Aprea Therapeutics Inc (APRE)
NASDAQ:APRE
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Aprea Therapeutics
(NASDAQ:APRE)
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Rating:49Neutral
Price Target:
$0.84
▼(-15.90% Downside)
Action:Reiterated
Date:05/14/26
The score is held back primarily by weak financial performance (ongoing losses and cash burn with dilution risk), partially offset by positive recent corporate developments (new financing extending runway and encouraging early APR-1051 clinical signals). Technicals are neutral-to-mildly improving but still below the 200-day trend, and valuation support is limited due to negative earnings and no dividend.
Positive Factors
Early clinical proof-of-concept (APR-1051)
Early, reproducible tumor responses and tolerability for APR-1051 provide durable proof-of-concept, raising the program’s probability of advancement into later-stage trials, supporting enrollment expansion and potential partnerships or investigator interest that materially strengthen the company’s long-term development pathway.
Negative Factors
Persistent cash burn
Consistent negative operating and free cash flow signal ongoing reliance on external capital to fund R&D. Even with current cash, sustained burn risks needing additional financing if trials extend, which can dilute shareholders and constrain strategic flexibility over the medium term.
Read all positive and negative factors
Positive Factors
Negative Factors
Early clinical proof-of-concept (APR-1051)
Early, reproducible tumor responses and tolerability for APR-1051 provide durable proof-of-concept, raising the program’s probability of advancement into later-stage trials, supporting enrollment expansion and potential partnerships or investigator interest that materially strengthen the company’s long-term development pathway.
Read all positive factors
Aprea Therapeutics (APRE) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$11.76M
Dividend YieldN/A
Average Volume (3M)55.77K
Price to Earnings (P/E)―
Beta (1Y)2.12
Revenue Growth-90.40%
EPS Growth34.76%
CountryUS
Employees8
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-1.75
Shares Outstanding12,382,776
10 Day Avg. Volume84,633
30 Day Avg. Volume55,770
Financial Highlights & Ratios
PEG Ratio0.02
Price to Book (P/B)0.45
Price to Sales (P/S)0.00
P/FCF Ratio-0.43
Enterprise Value/Market Cap-3.43
Enterprise Value/Revenue-341.17
Enterprise Value/Gross Profit22.39
Enterprise Value/Ebitda3.21
Forecast
1Y Price Target
$4.07Price Target Upside306.67% Upside
Rating ConsensusStrong Buy
Number of Analyst Covering3
EPS Forecast (FY)-0.7
Revenue Forecast (FY)N/A
Aprea Therapeutics Business Overview & Revenue Model
Company Description
Aprea Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing and commercializing novel cancer therapeutics that target DNA damage response pathways. Its lead product candidate is ATRN-119, an oral ATR inhibitor that ...
How the Company Makes Money
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Aprea Therapeutics Financial Statement Overview
Summary
Income Statement
12
Very Negative
Balance Sheet
55
Neutral
Cash Flow
18
Very Negative
| Breakdown | TTM | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 118.11K | 0.00 | 1.50M | 583.23K | 0.00 | 0.00 |
| Gross Profit | -1.80M | 0.00 | -7.86M | 576.18K | -16.40M | -271.68K |
| EBITDA | -12.56M | -13.21M | -14.30M | -14.28M | -37.37M | -36.86M |
| Net Income | -11.95M | -12.60M | -12.96M | -14.29M | -112.66M | -36.54M |
Balance Sheet | ||||||
| Total Assets | 48.11M | 15.93M | 23.98M | 22.65M | 30.16M | 56.82M |
| Cash, Cash Equivalents and Short-Term Investments | 46.47M | 14.60M | 22.85M | 21.61M | 28.79M | 53.08M |
| Total Debt | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 190.47K |
| Total Liabilities | 5.30M | 3.49M | 4.67M | 4.39M | 4.51M | 7.32M |
| Stockholders Equity | 42.82M | 12.44M | 19.31M | 18.26M | 25.64M | 49.51M |
Cash Flow | ||||||
| Free Cash Flow | -12.22M | -12.89M | -13.57M | -12.27M | -25.01M | -37.69M |
| Operating Cash Flow | -12.22M | -12.89M | -13.56M | -12.18M | -25.01M | -37.69M |
| Investing Cash Flow | 0.00 | 0.00 | -15.48K | -93.09K | 0.00 | 0.00 |
| Financing Cash Flow | 39.38M | 4.64M | 14.82M | 5.14M | 682.97K | 1.75M |
Aprea Therapeutics Technical Analysis
Positive
1.00
Price Trends
0.83
Positive
0.82
Positive
1.09
Negative
Market Momentum
0.02
Negative
56.49
Neutral
64.00
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For APRE, the sentiment is Positive. The current price of 1 is above the 20-day moving average (MA) of 0.88, above the 50-day MA of 0.83, and below the 200-day MA of 1.09, indicating a neutral trend. The MACD of 0.02 indicates Negative momentum. The RSI at 56.49 is Neutral, neither overbought nor oversold. The STOCH value of 64.00 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for APRE.
