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Gh Research Plc (GHRS)
NASDAQ:GHRS

GH Research (GHRS) AI Stock Analysis

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GHRS

GH Research

(NASDAQ:GHRS)

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Neutral 52 (OpenAI - 5.2)
Rating:52Neutral
Price Target:
$17.00
▲(0.06% Upside)
The score is held back primarily by weak operating fundamentals (no revenue, widening losses, and significant cash burn), partially offset by a strong, low-debt balance sheet. Technicals are moderately supportive with price above key moving averages, while valuation remains constrained due to negative earnings and no dividend data.
Positive Factors
Low leverage / conservative balance sheet
Extremely low debt reduces solvency and interest expense risk, giving management flexibility to fund clinical programs and engage partners without near-term forced repayment pressures. This structural strength supports sustained R&D investment and lowers bankruptcy risk during pivotal trials.
Material cash reserves
A nearly $294M cash and marketable securities balance materially extends runway versus operating burn, enabling initiation and conduct of a global Phase 3 program and regulatory interactions without immediate reliance on dilutive financing. This preserves execution optionality for 2-6+ months.
Regulatory milestone — FDA lifted clinical hold
Removal of the FDA clinical hold is a durable structural advancement: it permits U.S. subject enrollment, allows alignment on a global pivotal Phase 3 design, and materially improves the company's ability to pursue a coherent global development pathway, reducing a key regulatory bottleneck.
Negative Factors
Pre-commercial, zero revenue profile
No commercial revenues mean the company must rely on financing to fund operations long-term. This structural dependence increases execution and financing risk, as failure or delay in clinical programs would directly impair the firm’s ability to self-fund continued R&D and development activities.
Large and recurring cash burn
Consistent negative operating and free cash flow at ~-$42M per year is a persistent drain that will require ongoing funding. Even with strong cash balances, sustained burn elevates dilution and refinancing risk over the medium term if development timelines extend or additional trials are required.
Widening net losses and negative ROE
Growing operating losses and deeply negative returns on equity indicate the current capital base is not generating earnings. Structurally, this heightens reliance on capital markets, risks shareholder dilution, and limits internal funding for commercial expansion absent successful clinical outcomes.

GH Research (GHRS) vs. SPDR S&P 500 ETF (SPY)

GH Research Business Overview & Revenue Model

Company DescriptionGH Research PLC, a clinical-stage biopharmaceutical company, engages in developing various therapies for the treatment of psychiatric and neurological disorders. The company focuses on developing 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) therapies for the treatment of patients with treatment-resistant depression (TRD). Its lead program is GH001, an inhalable 5-MeO-DMT product candidate that has completed two Phase 1 clinical trials and Phase 1/2 clinical trial in patients with TRD. The company also develops GH002, an injectable 5-MeO-DMT product candidate; and GH003, an intranasal 5-MeO-DMT product candidate, which are in preclinical development trials with a focus on psychiatric and neurological disorders. GH Research PLC was incorporated in 2018 and is based in Dublin, Ireland.
How the Company Makes MoneyGH Research makes money primarily through the development and eventual commercialization of its pharmaceutical products. Revenue streams are anticipated from the sale of proprietary medications following successful clinical trials and regulatory approval. Additionally, the company may engage in strategic partnerships or collaborations with larger pharmaceutical firms, potentially receiving milestone payments, royalties, or licensing fees. However, as a clinical-stage company, it currently relies on funding from investors, grants, and partnerships to support its research and development activities.

