Record Revenue Growth
Total revenue of $216.0M in Q1 2026, up 79% year-over-year, driven primarily by molecular profiling services.
Molecular Profiling Revenue Surge
Molecular profiling services revenue of $211.0M, up 85% year-over-year, supported by both volume growth and higher ASPs.
Volume and Exit Run-Rate Improvement
Completed 52,800 therapy selection cases in Q1, up 15% year-over-year. Exit run-rate for February–March implied ~56,000 completed cases and management expects Q2 >58,000 cases (~10% sequential growth).
Substantial ASP and Gross Margin Expansion
Clinical ASP increased markedly (clinical ASP up 61% YoY). Tissue ASP increased ~70% to over $4,300 and blood ASP increased ~14% to just under $2,500. Molecular profiling gross margin improved to 65% GAAP (from 47% in prior-year Q1), an increase of ~1,800 basis points YoY.
Profitability and Cash Generation
Positive adjusted EBITDA of $26M and positive free cash flow of roughly $22.5–$23M in the quarter; fourth consecutive quarter with both metrics positive.
Strong Balance Sheet and Financing Flexibility
Cash on hand slightly above $825M (up ~$23.4M in the quarter). Refinance completed: new $400M facility led by Blue Owl & Blackstone, saves ~ $6M in annual interest, extends maturity to April 2031 and includes $300M delayed draw term loan for acquisitions.
Large and Growing Data & Commercial Footprint
Platform dataset surpassed 1.07M profiled cases (including >677k whole exomes, 728k whole transcriptomes, ~790k matched profiles). Supporting >6,100 ordering oncologists; ~70% of orders via EHR/portal; >3,000 physicians using EMR integrations.
Product Launches and Pipeline Progress
Launched Caris ChromaSeq (Apr 1) and Caris MI Clarity; Caris ChromaSeq received MolDX pricing at $3,228. Caris Detect (MCED) achieved CLIA validation readout and is in beta/commercial prep with Everlywell.
Caris Detect ACHIEVE-1 Performance
ACHIEVE-1: overall stage I–II sensitivity 60.3% and asymptomatic specificity 99.2% in a 3,014-subject high-risk cohort. Stage sensitivities: Stage I 56.8%, Stage II 67.7%, Stage III 79.0%, Stage IV 98.6%. Cancer-type sensitivities (stage I–II) include breast 53.7%, prostate 74.1%, lung 73.4%, head & neck 81.3%, pancreatic 70%.
Commercial Momentum in Caris Assure and Sales Expansion
Caris Assure volume grew 58% year-over-year and blood volume growth guidance remains high (high-50s to low-60s % range). Field organization expanded from 82 to 146 territories; >270 sales reps at quarter end progressing toward a ~300-person goal, with activations in Feb–Mar up ~20% YoY in same period.