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Codexis (CDXS)
NASDAQ:CDXS
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Codexis (CDXS) AI Stock Analysis

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Codexis

(NASDAQ:CDXS)

Rating:53Neutral
Price Target:
$3.00
▲(4.90%Upside)
Codexis' overall stock score reflects significant financial challenges and poor valuation metrics, balanced by positive technical momentum and optimistic sentiment from the latest earnings call. The company's strategic advancements and strong cash position provide a cautious outlook for future growth.
Positive Factors
Business Expansion
CDXS delivered the first order to a large pharma customer and secured an initial order from a second customer, which is a drug innovator.
Contracts and Orders
The company secured the first revenue-generating contract for the ECO Synthesis Innovation Lab and met industrial grade criteria across first-generation enzymes.
Future Prospects
Management remains confident in the steep second-half ramp due to momentum with the ligase product and ECO partnership growth.
Negative Factors
Financial Performance
Q4 revenues of $21.5M missed consensus estimates of $27.4M.
Revenue Decline
Revenues of $7.5M were 56% lower year-over-year, missing expectations by $2.2M.

Codexis (CDXS) vs. SPDR S&P 500 ETF (SPY)

Codexis Business Overview & Revenue Model

Company DescriptionCodexis, Inc. (CDXS) is a biotechnology company that focuses on the development and commercialization of enzymes for a wide range of applications. Operating primarily in the biopharmaceutical and industrial sectors, Codexis utilizes its proprietary CodeEvolver® platform technology to engineer enzymes that enhance the efficacy and efficiency of pharmaceutical manufacturing, food processing, and other industrial processes. The company aims to provide sustainable solutions that improve product quality and reduce environmental impact.
How the Company Makes MoneyCodexis generates revenue through the sale of its engineered enzymes and related products, as well as through licensing its proprietary CodeEvolver® technology to partners in various industries. The company engages in strategic collaborations and partnerships with pharmaceutical companies, which often involve milestone payments, royalties, and development fees. Additionally, Codexis derives income from research and development agreements, where it collaborates with other companies to innovate and optimize enzyme solutions tailored to specific customer needs.

Codexis Earnings Call Summary

Earnings Call Date:May 14, 2025
(Q1-2025)
|
% Change Since: 15.79%|
Next Earnings Date:Jul 31, 2025
Earnings Call Sentiment Neutral
Despite challenges such as a significant year-over-year revenue decline and increased net loss, Codexis maintains a strong financial position and projects future growth driven by advancements in its ecosynthesis platform and machine learning capabilities. The sentiment remains cautiously positive due to strategic progress in key areas.
Q1-2025 Updates
Positive Updates
Strong Financial Position
Codexis maintained a strong cash position, with $59.8 million in cash, cash equivalents, and investments, expected to fund operations until cash flow positivity by the end of 2026.
Pharma Biocatalysis Revenue Growth
Despite a delay in a $2.5 million payment, Codexis is confident in revenue growth for 2025, driven by new customers and commercial milestones in the Pharma Biocatalysis sector.
Ecosynthesis Platform Progress
Codexis has made significant progress with its ecosynthesis platform, signing its first revenue-generating ECO Contract and showcasing technical advancements at the TIDES meeting.
Improved Product Gross Margin
Product gross margin improved to 55% in Q1 2025, up from 49% in Q1 2024, driven by a shift to more profitable products.
Machine Learning Integration
Codexis successfully launched a machine learning tool for optimized enzyme selection, reducing process development time and cost for customers.
Negative Updates
Q1 Revenue Decline
Total revenue for Q1 2025 was $7.5 million, a significant decrease from $17.1 million in Q1 2024, primarily due to non-recurring large orders from the previous year.
Increased Net Loss
The net loss for Q1 2025 increased to $20.7 million from $11.5 million in Q1 2024, driven by increased R&D expenses and variability in client ordering patterns.
Delayed $2.5 Million Payment
A $2.5 million order from a Pharma Biocatalysis customer was delayed, impacting Q1 revenue results.
Company Guidance
During the Codexis First Quarter 2025 Earnings Conference Call, management reiterated their 2025 revenue guidance and shared various metrics underscoring their confidence in meeting these targets. The Q1 revenue was $7.5 million, with a product gross margin of 55%, up from 49% in Q1 2024. Despite the revenue drop from $17.1 million in Q1 2024, the company emphasized that revenue is expected to ramp up in the second half of 2025, largely driven by their ecosynthesis platform and increasing orders for their double-stranded RNA ligase from large pharma customers. The company maintains a strong cash position with $59.8 million in cash and investments, supporting operations through to their projected cash flow positivity by the end of 2026. Management highlighted that their ecosynthesis technology could reduce costs by 70% and enable five times larger batch sizes compared to traditional methods, which is crucial as more siRNA pipeline assets advance through clinical trials.

