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Ginkgo Bioworks Holdings (DNA)
NYSE:DNA
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Ginkgo Bioworks Holdings (DNA) AI Stock Analysis

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DNA

Ginkgo Bioworks Holdings

(NYSE:DNA)

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Neutral 46 (OpenAI - 4o)
Rating:46Neutral
Price Target:
$11.00
▼(-2.65% Downside)
Ginkgo Bioworks Holdings faces significant challenges with profitability and cash flow, as reflected in its financial performance and valuation scores. The technical analysis indicates bearish momentum, while the earnings call provides some optimism with strategic cost reductions and a strong cash position. However, the overall outlook remains cautious due to ongoing revenue declines and operational inefficiencies.
Positive Factors
Strong Cash Position
A strong cash position with no bank debt provides Ginkgo Bioworks with financial flexibility to invest in growth opportunities and weather economic downturns.
BARDA Award
Securing a BARDA award enhances Ginkgo's credibility and financial resources, supporting innovation in biomanufacturing and strengthening its market position.
Extended Partnership with Bayer
The extended partnership with Bayer highlights Ginkgo's capability in microbial engineering, securing long-term collaboration with a major industry player.
Negative Factors
Significant Revenue Decline in Cell Engineering
A significant decline in Cell Engineering revenue indicates challenges in maintaining growth and could impact the company's overall financial performance.
Increased Cell Engineering Segment Operating Loss
Rising operating losses in the Cell Engineering segment suggest inefficiencies and could hinder Ginkgo's profitability and cash flow improvements.
Negative Adjusted EBITDA
A negative adjusted EBITDA indicates ongoing operational challenges and may limit Ginkgo's ability to reinvest in its business for future growth.

Ginkgo Bioworks Holdings (DNA) vs. SPDR S&P 500 ETF (SPY)

Ginkgo Bioworks Holdings Business Overview & Revenue Model

Company DescriptionGinkgo Bioworks Holdings, Inc., together with its subsidiaries, develops platform for cell programming. Its platform is used to program cells to enable biological production of products, such as novel therapeutics, food ingredients, and chemicals derived from petroleum. The company serves various end markets, including specialty chemicals, agriculture, food, consumer products, and pharmaceuticals. Ginkgo Bioworks has a partnership with Selecta Biosciences, Inc. to develop ImmTOR technology platform. Ginkgo Bioworks Holdings, Inc. was founded in 2008 and is headquartered in Boston, Massachusetts.
How the Company Makes MoneyGinkgo Bioworks generates revenue through several key streams primarily focused on its partnerships and customer contracts in the biotechnology sector. The company collaborates with various organizations, including pharmaceutical, agricultural, and industrial companies, to develop custom organisms tailored to specific needs. Revenue is generated from service fees for its organism design and development services, as well as from licensing agreements that allow partners to utilize Ginkgo's proprietary technologies. Additionally, Ginkgo may earn royalties from commercialized products developed using its engineered organisms. Significant partnerships with major corporations enhance Ginkgo’s revenue potential by providing access to larger markets and more substantial projects, contributing notably to its earnings.

Ginkgo Bioworks Holdings Key Performance Indicators (KPIs)

Any
Any
Total Active Programs
Total Active Programs
Counts the number of ongoing projects or initiatives, indicating the company's innovation capacity and potential for future revenue streams.
Chart InsightsGinkgo Bioworks' active programs surged until late 2024, but a sharp decline followed, likely due to macroeconomic pressures and reduced demand for outsourcing R&D services. Despite this, the company is strategically expanding into new tools businesses and securing government contracts, which may offset some challenges. The earnings call highlighted significant cost reductions and improved profitability metrics, indicating a focus on financial resilience. However, ongoing net losses and a tough biotech capital market remain concerns, suggesting a cautious outlook for future program growth.
Data provided by:Main Street Data

