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Xeris Pharmaceuticals (XERS)
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Xeris Pharmaceuticals (XERS) AI Stock Analysis

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XERS

Xeris Pharmaceuticals

(NASDAQ:XERS)

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Neutral 49 (OpenAI - 4o)
Rating:49Neutral
Price Target:
$7.50
▼(-17.40% Downside)
Xeris Pharmaceuticals' overall stock score is driven by its strong earnings call performance, which highlights record revenue growth and strategic plans for future growth. However, significant challenges in financial stability, profitability, and bearish technical indicators weigh heavily on the score.
Positive Factors
Revenue Growth
Strong revenue growth indicates successful product adoption and market expansion, providing a solid foundation for future earnings.
Product Performance
RECORLEV's substantial revenue growth underscores its market acceptance and potential as a key revenue driver, enhancing long-term business prospects.
Cash Flow and Profitability
Achieving positive cash flow and net income marks a critical milestone, improving financial stability and supporting future investments.
Negative Factors
Financial Leverage
High financial leverage poses risks to financial stability, potentially limiting flexibility and increasing vulnerability to market fluctuations.
Profitability Challenges
Ongoing profitability challenges highlight operational inefficiencies, which could hinder long-term growth and shareholder value.
Increased Expenses
Rising expenses, particularly in R&D, could pressure margins and require careful management to ensure sustainable growth.

Xeris Pharmaceuticals (XERS) vs. SPDR S&P 500 ETF (SPY)

Xeris Pharmaceuticals Business Overview & Revenue Model

Company DescriptionXeris Pharmaceuticals, Inc. is a biotechnology company focused on developing and commercializing innovative therapeutics for the treatment of chronic and acute diseases. The company primarily operates in the pharmaceutical sector, specializing in formulation technologies that allow for the delivery of biologics and other complex drugs. Xeris is known for its proprietary formulations of injectable medications, including its flagship product, XeriJect, which aims to enhance the convenience and efficacy of drug delivery for patients with diabetes and other conditions.
How the Company Makes MoneyXeris Pharmaceuticals generates revenue primarily through the commercialization of its proprietary products, such as XeriJect and other formulations in its pipeline. The company's revenue model includes sales of these products to healthcare providers and patients, as well as potential licensing agreements with larger pharmaceutical companies. Additionally, Xeris may benefit from partnerships that provide upfront payments, milestone payments, and royalties based on sales of partnered products. The company’s focus on innovative delivery systems positions it to capture market share in the growing injectable drug market, thereby contributing to its overall earnings.

Xeris Pharmaceuticals Earnings Call Summary

Earnings Call Date:Nov 06, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Mar 11, 2026
Earnings Call Sentiment Positive
The earnings call highlighted Xeris Biopharma's strong financial performance with record revenue growth and successful product performance, particularly for RECORLEV. However, there are increased expenses and potential competitive challenges on the horizon. Despite these concerns, the company's positive financial milestones and strategic growth plans suggest an optimistic outlook.
Q3-2025 Updates
Positive Updates
Record-Breaking Revenue Growth
Total product revenue exceeded $74 million, representing a 40% increase year-over-year. The full year total revenue guidance was raised to be in the range of $285 million to $290 million, a 42% increase at the midpoint.
RECORLEV Performance
RECORLEV remained the primary growth engine with revenue of $37 million in the quarter, a year-over-year increase of 109%. The average number of patients on therapy grew by 108% versus the same period last year.
Gvoke and KEVEYIS Performance
Gvoke delivered a solid quarter with revenue of more than $25 million, up nearly 10% from the same period last year. KEVEYIS revenue was approximately $12 million, driven by growth in the average number of patients on therapy.
Financial Milestones
The company generated significant positive cash flow and net income for the first time in its history. Adjusted EBITDA for the quarter was $17.4 million, improving more than $20 million compared to Q3 2024.
Negative Updates
Increased Expenses
R&D expenses increased by $1.6 million compared to the previous year, primarily due to continued investment in the pipeline and technology platforms. SG&A expenses also rose by approximately 3% due to incremental personnel-related expenses.
Potential Impact of Competition
There is anticipation of new competition from Corcept's relacorilant, which could impact RECORLEV, though the company remains optimistic about overall market growth.
Company Guidance
During the Xeris Biopharma Q3 2025 earnings call, the company provided robust guidance, highlighting a record-setting quarter with total product revenue exceeding $74 million, marking a 40% year-over-year increase. The company raised the lower end of its full-year total revenue guidance to between $285 million and $290 million, reflecting a 42% increase at the midpoint compared to 2024. Key metrics driving this growth included a 109% increase in RECORLEV revenue, reaching $37 million, and a 108% rise in the average number of patients on RECORLEV therapy. Gvoke's revenue was over $25 million, up nearly 10% year-over-year, while KEVEYIS generated approximately $12 million, driven by new patient additions. Additionally, the company reported improving gross margins at 85%, significant positive cash flow, and net income for the first time. Looking forward, Xeris plans strategic investments in its RECORLEV commercial organization and the development of XP-8121, aiming to maintain positive adjusted EBITDA amidst a continued focus on scalable growth.