GH Research Financial Statement Overview

Summary
GH Research is in the early stages of revenue generation and faces significant challenges in terms of profitability and operational cash flow. The company has a strong equity base and low debt, which are positives. However, ongoing losses and negative cash flows are major concerns that need to be addressed to achieve long-term financial health.
Income Statement
18
Very Negative
GH Research shows weak financial performance with consistently negative net income and EBIT. The gross profit margin is negative due to costs exceeding the revenue. However, the company has shown some revenue generation in the latest TTM, indicating potential for future growth.
Balance Sheet
76
Positive
The balance sheet is relatively stable with a high equity ratio and low total debt, indicating strong financial stability. However, the company’s assets have been declining over time, and the return on equity is negative due to consistent losses.
Cash Flow
34
Negative
The cash flow statement indicates negative operating cash flow, reflecting ongoing operational challenges. Despite this, the company maintains a strong cash position, suggesting potential for future investment and growth.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue0.000.000.000.000.000.00
Gross Profit-171.00K0.000.000.000.000.00
EBITDA-42.55M-38.60M-35.21M-22.41M-9.17M0.00
Net Income-42.92M-38.96M-35.59M-22.46M-9.20M-446.00K
Balance Sheet
Total Assets302.02M188.27M226.30M254.36M279.92M5.91M
Cash, Cash Equivalents and Short-Term Investments288.51M149.32M161.56M165.96M276.78M5.89M
Total Debt582.00K624.00K974.00K0.000.000.00
Total Liabilities10.63M9.32M7.33M4.55M2.75M246.00K
Stockholders Equity291.40M178.95M218.97M249.82M277.18M5.67M
Cash Flow
Free Cash Flow-42.56M-42.33M-33.44M-26.27M-15.39M-330.00K
Operating Cash Flow-42.43M-42.28M-33.34M-26.20M-15.28M-330.00K
Investing Cash Flow59.32M65.14M-54.10M-84.69M-104.00K0.00
Financing Cash Flow140.69M-304.00K-204.00K0.00286.45M5.50M

GH Research Technical Analysis

Technical Analysis Sentiment
Positive
Last Price16.99
Price Trends
50DMA
14.18
Positive
100DMA
13.82
Positive
200DMA
13.05
Positive
Market Momentum
MACD
0.83
Negative
RSI
62.41
Neutral
STOCH
67.98
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For GHRS, the sentiment is Positive. The current price of 16.99 is above the 20-day moving average (MA) of 14.39, above the 50-day MA of 14.18, and above the 200-day MA of 13.05, indicating a bullish trend. The MACD of 0.83 indicates Negative momentum. The RSI at 62.41 is Neutral, neither overbought nor oversold. The STOCH value of 67.98 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for GHRS.

GH Research Risk Analysis

GH Research disclosed 43 risk factors in its most recent earnings report. GH Research reported the most risks in the "Legal & Regulatory" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 3 New Risks
1.
Raising additional capital may cause dilution to holders of our ordinary shares, restrict our operations or require us to relinquish rights to our technologies or product candidates. Q4, 2024
2.
We are a clinical-stage biopharmaceutical company and we have incurred significant losses since our inception. We expect that we will continue to incur significant losses for the foreseeable future. Q4, 2024
3.
We will need substantial additional funding, which may not be available on acceptable terms, or at all. If we are unable to raise capital when needed, we could be forced to delay, reduce or eliminate our product discovery and development programs or commercialization efforts. Q4, 2024

GH Research Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
66
Neutral
$1.27B1,280.560.44%26.54%
53
Neutral
$1.34B-12.86-64.93%-36.36%-945.72%
52
Neutral
$1.05B-23.23-17.86%8.16%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
51
Neutral
$1.24B-4.72-96.11%31.16%
50
Neutral
$1.32B-4.20-41.14%-16.50%33.02%
50
Neutral
$720.24M-2.70-112.34%647.13%26.79%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
GHRS
GH Research
16.99
8.11
91.33%
RLAY
Relay Therapeutics
7.35
2.89
64.80%
TSHA
Taysha Gene Therapies
4.56
3.03
198.04%
SANA
Sana Biotechnology
4.58
1.42
44.94%
PHAR
Pharming Group
18.44
8.43
84.22%
PRME
Prime Medicine, Inc.
3.98
1.09
37.72%