Ginkgo Bioworks Holdings Earnings Call Summary

Earnings Call Date:Nov 06, 2025
(Q3-2025)
|
Next Earnings Date:Mar 04, 2026
Earnings Call Sentiment Neutral
The earnings call highlighted significant achievements in cost reductions and cash position, as well as strategic expansions and partnerships. However, these were offset by notable challenges in revenue declines and increased operating losses in the Cell Engineering segment. While the company is making strategic moves to position itself for future growth, the current financial metrics present a mixed picture.
Q3-2025 Updates
Positive Updates
Significant Cash Burn Reduction
Ginkgo achieved a dramatic reduction in quarterly cash burn over the last year, decreasing from $114 million in Q3 2024 to $28 million in Q3 2025, a 75% decrease.
Strong Cash Position
The company maintains a robust cash position with $462 million in cash and cash equivalents and no bank debt as of Q3 2025.
Expansion of Frontier Autonomous Lab
Ginkgo is expanding its frontier autonomous lab in Boston, which includes the world's largest RAC install, demonstrating advancements in AI and robotics integration.
BARDA Award
Ginkgo and its partners secured a $22 million award from BARDA for monoclonal antibody manufacturing to improve national security and reduce drug manufacturing costs.
Extended Partnership with Bayer
Ginkgo extended its 5-year partnership with Bayer to engineer microbes for fertilizer production, highlighting a long-term collaboration with a major agricultural company.
Negative Updates
Significant Revenue Decline in Cell Engineering
Cell Engineering revenue was $29 million in Q3 2025, down 61% compared to Q3 2024, mainly due to a $45 million noncash revenue in 2024 from a terminated agreement.
Decreased Revenue-Generating Cell Engineering Programs
The number of revenue-generating Cell Engineering programs decreased by 5% year-over-year, attributed to ongoing program rationalization.
Increased Cell Engineering Segment Operating Loss
Cell Engineering segment operating loss increased to $37 million in Q3 2025 from $5 million in the prior year, largely due to a $21 million shortfall related to a Google Cloud contract.
Negative Adjusted EBITDA
Total adjusted EBITDA in Q3 2025 was negative $56 million, compared to negative $20 million in Q3 2024, influenced by the Google Cloud shortfall expense.
Company Guidance
In the recent call, Ginkgo Bioworks provided detailed guidance on their financial and strategic outlook. For the full year 2025, they reaffirmed their overall revenue guidance of $167 million to $187 million, with Cell Engineering revenue projected at $117 million to $137 million, and Biosecurity revenue expected to be at least $40 million. They also highlighted a significant reduction in cash burn, reporting a 75% decrease from $114 million in Q3 of 2024 to $28 million in Q3 of 2025. The company holds $462 million in cash and cash equivalents with no bank debt, underscoring their strong financial position. Despite a 61% decline in Cell Engineering revenue due to a $45 million noncash revenue in the prior year, they supported 102 revenue-generating programs, attributing a 5% decrease to program rationalization. Biosecurity revenue reached $9 million with a segment gross margin of 19%. In terms of expenses, Cell Engineering R&D costs dropped 8% to $51 million, and G&A expenses decreased 47% to $12 million. Adjusted EBITDA was reported at negative $56 million, down from negative $20 million in the previous year, influenced by a $21 million Google Cloud contract shortfall and the prior year's noncash revenue. Looking ahead, Ginkgo is focused on expanding its AI and automation initiatives, aiming for a significant shift towards a tools business model by 2030, potentially making up 80% of their revenue mix.

Ginkgo Bioworks Holdings Financial Statement Overview

Summary
Ginkgo Bioworks Holdings shows strong gross margins but struggles with profitability and cash flow, reflecting operational inefficiencies and growth challenges. The balance sheet is relatively stable, but the company needs to address its negative cash flows and improve its return on equity to enhance financial health.
Income Statement
45
Neutral
The company exhibits a strong gross profit margin of over 82% in TTM, indicating effective cost management. However, the net profit margin is significantly negative, reflecting substantial losses. Revenue has declined over the past year, suggesting challenges in growth. The negative EBIT and EBITDA margins further highlight operational inefficiencies.
Balance Sheet
55
Neutral
The debt-to-equity ratio is moderate, indicating a balanced approach to leveraging. However, the return on equity is negative, reflecting ongoing losses and inefficiencies in generating shareholder value. The equity ratio remains stable, suggesting a solid asset base relative to equity.
Cash Flow
40
Negative
The company faces negative operating and free cash flows, indicating cash burn. The free cash flow to net income ratio is above 1, suggesting that cash flow losses are less severe than accounting losses. However, the negative growth in free cash flow highlights ongoing cash management challenges.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue230.81M227.04M251.46M477.71M313.84M76.66M
Gross Profit189.72M188.49M197.45M273.49M184.15M61.05M
EBITDA-312.44M-484.39M-821.29M-2.06B-1.81B-108.58M
Net Income-315.19M-547.03M-892.87M-2.10B-1.83B-126.61M
Balance Sheet
Total Assets1.23B1.38B1.67B2.54B2.07B675.15M
Cash, Cash Equivalents and Short-Term Investments473.69M561.57M944.07M1.32B1.55B380.80M
Total Debt428.83M467.73M241.77M442.59M23.03M17.00M
Total Liabilities618.06M661.39M568.19M803.04M503.61M205.10M
Stockholders Equity612.95M716.06M1.10B1.74B1.51B461.38M
Cash Flow
Free Cash Flow-274.17M-382.13M-336.30M-304.47M-310.34M-193.65M
Operating Cash Flow-237.71M-319.58M-295.50M-252.20M-253.82M-135.83M
Investing Cash Flow-285.86M-62.24M-80.69M-67.39M-73.26M-67.12M
Financing Cash Flow-973.00K-1.74M-3.22M95.34M1.53B90.32M

Ginkgo Bioworks Holdings Technical Analysis

Technical Analysis Sentiment
Negative
Last Price11.30
Price Trends
50DMA
12.67
Negative
100DMA
12.19
Negative
200DMA
10.45
Positive
Market Momentum
MACD
-0.43
Positive
RSI
39.95
Neutral
STOCH
9.23
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For DNA, the sentiment is Negative. The current price of 11.3 is below the 20-day moving average (MA) of 13.09, below the 50-day MA of 12.67, and above the 200-day MA of 10.45, indicating a neutral trend. The MACD of -0.43 indicates Positive momentum. The RSI at 39.95 is Neutral, neither overbought nor oversold. The STOCH value of 9.23 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for DNA.