Aprea Therapeutics Risk Analysis
Aprea Therapeutics disclosed 79 risk factors in its most recent earnings report. Aprea Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Aprea Therapeutics Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
50 Neutral | $22.39M | -1.78 | -74.15% | ― | -24.96% | 46.11% | |
50 Neutral | $16.44M | -0.32 | -189.72% | ― | ― | 80.68% | |
49 Neutral | $11.76M | -0.45 | -87.05% | ― | -90.40% | 34.76% | |
48 Neutral | $8.41M | -0.25 | -253.43% | ― | ― | 97.61% | |
45 Neutral | $9.35M | -0.65 | -334.42% | ― | ― | 11.92% |
* Healthcare Sector Average
APRE
Aprea Therapeutics
0.91
-0.81
-47.09%
ERNA
Eterna Therapeutics
11.43
-78.19
-87.25%
QNRX
Quoin Pharmaceuticals
4.84
-5.02
-50.91%
NCNA
Nucana
2.00
-5.80
-74.36%
VYNE
VYNE Therapeutics
0.68
-0.32
-32.10%
INAB
IN8bio
1.69
-2.63
-60.85%
Aprea Therapeutics Corporate Events
Business Operations and StrategyFinancial DisclosuresPrivate Placements and Financing
Aprea Therapeutics Highlights Q1 2026 Results and Clinical Progress
Positive
May 13, 2026
On May 13, 2026, Aprea Therapeutics reported first-quarter 2026 results and a corporate update, highlighting clinical progress for WEE1 inhibitor APR-1051 in the Phase 1 ACESOT-1051 trial, including two partial responses and generally favorable to...
Business Operations and StrategyPrivate Placements and Financing
Aprea Therapeutics Raises $30M to Advance Oncology Pipeline
Positive
Apr 1, 2026
Aprea Therapeutics, Inc., a clinical-stage precision oncology company developing targeted therapies for biomarker-defined cancers, has advanced a pipeline led by APR-1051, a WEE1 kinase inhibitor, and ATRN-119, an ATR inhibitor, for solid tumor in...
Business Operations and StrategyPrivate Placements and Financing
Aprea Therapeutics Announces $30 Million Private Placement
Positive
Mar 30, 2026
On March 30, 2026, Aprea Therapeutics entered into a securities purchase agreement for an oversubscribed private placement of pre-funded and common stock warrants to raise approximately $30 million in gross proceeds, with closing expected on or ab...
Business Operations and StrategyExecutive/Board ChangesFinancial DisclosuresPrivate Placements and Financing
Aprea Highlights Early APR-1051 Data and Financial Update
Positive
Mar 16, 2026
On March 16, 2026, Aprea reported fourth-quarter and full-year 2025 results and highlighted early clinical proof-of-concept for WEE1 inhibitor APR-1051 in the Phase 1 ACESOT-1051 trial, where two PPP2R1A-mutated endometrial cancer patients achieve...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.