Administration Complexity And Safety ConcernsComplex handling and administration requirements and potential safety issues when combining the therapy with chemotherapy may restrict use in community settings and curb adoption.
Clinical Adoption BarriersReliance on surgical resection as a foundational treatment and absence of head-to-head comparisons versus standard immunotherapies could limit clinician uptake despite favorable trial results.
Financial And Manufacturing RisksSignificant cash burn, elevated short interest, and unresolved manufacturing readiness concerns for the regulatory submission could create financing pressure and weigh on investor confidence.