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Kyverna Therapeutics, Inc.
(NASDAQ:KYTX)
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Rating:46Neutral
Price Target:
$7.50
▲(1.21% Upside)
Action:Reiterated
Date:07/27/26
KYTX scores low primarily due to weak financial performance (no revenue, widening losses, and substantial cash burn) and bearish technicals (price below major moving averages with negative MACD and sub-50 RSI). Offsetting factors include a relatively low-debt balance sheet for an early-stage biotech and constructive corporate events that improve commercialization and financing readiness, but these positives do not fully counter the current fundamental and trend headwinds.
Positive Factors
Manufacturing Capacity
A five-year manufacturing and testing agreement with a CDMO creates durable commercial readiness by securing scalable supply for miv-cel. This reduces execution risk around product launch, supports BLA submission workstreams, and lowers operational bottleneck risk during commercialization.
Negative Factors
High Cash Burn
Sustained, large negative operating and free cash flow materially shortens runway absent new funding or revenue. Persistent burn forces recurring financing choices, risks dilution or restrictive debt, and constrains multi-program investment even if lead assets progress favorably.
Read all positive and negative factors
Positive Factors
Negative Factors
Manufacturing Capacity
A five-year manufacturing and testing agreement with a CDMO creates durable commercial readiness by securing scalable supply for miv-cel. This reduces execution risk around product launch, supports BLA submission workstreams, and lowers operational bottleneck risk during commercialization.
Read all positive factors
Kyverna Therapeutics, Inc. (KYTX) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$505.26M
Dividend YieldN/A
Average Volume (3M)1.25M
Price to Earnings (P/E)―
Beta (1Y)1.75
Revenue GrowthN/A
EPS Growth20.07%
CountryUS
Employees130
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-2.94
Shares Outstanding61,843,445
10 Day Avg. Volume1,152,977
30 Day Avg. Volume1,250,395
Financial Highlights & Ratios
PEG Ratio-0.28
Price to Book (P/B)1.79
Price to Sales (P/S)0.00
P/FCF Ratio-2.71
Enterprise Value/Market Cap<0.01
Enterprise Value/RevenueN/A
Enterprise Value/Gross Profit>-0.01
Enterprise Value/Ebitda>-0.01
Forecast
1Y Price Target
$30.33Price Target Upside309.36% Upside
Rating ConsensusStrong Buy
Number of Analyst Covering4
EPS Forecast (FY)-2.81
Revenue Forecast (FY)N/A
Kyverna Therapeutics, Inc. Business Overview & Revenue Model
Company Description
Kyverna Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing cell therapies for patients with autoimmune diseases. Its lead product candidate is KYV-101, an autologous CD19 CAR T-cell product candidate for the trea...
How the Company Makes Money
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Kyverna Therapeutics, Inc. Earnings Call Summary
Earnings Call Date:Nov 13, 2024
(Q3-2024)
| % Change Since: |
Next Earnings Date:Nov 18, 2026
Earnings Call Sentiment Positive
The earnings call revealed significant advancements in Chimera's immunology pipeline, particularly with the initiation of KT61 and advancement of KT474. However, the deprioritization of the oncology program and extended timelines for KT474 indicate strategic shifts that could pose challenges. The financial stability and focus on promising immunology assets contribute to an overall positive outlook.Positive Updates
Phase One Study of KT61 Initiated
Chimera Therapeutics has started the phase one study of KT61, a first-in-class oral STAT6 degrader. This marks the first STAT6 medicine to enter clinical development, with potential to transform treatment paradigms for diseases like atopic dermatitis, asthma, and COPD.
Negative Updates
Oncology Program Deprioritized
Chimera has decided to advance only KT333 and KT253 beyond phase one with a partner, reallocating resources towards the immunology pipeline.
Read all updates
Q3-2024 Updates
Positive
Negative
Phase One Study of KT61 Initiated
Chimera Therapeutics has started the phase one study of KT61, a first-in-class oral STAT6 degrader. This marks the first STAT6 medicine to enter clinical development, with potential to transform treatment paradigms for diseases like atopic dermatitis, asthma, and COPD.
