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CStone Pharmaceuticals (HK:2616)
:2616
Hong Kong Market
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CStone Pharmaceuticals (2616) AI Stock Analysis

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HK:2616

CStone Pharmaceuticals

(2616)

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Neutral 44 (OpenAI - 4o)
Rating:44Neutral
Price Target:
HK$7.50
▲(19.81% Upside)
CStone Pharmaceuticals faces significant financial challenges with declining revenue and persistent losses, which heavily impact its overall score. Technical indicators suggest mixed momentum, while valuation metrics highlight ongoing profitability issues. The absence of earnings call and corporate events data limits additional insights.

CStone Pharmaceuticals (2616) vs. iShares MSCI Hong Kong ETF (EWH)

CStone Pharmaceuticals Business Overview & Revenue Model

Company DescriptionCStone Pharmaceuticals, a biopharmaceutical company, researches, develops, and commercializes immuno-oncology and precision medicines to address the unmet medical needs of cancer patients in China and internationally. It offers Sugemalimab, a monoclonal antibody against programmed death (PD) ligand 1; GAVRETO, an RET inhibitor for the treatment of patients with advanced or metastatic RET-mutant medullary and RET fusion-positive thyroid cancers; and avapritinib, a KIT/PDGFRA inhibitor to treat adults with unresectable or metastatic gastrointestinal stromal tumors harboring a PDGFRA exon 18 mutation. The company's product pipeline includes Nofazinlimab, a PD-1 antibody for the treatment of patients with hepatocellular carcinoma; Ivosidenib, an isocitrate dehydrogenase 1 (IDH1) inhibitor to treat adults with relapsed or refractory acute myeloid leukemia with an IDH1 mutation; and Fisogatinib, an FGFR4 inhibitor to treat hepatocellular carcinoma. Its products also comprise CS1002, CS2006, CS3002, CS3005, CS2007, CS2008, and CS500 for solid tumors; and CS5001 for solid tumors and hematologic malignancies. The company was incorporated in 2015 and is headquartered in Shanghai, China.
How the Company Makes MoneyCStone Pharmaceuticals generates revenue primarily through the development and commercialization of its oncology therapies. The company earns money by licensing its drug candidates to pharmaceutical partners, engaging in co-development agreements, and receiving milestone payments and royalties based on the progress and sales of these drugs. Additionally, CStone may derive revenue from partnerships with other biopharmaceutical companies for joint research and development projects. The company also benefits from strategic collaborations that provide funding and resources for advancing its pipeline of innovative cancer treatments.

CStone Pharmaceuticals Financial Statement Overview

Summary
CStone Pharmaceuticals is facing significant financial challenges, with declining revenue and persistent losses. Despite a solid equity position, ongoing negative cash flow and profitability issues pose substantial risks.
Income Statement
40
Negative
CStone Pharmaceuticals has shown a challenging revenue trajectory with declining revenue over the recent years. The company has consistently reported negative EBIT and EBITDA margins, indicating ongoing operational challenges. The net profit margin is also negative, reflecting significant losses, though the scale of losses has decreased over the last year.
Balance Sheet
55
Neutral
The balance sheet shows a moderate debt-to-equity ratio and a healthy equity ratio, suggesting a strong capital base relative to debt. The company has maintained a reasonable balance of assets to liabilities, but the consistent negative net income is a potential risk for long-term sustainability.
Cash Flow
30
Negative
CStone Pharmaceuticals has not demonstrated positive free cash flow in recent years, which is critical for financial health. The operating cash flow is negative, further highlighting liquidity challenges. The absence of growth in free cash flow and reliance on financing activities for cash raises concerns about cash flow sustainability.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue177.77M407.20M463.84M481.36M243.72M1.04B
Gross Profit21.73M240.15M304.30M278.38M136.89M797.41M
EBITDA-216.63M-76.43M-297.23M-849.66M-1.90B-1.20B
Net Income-242.00M-91.21M-367.23M-902.68M-1.92B-1.22B
Balance Sheet
Total Assets1.19B1.39B1.66B1.64B2.27B3.76B
Cash, Cash Equivalents and Short-Term Investments690.10M672.94M1.05B1.04B1.73B3.39B
Total Debt391.37M355.97M363.45M286.29M174.20M83.86M
Total Liabilities876.86M1.03B1.21B1.19B1.06B808.29M
Stockholders Equity315.04M363.87M456.83M449.33M1.21B2.95B
Cash Flow
Free Cash Flow-156.05M-343.18M-653.89M-714.29M-1.63B-579.52M
Operating Cash Flow-156.05M-343.18M-588.84M-612.47M-1.48B-508.07M
Investing Cash Flow-149.95M-247.68M619.61M365.12M-826.55M1.18B
Financing Cash Flow22.58M-12.90M388.36M28.47M92.30M1.39B