GH Research Corporate Events

GH Research Showcases GH001 Depression Data at ACNP 2026 Mini‑Panel
Jan 15, 2026

On January 15, 2026, GH Research announced that it would present results from three clinical trials of its investigational antidepressant GH001 at a mini‑panel during the 64th American College of Neuropsychopharmacology annual meeting, held January 12‑15, 2026 in Nassau, Bahamas. The session, chaired by psychiatrist Michael E. Thase, features data from a Phase 2b double‑blind, randomized, controlled trial with a six‑month open‑label extension in treatment‑resistant depression, as well as Phase 2a trials in postpartum depression and bipolar II depression, highlighting GH001’s rapid antidepressant effects, improvements in anhedonia and maternal functioning, favorable tolerability, and rapid elimination from breast milk; the high‑profile scientific forum underscores GH Research’s bid to position GH001 within the emerging class of rapid‑acting psychoactive therapies for hard‑to‑treat depressive disorders and may strengthen its visibility among clinicians, researchers and potential partners.

The most recent analyst rating on (GHRS) stock is a Hold with a $16.00 price target. To see the full list of analyst forecasts on GH Research stock, see the GHRS Stock Forecast page.

GH Research Showcases Positive GH001 Phase 2b Data in Treatment-Resistant Depression at ACNP 2026
Jan 13, 2026

On January 13, 2026, GH Research PLC announced that it would present clinical results from its Phase 2b GH001-TRD-201 trial in treatment-resistant depression at the Promising Targets Oral Session of the 64th American College of Neuropsychopharmacology annual meeting, held January 12–15, 2026, in Nassau, Bahamas. The ACNP presentation, delivered by Professor Michael E. Thase, highlights data indicating that GH001 improved illness severity, anxiety symptoms and quality of life over up to six months of follow-up, underscoring the candidate’s potential to address the substantial unmet need in treatment-resistant depression and reinforcing GH Research’s positioning among emerging developers of fast-acting psychedelic medicines.

The most recent analyst rating on (GHRS) stock is a Hold with a $18.00 price target. To see the full list of analyst forecasts on GH Research stock, see the GHRS Stock Forecast page.

GH Research to Present Six-Month Safety and Efficacy Data on Inhaled GH001 in Depression at 2026 ACNP Meeting
Jan 8, 2026

On January 8, 2025, GH Research PLC reported that it will present new clinical data from its GH001-TRD-201 and GH001-BD-202 trials at the 64th American College of Neuropsychopharmacology annual meeting, to be held January 12–15, 2026, in Paradise Island, Bahamas. The accepted posters cover Phase 2b results on rapid antidepressant effects of inhaled GH001 in treatment-resistant depression, detailed safety findings regarding suicidal ideation and behavior in TRD patients, and Phase 2a data in bipolar II disorder with a current major depressive episode. The TRD Phase 2b study, which included a 7‑day randomized, double-blind period followed by a six‑month open-label extension, found that GH001 was generally well tolerated, produced significant reductions in depressive symptoms and did not increase suicidal ideation or suicidal behavior over six months, with no treatment-emergent events involving suicidal intent or behavior and only one transient case of suicidal ideation. These findings, together with the broader program data being showcased at a major neuropsychopharmacology forum, underscore GH001’s potential as a rapid-acting antidepressant option for high-risk TRD and bipolar depression populations, addressing a significant unmet need for therapies that do not exacerbate suicide risk.

The most recent analyst rating on (GHRS) stock is a Buy with a $29.00 price target. To see the full list of analyst forecasts on GH Research stock, see the GHRS Stock Forecast page.

GH Research Wins FDA Clearance to Advance GH001 for Treatment-Resistant Depression
Jan 5, 2026

On January 5, 2026, GH Research announced that the U.S. Food and Drug Administration lifted the clinical hold on its investigational TRD therapy GH001, clearing the drug for clinical investigation in the United States and enabling U.S. patient enrollment. The company plans to align with the FDA on a global Phase 3 program modeled on its Phase 2b trial, which previously met its primary endpoint with a strong MADRS score reduction, high rapid-remission rates, short treatment sessions, and a favorable safety profile, potentially strengthening GH Research’s competitive position in next-generation depression treatments and supporting the integration of GH001 into existing interventional psychiatry practices if later-stage data are positive.

