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Akeso, Inc. (HK:9926)
:9926
Hong Kong Market

Akeso, Inc. (9926) AI Stock Analysis

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HK

Akeso, Inc.

(9926)

Rating:55Neutral
Price Target:
HK$99.00
▲(4.38%Upside)
Akeso, Inc.'s stock score is primarily influenced by its financial performance, which shows strong gross margins but significant profitability and cash flow issues. Technical analysis suggests positive market momentum, although caution is warranted due to potential overbought conditions. Valuation is a concern with a negative P/E ratio and no dividend yield, indicating limited immediate returns.
Positive Factors
Clinical Trials
The HARMONi-6 trial evaluating Ivonescimab plus chemotherapy has shown strongly positive PFS results at the interim analysis, achieving statistical significance.
Financial Performance
Ivonescimab and Cadonilimab inclusion in the NRDL earlier this year is anticipated to drive Akeso’s product sales growth by 60% YoY to RMB3.3bn in FY25.
Regulatory Approval
Ivonescimab showed a notable efficacy advantage and was recently approved in China for first-line treatment of PD-L1 positive NSCLC.
Negative Factors
Market Competition
While Ivonescimab possesses strong potential for success in global markets, the competition in the international landscape remains intense and could impact market penetration.
Regulatory Challenges
Despite the recent approval in China, regulatory hurdles in other countries could pose challenges for the global expansion of Ivonescimab.

Akeso, Inc. (9926) vs. iShares MSCI Hong Kong ETF (EWH)

Akeso, Inc. Business Overview & Revenue Model

Company DescriptionAkeso, Inc., a biopharmaceutical company, researches, develops, manufactures, and commercializes therapies. The company develops AK104, a PD-1/CTLA-4 bi-specific antibody to treat cervical cancer, gastric cancer (GC), gastroesophageal junction (GEJ) adenocarcinoma, hepatocellular carcinoma (HCC), non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), nasopharyngeal carcinoma (NPC), clear cell renal cell carcinoma, and solid tumors; and AK112, a PD-1/VEGF bi-specific antibody to treat solid and gynecological tumors, NSCLC, SCLC, and triple-negative breast cancer (TNBC). It is also developing AK105, a PD-1 monoclonal antibody to treat NSCLC, NPC, classic Hodgkin's lymphoma (R/R cHL), HCC, head and neck cancer, thyroid cancer, mesothelioma and thymic cancer, ESCC, UC, GC, GEJ, cholangiocarcinoma, neuroendocrine tumor, and mismatch repair deficient solid tumor; AK117, a CD47 monoclonal antibody to treat myelodysplastic syndrome, acute myeloid leukemia, GC, GEJ, ESCC, TNBC, HNSCC, R/R cHL, NPC, NSCLC, and solid tumors/lymphoma; AK119, a CD73 monoclonal antibody for treating solid tumors; and AK109, a VEGFR-2 monoclonal antibody to treat solid tumors and gastric cancer. In addition, the company develops AK120, an IL-4R monoclonal antibody to treat moderate-to-severe atopic dermatitis and asthma, and eosinophilic esophagitis; AK101, an IL-12/IL-23 monoclonal antibody to treat moderate-to-severe psoriasis and ulcerative colitis; AK111, an IL-17 monoclonal antibody to treat moderate-to-severe psoriasis and ankylosing spondylitis; and AK102, a PCSK9 monoclonal antibody to treat hypercholesterolemia. Further, its preclinical product includes AK127, a TIGIT monoclonal antibody to treat solid tumors; and AK115, a NGF monoclonal antibody. The company has collaboration agreements with Pfizer Pharmaceuticals, AstraZeneca Pharmaceuticals, and MD Anderson Medical Institute. Akeso, Inc. was founded in 2012 and is headquartered in Zhongshan, the People's Republic of China.
How the Company Makes MoneyAkeso, Inc. generates revenue primarily through the development and commercialization of its proprietary therapies. The company's revenue model includes licensing agreements, where it partners with other pharmaceutical companies to co-develop and market its drugs, sharing profits and royalties. Additionally, Akeso earns money from the sale of its approved therapies directly to healthcare providers and institutions. Significant partnerships with other biopharmaceutical firms enhance its research capabilities and expand its market reach, contributing to its earnings.

