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Cellectar Biosciences (CLRB)
NASDAQ:CLRB

Cellectar Biosciences (CLRB) AI Stock Analysis

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Cellectar Biosciences

(NASDAQ:CLRB)

Rating:34Underperform
Price Target:
Cellectar Biosciences faces significant financial challenges with no revenue generation and heavy reliance on external financing. Technical indicators suggest a bearish trend, and the company's valuation is weakened by negative earnings. Although the earnings call highlighted some clinical and regulatory progress, these are overshadowed by financial and operational setbacks, leading to a below-average overall stock score.
Positive Factors
Financial Position
The company has $34M in cash (above the market cap of ~$10M) and with reduced opex, should have runway into late 2025 and paths forward with earlier-stage assets on what is viewed as a de-risked PDC platform.
Market Opportunities
The radiopharma space is described as active with new opportunities ahead, suggesting potential growth for Cellectar Biosciences.
Regulatory Approval
Cellectar recently held a meeting with the FDA, which confirmed a clear path to accelerated approval for Iopofosine-131 in Waldenstrom’s macroglobulinemia.
Negative Factors
Earnings Performance
Cellectar filed its 10-Q and reported 1Q25 results with a net loss of ($6.6M) and ended the period with $13.9M in cash on the balance sheet, which should fund the company into 4Q25.
Regulatory Challenges
Cellectar announced that after discussions with FDA, the agency is requiring a confirmatory study to support accelerated approval for Iopofosine-131 in Waldenstrom’s macroglobulinemia (WM).
Strategic Uncertainty
As the company now seeks strategic alternatives for its assets, there is significant uncertainty regarding the future development of these programs.

Cellectar Biosciences (CLRB) vs. SPDR S&P 500 ETF (SPY)

Cellectar Biosciences Business Overview & Revenue Model

Company DescriptionCellectar Biosciences, Inc., a clinical biopharmaceutical company, focuses on the discovery, development, and commercialization of drugs for the treatment of cancer. Its lead phospholipid drug conjugate (PDC) candidate is CLR 131 (iopofosine I-131), which is in Phase 2 clinical study in patients with relapsed or refractory (r/r) Waldenstrom's macroglobulinemia and B-cell malignancies; Phase 2B clinical study in r/r multiple myeloma (MM) patients; and Phase I study for various pediatric cancers, r/r head and neck cancers, and R/R MM. The company also develops CLR 1900, a PDC chemotherapeutic program that is in the preclinical development stage to treat solid tumors. It has collaborative PDC programs with Avicenna Oncology GMBH to develop CLR 2000 Series; Orano Med to develop CLR 12120 Series; IntoCell Inc; and LegoChemBio. The company was founded in 2002 and is headquartered in Florham Park, New Jersey.
How the Company Makes MoneyCellectar Biosciences makes money primarily through the development and commercialization of its targeted cancer therapies. The company's revenue model is largely dependent on the successful advancement of its drug candidates through clinical trials and eventual approval by regulatory bodies. Additionally, Cellectar may generate revenue through partnerships, licensing agreements, and collaborations with larger pharmaceutical companies, enabling shared development costs and promotional activities. These partnerships can provide upfront payments, milestone payments, and royalties on sales upon successful commercialization of their therapies.

Cellectar Biosciences Earnings Call Summary

Earnings Call Date:May 13, 2025
(Q1-2025)
|
% Change Since: 69.23%|
Next Earnings Date:Aug 18, 2025
Earnings Call Sentiment Neutral
The earnings call highlighted significant progress in clinical trials and a substantial reduction in net loss, suggesting strong operational improvements. However, financial constraints and reliance on strategic partnerships indicate challenges ahead.
Q1-2025 Updates
Positive Updates
Progress in iopofosine I 131 for Waldenstrom's Macroglobulinemia
Cellectar has made significant progress with iopofosine I 131, demonstrating unique efficacy and safety in Phase 2 trials for Waldenstrom's Macroglobulinemia (WM). Meetings with the FDA regarding accelerated approval and seeking EMA guidance for conditional approval are underway.
Decreased Research and Development Expenses
Research and development expenses decreased from $7.1 million in Q1 2024 to $3.4 million in Q1 2025, largely due to reduced patient follow-up activities and personnel costs.
Net Loss Reduction
Net loss for Q1 2025 was $6.6 million or $0.14 per share, significantly reduced from $26.6 million or $0.91 per share in Q1 2024.
Strong Pipeline Development
Cellectar's pipeline includes promising radiopharmaceutical candidates for pancreatic cancer and triple negative breast cancer, with ongoing studies and preparation for new trials.
Negative Updates
Decreased Cash and Cash Equivalents
Cash and cash equivalents decreased from $23.3 million as of December 31, 2024, to $13.9 million as of March 31, 2025, indicating financial constraints.
Uncertainty in Funding and Strategic Alternatives
The initiation and timing of new trials depend on obtaining necessary funds. Cellectar is exploring strategic alternatives, including mergers and acquisitions, to maximize shareholder value.
Company Guidance
During the Cellectar Biosciences first quarter 2025 conference call, the company presented significant progress in its clinical development pipeline, notably with iopofosine I 131 for Waldenstrom's Macroglobulinemia (WM). The Phase 2 CLOVER WaM trial of iopofosine I 131 demonstrated a major response rate of 58.2% in the overall patient population and 59% in post-BTKI patients, indicating substantial efficacy compared to the typical 10-20% response rates of existing treatments. Cellectar is pursuing accelerated approval from the FDA and conditional approval from the EMA, with a Phase 3 trial planned to enroll about 100 patients per arm. Financially, the company reported a net loss of $6.6 million ($0.14 per share) for Q1 2025, a significant improvement from the $26.6 million ($0.91 per share) loss in Q1 2024, with cash reserves of $13.9 million expected to fund operations into Q4 2025. The company is also exploring strategic alternatives to maximize shareholder value, including potential mergers or acquisitions.