Read all positive updates
Company Guidance
During the Chimera Therapeutics Q3 2024 earnings call, significant guidance was provided, highlighting several key metrics and strategic directions. The company has initiated a Phase 1 study of KT61, an oral STAT6 degrader, with expectations to complete the Healthy Volunteer Study in the first half of 2025. The program aims to address diseases with TH2 inflammation, affecting over 150 million patients across the US, Europe, and Japan. Additionally, Chimera has advanced its KT474 program, transitioning it to expanded Phase 2B studies, supported by partner Sanofi, and is preparing KT295, a new lead candidate in their TIC2 program, for Phase 1 trials in 2025. Financially, Chimera raised approximately $600 million in 2024, boasting a cash runway into mid-2027, and reported $3.7 million in revenue for the quarter, attributed to their Sanofi collaboration. The company is strategically reallocating resources to prioritize their growing immunology pipeline, with plans to share further guidance on clinical developments next year.Kyverna Therapeutics, Inc. Financial Statement Overview
Summary
Income Statement
18
Very Negative
Balance Sheet
58
Neutral
Cash Flow
22
Negative
| Breakdown | TTM | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 0.00 | 0.00 | 0.00 | 0.00 | 7.03M | 5.66M |
| Gross Profit | -351.00K | 0.00 | -2.13M | -1.71M | 7.03M | 5.66M |
| EBITDA | -151.60M | -159.02M | -125.20M | -58.47M | -27.78M | -25.76M |
| Net Income | -152.64M | -161.31M | -127.48M | -60.37M | -28.89M | -26.35M |
Balance Sheet | ||||||
| Total Assets | 219.82M | 293.83M | 304.64M | 75.19M | 66.92M | 85.49M |
| Cash, Cash Equivalents and Short-Term Investments | 199.43M | 279.25M | 285.98M | 57.54M | 51.32M | 76.07M |
| Total Debt | 33.00M | 29.03M | 8.24M | 9.08M | 10.56M | 5.55M |
| Total Liabilities | 54.27M | 61.55M | 38.06M | 26.02M | 20.25M | 131.74M |
| Stockholders Equity | 165.55M | 232.28M | 266.59M | 49.18M | 46.68M | -46.25M |
Cash Flow | ||||||
| Free Cash Flow | -159.43M | -153.72M | -116.45M | -53.03M | -36.88M | -23.44M |
| Operating Cash Flow | -158.75M | -153.71M | -114.25M | -52.41M | -36.11M | -22.16M |
| Investing Cash Flow | -8.80M | 40.02M | -160.90M | -8.79M | -14.10M | -1.29M |
| Financing Cash Flow | 145.92M | 141.17M | 337.11M | 58.12M | 11.88M | 72.52M |
Kyverna Therapeutics, Inc. Technical Analysis
Positive
7.41
Price Trends
8.04
Positive
8.54
Negative
8.31
Negative
Market Momentum
>-0.01
Negative
54.97
Neutral
60.20
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For KYTX, the sentiment is Positive. The current price of 7.41 is below the 20-day moving average (MA) of 7.65, below the 50-day MA of 8.04, and below the 200-day MA of 8.31, indicating a neutral trend. The MACD of >-0.01 indicates Negative momentum. The RSI at 54.97 is Neutral, neither overbought nor oversold. The STOCH value of 60.20 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for KYTX.
Kyverna Therapeutics, Inc. Risk Analysis
Kyverna Therapeutics, Inc. disclosed 83 risk factors in its most recent earnings report. Kyverna Therapeutics, Inc. reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Kyverna Therapeutics, Inc. Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
55 Neutral | $648.22M | -6.26 | -162.74% | ― | ― | ― | |
52 Neutral | $410.65M | -2.46 | -64.25% | ― | ― | -29.71% | |
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
49 Neutral | $290.47M | -1.88 | -57.61% | ― | -94.10% | -122.58% | |
47 Neutral | $170.83M | -4.64 | -74.36% | ― | 35.89% | 58.70% | |
46 Neutral | $505.26M | -2.78 | -81.91% | ― | ― | 20.07% | |
41 Neutral | $63.92M | -1.80 | -300.90% | ― | 0.99% | -3014.75% |
* Healthcare Sector Average
KYTX
Kyverna Therapeutics, Inc.
8.17
4.63
130.79%
CDXS
Codexis
1.56
-1.44
-48.00%
HRTX
Heron Therapeutics
0.34
-0.96
-74.15%
SLN
Silence Therapeutics
13.72
8.20
148.55%
AVIR
Atea Pharmaceuticals
5.12
1.59
45.04%
TRDA
Entrada Therapeutics Inc
7.46
1.94
35.14%
Kyverna Therapeutics, Inc. Corporate Events
Business Operations and Strategy
Kyverna secures long-term miv-cel manufacturing partnership
Positive
Jul 27, 2026
On July 23, 2026, Kyverna Therapeutics entered into a five-year clinical and commercial supply agreement with ElevateBio that replaces a 2023 development and manufacturing pact for miv-cel. ElevateBio will provide flexible, scalable manufacturing ...
Business Operations and StrategyPrivate Placements and Financing
Kyverna Therapeutics Amends Term Loan, Extends Capital Access
Positive
Jul 9, 2026
Kyverna Therapeutics amended its existing $150 million term loan facility with Oxford Finance, originally agreed on October 31, 2025, after drawing $25 million from the initial Term A tranche on November 3, 2025. On July 8, 2026, effective June 30...
Executive/Board ChangesShareholder Meetings
Kyverna Therapeutics Stockholders Approve Directors and Auditor
Positive
Jun 2, 2026
On May 27, 2026, Kyverna Therapeutics, Inc. held its 2026 Annual Meeting of Stockholders, where approximately 73% of the 60.5 million outstanding shares were represented, establishing a quorum and enabling the company to conduct official business....
Business Operations and StrategyExecutive/Board Changes
Kyverna Therapeutics Names Gregory Martini as New CFO
Positive
May 18, 2026
Kyverna Therapeutics appointed Gregory (Greg) Martini as chief financial officer, effective May 18, 2026, succeeding Marc Grasso, M.D., who will remain as a strategic advisor through at least August 1, 2026 to support a seamless transition. Martin...
Business Operations and StrategyExecutive/Board Changes
Kyverna Therapeutics Appoints Chief Commercial Officer for Growth
Positive
May 4, 2026
On May 4, 2026, Kyverna Therapeutics appointed veteran biopharmaceutical executive Nadia Dac as Chief Commercial Officer, underscoring its shift toward becoming a commercial-stage cell therapy company. Kyverna develops miv-cel, a CD19-targeting CA...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.