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LENZ Therapeutics (LENZ)
NASDAQ:LENZ
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LENZ Therapeutics (LENZ) AI Stock Analysis

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LENZ

LENZ Therapeutics

(NASDAQ:LENZ)

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Neutral 46 (OpenAI - 4o)
Rating:46Neutral
Price Target:
LENZ Therapeutics is navigating significant financial challenges with ongoing losses and negative cash flows, underscoring the need for strategic improvement to achieve profitability. While the earnings call highlights positive regulatory and commercial developments, the stock is burdened by a weak valuation profile due to negative earnings. The technical analysis presents a neutral to slightly bearish outlook, which, combined with financial hurdles, results in a cautious overall score.
Positive Factors
Regulatory Progress
Regulatory progress without significant issues positions LENZ well for FDA approval, enhancing its ability to bring LNZ100 to market and capture market share.
Strong Financial Position
A robust cash position provides LENZ with the financial runway necessary to support its pre-launch activities and strategic initiatives, reducing liquidity risks.
Intellectual Property Strength
A strong patent portfolio protects LENZ's innovations, ensuring competitive advantage and potential market exclusivity until at least 2044.
Negative Factors
Persistent Financial Losses
Ongoing financial losses highlight operational challenges, affecting LENZ's ability to achieve profitability and requiring strategic pivots for sustainable growth.
Delayed Product Availability
Delays in product availability post-approval could hinder revenue generation and market penetration, impacting LENZ's growth trajectory.
Increased Operating Expenses
Rising operating expenses due to increased headcount and pre-launch activities may pressure margins, necessitating efficient cost management.

LENZ Therapeutics (LENZ) vs. SPDR S&P 500 ETF (SPY)

LENZ Therapeutics Business Overview & Revenue Model

Company DescriptionLENZ Therapeutics, Inc., a biopharmaceutical company, focuses on developing and commercializing therapies to improve vision in the United States. Its product candidates include LNZ100 and LNZ101 which are in Phase III clinical trials for the treatment of presbyopia. The company is headquartered in Del Mar, California.
How the Company Makes MoneyLENZ Therapeutics makes money primarily through the development and commercialization of its pharmaceutical products designed to treat eye diseases. The company generates revenue by advancing its drug candidates through clinical trials, obtaining regulatory approvals, and subsequently marketing these drugs to healthcare providers and patients. Additionally, LENZ may engage in strategic partnerships or licensing agreements with other pharmaceutical companies, which can provide upfront payments, milestone payments, and royalties based on product sales. These collaborations can significantly contribute to the company's earnings, allowing LENZ to leverage external resources and market reach while focusing on its core research and development activities.

LENZ Therapeutics Earnings Call Summary

Earnings Call Date:Nov 05, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Mar 25, 2026
Earnings Call Sentiment Positive
The earnings call presented a generally positive outlook for LENZ, highlighted by the successful early launch of VIZZ and significant financial backing. While there were minor issues with transient side effects and initial retail availability, the overall sentiment was bolstered by strong prescription metrics, high awareness among doctors, and strategic partnerships.
Q3-2025 Updates
Positive Updates
FDA Approval and Commercial Launch of VIZZ
LENZ achieved FDA approval for VIZZ ahead of schedule in July 2025 and successfully launched the product in the U.S. in early October 2025.
Strong Initial Prescription Metrics
Within the first month of launch, over 5,000 paid prescriptions were filled, and more than 2,500 doctors prescribed VIZZ, with 40% writing multiple prescriptions.
High Awareness Among Eye Care Professionals
A survey in mid-October 2025 showed 90% awareness of VIZZ among eye care professionals, indicating strong engagement and interest.
Strategic Financial Moves
LENZ raised over $123 million through direct placements, bringing their total cash position to approximately $324 million, ensuring a strong financial foundation for the VIZZ launch.
Partnership with Sarah Jessica Parker
LENZ announced Sarah Jessica Parker as the spokesperson for their upcoming direct-to-consumer campaign, which is set to launch in early 2026.
Negative Updates
Transient Side Effects
Some users experienced transient redness and stinging upon application of VIZZ, although these effects were reported to be short-lived.
Limited Initial Retail Pharmacy Availability
In the initial weeks of launch, VIZZ was only available through e-pharmacy, with full retail pharmacy availability expected by mid-November 2025.
Company Guidance
In the third quarter of 2025, LENZ Therapeutics provided guidance that highlighted the successful FDA approval and commercial launch of VIZZ, an aceclidine-based eye drop for presbyopia, with more than 2,500 doctors prescribing it and over 5,000 prescriptions filled in October alone. CEO Evert Schimmelpennink emphasized the rapid adoption and positive feedback from eye care professionals, noting a 90% awareness among doctors. The company distributed over 70,000 samples to 7,000 offices and reported a $324 million cash position after raising $123 million from a direct placement. The guidance also detailed a strategic direct-to-consumer campaign featuring Sarah Jessica Parker, set to launch in early 2026, aiming to further boost consumer engagement and prescription uptake.

