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Caris Life Sciences, Inc. (CAI)
NASDAQ:CAI
US Market
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Caris Life Sciences, Inc. (CAI) AI Stock Analysis

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CAI

Caris Life Sciences, Inc.

(NASDAQ:CAI)

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Neutral 47 (OpenAI - 4o)
Rating:47Neutral
Price Target:
$24.00
▼(-0.37% Downside)
The overall stock score is primarily influenced by significant financial challenges and bearish technical indicators. However, the recent earnings call provided a positive outlook with record revenue growth and improved profitability, partially offsetting the negative financial and technical aspects.
Positive Factors
Revenue Growth
The significant revenue growth indicates strong demand for Caris's molecular profiling services, enhancing its competitive position in precision medicine.
Improved Gross Margins
Higher gross margins reflect improved operational efficiency and cost management, contributing to sustainable profitability.
Strong Balance Sheet
A strong cash position provides strategic flexibility for future investments in technology and product development, supporting long-term growth.
Negative Factors
Financial Instability
Ongoing financial instability, marked by negative cash flows and high leverage, poses risks to Caris's ability to sustain operations and invest in growth.
Challenges in Pharma Revenue
Sequential decline in pharma revenue highlights potential volatility and dependency on specific projects, impacting revenue stability.
Complex MRD Approval Process
The complex approval process for MRD products may delay market entry, affecting the company's ability to capitalize on new product opportunities.

Caris Life Sciences, Inc. (CAI) vs. SPDR S&P 500 ETF (SPY)

Caris Life Sciences, Inc. Business Overview & Revenue Model

Company DescriptionCaris Life Sciences, Inc., an artificial intelligence TechBio company, provides molecular profiling services in the United States and internationally. It develops and commercializes solutions to transform healthcare using molecular information, and machine learning algorithms. The company's molecular profiling services portfolio includes MI Profile, a tissue-based molecular profiling solution; and Caris Assure, a blood-based molecular profiling solution for cancer treatment. It also offers pharma research and development services comprising laboratory delivery, strategic data, and research services to biopharmaceutical customers. The company was founded in 2008 and is headquartered in Irving, Texas.
How the Company Makes MoneyCaris Life Sciences generates revenue through the provision of its molecular profiling services to healthcare providers, hospitals, and oncologists. The company charges fees for its tests, which analyze tumor samples to identify genetic alterations and biomarkers that can inform treatment decisions. Key revenue streams include payments for individual tests, subscription models for ongoing services, and partnerships with pharmaceutical companies for drug development and clinical trials. Additionally, Caris may benefit from collaborations with academic institutions and research organizations, which can lead to increased usage of its profiling services in research and clinical practice.

Caris Life Sciences, Inc. Earnings Call Summary

Earnings Call Date:Nov 05, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Aug 18, 2026
Earnings Call Sentiment Positive
Caris Life Sciences delivered an outstanding quarter with record-breaking revenue growth, improved gross margins, and positive profitability metrics. The company achieved significant milestones including a strong balance sheet and increased ASP. However, challenges remain in pharma revenue and the dependency on revenue true-ups. The complex process for MRD approval also presents a challenge.
Q3-2025 Updates
Positive Updates
Record-Breaking Revenue Growth
Total revenues increased 113% year-over-year to $216.8 million. Molecular profiling services revenues rose by over 121% year-over-year to $207.6 million.
Significant Increase in ASP
ASP increased to $4,089 per profile, representing growth of 87% year-over-year. This was primarily due to the new CMS rate of $8,455.
Improved Gross Margins
Gross margins improved significantly to 68%, up from 43.7% in the previous year.
Positive Adjusted EBITDA and Net Income
Generated positive adjusted EBITDA of $51.2 million and net income of $24.3 million. Achieved positive free cash flow of $55.3 million.
Strong Balance Sheet
Cash on hand grew to $760 million, an increase of 4.7% sequentially, providing strategic flexibility.
Clinical Case Volume Growth
Clinical case volumes grew by 18.2% year-over-year, with Caris Assure producing 66% year-over-year case volume growth.
Negative Updates
Challenges in Pharma Revenue
Pharma R&D services revenue declined sequentially, though it was up 18% year-over-year. Several projects and associated customer spend shifted into Q4.
Dependency on Revenue True-Ups
Revenue true-up of $37.9 million due to increased payment activity from commercial payers highlights dependency on true-ups for revenue.
Complex Process for MRD Approval
The process for obtaining MRD CMS approval is complex and lengthy, with no specific launch dates provided.
Company Guidance
During the Caris Life Sciences Third Quarter 2025 Earnings Call, the company reported a remarkable 113% year-over-year increase in total revenues, reaching $216.8 million. This growth was driven by a 121% rise in molecular profiling services to $207.6 million and an 18.3% increase in pharma R&D services to $9.2 million. Clinical case volumes grew 18.2% year-over-year, with molecular profiling revenue seeing an 87% rise in average selling price (ASP) to $4,089 per profile. The company's gross margins improved significantly to 68%, and they achieved a positive adjusted EBITDA of $51.2 million, net income of $24.3 million, and positive free cash flow of $55.3 million. The call highlighted the strategic flexibility provided by a cash reserve of nearly $760 million, allowing for continued investment in technology platforms and new product development.