CStone Pharmaceuticals Technical Analysis

Technical Analysis Sentiment
Negative
Last Price6.26
Price Trends
50DMA
8.73
Negative
100DMA
7.34
Negative
200DMA
5.18
Positive
Market Momentum
MACD
-0.61
Negative
RSI
35.98
Neutral
STOCH
17.84
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For HK:2616, the sentiment is Negative. The current price of 6.26 is below the 20-day moving average (MA) of 6.99, below the 50-day MA of 8.73, and above the 200-day MA of 5.18, indicating a neutral trend. The MACD of -0.61 indicates Negative momentum. The RSI at 35.98 is Neutral, neither overbought nor oversold. The STOCH value of 17.84 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for HK:2616.

CStone Pharmaceuticals Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
HK$11.53B45.1413.34%206.58%
HK$10.45B54.916.73%23.37%
$7.86B-0.30-43.30%2.27%22.53%-2.21%
HK$11.43B17.5335.80%59.70%239.97%
HK$9.18B-20.28-95.84%-55.64%-158.67%
HK$3.34B-129.05%-18.99%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
HK:2616
CStone Pharmaceuticals
6.26
4.21
205.37%
HK:9966
Alphamab Oncology
11.50
7.63
197.16%
HK:2142
HBM Holdings Ltd.
13.47
12.27
1022.50%
HK:2179
Jiangsu Recbio Technology Co., Ltd. Class H
6.98
-1.42
-16.90%
HK:2256
Abbisko Cayman Limited
14.56
10.20
233.94%
HK:6955
Shandong Boan Biotechnology Company., Limited. Class H
10.46
1.28
13.94%

CStone Pharmaceuticals Corporate Events

CStone Pharmaceuticals CEO Increases Shareholding, Signaling Confidence in Future Growth
Oct 23, 2025

CStone Pharmaceuticals announced that its CEO, Dr. Jianxin Yang, along with senior management, has increased their shareholding in the company by purchasing 1,000,000 shares, with Dr. Yang acquiring 700,000 shares. This move underscores their confidence in the company’s long-term investment value and growth prospects, as well as their commitment to its future business success. The board views this increase in shareholding as a sign of strong belief in the company’s ability to maintain steady operations and achieve rapid growth, which could positively impact stakeholder confidence.

The most recent analyst rating on (HK:2616) stock is a Hold with a HK$7.50 price target. To see the full list of analyst forecasts on CStone Pharmaceuticals stock, see the HK:2616 Stock Forecast page.

CStone Pharmaceuticals Unveils Promising Phase I Data for Innovative Cancer Therapy
Oct 20, 2025

CStone Pharmaceuticals announced the first disclosure of preliminary Phase I data for CS2009, a PD-1/VEGF/CTLA-4 trispecific antibody, at the 2025 ESMO Annual Congress. The study, conducted in Australia and China, evaluates the safety and antitumor activity of CS2009 in patients with advanced solid tumors, showing favorable safety and tolerability with no dose-limiting toxicity reported. This development marks a significant step in CStone’s efforts to innovate cancer treatment, potentially enhancing its industry positioning and offering new hope for stakeholders involved.

