Competitive PressureKYV-101, along with other DNA-modified CAR-T therapeutics, may face tough competition from RNA-modified CAR-Ts that can be dosed multiple times and at higher aggregate dose levels per cycle.
Efficacy ConcernsLackluster KYV-101 data to date have implications for DNA-based CAR-Ts, and the ability for a low-dose, one-time DNA-modified CAR-T therapy to produce deep and durable responses in the autoimmune setting remains questionable.
Financial PerformanceKyverna reported its 2Q24 financial results, recording a net loss of $0.67 per share in 2Q24, vs. prior estimate of a net loss of $0.41 per share.