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Zai Lab (ZLAB)
NASDAQ:ZLAB
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Zai Lab (ZLAB) AI Stock Analysis

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ZLAB

Zai Lab

(NASDAQ:ZLAB)

Rating:52Neutral
Price Target:
$33.00
▲(0.61% Upside)
Zai Lab's overall score is driven by strong earnings call insights, indicating potential future growth and profitability. However, financial performance and valuation scores are weighed down by ongoing losses and cash flow issues, while technical indicators suggest neutral momentum.
Positive Factors
Revenue Growth
Consistent revenue growth indicates strong market demand and effective commercialization strategies, supporting long-term business expansion.
Pipeline Advancements
Advancements in the pipeline, such as ZL-1310, enhance Zai Lab's competitive position and potential for future revenue streams.
Profitability Prospects
Achieving profitability will improve financial stability and investor confidence, enabling reinvestment into growth initiatives.
Negative Factors
Profitability Challenges
Ongoing profitability challenges may hinder financial flexibility and necessitate strategic adjustments to improve margins.
Cash Flow Issues
Cash flow issues can limit operational capabilities and investment in growth, posing risks to long-term sustainability.
Supply Constraints
Supply constraints could impact revenue growth and market share, necessitating strategic management to mitigate disruptions.

Zai Lab (ZLAB) vs. SPDR S&P 500 ETF (SPY)

Zai Lab Business Overview & Revenue Model

Company DescriptionZai Lab Limited develops and commercializes therapies to treat oncology, autoimmune disorders, infectious diseases, and neuroscience primarily in Mainland China and Hong Kong. The company's commercial products include Zejula, a once-daily small-molecule poly polymerase 1/2 inhibitor; Optune, a device that delivers tumor treating fields; NUZYRA for acute bacterial skin and skin structure infections, and community acquired bacterial pneumonia; and Qinlock to treat gastrointestinal stromal tumors. It also develops Odronextamab to treat follicular lymphoma, diffuse large B-cell lymphoma, and other B-celllymphomas; Repotrectinib, a tyrosine kinase inhibitor (TKI) to target ROS1 and TRK A/B/C in TKI-naïve- or -pretreated cancer patients; Margetuximab for the treatment of breast and gastroesophageal cancers; Adagrasib for treating KRAS-G12C-mutated NSCLC, colorectal cancer, pancreatic cancer, and other solid tumors; and Bemarituzumab to treat gastric and gastroesophageal junction cancer. In addition, the company develops CLN-081 for the treatment of patients with EGFR exon 20 insertion NSCLC; Elzovantinib, an orally bioavailable multi-targeted kinase inhibitor; Tebotelimab, a tetravalent IgG4 monoclonal antibody; Retifanlimab that inhibits interactions between PD-1 and its ligands; ZL-2309, an orally active, selective, and ATP-competitive cell division cycle 7 (CDC7) kinase inhibitor; ZL-1201, a humanized IgG4 monoclonal antibody; Efgartigimod to reduce disease-causing immunoglobulin G antibodies; ZL-1102, a human nanobody targeting interleukin- 17A; KarXT for the treatment of psychiatric and neurological conditions; ZL-2313, an investigational inhibitor of triple-mutant EGFR harboring; ZL-2314, an investigational inhibitor of double-mutant EGFR harboring; and Sulbactam/durlobactam for the treatment of serious infections caused by Acinetobacter. Zai Lab Limited was incorporated in 2013 and is headquartered in Shanghai, China.
How the Company Makes MoneyZai Lab generates revenue through multiple streams primarily focused on the development and commercialization of its therapeutic products. The company earns money from product sales of its approved therapies, as well as milestone payments from partnerships with larger pharmaceutical companies. These partnerships often involve collaboration agreements where Zai Lab retains certain rights to develop and market drugs in specific territories, further enhancing its revenue potential. Additionally, Zai Lab may receive royalties on sales from partnered products, which contribute to its overall earnings. The company's strategic focus on innovative therapies, coupled with a strong pipeline of drug candidates, positions it to capitalize on growing market opportunities within the biopharmaceutical industry.

Zai Lab Earnings Call Summary

Earnings Call Date:Aug 07, 2025
(Q2-2025)
|
% Change Since: |
Next Earnings Date:Nov 11, 2025
Earnings Call Sentiment Positive
The earnings call presents a generally positive outlook for Zai Lab, with strong revenue growth and a clear path towards profitability. VYVGART shows significant promise in the Chinese market, supported by updated guidelines. However, there are challenges such as competitive pressures on ZEJULA and supply issues affecting XACDURO. The company's diversified pipeline and strategic use of AI and local expertise provide a solid foundation for future growth.
Q2-2025 Updates
Positive Updates
Strong Revenue Growth
Total revenue grew 9% year-over-year to $110 million in the second quarter, driven by higher sales of VYVGART and other products.
Profitability on Horizon
Zai Lab is on track to achieve profitability in the fourth quarter of 2025 on an adjusted basis, with operating loss reduced by 37%.
VYVGART Momentum
Strong commercial execution for VYVGART in gMG with record levels of patient utilization and new patient starts, supported by updated national MG guidelines in China.
Pipeline Advancements
Progress in the pipeline with promising data for ZL-1310 in small cell lung cancer and multiple upcoming regulatory submissions.
Negative Updates
ZEJULA Performance
ZEJULA experienced a softer quarter due to evolving competitive dynamics within the PARP class, though signs of stabilization are emerging.
Supply Constraints
Supply constraints may limit near-term growth for XACDURO, a product with strong underlying demand.
Company Guidance
During the second quarter of 2025, Zai Lab reaffirmed its full-year revenue guidance of USD 560 million to USD 590 million and announced its trajectory towards achieving profitability in the fourth quarter. The company emphasized strong commercial execution, particularly with VYVGART, which showed record levels of patient utilization and increasing treatment duration, positioning it for significant long-term growth in China. Zai Lab's regional business is poised for substantial growth with the expected approvals of KarXT in schizophrenia and TIVDAK in cervical cancer. The company is also advancing its global R&D pipeline, with ZL-1310 (DLL3 ADC) demonstrating promising results in small cell lung cancer. Furthermore, Zai Lab is exploring label expansion opportunities for VYVGART across multiple immunology indications and expects it could exceed $1 billion in peak sales. Overall, Zai Lab continues to leverage its scalable commercial model and strategic investments to drive long-term growth and value.