The most recent analyst rating on (HK:2616) stock is a Hold with a HK$7.50 price target. To see the full list of analyst forecasts on CStone Pharmaceuticals stock, see the HK:2616 Stock Forecast page.

CStone Pharmaceuticals Gains CHMP Positive Opinion for Sugemalimab in Stage III NSCLC
Oct 17, 2025

CStone Pharmaceuticals announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has issued a positive opinion recommending the approval of sugemalimab as a monotherapy for unresectable stage III non-small cell lung cancer (NSCLC) in Europe. This development, based on the pivotal Phase III GEMSTONE-301 study, could solidify sugemalimab’s role as a core immunotherapy for lung cancer, enhancing its market presence and commercial potential. If approved, it will become the second PD-(L)1 antibody available in Europe for stage III NSCLC, addressing a critical unmet need and bringing new hope to patients.

The most recent analyst rating on (HK:2616) stock is a Hold with a HK$7.50 price target. To see the full list of analyst forecasts on CStone Pharmaceuticals stock, see the HK:2616 Stock Forecast page.

CStone Pharmaceuticals to Present Groundbreaking Clinical Data at ESMO 2025
Oct 13, 2025

CStone Pharmaceuticals announced its participation in the 2025 European Society for Medical Oncology Congress, where it will present data from its ongoing clinical trials. The company will showcase the world’s first clinical data for a PD-1/VEGF/CTLA-4 trispecific antibody, CS2009, in advanced solid tumor patients, and provide an update on the ROR1-targeting ADC, CS5001. These presentations highlight CStone’s commitment to advancing innovative cancer therapies and may enhance its positioning in the biopharmaceutical industry.

The most recent analyst rating on (HK:2616) stock is a Hold with a HK$7.50 price target. To see the full list of analyst forecasts on CStone Pharmaceuticals stock, see the HK:2616 Stock Forecast page.

CStone Pharmaceuticals Initiates Global Phase II Trial for Innovative Cancer Therapy
Sep 23, 2025

CStone Pharmaceuticals announced the enrollment of the first patient in Australia for their global Phase II clinical trial of CS2009, a PD-1/VEGF/CTLA-4 trispecific antibody. This trial, which will expand to the United States, aims to evaluate the drug’s safety, tolerability, and efficacy across multiple tumor types, including lung, liver, colorectal, ovarian, breast, and cervical cancers. The Phase I study showed promising results with favorable safety and significant antitumor activity, suggesting potential advancements in treatment options for various cancers.

The most recent analyst rating on (HK:2616) stock is a Hold with a HK$6.50 price target. To see the full list of analyst forecasts on CStone Pharmaceuticals stock, see the HK:2616 Stock Forecast page.

CStone Pharmaceuticals Appoints Kenneth Jarrett as Independent Director
Sep 22, 2025

CStone Pharmaceuticals has appointed Mr. Kenneth Howard Jarrett as an independent non-executive director, effective September 23, 2025. Mr. Jarrett brings over 40 years of experience in government and business relations, strategic planning, and key relationship building, having held significant positions in U.S. consulates and private sector organizations. His appointment is expected to strengthen CStone’s strategic and audit committees, potentially enhancing the company’s governance and strategic direction. This move may positively impact CStone’s standing in the biopharmaceutical industry, offering stakeholders confidence in its leadership and future growth prospects.

The most recent analyst rating on (HK:2616) stock is a Hold with a HK$6.50 price target. To see the full list of analyst forecasts on CStone Pharmaceuticals stock, see the HK:2616 Stock Forecast page.

CStone Pharmaceuticals Announces Board Composition and Roles
Sep 22, 2025

CStone Pharmaceuticals has announced the composition of its board of directors and their respective roles within the company. This announcement highlights the company’s leadership structure, which includes a mix of executive, non-executive, and independent directors, and outlines the membership of various board committees, reflecting the company’s commitment to governance and strategic oversight.

