Promising Outlook on Xenon Pharmaceuticals: Buy Rating Backed by Innovative Pain Treatment Developments11:49 AM F r o m : Research S e n t : 1:55 PM S u b j e c t : Xenon Pharmaceu cals Inc. (NASDAQ:XENE, $39.55). Webinar Encouraging. Both have advanced into phase 1 testing in healthy volunteers with results expected next year. Trial design was not discussed in detail, however, results should include safety/tolerability, PK and possibly PD and induced pain response endpoints. Based on the emerging profiles of XEN1120 and XEN1701, both could be attractive in multiple pain settings including acute and chronic nociceptive (tissue injury) as well as neuropathic (nervous system dysfunction) pain - together affecting 125-130 million individuals in the U.S.