Codexis Financial Statement Overview

Summary
Codexis faces significant financial challenges including declining revenues, persistent net losses, and high leverage. The negative cash flow and profitability metrics indicate a need for strategic financial management to stabilize the company's financial health.
Income Statement
45
Neutral
Codexis has faced declining revenues and consistent net losses. TTM revenue decreased by 16.05% compared to the previous annual period. The gross profit margin is healthy at approximately 69.06% for TTM, but the net profit margin remains deeply negative at -149.45%. The company struggles with profitability as indicated by negative EBIT and EBITDA margins.
Balance Sheet
40
Negative
Codexis has a precarious balance sheet with a debt-to-equity ratio of 1.20, indicating high leverage. The equity ratio is around 42.65% for TTM, showing moderate equity financing. Return on equity is negative, reflecting the company's unprofitable operations. The company needs to address its high debt levels and improve profitability to stabilize its financial health.
Cash Flow
38
Negative
The cash flow situation is concerning with negative free cash flow and operating cash flow for TTM. The free cash flow to net income ratio is positive due to large adjustments, but the operating cash flow to net income ratio is negative, highlighting cash generation issues. The company continues to burn cash, necessitating improvements in operational efficiency.
BreakdownDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue59.34M70.14M138.59M104.75M69.06M
Gross Profit43.06M57.33M100.56M82.55M55.31M
EBITDA-58.52M-49.28M-23.07M-16.75M-19.37M
Net Income-65.28M-76.24M-33.59M-21.28M-24.01M
Balance Sheet
Total Assets149.01M136.56M250.39M246.38M221.65M
Cash, Cash Equivalents and Short-Term Investments73.46M65.12M113.98M116.80M150.12M
Total Debt59.90M16.02M43.64M47.65M24.95M
Total Liabilities82.08M49.95M105.60M81.99M51.54M
Stockholders Equity66.93M86.61M144.80M164.39M170.10M
Cash Flow
Free Cash Flow-53.72M-57.06M2.98M-28.09M-20.21M
Operating Cash Flow-49.41M-52.64M11.28M-14.27M-16.46M
Investing Cash Flow-56.98M-4.86M-13.58M-21.42M-5.75M
Financing Cash Flow60.52M8.17M-575.00K3.77M80.81M

Codexis Technical Analysis

Technical Analysis Sentiment
Positive
Last Price2.86
Price Trends
50DMA
2.49
Positive
100DMA
2.56
Positive
200DMA
3.41
Negative
Market Momentum
MACD
0.14
Negative
RSI
57.85
Neutral
STOCH
52.22
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CDXS, the sentiment is Positive. The current price of 2.86 is above the 20-day moving average (MA) of 2.66, above the 50-day MA of 2.49, and below the 200-day MA of 3.41, indicating a neutral trend. The MACD of 0.14 indicates Negative momentum. The RSI at 57.85 is Neutral, neither overbought nor oversold. The STOCH value of 52.22 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for CDXS.

Codexis Risk Analysis

Codexis disclosed 49 risk factors in its most recent earnings report. Codexis reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Codexis Peers Comparison

Overall Rating
UnderperformOutperform
Sector (46)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
57
Neutral
$323.30M322.49%-30.66%36.48%
53
Neutral
$232.79M-115.53%-32.89%-5.03%
48
Neutral
$173.00M-115.28%22.99%
47
Neutral
$305.52M-30.47%-22.66%
46
Neutral
C$197.02M-3.33-23.14%2.65%20.75%-0.36%
IKIKT
46
Neutral
$138.28M-79.02%-100.00%38.72%
45
Neutral
$441.06M-32.12%10.98%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
CDXS
Codexis
2.88
-0.42
-12.73%
FHTX
Foghorn Therapeutics
6.10
0.06
0.99%
IKT
Inhibikase Therapeutics
1.90
0.44
30.14%
AVIR
Atea Pharmaceuticals
3.46
-0.22
-5.98%
TERN
Terns Pharmaceuticals
5.60
-3.09
-35.56%
NVCT
Nuvectis Pharma
7.95
1.43
21.93%

Codexis Corporate Events

Executive/Board ChangesShareholder Meetings
Codexis Stockholders Approve Key Proposals at Annual Meeting
Neutral
Jun 11, 2025

Codexis recently held its Annual Meeting where stockholders voted on several key proposals. David V. Smith and Dennis P. Wolf were elected as directors for a term expiring in 2028. Stockholders also ratified KPMG LLP as the independent registered public accounting firm for the fiscal year ending December 31, 2025, approved executive compensation on a non-binding basis, and approved an amendment to the 2019 Incentive Award Plan.

The most recent analyst rating on (CDXS) stock is a Buy with a $9.00 price target. To see the full list of analyst forecasts on Codexis stock, see the CDXS Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jul 11, 2025