The most recent analyst rating on (HK:2616) stock is a Hold with a HK$6.50 price target. To see the full list of analyst forecasts on CStone Pharmaceuticals stock, see the HK:2616 Stock Forecast page.

CStone Pharmaceuticals to Present Novel Antibody at ACAAI 2025
Sep 15, 2025

CStone Pharmaceuticals announced that its bispecific antibody CS2015, targeting OX40L and TSLP, will be showcased at the ACAAI 2025 Annual Scientific Meeting in Orlando. This novel therapeutic agent aims to address Type 2 inflammatory diseases such as atopic dermatitis, asthma, and COPD. The presentation highlights CStone’s strategic focus on innovative treatments for autoimmune and inflammation conditions, potentially enhancing its market position and offering new solutions for patients.

The most recent analyst rating on (HK:2616) stock is a Hold with a HK$6.50 price target. To see the full list of analyst forecasts on CStone Pharmaceuticals stock, see the HK:2616 Stock Forecast page.

CStone Pharmaceuticals Grants Share Options and RSUs to Key Personnel
Aug 27, 2025

CStone Pharmaceuticals announced the grant of 4,800,000 share options and 1,930,000 restricted share units (RSUs) to select directors and employees under its Post-IPO ESOP and RSU schemes. This strategic move aims to incentivize key personnel and align their interests with the company’s long-term growth objectives, potentially enhancing CStone’s competitive positioning in the biopharmaceutical industry.

The most recent analyst rating on (HK:2616) stock is a Hold with a HK$6.50 price target. To see the full list of analyst forecasts on CStone Pharmaceuticals stock, see the HK:2616 Stock Forecast page.

CStone Pharmaceuticals Reports Significant Revenue Decline in H1 2025
Aug 14, 2025

CStone Pharmaceuticals announced a significant decrease in revenue for the first half of 2025, with a drop of 80.5% compared to the same period in 2024, primarily due to price adjustments and a lack of new out-licensing deals. Despite increased research and development expenses, the company reported a shift from profit to loss, highlighting challenges in its financial performance and strategic adjustments in anticipation of future market opportunities.

CStone Pharmaceuticals Schedules Board Meeting for Interim Results Review
Aug 4, 2025

CStone Pharmaceuticals has announced a board meeting scheduled for August 14, 2025, to review and approve the company’s unaudited interim results for the first half of 2025. The meeting will also consider the possibility of an interim dividend, which could impact shareholder returns and reflect the company’s financial health.

CStone Pharmaceuticals Advances Phase III Study for Liver Cancer Treatment
Jul 31, 2025

Study Overview: CStone Pharmaceuticals is conducting a Phase III study titled ‘A Multi-Center, Double-Blind, Randomized, Phase III Study to Investigate the Efficacy and Safety of Nofazinlimab (CS1003) in Combination With Lenvatinib Compared to Placebo in Combination With Lenvatinib as First-Line Therapy in Subjects With Advanced Hepatocellular Carcinoma (HCC)’. The study aims to evaluate the efficacy and safety of Nofazinlimab combined with lenvatinib versus a placebo combined with lenvatinib in patients with advanced hepatocellular carcinoma, who have not received prior systemic treatment and are ineligible for locoregional therapy.

CStone Pharmaceuticals to Present Key Oncology Advances at ESMO 2025
Jul 28, 2025

CStone Pharmaceuticals announced its participation in the European Society for Medical Oncology (ESMO) Congress 2025, where it will present significant clinical advancements from its Pipeline 2.0. The company will debut the first-in-human Phase Ia data for its novel PD-1/VEGF/CTLA-4 trispecific antibody, CS2009, and the Phase Ib study design for its ROR1-targeting antibody-drug conjugate, CS5001. These developments highlight CStone’s commitment to pioneering cancer treatments and enhancing its position in the global oncology market.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Oct 10, 2025