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Karyopharm Therapeutics (KPTI)
NASDAQ:KPTI
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Karyopharm Therapeutics (KPTI) AI Stock Analysis

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KPTI

Karyopharm Therapeutics

(NASDAQ:KPTI)

Rating:44Neutral
Price Target:
$4.50
▲(1.58%Upside)
Karyopharm Therapeutics' overall score is heavily impacted by significant financial challenges, including high leverage and negative equity. While there are promising clinical developments and strategic explorations, these are overshadowed by the company's ongoing financial instability and poor valuation metrics.
Positive Factors
Market Expansion
Reimbursement approvals were received in the UK, Italy, France, China, and South Korea in 2024.
Regulatory Approval
Xpovio previously received FDA Fast Track Designation for the treatment of patients with myelofibrosis.
Revenue Growth
Karyopharm reported 4Q24 Xpovio net product revenue of $29.3M, compared to $25.1M for 4Q23.
Negative Factors
Competition
Challenges of rising competition and higher gross-to-net adjustments were noted as headwinds to sales.
Financial Performance
KPTI reported net product revenue of $21.1M for Xpovio, which was below consensus estimates and down approximately 28% from the previous quarter.
Workforce Reduction
Karyopharm announced that it would be reducing its workforce by roughly 20% after confidential discussions with potential investors regarding potential financing transactions failed to yield any results.

Karyopharm Therapeutics (KPTI) vs. SPDR S&P 500 ETF (SPY)

Karyopharm Therapeutics Business Overview & Revenue Model

Company DescriptionKaryopharm Therapeutics Inc. is a pharmaceutical company focused on the discovery, development, and commercialization of novel drugs for the treatment of cancer and other major diseases. Headquartered in Newton, Massachusetts, the company is primarily engaged in developing therapies that target nuclear transport and related pathways. Their lead compound, selinexor, is a first-in-class, oral selective inhibitor of nuclear export (SINE) compound that has been approved for the treatment of multiple myeloma and diffuse large B-cell lymphoma.
How the Company Makes MoneyKaryopharm Therapeutics generates revenue primarily through the sale of its pharmaceutical products, particularly selinexor, which is marketed under the brand name XPOVIO. The company earns revenue from product sales in the United States and collaborates with international partners for distribution outside the U.S. Additionally, Karyopharm engages in licensing agreements and strategic partnerships with other pharmaceutical companies to expand its market reach and support drug development, which can include upfront payments, milestone payments, and royalties on sales. The company also invests in research and development to expand its pipeline of investigational drugs, aiming to bring additional products to market and diversify its revenue streams.

Karyopharm Therapeutics Earnings Call Summary

Earnings Call Date:May 12, 2025
(Q1-2025)
|
% Change Since: -27.97%|
Next Earnings Date:Jul 31, 2025
Earnings Call Sentiment Neutral
The earnings call highlighted significant progress in clinical trials and potential market opportunities, particularly in myelofibrosis, but was tempered by financial challenges related to product returns and cash runway concerns. The data on selinexor is promising, but the financials indicate areas of concern that need addressing.
Q1-2025 Updates
Positive Updates
Phase 3 SENTRY Trial Progress
The Phase 3 SENTRY trial in JAKi-naïve myelofibrosis patients has passed its prespecified futility analysis and continues as planned without modifications. Enrollment is at approximately 80% of the target, with completion expected in the June-July timeframe.
Encouraging Selinexor Data
New clinical data shows selinexor may have an impact across key hallmarks of myelofibrosis, with more than double the SVR35 rate compared to ruxolitinib alone and meaningful symptom improvement.
Myelofibrosis Commercial Opportunity
If approved, selinexor in myelofibrosis has a peak revenue potential of up to $1 billion in the U.S. alone, with expected rapid commercial uptake.
Royalty Revenue Growth
Royalty revenue increased 57% to $1.7 million in Q1 2025 compared to Q1 2024, reflecting increasing global demand for XPOVIO and NEXPOVIO.
Negative Updates
Net Product Revenue Impacted
Net product revenue was $21.1 million, adversely impacted by a $5 million increase in the product return reserve due to atypical returns of expired high-dose products.
Cash Position and Runway
The company exited Q1 2025 with $70.3 million in cash, cash equivalents, restricted cash, and investments, with a need to explore opportunities to extend the cash runway.
Company Guidance
During Karyopharm Therapeutics' First Quarter 2025 Financial Results Conference Call, the company provided several updates on its ongoing projects and financial guidance. They announced that the Phase 3 SENTRY trial in JAKi-naïve myelofibrosis patients has successfully passed its futility analysis and continues as planned, with approximately 80% of the targeted 350 patients enrolled, expecting to complete enrollment by June-July 2025. The company highlighted the potential of selinexor in combination with ruxolitinib to significantly improve patient outcomes in myelofibrosis, with a peak revenue potential of approximately $1 billion in the U.S. alone. For the first quarter of 2025, Karyopharm reported total revenue of $30 million, including U.S. XPOVIO net product revenue of $21.1 million, impacted by a $5 million increase in product return reserves. Despite this, they maintain a total revenue guidance of $140 million to $155 million for the full year 2025, projecting to be at the lower end of this range. The company also noted progress in their endometrial cancer and multiple myeloma trials, with significant commercial opportunities on the horizon.