Akeso, Inc. Financial Statement Overview

Summary
Akeso, Inc. exhibits a mixed financial profile with strong gross margins but persistent profitability issues. The balance sheet is moderately leveraged, but cash flow challenges highlight potential liquidity risks. The company needs to improve operational efficiency and cash management to enhance overall financial health.
Income Statement
45
Neutral
Akeso, Inc. has demonstrated inconsistent revenue growth, with a significant decline from 2023 to 2024. The gross profit margin remains strong, but the company has faced negative net profit margins in recent years, indicating ongoing profitability challenges. The EBIT and EBITDA margins have also been negative, highlighting operational inefficiencies.
Balance Sheet
55
Neutral
The company's balance sheet shows a moderate debt-to-equity ratio, suggesting manageable leverage. Equity ratio is relatively stable, reflecting a balanced asset structure. However, the negative ROE indicates that the company is not currently generating positive returns on equity, posing a risk to shareholder value.
Cash Flow
50
Neutral
Cash flow from operations has been negative in 2024, reflecting challenges in cash generation. Free cash flow has decreased, and the ratio of operating cash flow to net income indicates inefficiencies in cash management. Despite this, the financing cash flow suggests some level of external capital support.
BreakdownDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue2.12B4.53B837.66M225.63M0.00
Gross Profit1.83B4.39B734.54M195.41M-1.90M
EBITDA-604.99M2.17B-1.27B-1.32B-1.01B
Net Income-514.51M2.03B-1.17B-1.07B-1.04B
Balance Sheet
Total Assets12.75B9.18B5.50B4.81B3.86B
Cash, Cash Equivalents and Short-Term Investments7.32B2.40B2.29B2.65B2.80B
Total Debt3.95B2.99B1.88B859.42M198.99M
Total Liabilities6.00B4.66B2.95B1.53B405.73M
Stockholders Equity6.81B4.69B2.64B3.16B3.19B
Cash Flow
Free Cash Flow-1.12B1.59B-2.02B-1.71B-1.06B
Operating Cash Flow-527.62M2.47B-1.24B-1.00B-617.77M
Investing Cash Flow-1.52B-4.00B-889.75M-579.59M-555.70M
Financing Cash Flow3.39B960.89M1.49B1.59B2.88B

Akeso, Inc. Technical Analysis

Technical Analysis Sentiment
Positive
Last Price94.85
Price Trends
50DMA
87.71
Positive
100DMA
78.46
Positive
200DMA
71.29
Positive
Market Momentum
MACD
3.22
Negative
RSI
56.31
Neutral
STOCH
54.40
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For HK:9926, the sentiment is Positive. The current price of 94.85 is above the 20-day moving average (MA) of 90.53, above the 50-day MA of 87.71, and above the 200-day MA of 71.29, indicating a bullish trend. The MACD of 3.22 indicates Negative momentum. The RSI at 56.31 is Neutral, neither overbought nor oversold. The STOCH value of 54.40 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for HK:9926.

Akeso, Inc. Peers Comparison

Overall Rating
UnderperformOutperform
Sector (54)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
55
Neutral
HK$88.01B-8.98%-54.66%-123.11%
54
Neutral
€4.79B18.24-49.50%1.83%13.92%-2.48%
$11.94B49.056.14%1.53%
$17.34B-0.72%
$12.96B25.098.17%
53
Neutral
HK$42.54B-56.68%52.25%11.46%
51
Neutral
HK$35.20B-19.78%25.96%39.58%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
HK:9926
Akeso, Inc.
94.85
57.70
155.32%
SBMFF
Sino Biopharmaceutical
0.65
0.31
91.18%
IVBXF
Innovent Biologics
10.08
5.37
114.01%
WXIBF
Wuxi Biologics (Cayman)
2.85
1.36
91.28%
HK:9995
RemeGen Co. Ltd. Class H
55.55
32.95
145.80%
HK:1877
Shanghai Junshi Biosciences Co., Ltd. Class H
20.90
9.42
82.06%

Akeso, Inc. Corporate Events

Akeso, Inc. Announces Extraordinary General Meeting for Key Resolutions
Jun 11, 2025

Akeso, Inc. has announced an extraordinary general meeting to be held on June 30, 2025, in Zhongshan, Guangdong, China. The meeting will address resolutions to grant 3,000,000 share options and 2,000,000 RSUs to Dr. Xia under the company’s existing schemes, indicating a strategic move to incentivize key leadership and align their interests with the company’s growth objectives.

The most recent analyst rating on (HK:9926) stock is a Buy with a HK$58.97 price target. To see the full list of analyst forecasts on Akeso, Inc. stock, see the HK:9926 Stock Forecast page.

Akeso, Inc. Announces Annual General Meeting with Key Resolutions
Jun 8, 2025

Akeso, Inc. has announced its upcoming annual general meeting, scheduled for June 30, 2025, in Zhongshan, Guangdong, China. The meeting will address several key resolutions, including the adoption of the company’s audited financial statements for 2024, the re-election of retiring directors, and the re-appointment of Ernst & Young as auditors. Additionally, the meeting will consider authorizing the board to manage the issuance of additional shares, which could impact the company’s capital structure and shareholder value.

