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CStone Pharmaceuticals (HK:2616)
:2616
Hong Kong Market
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CStone Pharmaceuticals (2616) AI Stock Analysis

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HK:2616

CStone Pharmaceuticals

(2616)

Rating:49Neutral
Price Target:
HK$6.50
▼(-3.56%Downside)
CStone Pharmaceuticals' overall stock score is primarily influenced by its challenging financial performance, with persistent losses and negative cash flow impacting the score significantly. While technical indicators are positive, suggesting potential short-term bullish momentum, the company's valuation remains a concern due to its negative P/E ratio and lack of dividends. The absence of recent earnings call data and corporate events means these components did not influence the score.

CStone Pharmaceuticals (2616) vs. iShares MSCI Hong Kong ETF (EWH)

CStone Pharmaceuticals Business Overview & Revenue Model

Company DescriptionCStone Pharmaceuticals (2616) is a biopharmaceutical company focused on the development and commercialization of innovative oncology therapies. The company operates in the biotechnology and pharmaceutical sectors, specializing in the research and development of immune-oncology and precision medicine treatments. With a robust pipeline of drug candidates, CStone aims to address significant unmet medical needs in cancer treatment.
How the Company Makes MoneyCStone Pharmaceuticals generates revenue primarily through the development and commercialization of its oncology therapies. The company earns money by licensing its drug candidates to pharmaceutical partners, engaging in co-development agreements, and receiving milestone payments and royalties based on the progress and sales of these drugs. Additionally, CStone may derive revenue from partnerships with other biopharmaceutical companies for joint research and development projects. The company also benefits from strategic collaborations that provide funding and resources for advancing its pipeline of innovative cancer treatments.

CStone Pharmaceuticals Financial Statement Overview

Summary
CStone Pharmaceuticals faces significant financial challenges, including declining revenue and persistent losses, as evidenced by negative EBIT, EBITDA, and net profit margins. Although the balance sheet is moderately strong with a reasonable debt-to-equity ratio, ongoing negative cash flow and reliance on financing for liquidity are concerning.
Income Statement
40
Negative
CStone Pharmaceuticals has shown a challenging revenue trajectory with declining revenue over the recent years. The company has consistently reported negative EBIT and EBITDA margins, indicating ongoing operational challenges. The net profit margin is also negative, reflecting significant losses, though the scale of losses has decreased over the last year.
Balance Sheet
55
Neutral
The balance sheet shows a moderate debt-to-equity ratio and a healthy equity ratio, suggesting a strong capital base relative to debt. The company has maintained a reasonable balance of assets to liabilities, but the consistent negative net income is a potential risk for long-term sustainability.
Cash Flow
30
Negative
CStone Pharmaceuticals has not demonstrated positive free cash flow in recent years, which is critical for financial health. The operating cash flow is negative, further highlighting liquidity challenges. The absence of growth in free cash flow and reliance on financing activities for cash raises concerns about cash flow sustainability.
BreakdownDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue407.20M463.84M481.36M243.72M1.04B
Gross Profit240.15M304.30M278.38M136.89M797.41M
EBITDA-76.43M-297.23M-849.66M-1.90B-1.20B
Net Income-91.21M-367.23M-964.61M-1.99B-1.22B
Balance Sheet
Total Assets1.39B1.66B1.64B2.27B3.76B
Cash, Cash Equivalents and Short-Term Investments672.94M1.05B1.04B1.73B3.39B
Total Debt355.97M363.45M286.29M174.20M83.86M
Total Liabilities1.03B1.21B1.19B1.06B808.29M
Stockholders Equity363.87M456.83M449.33M1.21B2.95B
Cash Flow
Free Cash Flow-343.18M-653.89M-714.29M-1.63B-579.52M
Operating Cash Flow-343.18M-588.84M-612.47M-1.48B-508.07M
Investing Cash Flow-247.68M619.61M365.12M-826.55M1.18B
Financing Cash Flow-12.90M388.36M28.47M92.30M1.39B

CStone Pharmaceuticals Technical Analysis

Technical Analysis Sentiment
Positive
Last Price6.74
Price Trends
50DMA
5.07
Positive
100DMA
4.06
Positive
200DMA
3.19
Positive
Market Momentum
MACD
0.73
Positive
RSI
59.33
Neutral
STOCH
43.77
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For HK:2616, the sentiment is Positive. The current price of 6.74 is above the 20-day moving average (MA) of 6.37, above the 50-day MA of 5.07, and above the 200-day MA of 3.19, indicating a bullish trend. The MACD of 0.73 indicates Positive momentum. The RSI at 59.33 is Neutral, neither overbought nor oversold. The STOCH value of 43.77 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for HK:2616.

