identify the area within the brain where blood flow has been blocked or reduced due to stroke; Cardiolite, an injectable Tc-99m-labeled imaging agent; Thallium-201 to detect cardiovascular disease; and Gallium-67 to detect various infections and cancerous tumors. The company also offers AZEDRA, a radiotherapeutic to treat adult and pediatric patients; Automated Bone Scan Index that calculates the disease burden of prostate cancer by quantifying the hotspots on bone scans; and Cobalt (Co 57), a non-pharmaceutical radiochemical; RELISTOR for opioid-induced constipation; and PYLARIFY for visualization of lymph nodes, bone, and soft tissue metastases to determine the presence or absence of recurrent and/or metastatic prostate cancer. It also develops flurpiridaz F 18 to assess blood flow to the heart; 1095, a PSMA-targeted iodine-131 labeled small molecule; LMI 1195 for neuroblastoma tumors in pediatric and adults; PYLARIFY AI, an AI-based medical device software to perform standardized quantitative assessment of PSMA PET/CT images in prostate cancer; and leronlimab, an investigational humanized monoclonal antibody. The company serves radio pharmacies, distributors, integrated delivery networks, hospitals, clinics, and group practices. It has strategic partnerships with NanoMab Technology Limited; Bausch Health Companies, Inc.; GE Healthcare Limited; Curium; Bayer AG; CytoDyn Inc.; ROTOP; FUJIFILM; Regeneron Pharmaceuticals, Inc.; and POINT Biopharma US Inc. The company was founded in 1956 and is headquartered in North Billerica, Massachusetts.
How the Company Makes MoneyLantheus makes money by selling its diagnostic imaging agents and products to hospitals, clinics, and other healthcare providers. The company's revenue is primarily generated through the commercialization of its proprietary imaging agents, which are used to enhance the diagnostic capabilities of PET and SPECT imaging technologies. Lantheus also engages in strategic partnerships and collaborations with other pharmaceutical and biotechnology companies to expand its product offerings and reach in the market. Additionally, the company's revenue streams are supported by ongoing research and development efforts that lead to the introduction of new products and enhancements to existing ones, thereby sustaining and growing its market presence.

Lantheus Earnings Call Summary

Earnings Call Date:Aug 06, 2025
(Q2-2025)
|
% Change Since: -24.47%|
Next Earnings Date:Oct 30, 2025
Earnings Call Sentiment Neutral
The earnings call reflects a mixed sentiment with significant challenges in maintaining PYLARIFY's market share and pricing pressures impacting financial projections for 2025. However, strategic advancements in the pipeline, particularly in neurology and the new PYLARIFY formulation, along with a robust stock repurchase program, signal confidence in the company's long-term growth and stabilization efforts.
Q2-2025 Updates
Positive Updates
FDA Acceptance of New PYLARIFY Formulation
The FDA has accepted the NDA for a new formulation of PYLARIFY, which will increase batch size by approximately 50%, enabling increased patient access, supply resilience, and enhanced production efficiency.
Expansion in Neurology Franchise
Lantheus grew its neurology franchise with the addition of Neuraceq, approved for broader diagnosis of Alzheimer's disease, with an expanded label by the FDA. The US Alzheimer's PET imaging market is estimated to exceed $1.5 billion by the end of the decade.
Stock Repurchase Program
The Board authorized a new $400 million stock repurchase program, reflecting confidence in the company's intrinsic value and long-term strategy.
DEFINITY Performance
Sales of DEFINITY were up 7.5% year-over-year, indicating strong performance despite competitor re-entries.
Negative Updates
Reduction in PYLARIFY Sales
Sales of PYLARIFY were $251 million during the quarter, down 8.3% from last year, with competitive pricing pressures impacting volume growth and leading to share losses.
Lowered Financial Outlook for 2025
The company lowered its financial outlook for 2025, reducing the PYLARIFY revenue range to $940 million to $965 million and adjusted EPS to $5.50 to $5.70.
Impact of MUC-Based Reimbursement on PSMA PET
MUC-based reimbursement and aggressive discounting by competitors led to customer reassessment and renegotiation of strategic partnerships, affecting volumes and pricing.
Gross Profit Margin Decrease
Gross profit margin for the second quarter was 67.6%, a decrease of 80 basis points due to unfavorable pricing impacts and the inclusion of manufacturing infrastructure costs.
Company Guidance
During Lantheus' Second Quarter 2025 Conference Call, the company provided updated guidance, reflecting its challenges and strategic actions within the PSMA PET market, notably with PYLARIFY. The company reported a U.S. quarterly volume growth of PYLARIFY at 2% year-over-year and over 4% sequentially, although overall sales were down 8.3% compared to the prior year. Lantheus announced a revised full-year revenue expectation of $1.475 billion to $1.51 billion, down from the previous guidance of $1.55 billion to $1.585 billion. The adjusted earnings per share (EPS) guidance was lowered to a range of $5.50 to $5.70 from the prior range of $6.60 to $6.70. The company anticipates a continued low single-digit volume growth for PYLARIFY through the remainder of 2025, despite competitive pricing pressures that have led to renegotiations and strategic decisions to walk away from certain accounts. Lantheus also highlighted the potential growth of its Alzheimer's portfolio, estimating the U.S. Alzheimer's disease PET imaging market could reach $1.5 billion by the end of the decade, with Neuraceq being forecasted to contribute $40 million to $45 million in revenue for the partial third and full fourth quarter of 2025. Additionally, Lantheus announced a new $400 million stock repurchase program, reflecting the company's confidence in its strategic direction and long-term growth potential.

