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Ginkgo Bioworks Holdings, Inc. (DNA)
:DNA
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Ginkgo Bioworks Holdings (DNA) AI Stock Analysis

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DNA

Ginkgo Bioworks Holdings

(NYSE:DNA)

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Underperform 40 (OpenAI - 4o)
Rating:40Underperform
Price Target:
$8.50
▲(5.85% Upside)
Ginkgo Bioworks Holdings faces significant financial challenges with declining revenues and substantial losses, which are the most impactful factors in the overall score. Technical indicators also suggest a bearish outlook, and the negative P/E ratio reflects ongoing profitability issues. While strategic expansions and cost reductions are positive, they are insufficient to outweigh the current financial and technical weaknesses.
Positive Factors
Cash Position
A strong cash position with no bank debt provides financial flexibility and stability, allowing Ginkgo to invest in growth initiatives and weather economic uncertainties.
Strategic Partnerships
Long-term partnerships with major companies like Bayer enhance Ginkgo's market position and revenue potential, supporting sustainable business growth through collaborative innovation.
AI and Automation Initiatives
Investing in AI and automation positions Ginkgo for future efficiency gains and revenue diversification, aligning with industry trends towards digital transformation.
Negative Factors
Revenue Decline
Significant revenue decline in key segments like Cell Engineering indicates challenges in maintaining growth, which can impact long-term financial health and market competitiveness.
Operating Losses
Rising operating losses in core segments suggest operational inefficiencies and cost management issues, potentially affecting profitability and strategic execution.
Negative Cash Flows
Persistent negative cash flows limit the company's ability to fund operations and growth internally, increasing reliance on external financing and impacting long-term viability.

Ginkgo Bioworks Holdings (DNA) vs. SPDR S&P 500 ETF (SPY)

Ginkgo Bioworks Holdings Business Overview & Revenue Model

Company DescriptionGinkgo Bioworks Holdings, Inc. is a biotechnology company that specializes in organism engineering. Founded in 2008 and headquartered in Boston, Massachusetts, Ginkgo operates in various sectors, including pharmaceuticals, agriculture, and food production. The company leverages its proprietary platform to design custom microbes for a range of applications, from producing ingredients for consumer products to optimizing agricultural outputs. Ginkgo's core services include strain development, fermentation, and bio-manufacturing, aimed at creating more sustainable and efficient solutions in biotechnology.
How the Company Makes MoneyGinkgo Bioworks generates revenue through several key streams primarily focused on its partnerships and customer contracts in the biotechnology sector. The company collaborates with various organizations, including pharmaceutical, agricultural, and industrial companies, to develop custom organisms tailored to specific needs. Revenue is generated from service fees for its organism design and development services, as well as from licensing agreements that allow partners to utilize Ginkgo's proprietary technologies. Additionally, Ginkgo may earn royalties from commercialized products developed using its engineered organisms. Significant partnerships with major corporations enhance Ginkgo’s revenue potential by providing access to larger markets and more substantial projects, contributing notably to its earnings.

Ginkgo Bioworks Holdings Key Performance Indicators (KPIs)

Any
Any
Total Active Programs
Total Active Programs
Counts the number of ongoing projects or initiatives, indicating the company's innovation capacity and potential for future revenue streams.
Chart InsightsGinkgo Bioworks' active programs surged until late 2024, but a sharp decline followed, likely due to macroeconomic pressures and reduced demand for outsourcing R&D services. Despite this, the company is strategically expanding into new tools businesses and securing government contracts, which may offset some challenges. The earnings call highlighted significant cost reductions and improved profitability metrics, indicating a focus on financial resilience. However, ongoing net losses and a tough biotech capital market remain concerns, suggesting a cautious outlook for future program growth.
Data provided by:The Fly

