Strong Revenue Growth
Total revenue of $15.2M in Q1 2026 versus $7.5M in Q1 2025, an increase of approximately 102.7%, driven primarily by recognition of revenue from the Merck technology transfer agreement.
Improved Product Gross Margin
Product gross margin improved to 71% in Q1 2026 from 55% in Q1 2025, a 16 percentage-point increase driven by favorable product mix and replacement of low-margin products.
Narrowed Net Loss
Net loss was $8.7M in Q1 2026 compared to a loss of $20.7M in Q1 2025, an improvement of $12.0M (≈58% reduction in the loss).
ECO Synthesis Technical Breakthroughs
ECO Synthesis platform now demonstrates stereochemical control at both 3' and 5' ends of siRNA, enabling stereopure products with potential for improved potency and product quality; data on stereochemistry to be presented at TIDES and additional activity data forthcoming.
Commercial Traction and Pipeline
Over 50 commercial opportunities in the sales pipeline across ~40 companies, active engagements with 3 CDMO partners (described as progressing positively), and multiple conversations with large and emerging drug developers.
Stable, Profitable Small-Molecule Biocatalysis Business
Small-molecule biocatalysis remains profitable and supports platform investments; Codexis supplies enzymes for 13 branded commercial pharmaceutical products and recently participated in a new approval (islatravir) with Merck.
Reiterated 2026 Guidance and Capital Plan
Reiterated 2026 revenue guidance of $72M to $76M and stated cash runway sufficient to fund operations and capital expenditures through the end of 2027, including GMP facility build-out.
Scale-Up Progress and Facility Plans
Operational scale: moving from lab scale to ~100 g and targeting 0.5 kg scale by year-end 2026; Hayward GMP facility retrofit design underway with permit application in Q2 2026 and expected operational readiness by end of 2027.