Xeris Pharmaceuticals Financial Statement Overview

Summary
Xeris Pharmaceuticals is experiencing revenue growth but faces significant challenges in profitability and financial stability. The high leverage and negative equity position pose risks, while cash flow management remains a critical area for improvement.
Income Statement
45
Neutral
Xeris Pharmaceuticals shows a positive revenue growth rate of 8.18% in the TTM, indicating a growing top line. However, the company is struggling with profitability, as evidenced by a negative net profit margin of -13.01% and a negative EBIT margin. The gross profit margin remains strong at 81.14%, but the company needs to address its operational inefficiencies to improve overall profitability.
Balance Sheet
30
Negative
The balance sheet reveals significant financial leverage with a high debt-to-equity ratio of -13.32 in the TTM, indicating potential financial risk. The negative stockholders' equity suggests that liabilities exceed assets, which is concerning. Return on equity is positive at 1.14%, but this is due to negative equity, which distorts the metric.
Cash Flow
40
Negative
The cash flow statement shows a concerning decline in free cash flow growth of -398.69% in the TTM, highlighting cash management challenges. However, the free cash flow to net income ratio is positive at 1.05, indicating that the company is generating cash relative to its net losses. The operating cash flow to net income ratio is negative, reflecting ongoing operational cash flow issues.
BreakdownTTMDec 2024Dec 2023Dec 2023Dec 2023Dec 2023
Income Statement
Total Revenue266.14M203.07M163.91M163.91M163.91M163.91M
Gross Profit222.33M166.24M135.27M135.27M135.27M135.27M
EBITDA26.62M-13.99M-23.73M-23.73M-23.73M-23.73M
Net Income-15.64M-54.84M-62.26M-62.26M-62.26M-62.26M
Balance Sheet
Total Assets370.19M323.06M322.60M322.60M322.60M322.60M
Cash, Cash Equivalents and Short-Term Investments91.60M71.62M72.45M72.45M72.45M72.45M
Total Debt38.19M271.45M229.19M229.19M229.19M229.19M
Total Liabilities371.05M352.68M329.38M329.38M329.38M329.38M
Stockholders Equity-861.00K-29.61M-6.78M-6.78M-6.78M-6.78M
Cash Flow
Free Cash Flow19.82M-37.85M-49.29M-49.29M-49.29M-49.29M
Operating Cash Flow10.56M-36.98M-47.02M-47.02M-47.02M-47.02M
Investing Cash Flow9.65M4.88M-6.00M-6.00M-6.00M-6.00M
Financing Cash Flow12.05M36.17M-1.61M-1.61M-1.61M-1.61M

Xeris Pharmaceuticals Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price9.08
Price Trends
50DMA
8.26
Negative
100DMA
7.42
Negative
200DMA
5.99
Positive
Market Momentum
MACD
-0.45
Positive
RSI
37.98
Neutral
STOCH
42.03
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For XERS, the sentiment is Neutral. The current price of 9.08 is above the 20-day moving average (MA) of 7.89, above the 50-day MA of 8.26, and above the 200-day MA of 5.99, indicating a neutral trend. The MACD of -0.45 indicates Positive momentum. The RSI at 37.98 is Neutral, neither overbought nor oversold. The STOCH value of 42.03 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for XERS.

Xeris Pharmaceuticals Risk Analysis

Xeris Pharmaceuticals disclosed 83 risk factors in its most recent earnings report. Xeris Pharmaceuticals reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Xeris Pharmaceuticals Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
60
Neutral
$1.78B47.3015.02%1128.17%
58
Neutral
$2.06B-18.46%116.21%43.93%
57
Neutral
$3.16B-68.13%-8.75%-8.79%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
49
Neutral
$1.59B42.05%76.50%
48
Neutral
$1.69B-129.32%597.19%0.45%
44
Neutral
$1.40B-23.41%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
XERS
Xeris Pharmaceuticals
7.18
3.90
118.90%
SNDX
Syndax Pharmaceuticals
19.87
3.15
18.84%
ZYME
Zymeworks
27.33
13.24
93.97%
RCUS
Arcus Biosciences
25.56
10.12
65.54%
STOK
Stoke Therapeutics
31.21
19.10
157.72%
RAPP
Rapport Therapeutics, Inc.
29.43
6.59
28.85%

Xeris Pharmaceuticals Corporate Events

Xeris Biopharma Reports Strong Q3 2025 Financial Results
Nov 7, 2025

Xeris Biopharma Holdings, Inc. is a rapidly expanding biopharmaceutical company dedicated to enhancing patient lives through the development and commercialization of innovative therapeutic products. The company operates in the healthcare sector, with a focus on treatments for conditions such as endogenous Cushing’s syndrome, severe hypoglycemia, and primary periodic paralysis.

Xeris Biopharma Reports Record Revenue Growth in Earnings Call
Nov 7, 2025

Xeris Biopharma’s recent earnings call painted a picture of robust financial health and strategic optimism. The company reported record revenue growth, driven by strong product performance, particularly from RECORLEV. Despite facing increased expenses and potential competitive pressures, Xeris remains confident in its strategic growth plans and financial milestones, suggesting a positive outlook.

Xeris Pharmaceuticals Reports Record Revenue and Growth
Aug 13, 2025

Xeris Pharmaceuticals’ recent earnings call painted a picture of robust financial health and promising growth prospects. The company reported a record-breaking quarter with significant revenue growth and increased demand for its key products, particularly Recorlev. Despite some challenges, such as increased expenses and a slight decline in gross margin, the overall sentiment was positive, with raised revenue guidance and a favorable adjusted EBITDA.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 13, 2025