Ginkgo Bioworks Holdings Earnings Call Summary

Earnings Call Date:Nov 06, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Mar 04, 2026
Earnings Call Sentiment Neutral
The earnings call highlighted significant achievements in cost reductions and cash position, as well as strategic expansions and partnerships. However, these were offset by notable challenges in revenue declines and increased operating losses in the Cell Engineering segment. While the company is making strategic moves to position itself for future growth, the current financial metrics present a mixed picture.
Q3-2025 Updates
Positive Updates
Significant Cash Burn Reduction
Ginkgo achieved a dramatic reduction in quarterly cash burn over the last year, decreasing from $114 million in Q3 2024 to $28 million in Q3 2025, a 75% decrease.
Strong Cash Position
The company maintains a robust cash position with $462 million in cash and cash equivalents and no bank debt as of Q3 2025.
Expansion of Frontier Autonomous Lab
Ginkgo is expanding its frontier autonomous lab in Boston, which includes the world's largest RAC install, demonstrating advancements in AI and robotics integration.
BARDA Award
Ginkgo and its partners secured a $22 million award from BARDA for monoclonal antibody manufacturing to improve national security and reduce drug manufacturing costs.
Extended Partnership with Bayer
Ginkgo extended its 5-year partnership with Bayer to engineer microbes for fertilizer production, highlighting a long-term collaboration with a major agricultural company.
Negative Updates
Significant Revenue Decline in Cell Engineering
Cell Engineering revenue was $29 million in Q3 2025, down 61% compared to Q3 2024, mainly due to a $45 million noncash revenue in 2024 from a terminated agreement.
Decreased Revenue-Generating Cell Engineering Programs
The number of revenue-generating Cell Engineering programs decreased by 5% year-over-year, attributed to ongoing program rationalization.
Increased Cell Engineering Segment Operating Loss
Cell Engineering segment operating loss increased to $37 million in Q3 2025 from $5 million in the prior year, largely due to a $21 million shortfall related to a Google Cloud contract.
Negative Adjusted EBITDA
Total adjusted EBITDA in Q3 2025 was negative $56 million, compared to negative $20 million in Q3 2024, influenced by the Google Cloud shortfall expense.
Company Guidance
In the recent call, Ginkgo Bioworks provided detailed guidance on their financial and strategic outlook. For the full year 2025, they reaffirmed their overall revenue guidance of $167 million to $187 million, with Cell Engineering revenue projected at $117 million to $137 million, and Biosecurity revenue expected to be at least $40 million. They also highlighted a significant reduction in cash burn, reporting a 75% decrease from $114 million in Q3 of 2024 to $28 million in Q3 of 2025. The company holds $462 million in cash and cash equivalents with no bank debt, underscoring their strong financial position. Despite a 61% decline in Cell Engineering revenue due to a $45 million noncash revenue in the prior year, they supported 102 revenue-generating programs, attributing a 5% decrease to program rationalization. Biosecurity revenue reached $9 million with a segment gross margin of 19%. In terms of expenses, Cell Engineering R&D costs dropped 8% to $51 million, and G&A expenses decreased 47% to $12 million. Adjusted EBITDA was reported at negative $56 million, down from negative $20 million in the previous year, influenced by a $21 million Google Cloud contract shortfall and the prior year's noncash revenue. Looking ahead, Ginkgo is focused on expanding its AI and automation initiatives, aiming for a significant shift towards a tools business model by 2030, potentially making up 80% of their revenue mix.

Ginkgo Bioworks Holdings Financial Statement Overview

Summary
Ginkgo Bioworks Holdings is facing significant financial challenges with declining revenues, substantial losses, and negative cash flows. Despite a reasonable debt-to-equity ratio, persistent negative profitability and cash flow issues pose risks to financial stability.
Income Statement
30
Negative
Ginkgo Bioworks Holdings has experienced declining revenue over the TTM period with a significant negative revenue growth rate of -21.75%. The company shows strong gross profit margins, but the net profit margin is deeply negative, indicating substantial losses. EBIT and EBITDA margins are also negative, reflecting operational inefficiencies and high costs relative to revenue.
Balance Sheet
40
Negative
The company's debt-to-equity ratio has increased over time, indicating rising leverage, but remains moderate at 0.76. Return on equity is negative, reflecting ongoing losses. The equity ratio is relatively stable, suggesting a reasonable proportion of equity financing, but the overall financial health is weakened by persistent losses.
Cash Flow
35
Negative
Ginkgo Bioworks Holdings has negative operating and free cash flows, with a declining free cash flow growth rate of -31.73% in the TTM period. The operating cash flow to net income ratio is negative, indicating cash flow challenges. However, the free cash flow to net income ratio is positive, suggesting some ability to cover net losses with free cash flow.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue180.61M227.04M251.46M477.71M313.84M76.66M
Gross Profit131.31M188.49M197.45M273.49M184.15M61.05M
EBITDA-324.47M-484.39M-821.29M-2.06B-1.81B-108.58M
Net Income-339.55M-547.03M-892.87M-2.10B-1.83B-126.61M
Balance Sheet
Total Assets1.19B1.38B1.67B2.54B2.07B675.15M
Cash, Cash Equivalents and Short-Term Investments461.86M561.57M944.07M1.32B1.55B380.80M
Total Debt422.87M467.73M239.31M442.59M23.03M17.00M
Total Liabilities629.38M661.39M568.19M803.04M503.61M205.10M
Stockholders Equity559.78M716.06M1.10B1.74B1.51B461.38M
Cash Flow
Free Cash Flow-187.19M-382.13M-336.30M-304.47M-310.34M-193.65M
Operating Cash Flow-165.82M-319.58M-295.50M-252.20M-253.82M-135.83M
Investing Cash Flow-348.47M-62.24M-80.69M-67.39M-73.26M-67.12M
Financing Cash Flow9.43M-1.74M-3.22M95.34M1.53B90.32M