The most recent analyst rating on (GHRS) stock is a Buy with a $19.00 price target. To see the full list of analyst forecasts on GH Research stock, see the GHRS Stock Forecast page.

GH Research Sets January 5 Update on IND Status and Phase 3 Plans for Lead TRD Drug GH001
Jan 2, 2026

On January 2, 2026, GH Research PLC announced that it plans to provide an update on the status of its Investigational New Drug Application (IND) for its lead candidate GH001 with the U.S. Food and Drug Administration, along with details on its global pivotal Phase 3 program in treatment-resistant depression, on January 5, 2026. The planned update signals a key regulatory and clinical development milestone for the company, as progress on GH001’s IND and Phase 3 program will be central to its efforts to bring a potential practice-changing treatment for TRD to market and could materially influence its position in the competitive depression therapeutics landscape.

The most recent analyst rating on (GHRS) stock is a Hold with a $12.50 price target. To see the full list of analyst forecasts on GH Research stock, see the GHRS Stock Forecast page.

GH Research to Present Promising Results on GH001 at ACNP 2026
Nov 24, 2025

GH Research PLC announced its acceptance to present at the 64th American College of Neuropsychopharmacology annual meeting in January 2026, highlighting results from its GH001-TRD-201 clinical trial. The trial demonstrated significant improvements in patients with treatment-resistant depression, showing reductions in illness severity, anxiety symptoms, and enhancements in quality of life. These findings suggest that GH001 could provide durable therapeutic benefits with infrequent retreatments, potentially enhancing the company’s position in the psychiatric treatment market.

The most recent analyst rating on (GHRS) stock is a Buy with a $35.00 price target. To see the full list of analyst forecasts on GH Research stock, see the GHRS Stock Forecast page.

GH Research to Engage at Stifel 2025 Healthcare Conference
Nov 7, 2025

GH Research PLC announced its participation in the Stifel 2025 Healthcare Conference, which is set to occur in New York from November 11-13, 2025. The company plans to engage in a fireside chat and hold one-on-one investor meetings, highlighting its commitment to investor relations and industry engagement.

The most recent analyst rating on (GHRS) stock is a Buy with a $19.00 price target. To see the full list of analyst forecasts on GH Research stock, see the GHRS Stock Forecast page.

GH Research Reports Q3 2025 Financial Results
Nov 6, 2025

On November 6, 2025, GH Research PLC announced its financial results for the third quarter of 2025, highlighting significant operational losses. The company reported a loss from operations of $16.565 million for the quarter, compared to $12.621 million in the same period in 2024. Despite these losses, the company continues to focus on its research and development activities, as indicated by the substantial expenditure in this area. The financial results and business updates were made available through a press release and an investor presentation on the company’s website, reflecting GH Research’s ongoing commitment to transparency with its stakeholders.

The most recent analyst rating on (GHRS) stock is a Buy with a $19.00 price target. To see the full list of analyst forecasts on GH Research stock, see the GHRS Stock Forecast page.

GH Research’s GH001 Trial Results to be Presented at ACNP Meeting
Oct 17, 2025

GH Research PLC announced the acceptance of posters related to its GH001-TRD-201 clinical trial at the upcoming 64th American College of Neuropsychopharmacology annual meeting in January 2026. The trial results indicate that GH001, a synthetic form of mebufotenin, shows promise in reducing depressive symptoms without increasing the risk of suicidal ideation or behavior in patients with treatment-resistant depression, potentially enhancing the company’s position in the mental health treatment market.

The most recent analyst rating on (GHRS) stock is a Buy with a $19.00 price target. To see the full list of analyst forecasts on GH Research stock, see the GHRS Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jan 06, 2026