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Century Therapeutics (IPSC)
NASDAQ:IPSC
US Market

Century Therapeutics (IPSC) AI Stock Analysis

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IPSC

Century Therapeutics

(NASDAQ:IPSC)

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Neutral 54 (OpenAI - 5.2)
Rating:54Neutral
Price Target:
$2.00
▼(-6.54% Downside)
The score is held back mainly by persistent, significant cash burn and ongoing losses despite a decent balance-sheet position. Technicals are supportive but appear overbought, while valuation lacks earnings/dividend support; offsetting these, corporate events (Nasdaq compliance and new financing) improve near-term financial flexibility.
Positive Factors
Pipeline & technology leadership
Century’s Allo-Evasion 5.0 platform and multiple programs in IND-enabling stages create a durable competitive edge in off-the-shelf iPSC-derived cell therapies. Advancing CNTY-813 toward an IND in 2026 and expected early clinical readouts in 2027 supports sustained value creation across large indications.
Recent financing strengthens runway
An oversubscribed $135M institutional placement materially improves near-term liquidity and funds IND-enabling work, extending runway to reach key development milestones. The financing plus potential warrant proceeds and registration rights provides tangible, multi-quarter support for executing parallel programs.
Manageable leverage and positive equity
Improved debt-to-equity and positive equity provide structural financial flexibility uncommon in early-stage biotechs reliant on R&D. Manageable leverage enhances the company’s ability to fund programs, negotiate partnerships and absorb further investment rounds without severe solvency strain.
Negative Factors
Persistent cash burn
Sustained negative operating and free cash flow near -$112M TTM indicates a structural funding requirement to progress clinical programs. Even with recent financing, ongoing burn necessitates repeat capital raises or partner deals, creating dilution and execution risk over the coming 2–6 months.
Revenue volatility and limited visibility
Revenue appears lumpy and driven by collaboration or one-time items, producing a sharp TTM decline in growth. This variability undermines predictable internal funding and forecasting, leaving program continuity dependent on unpredictable partner payments or financing cadence.
Ongoing losses and negative returns
Negative ROE and persistent operating losses mean the business is not generating shareholder returns from operations; long-term value realization hinges on successful clinical outcomes or lucrative partnerships, which remain uncertain and binary in nature.

Century Therapeutics (IPSC) vs. SPDR S&P 500 ETF (SPY)

Century Therapeutics Business Overview & Revenue Model

Company DescriptionCentury Therapeutics, Inc., a biotechnology company, develops transformative allogeneic cell therapies for the treatment of solid tumor and hematological malignancies. The company's lead product candidate is CNTY-101, an allogeneic, induced pluripotent stem cells (iPSCs)-derived chimeric antigen receptors (CAR)-iNK cell therapy targeting CD19 for relapsed, refractory B-cell lymphoma. It is also developing CNTY-103, a CAR-iNK candidate targeting CD133 + EGFR for recurrent glioblastoma; CNTY-102, a CAR-iT targeting CD19 + CD79b for relapsed, refractory B-cell lymphoma and other B-cell malignancies; CNTY-104, a CAR-iT or CAR-iNK multi-specific candidate for acute myeloid leukemia; and CNTY-106, a CAR-iNK or CAR-iT multi-specific candidate for multiple myeloma. Century Therapeutics, Inc. was founded in 2018 and is headquartered in Philadelphia, Pennsylvania.
How the Company Makes MoneyCentury Therapeutics generates revenue primarily through collaborations and partnerships with larger pharmaceutical companies, which may include upfront payments, milestone payments, and royalties on future sales of developed therapies. Additionally, the company may receive funding from grants and investments to support its research and development efforts. By focusing on advancing its proprietary iPSC technology, Century aims to establish a strong pipeline of therapies that can be licensed or commercialized, contributing to its overall revenue growth.

