Strong Revenue Growth and Improved Product Margins
Quarter revenue increased to $38.9M from $21.5M (≈+81% YoY), and full-year revenue rose to $70.4M from $59.3M (≈+19% YoY). Product gross margin improved to 64% in 2025 from 56% in 2024 (+8 percentage points). Management expects gross margins to remain stable in 2026.
Material Non-Dilutive Financing from Merck
Signed a technology transfer agreement with Merck that contributed approximately $37.8M (also referenced as ~$38M) in non-dilutive capital in Q4 2025, materially strengthening the cash position.
Healthy Cash Position and Runway
Ended 2025 with $78.2M in cash, cash equivalents, and short-term investments, which management expects will fund planned operations and capex through 2027.
Concrete ECOsynthesis Technical Milestones and Scale-Up
Delivered 10 grams of commercially relevant siRNA using full sequential ECOsynthesis and are currently operating at 100-gram scale in the Eco Innovation Lab with a target of achieving ~0.5 kg (500 g) scale by year-end 2026. Additionally, a client used Codexis ligase to manufacture a 3 kg batch of siRNA via chemoenzymatic production.
Commercial Engagements and Partner Wins
Signed three CDMO agreements in 2025 (Bachem, Nitto Avecia, Axolabs) and announced an emerging biotech contract to supply 50 grams of fully enzymatic siRNA (a low seven-figure agreement split between services and product). Sales pipeline contains 55 opportunities across 40 companies, indicating strong market interest.
Quality and Infrastructure Progress
Modernized non-GMP production capability in Redwood City and achieved ISO 9001 certification; passed a facility and quality management inspection by a large pharmaceutical customer. Leased a GMP plant in 2025 with retrofit construction planned to begin H2 2026 and expected to be operational by end of 2027.
Improved Operating Profitability Metrics
Net loss for the full year narrowed to $44.0M from $65.3M in the prior year (improvement of $21.3M, ≈32.6% reduction in annual net loss). Quarterly results showed a positive net income of $9.6M compared with a prior-year quarter loss of $10.4M.