Ginkgo Bioworks Holdings Risk Analysis

Ginkgo Bioworks Holdings disclosed 70 risk factors in its most recent earnings report. Ginkgo Bioworks Holdings reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Ginkgo Bioworks Holdings Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
59
Neutral
$1.46B
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
46
Neutral
$686.13M-43.59%25.21%67.53%
45
Neutral
-29.62%6.66%
44
Neutral
$1.21B-29.42%
34
Underperform
$624.07M-31.16%50.77%
33
Underperform
$1.06B-109.12%7.58%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
DNA
Ginkgo Bioworks Holdings
11.30
2.81
33.10%
SANA
Sana Biotechnology
4.05
1.05
35.00%
TRML
Tourmaline Bio
47.98
19.22
66.83%
ERAS
Erasca
2.24
-0.90
-28.66%
RAPP
Rapport Therapeutics, Inc.
25.36
-1.33
-4.98%
MAZE
Maze Therapeutics, Inc.
29.63
14.63
97.53%

Ginkgo Bioworks Holdings Corporate Events

Ginkgo Bioworks Reports Q3 2025 Financial Results
Nov 7, 2025

Ginkgo Bioworks Holdings, Inc. is a biotechnology company specializing in the development of tools and technologies to make biology easier to engineer, focusing on sectors such as therapeutics, diagnostics, and manufacturing. The company also offers biosecurity solutions to address biological threats.

Business Operations and StrategyPrivate Placements and Financing
Ginkgo Bioworks Enters Sales Agreement for Stock Offering
Neutral
Sep 4, 2025

On September 4, 2025, Ginkgo Bioworks Holdings entered into a Sales Agreement with Allen & Company LLC to potentially sell up to $100 million of its Class A common stock in at-the-market offerings. The proceeds from these sales, if any, are intended for general corporate purposes, including financing operations and technology development. The agreement allows flexibility in selling shares and includes customary rights and termination options for both parties. This move could impact the company’s market positioning by providing additional capital to support its growth and operations in the competitive synthetic biology industry.

The most recent analyst rating on (DNA) stock is a Sell with a $9.00 price target. To see the full list of analyst forecasts on Ginkgo Bioworks Holdings stock, see the DNA Stock Forecast page.

Legal Proceedings
Ginkgo Bioworks Settles Stockholder Derivative Actions
Neutral
Aug 29, 2025

On May 27, 2025, Ginkgo Bioworks Holdings reached a Stipulation and Agreement of Settlement to resolve stockholder derivative actions against certain individuals. The settlement, preliminarily approved by the court on August 21, 2025, includes a $4,125,000 insurance-funded payment, corporate governance reforms, and the dismissal of the actions. A final hearing is set for December 18, 2025.

The most recent analyst rating on (DNA) stock is a Sell with a $9.00 price target. To see the full list of analyst forecasts on Ginkgo Bioworks Holdings stock, see the DNA Stock Forecast page.

Ginkgo Bioworks Earnings Call: Mixed Sentiment and Strategic Growth
Aug 13, 2025

Ginkgo Bioworks Holdings, Inc. recently held its earnings call, revealing a mixed sentiment. The company highlighted significant achievements in cost reduction and financial metrics, alongside successful product launches. However, challenges persist with lowered revenue guidance in the biosecurity segment and ongoing operating losses. Despite these hurdles, Ginkgo is strategically positioned for future growth, particularly in automation and life science tools.

Ginkgo Bioworks Reports Q2 2025 Financial Results
Aug 8, 2025

Ginkgo Bioworks Holdings, Inc. is a company that specializes in cell programming and biosecurity, providing tools for engineering biology and offering services across therapeutics, diagnostics, and manufacturing. In its latest earnings report for the second quarter of 2025, Ginkgo Bioworks announced a total revenue of $50 million, a slight decrease from the previous year. The company reported an 8% increase in cell engineering revenue, driven by demand from biopharma and government sectors, while biosecurity revenue saw a decline. Despite a net loss of $60 million, the company improved its adjusted EBITDA to a loss of $28 million, a significant improvement from the previous year, due to reduced operating expenses. Ginkgo Bioworks highlighted its strategic advancements, including the launch of new services and products, and the achievement of a $250 million cost-saving target ahead of schedule. The company continues to focus on expanding its automation and data capabilities, securing major contracts, and enhancing its service offerings. Looking ahead, Ginkgo Bioworks maintains its revenue outlook for 2025 and aims to reach adjusted EBITDA breakeven by the end of 2026, reflecting confidence in its strategic direction and financial discipline.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 07, 2025