The most recent analyst rating on (HK:9926) stock is a Buy with a HK$58.97 price target. To see the full list of analyst forecasts on Akeso, Inc. stock, see the HK:9926 Stock Forecast page.

Akeso’s Cadonilimab Gains Approval for First-Line Cervical Cancer Treatment
Jun 5, 2025

Akeso, Inc. announced that China’s National Medical Products Administration has approved the supplemental New Drug Application for cadonilimab as a first-line treatment for cervical cancer. This approval marks a significant advancement in addressing the unmet needs for immune-based therapies in cervical cancer, offering a new treatment option for patients at all stages of the disease. The approval is based on successful results from the COMPASSION-16/AK104-303 study, which demonstrated improved progression-free and overall survival rates. This development positions Akeso as a leader in innovative cancer treatments, potentially impacting the company’s market presence and offering hope to stakeholders in the healthcare sector.

The most recent analyst rating on (HK:9926) stock is a Buy with a HK$58.97 price target. To see the full list of analyst forecasts on Akeso, Inc. stock, see the HK:9926 Stock Forecast page.

Akeso, Inc. Grants Share Options and RSUs to Boost Employee Motivation
May 26, 2025

Akeso, Inc. announced the grant of 7,115,000 Share Options and Restricted Share Units (RSUs) to 114 grantees, including directors and employees, as part of its strategy to recognize contributions and motivate its workforce. The grant is considered fair and reasonable, with a 10-year validity period and a mixed vesting schedule to encourage long-term commitment and growth within the company.

The most recent analyst rating on (HK:9926) stock is a Buy with a HK$58.97 price target. To see the full list of analyst forecasts on Akeso, Inc. stock, see the HK:9926 Stock Forecast page.

Akeso’s Ivonescimab Gains NMPA Approval for NSCLC Treatment
Apr 27, 2025

Akeso, Inc. announced that its bi-specific antibody, ivonescimab, has received approval from the National Medical Products Administration for its use as a first-line treatment for non-small cell lung cancer (NSCLC) with positive PD-L1 expression. This approval is based on successful Phase III trial results demonstrating ivonescimab’s efficacy over pembrolizumab, marking a significant advancement in chemotherapy-free treatment options for NSCLC, and potentially enhancing Akeso’s position in the oncology market.

FDA Approves Akeso’s Penpulimab for Advanced Nasopharyngeal Carcinoma
Apr 25, 2025

Akeso, Inc. announced that the U.S. FDA has approved its PD-1 monoclonal antibody, penpulimab-kcqx, for the treatment of advanced nasopharyngeal carcinoma (NPC) in two indications. This approval marks a significant milestone for Akeso, expanding the treatment options for NPC patients in the U.S. and highlighting the company’s commitment to addressing critical unmet medical needs. The approval is based on international clinical trials and follows previous designations by the FDA, underscoring the therapy’s potential impact on improving patient outcomes.

Akeso’s Ivonescimab Shows Promising Results in Lung Cancer Trial
Apr 23, 2025

Akeso, Inc. announced that its PD-1/VEGF bispecific antibody, ivonescimab, combined with chemotherapy, has achieved positive results in a Phase III clinical trial for advanced squamous non-small cell lung cancer (sq-NSCLC). The trial, known as HARMONi-6, demonstrated statistically significant and clinically meaningful progression-free survival benefits compared to tislelizumab plus chemotherapy, with a favorable safety profile. These results position ivonescimab as a promising new treatment option for sq-NSCLC, potentially improving upon current standards of care and enhancing the clinical benefits of immunotherapy.

Akeso’s Ebdarokimab Receives Approval for Psoriasis Treatment in China
Apr 21, 2025

Akeso, Inc. announced that the National Medical Products Administration of China has approved the new drug application for Ebdarokimab, a treatment for moderate to severe plaque psoriasis. This approval marks a significant advancement for Akeso as it is their first Class 1 new drug approved for autoimmune diseases and the second non-oncology drug to receive marketing approval. Ebdarokimab has shown positive short-term and sustained long-term efficacy, significant improvement in patients’ quality of life, and a good safety profile. The drug is poised to address the growing needs of the psoriatic population in China, offering a cost-effective and convenient treatment option.

Akeso, Inc. Reports Significant Revenue Decline for 2024
Mar 30, 2025

Akeso, Inc. announced a significant decrease in its financial performance for the year ended December 31, 2024, with revenue dropping by 53.08% compared to the previous year. Despite an increase in commercial sales, the company’s gross profit also fell by 58.23%, leading to a net loss of RMB501.1 million, primarily due to the absence of a substantial upfront payment received in 2023 from a collaboration with SUMMIT.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jun 11, 2025