Arcturus Therapeutics (ARCT) AI Stock Analysis

• Market Cap: $304.67M
• Dividend Yield: N/A
• Average Volume (3M): 829.62K
• Price to Earnings (P/E): ―
• Beta (1Y): 2.35
• Revenue Growth: -26.88%
• EPS Growth: 13.41%
• Country: US
• Employees: 174
• Sector: Healthcare
• Sector Strength: 45
• Industry: Biotechnology
• EPS (TTM): -0.34
• Shares Outstanding: 27,154,530
• 10 Day Avg. Volume: 934,920
• 30 Day Avg. Volume: 829,622
• PEG Ratio: N/A
• Price to Book (P/B): N/A
• Price to Sales (P/S): N/A
• P/FCF Ratio: N/A
• Enterprise Value/Market Cap: 0.42
• Enterprise Value/Revenue: 1.09
• Enterprise Value/Gross Profit: 2.43
• Enterprise Value/Ebitda: -2.32
• 1Y Price Target: $25.40
• Price Target Upside: 139.85% Upside
• Rating Consensus: Moderate Buy
• Number of Analyst Covering: 7

• Rating: 52 Neutral
• Price Target: $11.50 ▲(8.59% Upside)

Arcturus Therapeutics' overall stock score is primarily impacted by its financial challenges, including declining revenues and negative cash flow. Technical indicators suggest a bearish trend, while valuation metrics reflect ongoing losses. However, the positive outlook from the earnings call, with progress in therapeutic programs and regulatory advancements, provides some optimism.

Positive Factors

Pipeline Progress

Advancements in ARCT-032 and ARCT-810 programs demonstrate strong R&D capabilities, potentially leading to new revenue streams and market leadership in RNA therapeutics.

Regulatory Advancements

Progress in regulatory filings for the CoStave vaccine indicates potential market entry, enhancing Arcturus' competitive position and expanding its product portfolio.

Financial Stability

A strong cash position and reduced operating expenses provide financial stability, allowing Arcturus to focus on strategic initiatives and long-term growth.

Negative Factors

Revenue Decline

Significant revenue decline indicates challenges in maintaining growth, potentially impacting financial sustainability if not addressed through new partnerships or product launches.

Negative Cash Flow

Persistent negative cash flow highlights operational inefficiencies and could strain resources, limiting investment in R&D and future growth opportunities.

Clinical Trial Challenges

Difficulties in clinical trial enrollment may delay product development timelines, affecting the company's ability to bring new therapies to market and achieve revenue targets.

Arcturus Therapeutics Business Overview & Revenue Model

Company Description

Arcturus Therapeutics Holdings Inc., an RNA medicines company, focuses on the development of vaccines for infectious, and liver and respiratory rare diseases in the United States. The company's development programs comprise LUNAR-OTC development program for ornithine transcarbamylase (OTC) deficiency; and LUNAR-CF program for cystic fibrosis lung disease caused by mutations in cystic fibrosis transmembrane conductance regulator (CFTR) gene, as well as vaccine programs include LUNAR-COV19 and LUNAR-FLU. It has collaboration partnerships with Vinbiocare Biotechnology Joint Stock Company for the manufacture of COVID-19 vaccines; Janssen Pharmaceuticals, Inc. to develop nucleic acid-based therapeutic candidates for the treatment of hepatitis B virus; Ultragenyx Pharmaceutical, Inc. to develop mRNA therapeutic candidates for rare disease targets; CureVac AG to develop mRNA therapeutic and vaccine candidates for various indications; Singapore Economic Development Board and Duke-NUS Medical School to develop LUNAR-COV19 vaccine; and Millennium Pharmaceuticals, Inc. to discover siRNA medicines for the treatment of non-alcoholic steatohepatitis. The company was founded in 2013 and is headquartered in San Diego, California.

How the Company Makes Money

Arcturus Therapeutics generates revenue through a combination of product development partnerships, licensing agreements, and potential future product sales. The company's revenue model includes upfront payments and milestone payments from collaborations with larger pharmaceutical companies, which can significantly contribute to its earnings. Key partnerships, such as those with pharmaceutical giants for the development and commercialization of RNA-based therapies, provide additional funding and resources. Additionally, Arcturus may eventually earn royalties from the sales of products developed under these agreements, further diversifying its revenue streams.

Arcturus Therapeutics Financial Statement Overview

Summary

Arcturus Therapeutics faces significant financial challenges, with declining revenues and persistent losses impacting profitability and cash flow. While the balance sheet remains relatively stable with low leverage, the negative cash flow trends and profitability issues pose risks to financial stability.

Income Statement

Arcturus Therapeutics has experienced a significant decline in revenue from 2022 to TTM, with a negative revenue growth rate. The gross profit margin is positive, but the net profit margin is negative due to substantial net losses. The EBIT and EBITDA margins are also negative, reflecting ongoing operational challenges.

Balance Sheet

The company's balance sheet shows a relatively low debt-to-equity ratio, indicating manageable leverage. However, the return on equity is negative due to net losses. The equity ratio is strong, suggesting a solid capital structure with a significant portion of assets financed by equity.

Cash Flow

Arcturus Therapeutics has negative free cash flow and operating cash flow, indicating cash burn. The free cash flow growth rate is negative, showing deterioration in cash generation. The ratios of operating and free cash flow to net income are not favorable, highlighting cash flow challenges.