Lantheus Financial Statement Overview

Summary
Lantheus showcases a strong financial position across all verticals. The income statement reflects impressive growth and profitability, while the balance sheet indicates financial stability and efficient leverage management. The cash flow statement highlights robust cash generation and liquidity. The company's financial performance is characterized by healthy growth, strong margins, and efficient cash management.
Income Statement
92
Very Positive
Lantheus exhibits impressive growth and profitability metrics. The TTM (Trailing-Twelve-Months) shows a robust gross profit margin of 64.05% and a strong net profit margin of 16.55%. Revenue growth has been exceptional, with significant increases year-over-year. The EBIT and EBITDA margins also reflect strong operational efficiency. Overall, the company demonstrates excellent revenue growth and healthy profitability in its income statement.
Balance Sheet
85
Very Positive
Lantheus maintains a solid balance sheet with a debt-to-equity ratio of 0.53, indicating moderate leverage. The company has a strong equity position, with an equity ratio of 56.65%, which signifies financial stability. Return on equity (ROE) is also impressive at 21.84%, highlighting effective use of equity to generate profits. The balance sheet reflects a healthy financial structure with a balanced approach to debt and equity.
Cash Flow
89
Very Positive
Lantheus demonstrates strong cash flow performance. The operating cash flow to net income ratio is 2.06, indicating efficient cash generation relative to net income. Free cash flow remains robust with a modest growth rate. The free cash flow to net income ratio of 1.86 suggests effective conversion of profits into cash. Overall, the company exhibits strong cash flow management and adequate liquidity.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue1.52B1.53B1.30B935.06M425.21M339.41M
Gross Profit969.38M988.29M709.54M581.70M187.69M138.76M
EBITDA422.57M515.27M491.00M81.83M-25.00M22.69M
Net Income271.00M312.44M326.66M28.07M-71.28M-13.47M
Balance Sheet
Total Assets2.12B1.98B1.65B1.32B863.78M869.82M
Cash, Cash Equivalents and Short-Term Investments695.57M912.81M713.66M415.65M98.51M79.61M
Total Debt796.00K619.44M616.95M558.07M174.76M218.40M
Total Liabilities949.29M892.33M835.26M874.11M399.35M355.62M
Stockholders Equity1.17B1.09B815.89M447.15M464.44M514.21M
Cash Flow
Free Cash Flow478.61M493.13M258.70M263.43M41.78M3.92M
Operating Cash Flow527.46M544.75M305.26M281.78M53.92M16.40M
Investing Cash Flow-370.59M-226.01M5.94M-276.55M3.68M-4.91M
Financing Cash Flow-218.42M-118.54M-13.06M311.69M-39.33M-21.86M