Caris Life Sciences, Inc. Financial Statement Overview

Summary
Caris Life Sciences, Inc. faces significant financial challenges with declining profitability, negative cash flows, and high leverage, indicating financial instability and risks to future growth.
Income Statement
45
Neutral
Caris Life Sciences, Inc. has experienced a decline in profitability over recent years, with negative net profit margins and EBIT margins indicating operational challenges. Revenue growth has been inconsistent, with a notable decline in 2020. The company has struggled to maintain positive margins, reflecting difficulties in managing costs relative to revenue.
Balance Sheet
30
Negative
The balance sheet shows significant financial leverage, with a negative stockholders' equity and a high debt-to-equity ratio in earlier years. This indicates potential financial instability and risk. The return on equity has been positive but low, suggesting limited returns for shareholders given the high leverage.
Cash Flow
40
Negative
Cash flow analysis reveals negative operating and free cash flows in recent years, indicating liquidity challenges. The free cash flow to net income ratio is positive, suggesting some efficiency in converting income to cash, but the overall cash flow position remains weak.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2020Dec 2019
Income Statement
Total Revenue519.15M412.26M306.13M258.49M294.01M416.54M
Gross Profit318.25M178.78M89.31M80.02M184.16M200.51M
EBITDA-86.22M-182.95M-260.80M-245.89M254.46M248.30M
Net Income-150.05M-281.89M-341.42M-320.83M27.73M31.01M
Balance Sheet
Total Assets984.57M343.73M412.90M717.42M2.61B2.90B
Cash, Cash Equivalents and Short-Term Investments755.49M66.15M121.59M409.62M132.54M46.46M
Total Debt426.74M424.26M217.27M270.87M1.75B2.10B
Total Liabilities506.21M2.84B2.56B2.42B1.91B2.21B
Stockholders Equity478.36M-2.50B-2.14B-1.70B702.24M693.24M
Cash Flow
Free Cash Flow27.20M-253.64M-298.42M-327.96M57.57M-65.14M
Operating Cash Flow38.38M-245.20M-276.10M-285.71M277.02M254.00M
Investing Cash Flow-11.17M52.93M214.77M-282.99M-33.97M-271.87M
Financing Cash Flow661.59M200.29M10.13M10.45M-249.88M-108.48M

Caris Life Sciences, Inc. Risk Analysis

Caris Life Sciences, Inc. disclosed 45 risk factors in its most recent earnings report. Caris Life Sciences, Inc. reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Caris Life Sciences, Inc. Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
47
Neutral
$8.77B
45
Neutral
$9.67M-0.19-81.97%-46.88%34.83%
40
Underperform
$996.00K-8.57%-52.17%
40
Underperform
$10.95M-0.41-67.47%9.63%
34
Underperform
$7.49M-0.16-189.72%70.57%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
CAI
Caris Life Sciences, Inc.
24.09
-3.16
-11.60%
INAB
IN8bio
1.70
-7.41
-81.34%
MSPR
MSP Recovery
0.41
-11.63
-96.59%
NLSP
NLS Pharmaceutics
4.01
-31.59
-88.74%
SNSE
Sensei Biotherapeutics
8.72
-3.28
-27.33%
BOLT
Bolt Biotherapeutics
4.74
-7.26
-60.50%

Caris Life Sciences, Inc. Corporate Events

Caris Life Sciences Reports Record Revenue Growth
Nov 7, 2025

Caris Life Sciences’ recent earnings call painted a picture of robust financial health and strategic growth, marked by record-breaking revenue and improved profitability metrics. The company celebrated significant achievements, including a strong balance sheet and increased average selling price (ASP). However, challenges such as pharma revenue fluctuations and the intricate process for MRD approval were also acknowledged.

Caris Life Sciences Reports Strong Q3 2025 Growth
Nov 6, 2025

Caris Life Sciences, Inc., headquartered in Irving, Texas, is a pioneering AI TechBio company specializing in precision medicine and molecular profiling services to advance healthcare through innovative diagnostic solutions.

Caris Life Sciences Reports Strong Q2 2025 Results
Aug 13, 2025

Caris Life Sciences, Inc., a leading AI TechBio company in the precision medicine sector, focuses on developing innovative diagnostic solutions through comprehensive molecular profiling and advanced AI technologies. In its second quarter of 2025 financial results, Caris Life Sciences reported a significant revenue increase of 81.3% to $181.4 million compared to the same period last year. The company also achieved a positive Adjusted EBITDA of $16.7 million and positive net cash flow from operating activities of $7.3 million, indicating strong operational performance.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 07, 2025