Phase 3 SENTRY Trial Progress
The Phase 3 SENTRY trial in JAKi-naïve myelofibrosis patients has passed its prespecified futility analysis and continues as planned without modifications. Enrollment is at approximately 80% of the target, with completion expected in the June-July timeframe.
Encouraging Selinexor Data
New clinical data shows selinexor may have an impact across key hallmarks of myelofibrosis, with more than double the SVR35 rate compared to ruxolitinib alone and meaningful symptom improvement.
Myelofibrosis Commercial Opportunity
If approved, selinexor in myelofibrosis has a peak revenue potential of up to $1 billion in the U.S. alone, with expected rapid commercial uptake.
Royalty Revenue Growth
Royalty revenue increased 57% to $1.7 million in Q1 2025 compared to Q1 2024, reflecting increasing global demand for XPOVIO and NEXPOVIO.