CStone Pharmaceuticals Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
67
Neutral
HK$6.91B173.081.43%2433.62%
65
Neutral
HK$9.19B50.279.52%185.36%
54
Neutral
HK$7.54B311.032.28%-57.55%-87.49%
51
Neutral
$7.38B0.34-69.01%2.37%16.35%0.39%
49
Neutral
HK$9.72B-22.23%-14.17%76.00%
42
Neutral
HK$3.74B-69.97%3.30%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
HK:2616
CStone Pharmaceuticals
6.74
5.50
443.55%
HK:2256
Abbisko Cayman Limited
10.16
7.42
270.80%
HK:2179
Jiangsu Recbio Technology Co., Ltd. Class H
7.80
-0.98
-11.16%
HK:2142
HBM Holdings Ltd.
9.02
7.72
593.85%
HK:9966
Alphamab Oncology
9.43
7.21
324.77%

CStone Pharmaceuticals Corporate Events

CStone Pharmaceuticals Schedules Board Meeting for Interim Results Review
Aug 4, 2025

CStone Pharmaceuticals has announced a board meeting scheduled for August 14, 2025, to review and approve the company’s unaudited interim results for the first half of 2025. The meeting will also consider the possibility of an interim dividend, which could impact shareholder returns and reflect the company’s financial health.

CStone Pharmaceuticals to Present Key Oncology Advances at ESMO 2025
Jul 28, 2025

CStone Pharmaceuticals announced its participation in the European Society for Medical Oncology (ESMO) Congress 2025, where it will present significant clinical advancements from its Pipeline 2.0. The company will debut the first-in-human Phase Ia data for its novel PD-1/VEGF/CTLA-4 trispecific antibody, CS2009, and the Phase Ib study design for its ROR1-targeting antibody-drug conjugate, CS5001. These developments highlight CStone’s commitment to pioneering cancer treatments and enhancing its position in the global oncology market.

CStone Pharmaceuticals Completes HK$467.28 Million Share Placing to Boost R&D
Jul 16, 2025

CStone Pharmaceuticals announced the successful completion of a placing of 100 million new shares, raising approximately HK$467.28 million. The funds will be primarily used for research and development of its ‘Pipeline 2.0’ assets, including clinical trials for CS2009 and CS5001, as well as preclinical assets like CS2015. This move strengthens CStone’s financial position to advance its innovative cancer treatment pipeline, potentially enhancing its market competitiveness and benefiting stakeholders.

CStone Pharmaceuticals Secures NMPA Approval for Local Manufacturing of GAVRETO® in China
Jul 10, 2025

CStone Pharmaceuticals announced that the National Medical Products Administration of China has approved the localized manufacturing of GAVRETO® (pralsetinib) for the Chinese market, starting in 2026. This transition from imported to locally manufactured products is expected to enhance supply chain flexibility and resilience, ensuring sustainable product access and strengthening GAVRETO®’s market position. The approval marks a significant milestone in CStone’s lifecycle management strategy, aiming to improve treatment accessibility for RET-positive patients in China.

CStone Pharmaceuticals Announces Share Placement to Raise HK$467 Million
Jul 9, 2025

CStone Pharmaceuticals has entered into a Placing Agreement to issue 100,000,000 new shares at HK$4.72 each, representing a discount to recent trading prices. This move is expected to raise approximately HK$467.28 million in net proceeds, which will support the company’s financial position and strategic initiatives. The Placing is contingent upon the approval of the Stock Exchange’s listing committee and other conditions, highlighting the company’s proactive approach to capital management and market positioning.

CStone Pharmaceuticals Partners with Istituto Gentili to Expand Sugemalimab’s Reach in Europe
Jul 8, 2025

CStone Pharmaceuticals has entered an exclusive licensing agreement with Istituto Gentili to commercialize its anti-PD-L1 monoclonal antibody, sugemalimab, across Western Europe and the UK. This partnership allows CStone to receive up to $192.5 million in milestone payments and recognizes close to 50% of net sales as revenue. The agreement expands sugemalimab’s reach to over 60 countries, enhancing its availability amid global pricing uncertainties in the US. This move strengthens CStone’s market position and aims to address unmet medical needs in oncology, particularly for non-small cell lung cancer (NSCLC).

CStone Pharmaceuticals Advances Clinical Trials for Innovative Cancer Therapy
Jul 7, 2025

CStone Pharmaceuticals announced a clinical progress update on CS2009, a novel trispecific antibody targeting PD-1, VEGFA, and CTLA-4. The ongoing global multicenter Phase I/II study is enrolling patients in Australia and China, with plans to expand to the United States. CS2009 has shown promising results in safety and efficacy, particularly in patients with advanced solid tumors. The study aims to advance the development of next-generation immuno-oncology therapeutics, potentially positioning CStone as a leader in this field.

