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Cellectar Biosciences (CLRB)
NASDAQ:CLRB
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Cellectar Biosciences (CLRB) AI Stock Analysis

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CLRB

Cellectar Biosciences

(NASDAQ:CLRB)

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Underperform 34 (OpenAI - 4o)
Rating:34Underperform
Price Target:
Cellectar Biosciences faces significant financial challenges with no revenue generation and heavy reliance on external financing. Technical indicators suggest a bearish trend, and the company's valuation is weakened by negative earnings. Although the earnings call highlighted some clinical and regulatory progress, these are overshadowed by financial and operational setbacks, leading to a below-average overall stock score.
Positive Factors
Clinical Success
High clinical success rates for iapopacine indicate strong therapeutic potential, enhancing the company's prospects for FDA approval and market entry.
Regulatory Progress
Regulatory alignment with the FDA for iopofosine's Phase 3 study provides a clear path to market approval, supporting long-term growth potential.
Financial Strengthening
Significant cash inflows from financing activities bolster the company's financial position, extending its cash runway and supporting ongoing R&D efforts.
Negative Factors
Regulatory Delays
Regulatory delays in NDA submission for iopofosine could postpone market entry, impacting revenue generation and strategic timelines.
Increased SG&A Expenses
Rising SG&A expenses due to pre-commercialization efforts may strain financial resources, affecting profitability and operational efficiency.
NASDAQ Compliance Challenges
Non-compliance with NASDAQ listing requirements poses a risk of delisting, which could limit access to capital markets and investor confidence.

Cellectar Biosciences (CLRB) vs. SPDR S&P 500 ETF (SPY)

Cellectar Biosciences Business Overview & Revenue Model

Company DescriptionCellectar Biosciences, Inc. (CLRB) is a clinical-stage biopharmaceutical company focused on discovering and developing drugs for the treatment of cancer. The company specializes in targeted phospholipid ether-drug conjugate (PDC) cancer therapies. Using its proprietary PDC platform, Cellectar aims to deliver effective treatments with minimal side effects by specifically targeting cancer cells and sparing healthy tissue.
How the Company Makes MoneyCellectar Biosciences makes money primarily through the development and commercialization of its targeted cancer therapies. The company's revenue model is largely dependent on the successful advancement of its drug candidates through clinical trials and eventual approval by regulatory bodies. Additionally, Cellectar may generate revenue through partnerships, licensing agreements, and collaborations with larger pharmaceutical companies, enabling shared development costs and promotional activities. These partnerships can provide upfront payments, milestone payments, and royalties on sales upon successful commercialization of their therapies.

Cellectar Biosciences Earnings Call Summary

Earnings Call Date:Nov 13, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Mar 18, 2026
Earnings Call Sentiment Positive
The earnings call highlighted significant regulatory advancements for iopofosine I-131, a strengthened financial position, and positive clinical developments. However, there are concerns about decreased cash reserves and the need for additional funding to proceed with key US trials. Overall, the achievements and progress in regulatory and clinical areas outweigh the challenges, indicating a positive outlook.
Q3-2025 Updates
Positive Updates
Regulatory Advancements for Iopofosine I-131
Received confirmation of eligibility to file for conditional marketing approval in the EU based on the Clover Wham study, with an 80% chance of success. Also planning to submit an NDA for accelerated approval in the US.
Financial Position Strengthened
Raised approximately $12.7 million in recent financings, with a strong balance sheet expected to fund operations into the third quarter of 2026.
Positive Clinical Developments
Initiation of phase 1b study of CLR125 for triple-negative breast cancer and CLR225 targeting pancreatic cancer. Positive data showcased at major conferences.
Reduced Expenses and Net Loss
Research and development expenses decreased to $2.5 million from $5.5 million, and general and administrative expenses decreased to $2.3 million from $7.8 million year-over-year. Net loss reduced to $4.4 million from $14.7 million.
Negative Updates
Decreased Cash and Equivalents
Cash and cash equivalents decreased to $12.6 million from $23.3 million as of December 31, 2024.
Funding Needed for US Trial
Approximately $10 million required to initiate the phase three confirmatory study for iopofosine in the US, with $15 million needed for sufficient enrollment.
Company Guidance
During Cellectar Biosciences' third quarter 2025 earnings call, the company highlighted several key metrics reflecting their progress and strategic plans. They reported cash and cash equivalents of $12.6 million at the end of the quarter, down from $23.3 million at the end of 2024, and raised approximately $12.7 million through recent financings. The company is advancing its lead asset, iopofosine I-131, which has shown promising results as a therapy for Waldenstrom's macroglobulinemia, with eligibility to file for conditional marketing approval in the EU. The FDA has requested twelve-month follow-up data, which Cellectar now plans to use to submit a New Drug Application under the accelerated approval pathway. Additionally, the company is progressing with its CLR125 and CLR225 radiopharmaceutical programs, targeting various solid tumors. Research and development expenses were approximately $2.5 million, while general and administrative expenses were $2.3 million for the quarter. The net loss for the quarter was $4.4 million, significantly reduced from the same period in 2024. These developments position Cellectar Biosciences for potential growth and strategic partnerships.