Ginkgo Bioworks Holdings Technical Analysis

Technical Analysis Sentiment
Negative
Last Price8.03
Price Trends
50DMA
11.91
Negative
100DMA
11.93
Negative
200DMA
10.09
Negative
Market Momentum
MACD
-1.09
Negative
RSI
42.25
Neutral
STOCH
89.41
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For DNA, the sentiment is Negative. The current price of 8.03 is below the 20-day moving average (MA) of 9.44, below the 50-day MA of 11.91, and below the 200-day MA of 10.09, indicating a bearish trend. The MACD of -1.09 indicates Negative momentum. The RSI at 42.25 is Neutral, neither overbought nor oversold. The STOCH value of 89.41 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for DNA.

Ginkgo Bioworks Holdings Risk Analysis

Ginkgo Bioworks Holdings disclosed 70 risk factors in its most recent earnings report. Ginkgo Bioworks Holdings reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Ginkgo Bioworks Holdings Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
59
Neutral
$1.83B-36.13%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
45
Neutral
-29.62%6.66%
44
Neutral
$1.40B-23.41%
40
Underperform
$551.98M-50.02%-17.13%51.74%
34
Underperform
$888.02M-32.00%45.66%
33
Underperform
$1.07B-96.11%31.16%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
DNA
Ginkgo Bioworks Holdings
9.11
0.41
4.71%
SANA
Sana Biotechnology
4.02
1.24
44.60%
TRML
Tourmaline Bio
47.98
21.94
84.25%
ERAS
Erasca
3.13
0.27
9.44%
RAPP
Rapport Therapeutics, Inc.
29.43
6.59
28.85%
MAZE
Maze Therapeutics, Inc.
38.00
23.00
153.33%

Ginkgo Bioworks Holdings Corporate Events

Ginkgo Bioworks Earnings Call: Mixed Sentiments and Strategic Moves
Nov 8, 2025

Ginkgo Bioworks Holdings, Inc. recently held its earnings call, revealing a mixed sentiment among stakeholders. While the company celebrated significant achievements in cost reductions and strategic partnerships, challenges such as revenue declines and increased operating losses in the Cell Engineering segment painted a complex picture of its financial health. Despite these hurdles, Ginkgo’s strategic maneuvers indicate a forward-looking approach aimed at future growth.

Ginkgo Bioworks Reports Q3 2025 Financial Results
Nov 7, 2025

Ginkgo Bioworks Holdings, Inc. is a biotechnology company specializing in the development of tools and technologies to make biology easier to engineer, focusing on sectors such as therapeutics, diagnostics, and manufacturing. The company also offers biosecurity solutions to address biological threats.

Business Operations and StrategyPrivate Placements and Financing
Ginkgo Bioworks Enters Sales Agreement for Stock Offering
Neutral
Sep 4, 2025

On September 4, 2025, Ginkgo Bioworks Holdings entered into a Sales Agreement with Allen & Company LLC to potentially sell up to $100 million of its Class A common stock in at-the-market offerings. The proceeds from these sales, if any, are intended for general corporate purposes, including financing operations and technology development. The agreement allows flexibility in selling shares and includes customary rights and termination options for both parties. This move could impact the company’s market positioning by providing additional capital to support its growth and operations in the competitive synthetic biology industry.

The most recent analyst rating on (DNA) stock is a Sell with a $9.00 price target. To see the full list of analyst forecasts on Ginkgo Bioworks Holdings stock, see the DNA Stock Forecast page.

Legal Proceedings
Ginkgo Bioworks Settles Stockholder Derivative Actions
Neutral
Aug 29, 2025

On May 27, 2025, Ginkgo Bioworks Holdings reached a Stipulation and Agreement of Settlement to resolve stockholder derivative actions against certain individuals. The settlement, preliminarily approved by the court on August 21, 2025, includes a $4,125,000 insurance-funded payment, corporate governance reforms, and the dismissal of the actions. A final hearing is set for December 18, 2025.

The most recent analyst rating on (DNA) stock is a Sell with a $9.00 price target. To see the full list of analyst forecasts on Ginkgo Bioworks Holdings stock, see the DNA Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 28, 2025