Century Therapeutics Financial Statement Overview

Summary
Balance sheet is relatively supportive (manageable leverage and positive equity), but the core risk is heavy and worsening cash burn (TTM operating cash flow and free cash flow around -$112M) alongside ongoing losses and volatile, declining TTM revenue.
Income Statement
34
Negative
TTM (Trailing-Twelve-Months) revenue is materially higher than prior annual periods (TTM $113.3M vs. 2024 $6.6M), but growth is sharply negative on a TTM basis (down ~69%), signaling volatility and limited visibility. Gross margin remains very strong (TTM ~94%), consistent with collaboration/other revenue mix, but profitability is still negative (TTM net margin ~-23%) with ongoing operating losses, albeit far improved versus the deeply negative margins seen in 2022–2024.
Balance Sheet
67
Positive
Leverage looks manageable for a development-stage biotech, with debt-to-equity improving in TTM (~0.25) versus 2024 (~0.33), and equity remains positive ($176.3M TTM). However, returns are negative (TTM return on equity ~-11.5%), reflecting continued losses, and total assets have declined versus 2022–2024, suggesting cash burn and/or asset drawdown over time.
Cash Flow
22
Negative
Cash generation is the key weakness: operating cash flow is strongly negative in TTM (-$112.0M) and free cash flow is also deeply negative (-$112.7M), indicating ongoing external funding needs. Free cash flow deteriorated versus the prior annual period (negative growth), and cash burn remains persistent across most years despite occasional fluctuation (e.g., positive operating cash flow in 2022).
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue113.34M6.59M2.23M5.20M0.000.00
Gross Profit107.01M6.59M2.23M5.20M-4.58M-1.75M
EBITDA-14.21M-111.47M-121.21M-121.20M-89.92M-51.44M
Net Income-26.48M-126.57M-136.67M-130.93M-95.82M-53.58M
Balance Sheet
Total Assets244.72M353.22M360.69M486.54M437.38M106.78M
Cash, Cash Equivalents and Short-Term Investments132.75M189.29M172.74M315.50M222.88M75.75M
Total Debt44.96M53.83M48.17M49.41M25.12M21.55M
Total Liabilities68.37M191.85M175.94M183.81M41.14M213.19M
Stockholders Equity176.35M161.36M184.75M302.74M396.24M-106.41M
Cash Flow
Free Cash Flow-112.69M-110.29M-102.08M-16.55M-133.97M-51.09M
Operating Cash Flow-112.02M-110.14M-88.35M14.05M-89.00M-41.27M
Investing Cash Flow115.75M47.48M61.13M-13.13M-298.34M-22.76M
Financing Cash Flow-482.00K74.56M-9.72M27.16M417.77M47.69M

Century Therapeutics Technical Analysis

Technical Analysis Sentiment
Positive
Last Price2.14
Price Trends
50DMA
1.53
Positive
100DMA
1.03
Positive
200DMA
0.79
Positive
Market Momentum
MACD
0.09
Positive
RSI
60.08
Neutral
STOCH
86.32
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For IPSC, the sentiment is Positive. The current price of 2.14 is above the 20-day moving average (MA) of 2.02, above the 50-day MA of 1.53, and above the 200-day MA of 0.79, indicating a bullish trend. The MACD of 0.09 indicates Positive momentum. The RSI at 60.08 is Neutral, neither overbought nor oversold. The STOCH value of 86.32 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for IPSC.

Century Therapeutics Risk Analysis

Century Therapeutics disclosed 90 risk factors in its most recent earnings report. Century Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Century Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
54
Neutral
$377.26M-6.88-14.23%4121.12%83.30%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
50
Neutral
$31.32M-1.58-104.58%1.18%
47
Neutral
$34.55M-0.17-66.96%71.83%
45
Neutral
$32.44M-1.00-133.09%11.11%20.65%
44
Neutral
$31.95M-0.24-405.03%49.43%
40
Underperform
$7.93M-0.32-526.36%-2.46%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
IPSC
Century Therapeutics
2.14
1.41
193.15%
TPST
Tempest Therapeutics
2.43
-8.75
-78.26%
ATNM
Actinium Pharmaceuticals
1.11
-0.06
-5.13%
BTAI
Bioxcel Therapeutics
1.62
-0.51
-23.94%
LTRN
Lantern Pharma
2.77
-1.56
-36.03%
CALC
CalciMedica
0.52
-1.83
-77.83%

Century Therapeutics Corporate Events

Delistings and Listing ChangesRegulatory Filings and ComplianceShareholder MeetingsStock Split
Century Therapeutics Regains Nasdaq Compliance, Halts Reverse Split
Positive
Jan 23, 2026

On January 22, 2026, Century Therapeutics, Inc. held a virtual special meeting of stockholders at which shareholders approved an amendment to the company’s certificate of incorporation authorizing a potential reverse stock split of its common shares at a ratio between 1-for-5 and 1-for-30, subject to the board’s discretion. On the same day, the company received notice from Nasdaq that it had regained compliance with the exchange’s minimum $1.00 bid price requirement and all other continued listing standards, leading Century Therapeutics to announce it does not intend to implement the reverse stock split, a decision that stabilizes its listing status and avoids the immediate dilutionary and structural impacts such a split might have had on existing shareholders.

The most recent analyst rating on (IPSC) stock is a Hold with a $2.00 price target. To see the full list of analyst forecasts on Century Therapeutics stock, see the IPSC Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Century Therapeutics Highlights Progress in Immune-Evasive Cell Therapies
Positive
Jan 12, 2026

On January 12, 2026, Century Therapeutics updated an investor slide presentation detailing progress across its cell therapy pipeline and plans to unlock the value of its programs in Type 1 diabetes and autoimmune disease. The company highlighted that CNTY-813 and CNTY-308, both incorporating its Allo-Evasion 5.0 technology for enhanced immune evasion and persistence, are in IND-enabling studies with CNTY-813 targeted for an investigational filing in 2026 and early clinical data expected in 2027, while CNTY-308 is anticipated to enter the clinic in 2026. Century also reported that patient enrollment is ongoing in the Phase 1/2 CARAMEL investigator-sponsored trial of CNTY-101 in autoimmune disease, and said its cash runway extends beyond planned key clinical milestones, underscoring its capacity to advance multiple high-impact programs in parallel and strengthen its position as a leader in immune-evasive allogeneic cell therapies.

