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OmniAb (OABI)
NASDAQ:OABI
US Market

OmniAb (OABI) AI Stock Analysis

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OABI

OmniAb

(NASDAQ:OABI)

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Neutral 49 (OpenAI - 5.2)
Rating:49Neutral
Price Target:
$2.00
▲(15.61% Upside)
Action:ReiteratedDate:03/05/26
The score is held down primarily by weak financial performance (shrinking revenue, large ongoing losses, and recent cash burn). Technicals are neutral and do not provide a strong offset, while valuation is difficult to support due to negative earnings. The latest earnings call adds some support via strong partner/program momentum and improved liquidity, but near-term revenue pressure and delayed milestones remain key risks.
Positive Factors
Platform & IP differentiation
OmniUltra expands the platform's biological diversity and creates a distinct product capability (ultra-long CDRH3s) that is hard to replicate. This strengthens durable competitive advantage, helps win partner programs across new target classes, and supports higher-margin discovery services over multiple years.
Partner & program scale
A large and growing base of partners and programs increases the long-run probability of milestones and downstream royalties. Portfolio breadth diversifies scientific and timing risk, enhances repeat service revenue potential, and makes the platform more defensible vs. single-program dependency.
Improved liquidity / low leverage
The private placement materially bolstered near-term cash reserves while the balance sheet retains low leverage. This combination reduces short-term solvency risk, buys runway to commercialize new platform offerings, and provides optionality to fund key R&D or business-development initiatives.
Negative Factors
Multi-year revenue decline
Sustained top-line contraction weakens operating leverage and the firm's ability to cover fixed R&D and platform costs. Persistent revenue declines reduce the expected cadence of milestone and royalty upside, limit internal reinvestment capacity, and make multi-year planning and scaling more difficult.
Persistent losses and weak cash flow
Ongoing negative operating and free cash flow signals structural funding needs if milestone timing does not improve. Continued losses force reliance on external financing, which can dilute shareholders or constrain strategic choices, and limit the company's ability to self-fund platform expansion or sustained commercial investments.
Milestone timing & revenue lability
Dependence on partner-triggered milestones makes revenue inherently lumpy; delays materially shift cash flow and forecasting. This timing risk undermines short-to-medium-term revenue visibility, can extend cash runway pressure, and raises the probability that reported partner progress will not translate to near-term monetization.

OmniAb (OABI) vs. SPDR S&P 500 ETF (SPY)

OmniAb Business Overview & Revenue Model

Company DescriptionOmniAb, Inc., a biotechnology company, provides therapeutic antibody discovery technologies in the United States. The company's discovery platform provides industry partners access to the diverse antibody repertoires and screening technologies to enable discovery of next-generation therapeutics. Its OmniAb platform is the biological intelligence of proprietary transgenic animals, including OmniRat, OmniChicken, and OmniMouse that have been genetically modified to generate antibodies with human sequences to facilitate development of human therapeutic candidates. The company's OmniFlic (transgenic rat) and OmniClic (transgenic chicken) address industry needs for bispecific antibody applications though a common light chain approach, and OmniTaur that features unique structural attributes of cow antibodies for complex targets. The company was founded in 2012 and is headquartered in Emeryville, California.
How the Company Makes MoneyOmniAb generates revenue primarily through its platform technology licensing agreements and collaborative research partnerships with pharmaceutical and biotech companies. The company earns money by charging fees for access to its proprietary antibody discovery platform, which allows clients to develop their own therapeutic candidates more efficiently. Additionally, OmniAb may receive milestone payments and royalties based on the sales of products developed using its technology. Strategic partnerships with larger pharmaceutical firms also contribute to its earnings, as these collaborations often involve upfront payments and shared development costs, enhancing the company's financial stability.

OmniAb Earnings Call Summary

Earnings Call Date:Nov 04, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:May 07, 2026
Earnings Call Sentiment Neutral
OmniAb's earnings call highlighted substantial progress in expanding partnerships and launching innovative technologies, notably OmniUltra and the xPloration program. However, financial challenges were evident with a decline in Q3 revenue and delayed milestones. Despite these setbacks, the company's strengthened financial position and strategic initiatives are promising.
Q3-2025 Updates
Positive Updates
Record Growth in Program Additions
The number of new program additions in Q3 2025 equaled the total number for all of 2024, indicating a significant uptick in new initiatives and partnerships.
Expansion of Active Partners
OmniAb reached a record high of over 100 active partners, showcasing the company's growing influence and successful partner engagement.
Successful Launch and Demand for xPloration
The xPloration partner access program is gaining strong traction, generating interest and new opportunities, and is expected to be accretive to earnings and cash flow.
OmnidAb-derived Program Enters Clinical Trials
The first OmnidAb-derived program entered human clinical trials, marking a significant milestone for the technology within a short timeframe since its launch.
Introduction of OmniUltra
OmniAb announced the launch of OmniUltra, the first transgenic chicken producing cow-like antibodies with ultra-long CDRH3s, opening new market opportunities.
Strengthened Financial Position
Closed a $30 million private placement in late August, enhancing financial flexibility and strengthening the balance sheet.
Negative Updates
Decrease in Revenue
Revenue for Q3 2025 was $2.2 million, down from $4.2 million in the same period in 2024, due to reduced milestones and lower service revenue.
Milestones Delayed to 2026
Several expected milestones for the second half of 2025 have been pushed to 2026, impacting revenue expectations.
Operating Expenses and Headcount Reduction
Operating expenses were $20.4 million, including a nonrecurring charge of $800,000 related to a headcount reduction.
Company Guidance
During OmniAb's third quarter 2025 financial results call, the company provided detailed guidance on several key metrics. They ended Q3 with 104 active partners, surpassing last year's program adds, and reported a total of 399 active programs, including a net addition of 36 programs year-to-date. Financially, OmniAb reported Q3 revenue of $2.2 million, down from $4.2 million the previous year, primarily due to a reduction in milestones and service revenue. Operating expenses decreased to $20.4 million from $23.9 million in Q3 2024. The company's cash balance as of September 30, 2025, was $59.5 million, bolstered by a $30 million private placement. OmniAb updated its 2025 revenue guidance to $18-$22 million and operating expenses to $82-$86 million. The company expects its cash balance to be between $52 million and $56 million by year-end.