Lantheus Technical Analysis

Technical Analysis Sentiment
Negative
Last Price54.86
Price Trends
50DMA
76.53
Negative
100DMA
85.40
Negative
200DMA
89.36
Negative
Market Momentum
MACD
-4.63
Positive
RSI
25.45
Positive
STOCH
40.23
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For LNTH, the sentiment is Negative. The current price of 54.86 is below the 20-day moving average (MA) of 71.70, below the 50-day MA of 76.53, and below the 200-day MA of 89.36, indicating a bearish trend. The MACD of -4.63 indicates Positive momentum. The RSI at 25.45 is Positive, neither overbought nor oversold. The STOCH value of 40.23 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for LNTH.

Lantheus Risk Analysis

Lantheus disclosed 50 risk factors in its most recent earnings report. Lantheus reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Lantheus Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
72
Outperform
$12.73B37.9113.39%18.42%1.47%
67
Neutral
$11.54B17.0918.36%0.67%13.03%-0.49%
66
Neutral
$5.02B13.7824.71%5.75%-37.03%
57
Neutral
$10.54B-19.77%5.49%-6.88%-6809.78%
55
Neutral
$18.31B-2.31%2.43%64.37%
51
Neutral
$7.39B0.36-62.86%2.37%15.48%-2.68%
51
Neutral
$3.25B-1.32%4.79%-2.32%35.46%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
LNTH
Lantheus
54.86
-42.40
-43.59%
RDY
Dr Reddy's Laboratories
13.60
-3.09
-18.51%
VTRS
Viatris
9.39
-2.16
-18.70%
NBIX
Neurocrine
125.60
-21.13
-14.40%
PRGO
Perrigo Company
22.83
-3.98
-14.85%
TEVA
Teva Pharmaceutical
16.29
-0.87
-5.07%

Lantheus Corporate Events

Product-Related AnnouncementsM&A TransactionsStock BuybackBusiness Operations and StrategyFinancial Disclosures
Lantheus Announces FDA Acceptance of New Drug Application
Positive
Aug 6, 2025

On August 6, 2025, Lantheus announced the FDA’s acceptance of a new drug application for a new formulation of its piflufolastat F-18 imaging agent, which could significantly increase patient access. The company also reported its second-quarter financial results, highlighting a revenue of $378 million and a strategic acquisition of Life Molecular Imaging, which expands its product portfolio and market reach. Additionally, Lantheus’ board authorized a $400 million stock repurchase program, reflecting confidence in its long-term growth strategy.

The most recent analyst rating on (LNTH) stock is a Buy with a $112.00 price target. To see the full list of analyst forecasts on Lantheus stock, see the LNTH Stock Forecast page.

Executive/Board ChangesM&A TransactionsBusiness Operations and Strategy
Lantheus Completes Acquisition of Life Molecular Imaging
Positive
Jul 22, 2025

On July 21, 2025, Lantheus completed its acquisition of Life Molecular Imaging Limited, enhancing its capabilities in Alzheimer’s disease diagnostics with the addition of Neuraceq, an F-18 PET imaging agent. The acquisition, valued at $350 million, strengthens Lantheus’s international presence and R&D capabilities. Additionally, Dr. Ludger Dinkelborg, former CEO of Life Molecular Imaging, was appointed as Lantheus’s Head of Research and Development, effective August 1, 2025, to lead various strategic areas, including Clinical Development and AI/Biomarkers Solutions.

The most recent analyst rating on (LNTH) stock is a Buy with a $125.00 price target. To see the full list of analyst forecasts on Lantheus stock, see the LNTH Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Aug 07, 2025