The most recent analyst rating on (IPSC) stock is a Hold with a $1.50 price target. To see the full list of analyst forecasts on Century Therapeutics stock, see the IPSC Stock Forecast page.

Business Operations and StrategyPrivate Placements and FinancingRegulatory Filings and Compliance
Century Therapeutics Announces Oversubscribed $135 Million Financing
Positive
Jan 8, 2026

On January 7, 2026, Century Therapeutics entered into a securities purchase agreement with institutional investors for an oversubscribed private placement expected to close on January 9, 2026, raising approximately $135 million in gross proceeds through the sale of about 117.4 million shares of common stock (or pre-funded warrants) and accompanying warrants priced in line with Nasdaq “Minimum Price” requirements. The financing, led by new investor TCGX with participation from RA Capital, Commodore Capital, Deep Track Capital, RTW Investments, Venrock Healthcare Capital Partners, the T1D Fund and others, strengthens Century’s balance sheet to support development of its lead iPSC-derived beta islet cell therapy candidate CNTY-813 for Type 1 diabetes, including funding toward an investigational new drug filing planned for 2026 and initial clinical data expected in 2027, and could deliver an additional roughly $153 million if all warrants are exercised, while also committing the company to register the resale of the issued securities under a new registration rights agreement.

The most recent analyst rating on (IPSC) stock is a Hold with a $1.50 price target. To see the full list of analyst forecasts on Century Therapeutics stock, see the IPSC Stock Forecast page.

Executive/Board Changes
Century Therapeutics announces resignation of board member
Neutral
Dec 29, 2025

On December 18, 2025, Century Therapeutics, Inc. announced that board member Carlo Rizzuto, Ph.D., resigned from its board of directors, effective the same day. The company emphasized that Rizzuto’s departure did not arise from any disagreement over its operations, policies, or practices, and publicly expressed appreciation for his distinguished service and lasting contributions to the organization.

The most recent analyst rating on (IPSC) stock is a Hold with a $0.90 price target. To see the full list of analyst forecasts on Century Therapeutics stock, see the IPSC Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Century Therapeutics Updates on Cell Therapy Advancements
Positive
Dec 12, 2025

On December 12, 2025, Century Therapeutics updated its slide presentation to reflect advancements in its cell therapy pipeline, which will be used in investor meetings. The company is progressing with its Allo-Evasion technology, with key programs like CNTY-101 in Phase 1/2 trials for autoimmune diseases and CNTY-813 in preclinical development for Type 1 Diabetes. The announcement highlights the company’s strategic focus on executing high-impact programs and extending its cash runway beyond key clinical milestones anticipated in late 2027.

The most recent analyst rating on (IPSC) stock is a Hold with a $0.56 price target. To see the full list of analyst forecasts on Century Therapeutics stock, see the IPSC Stock Forecast page.

Business Operations and StrategyExecutive/Board Changes
Century Therapeutics Expands Board with New Appointments
Positive
Dec 9, 2025

On December 9, 2025, Century Therapeutics announced the expansion of its Board of Directors from six to eight members, appointing Dr. Martin Murphy and Dr. Han Lee as new directors. Dr. Murphy, with extensive experience in life science investment and company creation, will serve on the Compensation and Nominating and Corporate Governance Committees, while Dr. Lee, with a strong background in capital formation and corporate development, will join the Audit and Compensation Committees. This strategic move is expected to enhance Century’s efforts to advance its iPSC-derived cell therapy programs, including its lead candidate CNTY-813 for type 1 diabetes, potentially delivering significant value to patients and stakeholders.

The most recent analyst rating on (IPSC) stock is a Hold with a $0.50 price target. To see the full list of analyst forecasts on Century Therapeutics stock, see the IPSC Stock Forecast page.

Business Operations and StrategyFinancial DisclosuresProduct-Related Announcements
Century Therapeutics Launches Type 1 Diabetes Program
Neutral
Nov 13, 2025

On November 13, 2025, Century Therapeutics announced the launch of its first program for Type 1 diabetes, CNTY-813, with plans to initiate IND-enabling studies by the end of 2025 and submit an IND in 2026. The company is also advancing CNTY-308 through IND-enabling studies for B-cell-mediated diseases, targeting clinical study initiation in 2026. Additionally, Century reported a net loss of $34.4 million for the third quarter of 2025, with a cash runway estimated to extend into the fourth quarter of 2027, reflecting a strategic focus on high-impact therapeutic areas and resource allocation.

The most recent analyst rating on (IPSC) stock is a Hold with a $0.50 price target. To see the full list of analyst forecasts on Century Therapeutics stock, see the IPSC Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jan 24, 2026