Cellectar Biosciences Financial Statement Overview

Summary
Cellectar Biosciences is in a challenging financial position with zero revenue generation and continuous operational losses. The company heavily relies on external financing for cash flow needs, and its balance sheet shows vulnerabilities with negative or fluctuating equity. The consistent lack of revenue and profitability raises significant concerns about its financial sustainability.
Income Statement
10
Very Negative
Cellectar Biosciences has consistently reported zero revenue over the years, indicating a lack of commercialized products. The company operates at a loss, with significant negative net income each year. The EBIT and EBITDA margins are negative, reflecting operational challenges and lack of profitability.
Balance Sheet
25
Negative
The company exhibits a high dependency on equity financing, as seen in fluctuating stockholder's equity and negative equity in 2023. The debt-to-equity ratio is low, indicating limited use of debt, but the overall financial position is weak due to ongoing losses and negative equity in recent years.
Cash Flow
30
Negative
Cellectar Biosciences shows recurring negative free cash flow, indicating insufficient cash generation from operations. The company relies on financing activities to sustain operations, as evidenced by large financing cash inflows. Operating cash flow has been consistently negative, reflecting operational inefficiencies.
Breakdown
Dec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income StatementTotal Revenue
0.000.000.000.000.00
Gross Profit
0.00-192.38K-238.87K-227.64K-207.93K
EBIT
-51.78M-38.96M-28.81M-24.13M-15.29M
EBITDA
-44.22M-38.77M-28.67M-23.98M-15.15M
Net Income Common Stockholders
-44.58M-37.98M-28.60M-23.97M-14.76M
Balance SheetCash, Cash Equivalents and Short-Term Investments
23.29M9.56M19.87M35.70M57.17M
Total Assets
25.47M12.08M21.59M37.20M58.66M
Total Debt
494.00K552.98K603.83K301.74K421.64K
Net Debt
-22.79M-9.01M-19.26M-35.40M-56.74M
Total Liabilities
11.18M25.85M6.08M4.16M3.86M
Stockholders Equity
14.29M-15.16M15.51M33.05M54.79M
Cash FlowFree Cash Flow
-47.69M-33.24M-25.45M-22.71M-14.00M
Operating Cash Flow
-47.58M-32.38M-25.22M-22.57M-13.93M
Investing Cash Flow
-104.19K-864.04K-225.97K-141.36K-62.35K
Financing Cash Flow
61.41M22.94M9.61M1.25M60.55M

Cellectar Biosciences Technical Analysis

Technical Analysis Sentiment
Positive
Last Price0.44
Price Trends
50DMA
0.29
Positive
100DMA
0.29
Positive
200DMA
0.92
Negative
Market Momentum
MACD
0.04
Negative
RSI
69.33
Neutral
STOCH
36.95
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CLRB, the sentiment is Positive. The current price of 0.44 is above the 20-day moving average (MA) of 0.31, above the 50-day MA of 0.29, and below the 200-day MA of 0.92, indicating a neutral trend. The MACD of 0.04 indicates Negative momentum. The RSI at 69.33 is Neutral, neither overbought nor oversold. The STOCH value of 36.95 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for CLRB.

Cellectar Biosciences Risk Analysis

Cellectar Biosciences disclosed 40 risk factors in its most recent earnings report. Cellectar Biosciences reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 3 New Risks
1.
Our stock price has experienced, and may continue to experience, price fluctuations. Q4, 2024
2.
We identified certain misstatements to our previously issued financial statements and have restated the financial statements described below, which has exposed us to additional risks and uncertainties. Q4, 2024
3.
The biopharmaceutical industry is subject to extensive regulatory obligations and policies that are subject to change, including due to judicial challenges. Q4, 2024

Cellectar Biosciences Peers Comparison

Overall Rating
UnderperformOutperform
Sector (54)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
54
Neutral
$5.38B3.31-45.11%3.29%16.82%0.04%
51
Neutral
$19.25M-49.39%473.46%62.25%
44
Neutral
$36.10M-197.11%
42
Neutral
$14.53M-122.28%
34
Underperform
$16.86M-208.72%56.38%
34
Underperform
$18.54M-616.17%71.39%
33
Underperform
$22.66M-78.32%47.73%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
CLRB
Cellectar Biosciences
0.44
-2.92
-86.90%
CANF
Can-Fite BioPharma
1.08
-2.55
-70.25%
GOVX
GeoVax Labs
1.14
-0.26
-18.57%
AKTX
Akari Therapeutics
1.17
-1.88
-61.64%
SLGL
Sol-Gel Technologies
6.90
-1.50
-17.86%
ELEV
Elevation Oncology
0.38
-2.97
-88.66%

Cellectar Biosciences Corporate Events

Executive/Board ChangesRegulatory Filings and Compliance
Cellectar Biosciences Enhances CEO and COO Severance Benefits
Neutral
Mar 17, 2025

On March 12, 2025, Cellectar Biosciences’ board approved amendments to the employment agreements of its CEO and COO, enhancing their severance benefits in the event of a change in control. Additionally, on March 11, 2025, the board adopted new by-laws to align with Delaware law, revising stockholder nomination procedures and reducing the quorum requirement for meetings.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.