Breakthrough Autonomous Lab Validation (OpenAI Collaboration)
Collaborated with OpenAI to connect GPT-5 as an "AI scientist" to Ginkgo's autonomous lab; achieved a 40% improvement vs state-of-the-art on a cell-free protein synthesis challenge over 6 experimental rounds. Demonstrates real-world AI-in-the-loop capability and strong differentiation for autonomous lab offering.
Large Government Contract and Deployment Momentum
Signed a $47 million contract with Pacific Northwest National Labs (DOE) to build a 97-RAC autonomous lab and installed the first 18 robots for the Genesis project, validating interest from federal research customers.
Nebula Facility Scale-Up and Market Demonstrations
Nebula (Boston) now a >50-RAC autonomous lab, hosted 590 visitors during SLAS tours; company plans to expand capacity from ~50 to 100 RACs by H1 to demonstrate scale and attract pharma, national labs and universities.
Material Cash Burn Improvement and 2026 Guidance
Full-year cash burn fell 55% from $383M (2024) to $171M (2025); Q4 cash burn down 15% from $55M to $47M. Provided 2026 cash-burn guidance of $125M–$150M, shifting guidance focus to runway and disciplined investment in autonomous labs.
Significant Reductions in R&D and G&A Expense
Cell Engineering R&D expense decreased 42% year-over-year (from $272M in 2024 to $159M in 2025) and R&D in Q4 decreased 44% (from $50M to $28M). Cell Engineering G&A fell 51% year-over-year (from $115M to $56M) and 40% in Q4 (from $20M to $12M), driven by restructuring.
Improved Segment and Adjusted EBITDA Performance
Cell Engineering operating loss improved materially: full-year loss narrowed from $219M (2024) to $96M (2025); Q4 operating loss narrowed from $38M to $17M. Total adjusted EBITDA improved: Q4 -$36M vs -$57M prior year, and full-year -$167M vs -$293M prior year.
Strategic Biosecurity Divestiture with Continued Minority Stake
Announced plan to divest Biosecurity business to allow focused investment in autonomous labs; company will retain a minority position and expects outside investors to accelerate the biosecurity prime opportunity while freeing Ginkgo capital for core strategy.
Commercial Traction on Data and Services
Datapoints business (data-generation for bio-AI) grew rapidly after a 1.5-year launch, working with ~10 of the top pharma companies and releasing public datasets. Ginkgo has completed ~250 Solutions partnerships over the last decade and is expanding cloud-lab and datapoints services.