LENZ Therapeutics Financial Statement Overview

Summary
LENZ Therapeutics faces significant financial challenges, including persistent losses and negative cash flows, despite a strong equity position and minimal leverage. The biotechnology industry is inherently high-risk, and LENZ's current financial trajectory highlights the need for strategic pivots to achieve profitability and sustainable growth. Investors should be cautious, considering the ongoing financial instability and liquidity risks.
Income Statement
20
Very Negative
The income statement reflects a challenging financial landscape for LENZ Therapeutics, as evidenced by consistent net losses and negative EBIT and EBITDA over multiple reporting periods. The absence of total revenue in recent periods signifies a lack of operational income, while net income remains negative, indicating sustained unprofitability. The firm's gross profit margin is also negative, further highlighting financial difficulties. These factors collectively illustrate significant financial hurdles.
Balance Sheet
50
Neutral
LENZ Therapeutics shows a strong equity position, with stockholders' equity accounting for a significant portion of its total assets, resulting in a healthy equity ratio. The debt-to-equity ratio is low, indicating minimal leverage and financial risk. While the company maintains substantial cash reserves, the consistent negative net income affects the return on equity. Overall, the balance sheet displays financial stability but is challenged by profitability concerns.
Cash Flow
30
Negative
The cash flow statement reveals significant cash outflows from operating activities, indicating operational challenges. Although financing activities have provided cash inflows, these are not yet translating into positive free cash flow or net income. The negative free cash flow growth rate suggests ongoing operational cash demands, while the operating cash flow to net income ratio reflects insufficient cash generation relative to net losses. These factors underscore liquidity concerns and the need for improved cash management.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue17.50M0.000.0015.00M0.000.00
Gross Profit17.34M-58.00K0.0015.00M-734.00K-121.00K
EBITDA-65.51M-49.71M-72.41M-10.47M-70.03M-68.21M
Net Income-58.88M-49.77M-69.97M-10.81M-70.76M-68.37M
Balance Sheet
Total Assets210.70M215.30M70.38M46.95M18.34M22.56M
Cash, Cash Equivalents and Short-Term Investments202.17M209.03M65.79M44.44M18.31M19.82M
Total Debt461.00K1.38M329.00K250.00K0.000.00
Total Liabilities16.78M11.22M163.09M71.12M32.55M32.36M
Stockholders Equity193.93M204.08M-92.71M-24.17M-14.21M-9.80M
Cash Flow
Free Cash Flow-46.16M-59.86M-60.41M-94.57M-58.59M-10.27M
Operating Cash Flow-45.22M-59.39M-60.38M-87.98M-52.85M-8.72M
Investing Cash Flow2.28M-154.48M-29.62M-241.86M-5.74M-1.54M
Financing Cash Flow27.18M199.00M80.70M597.00K417.47M30.08M

LENZ Therapeutics Technical Analysis

Technical Analysis Sentiment
Negative
Last Price28.40
Price Trends
50DMA
36.15
Negative
100DMA
35.75
Negative
200DMA
30.94
Negative
Market Momentum
MACD
-2.78
Negative
RSI
45.68
Neutral
STOCH
89.24
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For LENZ, the sentiment is Negative. The current price of 28.4 is above the 20-day moving average (MA) of 27.41, below the 50-day MA of 36.15, and below the 200-day MA of 30.94, indicating a neutral trend. The MACD of -2.78 indicates Negative momentum. The RSI at 45.68 is Neutral, neither overbought nor oversold. The STOCH value of 89.24 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for LENZ.

LENZ Therapeutics Risk Analysis

LENZ Therapeutics disclosed 64 risk factors in its most recent earnings report. LENZ Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

LENZ Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
70
Outperform
$1.18B5.75799.36%
60
Neutral
$1.63B43.1615.02%1128.17%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
48
Neutral
$1.45B-129.32%597.19%0.45%
46
Neutral
$888.64M-28.78%70.19%
45
Neutral
-29.62%6.66%
44
Neutral
$1.28B-23.41%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
LENZ
LENZ Therapeutics
27.72
-6.60
-19.23%
SNDX
Syndax Pharmaceuticals
17.05
1.45
9.29%
STOK
Stoke Therapeutics
27.93
16.66
147.83%
CVAC
CureVac
5.12
2.56
100.00%
TRML
Tourmaline Bio
47.98
25.26
111.18%
RAPP
Rapport Therapeutics, Inc.
26.85
4.33
19.23%

LENZ Therapeutics Corporate Events

Product-Related AnnouncementsBusiness Operations and Strategy
LENZ Therapeutics Hosts Commercial Day for LNZ100
Neutral
Apr 15, 2025

LENZ Therapeutics is hosting a Commercial Day on April 15, 2025, to provide updates on the potential approval and launch of LNZ100. The event will cover commercialization strategies, supply chain readiness, and insights from Key Opinion Leaders and Eye Care Professionals.

Spark’s Take on LENZ Stock

According to Spark, TipRanks’ AI Analyst, LENZ is a Underperform.

LENZ Therapeutics faces significant financial challenges with persistent losses and negative cash flows, despite a strong equity position. The negative P/E ratio and lack of dividend suggest a high-risk valuation. Technical indicators further highlight bearish sentiment. However, positive strides in regulatory progress and a promising future outlook from the earnings call provide some optimism. Investors should weigh these risks against potential long-term rewards.

To see Spark’s full report on LENZ stock, click here.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Apr 20, 2025