Karyopharm Therapeutics Financial Statement Overview

Summary
Karyopharm Therapeutics faces significant financial challenges with declining revenue, persistent net losses, high leverage, and negative equity. Cash flow is negative, necessitating reliance on external financing.
Income Statement
35
Negative
Karyopharm Therapeutics has experienced declining revenue over recent years, with a negative revenue growth rate of -0.55% from 2023 to 2024. The company also faces significant profitability challenges, as indicated by negative net profit margins and EBIT margins. Despite a relatively high gross profit margin of 95.87% in 2024, the persistent net losses highlight ongoing operational inefficiencies.
Balance Sheet
20
Very Negative
The balance sheet shows a concerning financial position with negative stockholders' equity, indicating liabilities exceed assets. The debt-to-equity ratio cannot be calculated due to negative equity, but the high total debt relative to assets suggests significant leverage. The equity ratio is negative, further emphasizing the financial instability and potential solvency risks.
Cash Flow
30
Negative
Karyopharm Therapeutics has negative free cash flow, which deteriorated by 37.66% from 2023 to 2024. The operating cash flow to net income ratio is negative, reflecting cash flow challenges. Although there was a positive financing cash flow, it is insufficient to offset the negative operating cash flow, indicating reliance on external financing.
BreakdownDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue145.24M146.03M157.07M209.82M108.08M
Gross Profit139.23M141.09M151.86M206.42M105.38M
EBITDA-38.60M-118.42M-139.31M-96.98M-167.85M
Net Income-76.42M-143.10M-165.29M-124.09M-196.27M
Balance Sheet
Total Assets164.42M240.44M358.17M305.31M313.05M
Cash, Cash Equivalents and Short-Term Investments108.71M191.44M277.97M228.62M273.45M
Total Debt194.52M177.02M172.98M169.29M117.93M
Total Liabilities350.44M376.64M374.83M384.98M262.50M
Stockholders Equity-186.02M-136.21M-16.66M-79.67M50.55M
Cash Flow
Free Cash Flow-127.63M-92.72M-149.67M-112.83M-160.38M
Operating Cash Flow-127.49M-92.72M-149.55M-107.12M-160.23M
Investing Cash Flow95.47M7.94M-104.26M141.84M-53.69M
Financing Cash Flow41.65M1.12M193.74M73.65M172.08M

Karyopharm Therapeutics Technical Analysis

Technical Analysis Sentiment
Positive
Last Price4.43
Price Trends
50DMA
4.50
Negative
100DMA
5.08
Negative
200DMA
8.14
Negative
Market Momentum
MACD
-0.08
Negative
RSI
50.02
Neutral
STOCH
52.32
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For KPTI, the sentiment is Positive. The current price of 4.43 is above the 20-day moving average (MA) of 4.40, below the 50-day MA of 4.50, and below the 200-day MA of 8.14, indicating a neutral trend. The MACD of -0.08 indicates Negative momentum. The RSI at 50.02 is Neutral, neither overbought nor oversold. The STOCH value of 52.32 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for KPTI.

Karyopharm Therapeutics Risk Analysis

Karyopharm Therapeutics disclosed 65 risk factors in its most recent earnings report. Karyopharm Therapeutics reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Karyopharm Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (63)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
63
Neutral
S$1.63B4.242.87%2.60%17.84%20.03%
49
Neutral
$125.65M-58.89%
45
Neutral
$62.37M-82.81%-92.95%-50.02%
44
Neutral
$41.99M41.08%1.19%61.65%
44
Neutral
$8.68M0.67121.75%
40
Underperform
$47.77M-75.45%14.06%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
KPTI
Karyopharm Therapeutics
4.43
-9.97
-69.24%
XFOR
X4 Pharmaceuticals
1.83
-24.11
-92.95%
CNTB
Connect Biopharma Holdings
2.35
1.04
79.39%
HOWL
Werewolf Therapeutics
1.37
-1.37
-50.00%
PEPG
PepGen Inc.
1.44
-16.58
-92.01%

Karyopharm Therapeutics Corporate Events

Private Placements and FinancingM&A TransactionsBusiness Operations and StrategyFinancial Disclosures
Karyopharm Therapeutics Explores Financing and Strategic Options
Negative
Jul 11, 2025

Karyopharm Therapeutics has been in discussions with potential investors to explore financing options to extend its cash runway, but no transaction has been finalized. The company is evaluating strategic alternatives, including potential mergers or sales, to maximize shareholder value. Additionally, Karyopharm is reducing its workforce by 20% to manage operating expenses, while continuing to focus on its commercial and clinical efforts in multiple myeloma and myelofibrosis. The company reported a net product revenue of $21.1 million in the first quarter of 2025, with a total revenue of $30 million, despite being impacted by increased returns of expired products.

The most recent analyst rating on (KPTI) stock is a Buy with a $45.00 price target. To see the full list of analyst forecasts on Karyopharm Therapeutics stock, see the KPTI Stock Forecast page.

Executive/Board ChangesShareholder Meetings
Karyopharm Therapeutics Stockholders Approve Equity Plan Amendment
Neutral
May 29, 2025

At the 2025 Annual Meeting of Stockholders held on May 28, Karyopharm Therapeutics Inc. announced that its stockholders approved an amendment to the 2022 Equity Incentive Plan, increasing the number of shares available by 450,000. Additionally, Garen G. Bohlin and Zhen Su were elected as Class III directors for a three-year term. The stockholders also approved the compensation of the company’s named executive officers and recommended annual advisory votes on this compensation. Furthermore, Ernst & Young LLP was ratified as the independent registered public accounting firm for the fiscal year ending December 31, 2025.

The most recent analyst rating on (KPTI) stock is a Buy with a $45.00 price target. To see the full list of analyst forecasts on Karyopharm Therapeutics stock, see the KPTI Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jul 24, 2025