Market ChallengesWith practical headwinds already slowing uptake in advanced patients, it's challenging to forecast much early-line use.
Population SizeWith nHCM accounting for a smaller population, the opportunity is unlikely to be much of a top-line driver.
Safety ConcernsODYSSEY revealed concerning safety signals for mavacamten in nonobstructive HCM, with LVEF <50% in 21.5% of patients, heart failure in 6.6%, and atrial tachyarrhythmias in 4.2%.