Cellectar Biosciences Financial Statement Overview

Summary
Cellectar Biosciences is in a challenging financial position with zero revenue generation and continuous operational losses. The company heavily relies on external financing for cash flow needs, and its balance sheet shows vulnerabilities with negative or fluctuating equity. The consistent lack of revenue and profitability raises significant concerns about its financial sustainability.
Income Statement
10
Very Negative
Cellectar Biosciences has consistently reported zero revenue over the years, indicating a lack of commercialized products. The company operates at a loss, with significant negative net income each year. The EBIT and EBITDA margins are negative, reflecting operational challenges and lack of profitability.
Balance Sheet
25
Negative
The company exhibits a high dependency on equity financing, as seen in fluctuating stockholder's equity and negative equity in 2023. The debt-to-equity ratio is low, indicating limited use of debt, but the overall financial position is weak due to ongoing losses and negative equity in recent years.
Cash Flow
30
Negative
Cellectar Biosciences shows recurring negative free cash flow, indicating insufficient cash generation from operations. The company relies on financing activities to sustain operations, as evidenced by large financing cash inflows. Operating cash flow has been consistently negative, reflecting operational inefficiencies.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue0.000.000.000.000.000.00
Gross Profit-52.28K0.000.000.000.000.00
EBITDA-29.39M-51.49M-38.77M-28.67M-23.98M-14.89M
Net Income-18.85M-44.58M-42.77M-31.79M-24.12M-15.09M
Balance Sheet
Total Assets14.63M25.47M12.08M21.59M37.20M58.66M
Cash, Cash Equivalents and Short-Term Investments12.55M23.29M9.56M19.87M35.70M57.17M
Total Debt431.93K494.00K552.98K603.83K301.74K421.64K
Total Liabilities5.25M11.18M25.85M12.05M4.16M3.86M
Stockholders Equity9.38M14.29M-13.78M9.54M33.05M54.79M
Cash Flow
Free Cash Flow-29.75M-47.69M-33.24M-25.45M-22.71M-14.00M
Operating Cash Flow-29.69M-47.58M-32.38M-25.22M-22.57M-13.93M
Investing Cash Flow-61.29K-104.19K-864.04K-225.97K-141.36K-62.35K
Financing Cash Flow8.04M61.41M22.94M9.61M1.25M60.55M

Cellectar Biosciences Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price3.73
Price Trends
50DMA
4.14
Negative
100DMA
4.52
Negative
200DMA
6.65
Negative
Market Momentum
MACD
-0.18
Negative
RSI
56.47
Neutral
STOCH
94.50
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CLRB, the sentiment is Neutral. The current price of 3.73 is above the 20-day moving average (MA) of 3.22, below the 50-day MA of 4.14, and below the 200-day MA of 6.65, indicating a neutral trend. The MACD of -0.18 indicates Negative momentum. The RSI at 56.47 is Neutral, neither overbought nor oversold. The STOCH value of 94.50 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for CLRB.

Cellectar Biosciences Risk Analysis

Cellectar Biosciences disclosed 42 risk factors in its most recent earnings report. Cellectar Biosciences reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Cellectar Biosciences Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
48
Neutral
$11.94M
43
Neutral
$15.60M
41
Neutral
$85.68M-2.54-90.24%-90.43%-382.07%
34
Underperform
$10.69M-0.16-145.42%79.31%
34
Underperform
$25.67M2.47-323.61%
31
Underperform
-196.76%36.27%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
CLRB
Cellectar Biosciences
3.73
-40.07
-91.48%
CANF
Can-Fite BioPharma
0.39
-1.60
-80.40%
NERV
Minerva Neurosciences
3.80
1.60
72.73%
ATON
AlphaTON Capital
1.71
-2.27
-57.04%
LPTX
Leap Therapeutics
2.28
-0.51
-18.28%
EQ
Equillium
0.86
0.14
19.44%

Cellectar Biosciences Corporate Events

Executive/Board ChangesRegulatory Filings and Compliance
Cellectar Biosciences Enhances CEO and COO Severance Benefits
Neutral
Mar 17, 2025

On March 12, 2025, Cellectar Biosciences’ board approved amendments to the employment agreements of its CEO and COO, enhancing their severance benefits in the event of a change in control. Additionally, on March 11, 2025, the board adopted new by-laws to align with Delaware law, revising stockholder nomination procedures and reducing the quorum requirement for meetings.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Apr 22, 2025