CStone Pharmaceuticals Updates Phase III Study on Nofazinlimab for Liver Cancer
Jul 4, 2025

CStone Pharmaceuticals has announced an update on their global multicenter Phase III study of nofazinlimab in hepatocellular carcinoma (HCC). The study, which involved 74 sites worldwide, evaluated the efficacy and safety of nofazinlimab combined with lenvatinib against a placebo-lenvatinib combination in patients with unresectable or metastatic HCC. The results showed a compelling trend in overall survival and meaningful improvements in progression-free survival and objective response rate, although statistical significance was not reached. Nofazinlimab demonstrated a manageable safety profile, with no new safety signals observed. CStone plans to engage with regulatory authorities to explore the registration pathway for this combination therapy, potentially impacting the company’s operations and positioning in the oncology market.

CStone Pharmaceuticals Unveils Promising Bispecific Antibody Targets for Autoimmune Diseases
Jul 3, 2025

CStone Pharmaceuticals announced the development of two bispecific antibodies, CS2013 and CS2015, targeting autoimmune and inflammatory diseases. These candidates, which have advanced to the preclinical candidate nomination stage, represent a strategic expansion into non-oncology therapeutic areas. CS2013 targets B-cell-mediated autoimmune diseases, while CS2015 addresses Th2-mediated inflammatory diseases. Both antibodies show potential for best-in-class or first-in-class status, with promising preclinical data indicating extended half-life and subcutaneous delivery potential. This development aligns with CStone’s vision to enhance global patient health through innovation.

CStone Pharmaceuticals Passes Key Resolutions at AGM
Jun 25, 2025

CStone Pharmaceuticals announced the successful passage of all resolutions at its annual general meeting held on June 25, 2025. Key decisions included the re-election of directors, authorization of the board to fix directors’ remuneration, and reappointment of Deloitte Touche Tohmatsu as the company’s auditor. Additionally, the company granted mandates for share issuance and buybacks, reflecting a strategic move to enhance operational flexibility and shareholder value.

CStone Pharmaceuticals Announces Board of Directors Composition
Jun 25, 2025

CStone Pharmaceuticals has announced the composition of its board of directors, detailing the roles and functions of each member. This announcement highlights the company’s commitment to strong governance and strategic oversight, which is crucial for its continued growth and competitiveness in the biopharmaceutical industry.

CStone Pharmaceuticals Strengthens Governance with New Nomination Committee
Jun 25, 2025

CStone Pharmaceuticals has established a Nomination Committee to oversee the nomination of directors and senior management, ensuring a structured and transparent process. The committee, formed by the board of directors, consists of at least three members, primarily independent non-executive directors, and is tasked with meeting at least once a year to discuss relevant matters. This initiative is expected to enhance corporate governance and provide shareholders with confidence in the company’s leadership selection processes.

CStone’s Sugemalimab Shows Promising Long-Term Survival in NSCLC Trial
Jun 19, 2025

CStone Pharmaceuticals announced the publication of long-term survival data from the Phase III GEMSTONE-302 trial in The Lancet Oncology, highlighting the efficacy of sugemalimab combined with platinum-based chemotherapy as a first-line treatment for metastatic non-small cell lung cancer (NSCLC). The study demonstrated significant improvements in overall survival and progression-free survival compared to placebo, reinforcing sugemalimab’s role as a standard therapy for advanced NSCLC in China and Europe. The trial’s results, published in top-tier journals, underscore sugemalimab’s clinical value and support its inclusion in treatment guidelines, with potential implications for expanding global access through commercialization partnerships.

CStone Pharmaceuticals Addresses Criticism of Independent Director
Jun 13, 2025

CStone Pharmaceuticals announced that the Stock Exchange of Hong Kong has publicly criticized Mr. Sun Hongbin, an independent non-executive director of the company, for conduct violations during his tenure at New Century Healthcare. The company’s board has assessed the situation and determined that the criticism does not impact CStone’s operations or business, but they will continue to monitor Mr. Sun’s eligibility to serve in his current role.

CStone Pharmaceuticals Announces 2025 AGM and Key Resolutions
Jun 3, 2025

CStone Pharmaceuticals has announced its Annual General Meeting (AGM) scheduled for June 25, 2025, in Shanghai, China. The AGM will address several key resolutions, including the re-election of board members, the authorization of director remuneration, and the reappointment of Deloitte Touche Tohmatsu as the company’s auditor. Additionally, the meeting will consider a resolution to authorize the board to issue new shares, subject to certain conditions, which could impact the company’s financial strategy and shareholder value.

CStone Pharmaceuticals Unveils Promising Cancer Therapies at AACR 2025
May 6, 2025

CStone Pharmaceuticals recently presented five preclinical studies at the 2025 AACR Annual Meeting, showcasing advancements in their innovative cancer therapy pipeline. Key highlights include the trispecific antibody CS2009, which targets PD-1, VEGFA, and CTLA-4, showing potential as a next-generation immune-oncology treatment with enhanced anti-tumor efficacy. Additionally, the bispecific antibody CS2011 demonstrated strong binding affinity to EGFR and HER3, effectively inhibiting tumor growth in various cancers. These developments underscore CStone’s commitment to advancing cancer treatment and potentially improving outcomes for patients.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Aug 02, 2025