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Sirnaomics Ltd. (HK:2257)
:2257
Hong Kong Market

Sirnaomics Ltd. (2257) AI Stock Analysis

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HK:2257

Sirnaomics Ltd.

(2257)

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Neutral 44 (OpenAI - 5.2)
Rating:44Neutral
Price Target:
HK$8.00
▲(0.00% Upside)
Action:ReiteratedDate:01/06/26
The score is primarily weighed down by weak financial performance (ongoing losses, negative equity, and negative free cash flow). Technical indicators are mixed and provide only modest support, while valuation is constrained by a loss-making profile and no dividend yield data.
Positive Factors
Proprietary RNAi platform & partnerships
A proprietary siRNA design and optimization platform plus academic and pharma collaborations provide durable R&D and commercialization advantages. These assets support sustained pipeline development, licensing opportunities, and reduced time-to-market vs. newcomers, bolstering long-term competitivenes.
Negative Factors
Negative stockholders' equity
Negative equity is a structural solvency concern that limits financial flexibility and access to capital. Over months this raises default and covenant risk, can deter partners or lenders, and may force dilutive financing or asset sales to sustain operations if cash burn persists.
Read all positive and negative factors
Positive Factors
Negative Factors
Proprietary RNAi platform & partnerships
A proprietary siRNA design and optimization platform plus academic and pharma collaborations provide durable R&D and commercialization advantages. These assets support sustained pipeline development, licensing opportunities, and reduced time-to-market vs. newcomers, bolstering long-term competitivenes.
Read all positive factors

Sirnaomics Ltd. (2257) vs. iShares MSCI Hong Kong ETF (EWH)

Sirnaomics Ltd. Business Overview & Revenue Model

Company Description
Sirnaomics Ltd., an RNA therapeutics biopharmaceutical company, focuses on the discovery and development of product candidates for indications with medical needs in the United Sates and the People's Republic of China. Its lead product candidates i...
How the Company Makes Money
Sirnaomics generates revenue primarily through a combination of product sales, research grants, and collaborations with other pharmaceutical companies. The company's revenue model is driven by the successful development and commercialization of it...

Sirnaomics Ltd. Financial Statement Overview

Summary
Financials are weak: deeply negative net margin (-289.0%) with negative EBIT/EBITDA margins, negative stockholders’ equity indicating elevated solvency risk, and materially negative free cash flow despite some improvement year over year.
Income Statement
20
Very Negative
Balance Sheet
15
Very Negative
Cash Flow
25
Negative
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue949.00K1.78M397.00K705.00K0.000.00
Gross Profit370.00K1.20M397.00K705.00K-12.67M0.00
EBITDA-15.48M-31.12M-72.36M-89.02M-1.66B-19.27M
Net Income-14.02M-51.38M-78.69M-88.30M-1.66B-43.77M
Balance Sheet
Total Assets21.30M28.33M75.79M163.93M240.65M110.18M
Cash, Cash Equivalents and Short-Term Investments6.87M11.77M43.93M105.23M211.99M103.12M
Total Debt7.21M8.06M8.85M10.76M7.04M91.87M
Total Liabilities40.40M44.33M51.33M52.37M30.36M204.36M
Stockholders Equity-5.12M-1.68M40.20M122.01M211.62M-94.43M
Cash Flow
Free Cash Flow-9.26M-19.84M-72.03M-107.54M-62.85M-21.15M
Operating Cash Flow-9.26M-19.73M-70.29M-88.71M-56.97M-19.00M
Investing Cash Flow1.94M2.14M-5.35M-32.61M-6.04M8.39M
Financing Cash Flow6.53M5.82M-5.61M15.89M170.96M100.37M

Sirnaomics Ltd. Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price8.00
Price Trends
50DMA
7.00
Negative
100DMA
7.68
Negative
200DMA
8.94
Negative
Market Momentum
MACD
-0.22
Negative
RSI
52.49
Neutral
STOCH
74.86
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For HK:2257, the sentiment is Neutral. The current price of 8 is above the 20-day moving average (MA) of 6.16, above the 50-day MA of 7.00, and below the 200-day MA of 8.94, indicating a neutral trend. The MACD of -0.22 indicates Negative momentum. The RSI at 52.49 is Neutral, neither overbought nor oversold. The STOCH value of 74.86 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for HK:2257.

Sirnaomics Ltd. Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
60
Neutral
HK$3.86B-16.66-14.53%9.41%-32.69%
52
Neutral
HK$3.70B-13.2611.40%79.98%-3.40%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
45
Neutral
HK$2.42B-14.44-27.70%-100.00%30.68%
44
Neutral
HK$717.58M-2.18191.92%83.89%
43
Neutral
HK$1.25B-2.47-27.44%-57.84%24.58%
42
Neutral
HK$13.59B-15.44-64.19%-55.64%-158.67%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
HK:2257
Sirnaomics Ltd.
6.54
3.49
114.43%
HK:1875
TOT BIOPHARM International Co. Ltd.
5.00
3.40
212.50%
HK:2197
Clover Biopharmaceuticals Ltd.
2.85
2.65
1325.00%
HK:2616
CStone Pharmaceuticals
9.35
7.13
321.17%
HK:3681
SinoMab Bioscience Ltd.
1.76
0.58
49.15%
HK:6628
Transcenta Holding Limited
2.82
1.68
147.37%

Sirnaomics Ltd. Corporate Events

Sirnaomics Completes Phase I Trial of Cancer Drug STP707 and Files Clinical Report with FDA
Dec 22, 2025
Sirnaomics Ltd. has announced that its subsidiary Sirnaomics, Inc. has completed a Phase I clinical trial of its investigational cancer drug STP707 in adults with advanced, metastatic or inoperable solid tumors that were no longer responding to st...
Sirnaomics Chairman Increases Stake, Signaling Confidence in Growth
Dec 8, 2025
Sirnaomics Ltd. announced that Dr. Poon Hung Fai, the company’s chairman and executive director, has increased his shareholding by purchasing 100,000 ordinary shares at an average price of HK$6.83 per share. This move reflects Dr. Poon&#8217...
Sirnaomics Ltd. Completes Partial Share Subscription to Boost Drug Development
Dec 7, 2025
Sirnaomics Ltd. announced the partial completion of a subscription agreement, resulting in the issuance of 1,003,700 new shares to Subscriber B at HK$12.00 per share. The termination of the remaining shares in the agreement was mutually agreed upo...
Sirnaomics Ltd. Announces Board of Directors and Committee Roles
Dec 1, 2025
Sirnaomics Ltd. has announced the composition of its board of directors, detailing the roles and functions of each member. The board includes executive, non-executive, and independent non-executive directors, with specific members assigned to the ...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jan 06, 2026