OmniAb Financial Statement Overview

Summary
Financial profile is pressured by multi-year revenue contraction, persistent large net losses, and renewed cash burn in 2024–2025. The key offset is a relatively conservative balance sheet with low leverage, which reduces near-term solvency risk but does not solve profitability/cash flow weakness.
Income Statement
22
Negative
Revenue has been shrinking for several years (down ~42% in 2023, down ~0.2% in 2024, and down ~11.5% in 2025), signaling weakening momentum. While gross profit remains very high (near ~98–100%), the business is not operating profitably: net losses are large and have persisted each year, with net margin deteriorating to roughly -347% in 2025. Losses improved versus 2024 in absolute dollars, but profitability is still far from breakeven.
Balance Sheet
68
Positive
The balance sheet looks relatively conservative for a biotech: leverage is low with debt-to-equity around ~0.06–0.08 across 2020–2025, which reduces financial risk. However, equity and total assets have trended down from 2022 to 2025, consistent with ongoing losses and cash usage. Returns on equity remain meaningfully negative each year, highlighting continued value erosion despite low debt.
Cash Flow
30
Negative
Cash generation is volatile and recently weak. After modestly positive operating and free cash flow in 2023 (and 2020), the company swung back to sizable cash burn in 2024 and 2025, with both operating cash flow and free cash flow solidly negative. Free cash flow also deteriorated sharply in 2024 before improving in 2025, but it remains negative overall—suggesting ongoing funding needs if conditions persist.
BreakdownDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue18.67M26.39M34.16M59.08M34.75M
Gross Profit18.36M26.39M34.16M59.08M34.75M
EBITDA-68.97M-50.92M-49.92M-8.40M-18.09M
Net Income-64.78M-62.03M-50.62M-22.33M-27.04M
Balance Sheet
Total Assets300.91M325.56M375.23M421.21M304.46M
Cash, Cash Equivalents and Short-Term Investments54.02M59.43M86.98M88.27M0.00
Total Debt20.33M23.16M25.56M25.80M13.85M
Total Liabilities33.89M37.94M60.64M79.84M70.16M
Stockholders Equity267.03M287.62M314.58M341.37M234.31M
Cash Flow
Free Cash Flow-37.02M-41.54M703.00K-20.75M-9.74M
Operating Cash Flow-36.45M-39.66M2.35M-3.59M-5.67M
Investing Cash Flow6.47M37.88M-18.38M-73.31M-4.03M
Financing Cash Flow27.91M13.02M-892.00K110.74M9.70M

OmniAb Technical Analysis

Technical Analysis Sentiment
Negative
Last Price1.73
Price Trends
50DMA
1.84
Negative
100DMA
1.78
Negative
200DMA
1.75
Negative
Market Momentum
MACD
-0.03
Negative
RSI
45.43
Neutral
STOCH
44.36
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For OABI, the sentiment is Negative. The current price of 1.73 is above the 20-day moving average (MA) of 1.73, below the 50-day MA of 1.84, and below the 200-day MA of 1.75, indicating a neutral trend. The MACD of -0.03 indicates Negative momentum. The RSI at 45.43 is Neutral, neither overbought nor oversold. The STOCH value of 44.36 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for OABI.

OmniAb Risk Analysis

OmniAb disclosed 77 risk factors in its most recent earnings report. OmniAb reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

OmniAb Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
58
Neutral
$389.07M-1.36-37.98%14.33%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
51
Neutral
$204.65M-1.85
50
Neutral
$620.72M-0.10-1072.48%
49
Neutral
$260.56M-3.25-22.37%3.36%5.15%
49
Neutral
$178.57M-4.31-39.78%-38.23%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
OABI
OmniAb
1.81
-1.60
-46.92%
RNAC
Cartesian Therapeutics
7.87
-10.05
-56.08%
TLSA
Tiziana Life Sciences
1.43
0.07
5.15%
AVIR
Atea Pharmaceuticals
4.98
1.97
65.45%
VOR
Vor Biopharma
15.05
-2.95
-16.39%
SGMT
Sagimet Biosciences, Inc. Class A
5.76
2.10
57.38%

OmniAb Corporate Events

Business Operations and StrategyRegulatory Filings and Compliance
OmniAb Updates Bylaws to Align with SEC Proxy Rules
Positive
Jan 30, 2026

On January 30, 2026, OmniAb, Inc.’s board approved amended and restated bylaws that took effect the same day, aligning the company’s governance framework with updated U.S. Securities and Exchange Commission universal proxy rules by stipulating that proxy solicitations for director nominees other than the board’s own must comply with Rule 14a-19. The revisions also tighten and modernize the procedural and disclosure requirements for shareholder director nominations and other business proposals at shareholder meetings—mandating more extensive background and ownership information from proposing shareholders, nominees and related parties—which is likely to strengthen the company’s control over the nomination process and enhance transparency in corporate governance.

The most recent analyst rating on (OABI) stock is a Hold with a $2.00 price target. To see the full list of analyst forecasts on OmniAb stock, see the OABI Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Mar 05, 2026