Breakdown	TTM	Dec 2024	Dec 2023	Dec 2022	Dec 2021	Dec 2020
Income Statement
Total Revenue	117.50M	138.39M	157.75M	205.75M	12.36M	9.54M
Gross Profit	52.92M	134.84M	154.79M	58.25M	-161.40M	-46.41M
EBITDA	-55.32M	-77.40M	-24.17M	13.70M	-201.66M	-70.64M
Net Income	-60.16M	-80.94M	-29.73M	9.35M	-203.67M	-72.15M
Balance Sheet
Total Assets	309.27M	344.07M	429.40M	450.39M	392.81M	476.46M
Cash, Cash Equivalents and Short-Term Investments	196.47M	237.03M	292.00M	391.88M	370.49M	462.89M
Total Debt	22.93M	28.55M	30.22M	94.75M	69.15M	20.75M
Total Liabilities	78.22M	103.09M	150.89M	180.07M	164.60M	79.90M
Stockholders Equity	231.05M	240.98M	278.51M	270.31M	228.21M	396.55M
Cash Flow
Free Cash Flow	-64.67M	-60.40M	-21.00M	24.27M	-138.45M	-44.60M
Operating Cash Flow	-5.78M	-59.75M	-18.10M	31.99M	-135.04M	-42.86M
Investing Cash Flow	-219.45K	-648.00K	-2.90M	-7.73M	-3.41M	-1.74M
Financing Cash Flow	1.30M	5.42M	-24.09M	-2.86M	48.02M	436.14M

Arcturus Therapeutics Technical Analysis

• Technical Analysis Sentiment: Negative
• Last Price: 10.59
• 50DMA: Negative
• 100DMA: Negative
• 200DMA: Negative
• MACD: Positive
• RSI: Positive
• STOCH: Positive

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ARCT, the sentiment is Negative. The current price of 10.59 is below the 20-day moving average (MA) of 18.54, below the 50-day MA of 18.43, and below the 200-day MA of 14.86, indicating a bearish trend. The MACD of -2.00 indicates Positive momentum. The RSI at 29.73 is Positive, neither overbought nor oversold. The STOCH value of 9.17 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for ARCT.

Arcturus Therapeutics Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
RIGL	―	$537.58M	5.46	376.09%	―	105.62%	―
CMPX	―	$681.14M	―	-51.84%	―	-100.00%	-25.75%
ARVN	―	$676.18M	―	―	―	―	―
ARCT	―	$304.67M	-4.76	-24.57%	―	-26.88%	13.41%
Sector *	―	$7.86B	-0.30	-43.30%	2.27%	22.53%	-2.21%
OLMA	―	$551.13M	―	-49.72%	―	―	6.82%
ERAS	―	$675.13M	―	-31.16%	―	―	50.77%

Arcturus Therapeutics Corporate Events

Arcturus Therapeutics Announces Phase 2 Trial Results

On October 22, 2025, Arcturus Therapeutics announced interim results from its Phase 2 clinical trial of ARCT-032, an investigational mRNA therapy for cystic fibrosis, marking a significant step in its therapeutic development. Additionally, the company is involved in a legal dispute with AbbVie Inc. and others over trade secrets, and is working with CSL Seqirus on regulatory processes for KOSTAIVE, a self-amplifying mRNA vaccine, facing new FDA requirements for additional data.

The most recent analyst rating on (ARCT) stock is a Buy with a $49.00 price target. To see the full list of analyst forecasts on Arcturus Therapeutics stock, see the ARCT Stock Forecast page.

Arcturus Therapeutics Partners on New COVID-19 Vaccine Launch

On September 26, 2025, Meiji Seika Pharma Co., Ltd., a subsidiary of Meiji Holdings Co., Ltd., launched KOSTAIVE®, a self-amplifying mRNA COVID-19 vaccine in Japan. This vaccine targets the SARS-CoV-2 Omicron sublineage JN.1 variant XEC and has shown efficacy against multiple variants in non-clinical studies. The launch follows a distribution agreement with CSL Seqirus for sales in Japan, marking a significant step in the company’s efforts to combat COVID-19.

The most recent analyst rating on (ARCT) stock is a Buy with a $45.00 price target. To see the full list of analyst forecasts on Arcturus Therapeutics stock, see the ARCT Stock Forecast page.

Arcturus Therapeutics’ Earnings Call Highlights Progress and Optimism

Arcturus Therapeutics’ recent earnings call conveyed a generally positive sentiment, highlighting significant progress in key therapeutic programs, financial stability, and advancements in regulatory processes. Despite a decrease in revenue, the company’s strategic restructuring and strong financial position, along with promising clinical trial results, contribute to an optimistic future outlook.

Arcturus Therapeutics’ COVID-19 Vaccine Approved in Japan

On August 29, 2025, Meiji Seika Pharma Co., Ltd., a subsidiary of Meiji Holdings Co., Ltd., announced the approval in Japan for KOSTAIVE®, a self-amplifying mRNA COVID-19 vaccine. This vaccine targets the SARS-CoV-2 Omicron sub lineage JN.1 variant XEC and has shown efficacy against several other variants in non-clinical studies. The vaccine is supplied as a two-dose vial and distribution is set to begin in late September 2025. This development follows a distribution agreement with CSL Seqirus for the Japanese market, potentially strengthening the company’s position in the vaccine industry.

The most recent analyst rating on (ARCT) stock is a Buy with a $54.00 price target. To see the full list of analyst forecasts on Arcturus Therapeutics stock, see the ARCT Stock Forecast page.

Arcturus Therapeutics Reports Q2 2025 Earnings and Pipeline Progress

Arcturus Therapeutics Holdings Inc., based in San Diego, is a commercial mRNA medicines company specializing in liver and respiratory rare disease therapeutics and infectious disease vaccines, utilizing its proprietary LUNAR® and STARR® mRNA technologies.