Analyst Downgrades And Valuation PressureAnalyst downgrades and price target reductions to levels near the announced takeout price reflect limited upside without a competing bidder and raise the risk of valuation compression for the stock.
Asset Base ReductionSeparation and spin-out of preclinical cardiac and collaboration assets will shrink Avidity's retained asset base, potentially reducing the company’s long-term standalone growth profile.
Regulatory And Clinical RiskDependence on successful clinical outcomes and regulatory approvals for key programs such as del-desiran, del-brax and del-zota creates material execution risk that could materially impact valuation if trials fail.