Safety ConcernsSome investors may remain concerned about liver toxicity and dose optimization, despite the DILI reclassification.
Safety ProfileConcerns have been raised regarding the utilization of Bezuclastinib in non-advanced systemic mastocytosis due to its less favorable safety profile compared to Ayvakit.
Stock Rating DowngradeA significant proportion of patients experienced AST/ALT elevations, hair color changes, and diarrhea, which contributed to the downgrade of the stock rating.