Zai Lab Financial Statement Overview

Summary
Zai Lab shows strong revenue growth but faces significant profitability challenges with negative profit margins and return on equity. The balance sheet is stable with low leverage, but cash flow issues highlight the need for improved operational efficiency.
Income Statement
45
Neutral
Zai Lab's revenue has shown consistent growth, with a TTM increase of 2.27%. However, the company is still operating at a loss, with negative net profit and EBIT margins. The gross profit margin is relatively healthy at 63.45%, indicating good control over production costs. The negative net profit margin of -60.26% highlights significant challenges in achieving profitability.
Balance Sheet
55
Neutral
The company maintains a low debt-to-equity ratio of 0.24, suggesting conservative leverage. However, the return on equity is negative at -33.35%, reflecting ongoing losses. The equity ratio is strong, indicating a solid capital structure with stockholders' equity making up a significant portion of total assets.
Cash Flow
40
Negative
Zai Lab's cash flow situation is concerning, with negative operating and free cash flows. The free cash flow growth rate is negative, and the operating cash flow to net income ratio is below 1, indicating inefficiencies in converting income to cash. The free cash flow to net income ratio is above 1, suggesting some ability to cover net losses with free cash flow.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue427.80M398.99M266.72M215.04M144.31M48.96M
Gross Profit267.14M251.13M170.90M141.02M92.07M32.22M
EBITDA-212.18M-234.57M-365.11M-384.66M-689.46M-262.96M
Net Income-212.52M-257.10M-334.62M-443.29M-704.47M-268.90M
Balance Sheet
Total Assets1.16B1.19B1.04B1.22B1.61B1.30B
Cash, Cash Equivalents and Short-Term Investments732.16M779.67M806.45M1.01B1.41B1.19B
Total Debt191.40M153.47M15.15M20.39M15.54M18.60M
Total Liabilities372.37M344.86M240.18M174.54M230.00M128.29M
Stockholders Equity791.74M840.90M796.12M1.05B1.38B1.17B
Cash Flow
Free Cash Flow-227.37M-276.39M-206.67M-392.63M-568.18M-226.72M
Operating Cash Flow-175.31M-214.87M-198.18M-367.64M-549.23M-216.06M
Investing Cash Flow-54.43M-375.19M-10.78M420.02M249.96M-554.83M
Financing Cash Flow332.01M349.89M-6.43M-1.73M820.20M1.13B

Zai Lab Technical Analysis

Technical Analysis Sentiment
Positive
Last Price32.80
Price Trends
50DMA
34.85
Negative
100DMA
34.23
Negative
200DMA
32.04
Positive
Market Momentum
MACD
-1.15
Negative
RSI
48.82
Neutral
STOCH
62.45
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ZLAB, the sentiment is Positive. The current price of 32.8 is below the 20-day moving average (MA) of 32.87, below the 50-day MA of 34.85, and above the 200-day MA of 32.04, indicating a neutral trend. The MACD of -1.15 indicates Negative momentum. The RSI at 48.82 is Neutral, neither overbought nor oversold. The STOCH value of 62.45 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for ZLAB.

Zai Lab Risk Analysis

Zai Lab disclosed 100 risk factors in its most recent earnings report. Zai Lab reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Zai Lab Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
76
Outperform
$4.18B29.2315.61%116.09%35.29%
73
Outperform
$3.98B17.7433.18%14.41%627.78%
62
Neutral
$5.28B-48.54%59.77%-92.92%
58
Neutral
$4.85B8.7633.08%96.00%
52
Neutral
$3.73B-28.39%32.56%33.33%
51
Neutral
$7.92B-0.36-43.38%2.24%22.38%-2.16%
51
Neutral
$4.23B-42.75%-60.63%-216.87%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ZLAB
Zai Lab
32.80
12.12
58.61%
ACAD
ACADIA Pharmaceuticals
23.61
7.47
46.28%
PTCT
PTC Therapeutics
61.09
27.32
80.90%
MRUS
Merus
69.58
19.38
38.61%
KRYS
Krystal Biotech
143.68
-50.59
-26.04%
ACLX
Arcellx Inc
76.19
-0.82
-1.06%
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Sep 13, 2025